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This meeting took place in 2011
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Mechanisms of Cardiac Growth, Death and Regeneration (X3)
Organizer(s) Richard N. Kitsis, Ivor J. Benjamin and Charles E. Murry
February 22—27, 2011
Keystone Resort • Keystone, CO USA
Abstract Deadline: Oct 21, 2010
Late Abstract Deadline: Nov 23, 2010
Scholarship Deadline: Oct 21, 2010
Early Registration Deadline: Dec 22, 2010
Supported by the Directors' Fund
Summary of Meeting:
Cardiovascular disease is the major cause of death in the world. Although advances have been made in our understanding of cardiac biology and pathobiology, significant conceptual and practical gaps remain. This meeting – in combination with a concurrent meeting on Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics – will address these gaps by focusing on fundamental mechanisms that regulate cardiac structure, function, and repair and how they relate to human disease. These paired cardiovascular-centric meetings bring diverse areas under an umbrella focused on the heart in health and disease. While primarily basic science-based, each meeting uniquely incorporates bench-to-bedside novel therapeutics sessions with the goal of broadening the attraction of this meeting to investigators from academia, pharma, biotechnology, and in the clinical enterprise. Both meetings deal with hypertrophy and heart failure, and disease. The focus of the Mechanisms of Cardiac Growth, Death and Regeneration meeting includes stem cells and stem cell/tissue engineering, and therefore this meeting occupies a unique position with respect to cardiac stem cell biology meetings.
View Scholarships/Awards
Cardiovascular disease is the major cause of death in the world. Although advances have been made in our understanding of cardiac biology and pathobiology, significant conceptual and practical gaps remain. This meeting – in combination with a concurrent meeting on Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics – will address these gaps by focusing on fundamental mechanisms that regulate cardiac structure, function, and repair and how they relate to human disease. These paired cardiovascular-centric meetings bring diverse areas under an umbrella focused on the heart in health and disease. While primarily basic science-based, each meeting uniquely incorporates bench-to-bedside novel therapeutics sessions with the goal of broadening the attraction of this meeting to investigators from academia, pharma, biotechnology, and in the clinical enterprise. Both meetings deal with hypertrophy and heart failure, and disease. The focus of the Mechanisms of Cardiac Growth, Death and Regeneration meeting includes stem cells and stem cell/tissue engineering, and therefore this meeting occupies a unique position with respect to cardiac stem cell biology meetings.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, FEBRUARY 22
WEDNESDAY, FEBRUARY 23
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
THURSDAY, FEBRUARY 24
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
FRIDAY, FEBRUARY 25
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
SATURDAY, FEBRUARY 26
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
SUNDAY, FEBRUARY 27
Conference Program Print | View meeting in 24 hr (international) time
TUESDAY, FEBRUARY 22
7:15—9:30 PM
Welcome and Keynote Session (Joint)
*
Richard N. Kitsis,
Albert Einstein College of Medicine, USA
*
Joseph M. Metzger,
University of Minnesota Medical School, USA
Robert J. Lefkowitz,
HHMI/Duke University Medical Center, USA
Pleiotropic Signaling from G Protein-Coupled Receptors
Pleiotropic Signaling from G Protein-Coupled Receptors
Joanna Wysocka,
Stanford University, USA
Chromatin, Enhancers and Emergence of Epigenomes in Development
Chromatin, Enhancers and Emergence of Epigenomes in Development
8:00—11:00 AM
Genetic and Epigenetic Specification of Cardiac Structure and Function (Joint)
Christine E. Seidman,
Harvard Medical School, USA
Finding Missing Mutations in DCM
Finding Missing Mutations in DCM
Elizabeth M. McNally,
Northwestern University, USA
Genetic Modifiers for Heart and Muscle Disease
Genetic Modifiers for Heart and Muscle Disease
Jean E. Schaffer,
Joslin Diabetes Center, Harvard Medical School, USA
Unexpected Regulators of Metabolic Stress
Unexpected Regulators of Metabolic Stress
Roger Foo,
Genome Institute of Singapore, Singapore
Short Talk: Distinct Epigenomic Features of Human Heart Failure
Short Talk: Distinct Epigenomic Features of Human Heart Failure
3:30—4:30 PM
Workshop 1: Early Independent Career Research Competition (Joint)
The Early Independent Career Research Competition will be for independent faculty (Independent Junior Research Faculty/Assistant Professors (not tenured)). There will be no reference to age. Abstracts submitted to this competition will be rated by the organizers. The top submissions will be selected for oral presentation in these sessions in addition to poster sessions. The referees will select a winner from the presenters. The winners from the two competitions will be announced on the final night of the meeting.
*
Ivor J. Benjamin,
University of Utah, USA
*
Leslie A. Leinwand,
University of Colorado Boulder, USA
*
Richard N. Kitsis,
Albert Einstein College of Medicine, USA
*
Charles E. Murry,
University of Washington, USA
Ching-Pin Chang,
Indiana University, USA
Chromatin Remodeling by Brg1 Regulates Cardiac Growth, Differentiation and Hypertrophy
Chromatin Remodeling by Brg1 Regulates Cardiac Growth, Differentiation and Hypertrophy
Maria I. Kontaridis,
Beth Israel Deaconess Medical Center, USA
Rapamycin Normalizes Hypertrophic Cardiomyopathy in a Mouse Model of LEOPARD Syndrome-Associated PTPN11 Mutation
Rapamycin Normalizes Hypertrophic Cardiomyopathy in a Mouse Model of LEOPARD Syndrome-Associated PTPN11 Mutation
Sharlene M. Day,
University of Pennsylvania, USA
Disrupted Sarcomere Stoichiometry and Heterogeneous Expression of Mutant Sarcomere Proteins in Human Hypertrophic Cardiomyopathy
Disrupted Sarcomere Stoichiometry and Heterogeneous Expression of Mutant Sarcomere Proteins in Human Hypertrophic Cardiomyopathy
Zoltan P. Arany,
University of Pennsylvania, USA
PGC-1alpha Regulates Cardiac Vascularity and Protects from Post-Partum Cardiomyopathy
PGC-1alpha Regulates Cardiac Vascularity and Protects from Post-Partum Cardiomyopathy
5:00—7:00 PM
Cardiac Stress Responses
Jeffrey Robbins,
Cincinnati Children's Hospital Medical Center, USA
Choices of a Stressed Cardiomyocyte: Necrosis, Apoptosis or Autophagy?
Choices of a Stressed Cardiomyocyte: Necrosis, Apoptosis or Autophagy?
Ivor J. Benjamin,
University of Utah, USA
Mammalian HSP-HSF Regulatory Network For Pretein Quality Control
Mammalian HSP-HSF Regulatory Network For Pretein Quality Control
Issei Komuro,
Tokyo University Graduate School, Japan
p53 as a Mediator of Cardiovascular Diseases
p53 as a Mediator of Cardiovascular Diseases
Jill Rafael-Fortney,
Ohio State University College of Medicine, USA
Short Talk: Claudin-5 Prevents Functional and Histological Indicators of Cardiomyopathy, and Represents a Novel Treatment Strategy for Heart Failure
Short Talk: Claudin-5 Prevents Functional and Histological Indicators of Cardiomyopathy, and Represents a Novel Treatment Strategy for Heart Failure
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
5:00—7:00 PM
Regulation of Cardiac Function
*
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
Howard A. Rockman,
Duke University Medical Center, USA
Beta-Arrestin Signaling and Cardiac Function
Beta-Arrestin Signaling and Cardiac Function
Walter J. Koch,
Temple University School of Medicine, USA
Novel Roles of GRKs in Cardiac Injury and Repair
Novel Roles of GRKs in Cardiac Injury and Repair
David A. Kass,
Johns Hopkins Hospital, USA
Cyclic GMP/PKG Modulation of Heart Disease
Cyclic GMP/PKG Modulation of Heart Disease
Ralph Knöll,
AstraZeneca and Karolinska Institutet, Sweden
Short Talk: Novel MLP-Interacting Proteins and Their Potential Role in Cardiomyopathy
Short Talk: Novel MLP-Interacting Proteins and Their Potential Role in Cardiomyopathy
8:00—11:00 AM
Directed Differentiation of Cardiac Progenitors
Michael D. Schneider,
Imperial College London, UK
Cardiopoiesis: Genetic Circuits for Cardiac Myocyte Creation by Stem Cells
Cardiopoiesis: Genetic Circuits for Cardiac Myocyte Creation by Stem Cells
Christine L. Mummery,
Leiden University Medical Center, Netherlands
Cardiomyocytes from Pleuripotent Stem Cells in Drug Discovery and Disease
Cardiomyocytes from Pleuripotent Stem Cells in Drug Discovery and Disease
Benoit G. Bruneau,
Gladstone Institutes, USA
Epigenetic Regulation of Heart Development
Epigenetic Regulation of Heart Development
Robert J. Schwartz,
Texas A&M University, USA
Short Talk: Trans-differentiation of Noncardiogenic Fibroblast into Cardiac Progenitors
Short Talk: Trans-differentiation of Noncardiogenic Fibroblast into Cardiac Progenitors
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
8:00—11:00 AM
New Insights into Cardiac Hypertrophy
*
Howard A. Rockman,
Duke University Medical Center, USA
Anthony Rosenzweig,
Massachusetts General Hospital, USA
SGK1 in Pathological Cardiac Hypertrophy, Failure, and Arrhythmias
SGK1 in Pathological Cardiac Hypertrophy, Failure, and Arrhythmias
Meredith Bond,
University of Maryland School of Medicine, USA
AKAPs in Healthy and Failing Heart
AKAPs in Healthy and Failing Heart
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
MicroRNA Control of Cardiovascular Development and Disease
MicroRNA Control of Cardiovascular Development and Disease
Joan Heller Heller Brown,
University of California, San Diego, USA
Ca++/calmodulin-Dependent Protein Kinase II in Heart Failure Development
Ca++/calmodulin-Dependent Protein Kinase II in Heart Failure Development
Zhi-Ping Liu,
University of Texas Southwestern Medical Center, USA
Short Talk: The Histone Trimethyl Demethylase, JMJD2A, Promotes Pressure Overload-Induced Cardiac Hypertrophy
Short Talk: The Histone Trimethyl Demethylase, JMJD2A, Promotes Pressure Overload-Induced Cardiac Hypertrophy
5:00—7:00 PM
Cardiac Death Programs
*
Richard N. Kitsis,
Albert Einstein College of Medicine, USA
Jeffery D. Molkentin,
Cincinnati Children's Hospital Medical Center, USA
Thrombosponin-4 as a Platform for the Adaptive ER Stress Response
Thrombosponin-4 as a Platform for the Adaptive ER Stress Response
Lorrie A. Kirshenbaum,
University of Manitoba, Canada
Novel Alternative Splicing of Death Gene Bnip3 Promotes Cell Survival of Post-Natal Ventricular Myocytes
Novel Alternative Splicing of Death Gene Bnip3 Promotes Cell Survival of Post-Natal Ventricular Myocytes
Junichi Sadoshima,
Rutgers New Jersey Medical School, USA
Signaling Mechanism of Autophagy in the Heart
Signaling Mechanism of Autophagy in the Heart
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
5:00—7:00 PM
Ca++ Dynamics and Heart Failure
*
Roger J. Hajjar,
Mount Sinai School of Medicine, USA
W. Jonathan Lederer,
University of Maryland Baltimore, USA
Stretch-dependent Ca2+ signaling in rat and mouse cardiac ventricular myocytes
Stretch-dependent Ca2+ signaling in rat and mouse cardiac ventricular myocytes
Joseph M. Metzger,
University of Minnesota Medical School, USA
New Delayed Ca2+ Buffer for the Failing Heart
New Delayed Ca2+ Buffer for the Failing Heart
Evangelia G. Kranias,
University of Cincinnati College of Medicine, USA
Ca-Cycling Circuits in Heart Failure
Ca-Cycling Circuits in Heart Failure
8:00—11:00 AM
'Wntch' Signaling in Cardiogenesis and Repair (Joint)
*
Charles E. Murry,
University of Washington, USA
Gordon M. Keller,
University Health Network, MaRS Centre, Canada
Induction and Specification of Cardiac Mesoderm from Human Pluripotent Stem Cells
Induction and Specification of Cardiac Mesoderm from Human Pluripotent Stem Cells
Kenneth R. Chien,
Karolinska Institutet, Sweden
Engineering Ventriculogenesis: Epigenetic and Modified RNA Pathway and Technology
Engineering Ventriculogenesis: Epigenetic and Modified RNA Pathway and Technology
3:30—4:30 PM
Workshop 2: Graduate Student and Postdoc Research Competition (Joint)
The postdoc/graduate student competition is open to all postdocs/graduate students. There will be no reference to age. Abstracts submitted to this competition will be rated by the organizers. The top submissions will be selected for oral presentation in these sessions in addition to poster sessions.
*
Ivor J. Benjamin,
University of Utah, USA
*
Richard N. Kitsis,
Albert Einstein College of Medicine, USA
*
Leslie A. Leinwand,
University of Colorado Boulder, USA
*
Charles E. Murry,
University of Washington, USA
Pontus Boström,
Dana Farber Cancer Institute, Harvard Medical School, USA
C/EBPbeta Controls Exercise-Induced Cardiac Growth and Protects Against Pathological Cardiac Remodeling
C/EBPbeta Controls Exercise-Induced Cardiac Growth and Protects Against Pathological Cardiac Remodeling
Oscar Abilez,
Stanford University, USA
In Vitro and In Silico Optogenetic Control of Differentiated Human Pluripotent Stem Cell-Derived Cardiomyocytes
In Vitro and In Silico Optogenetic Control of Differentiated Human Pluripotent Stem Cell-Derived Cardiomyocytes
Stacey L. Rentschler,
Washington University School of Medicine, USA
Notch Signaling Regulates Murine Atrioventricular Conduction and Formation of Accessory Pathways
Notch Signaling Regulates Murine Atrioventricular Conduction and Formation of Accessory Pathways
Jennifer M. Davis,
Cincinnati Children's Hospital Medical Center, USA
TRPC6 Promotes the Fibroblast to Myofibroblast Transition in Cardiac Fibroblasts
TRPC6 Promotes the Fibroblast to Myofibroblast Transition in Cardiac Fibroblasts
5:00—7:00 PM
Translating the (Pluri)Potential into Therapy
*
Doris A. Taylor,
Texas Heart Institute, USA
Bernd K. Fleischmann,
Bonn University, Germany
The Physiological Basis for Cardiac Repair by Stem Cells
The Physiological Basis for Cardiac Repair by Stem Cells
Joseph Gold,
Beckman Research Institute, City of Hope, USA
Development Human Embryonic Stem Cell-Derived Therapies for the Treatment of Human Disease: Applications in Spinal Cord Injury and Heart Failure
Development Human Embryonic Stem Cell-Derived Therapies for the Treatment of Human Disease: Applications in Spinal Cord Injury and Heart Failure
Joseph A. Hill,
University of Texas Southwestern Medical Center, USA
Short Talk: Mending the Broken Heart: Better Living Through Chemistry
Short Talk: Mending the Broken Heart: Better Living Through Chemistry
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
5:00—7:00 PM
Nutrition, Energetics, and Signaling
Leslie A. Leinwand,
University of Colorado Boulder, USA
Gender, Diet, and Cardiac Function
Gender, Diet, and Cardiac Function
DeWayne Townsend,
University of Minnesota Medical School, USA
Short Talk: Loss of Dystrobrevin Markedly Weakens the Interaction between Dystrophin and beta-Dystroglycan, but Cardiac Function is Maintained
Short Talk: Loss of Dystrobrevin Markedly Weakens the Interaction between Dystrophin and beta-Dystroglycan, but Cardiac Function is Maintained
8:00—11:00 AM
Identification and Manipulation of Progenitor Cells
*
Benoit G. Bruneau,
Gladstone Institutes, USA
Charles E. Murry,
University of Washington, USA
Human Cardiogenesis: Lessons on Growing Cardiomyocytes and Myocardium from Pluripotent Cells
Human Cardiogenesis: Lessons on Growing Cardiomyocytes and Myocardium from Pluripotent Cells
Daniel J. Garry,
University of Minnesota, USA
Nkx2-5 Transcriptional Networks and Cardiogenesis
Nkx2-5 Transcriptional Networks and Cardiogenesis
Bernhard Kühn,
Children's Hospital of Pittsburgh, USA
Inducing Myocardial Regeneration to Hreat Heart Disease
Inducing Myocardial Regeneration to Hreat Heart Disease
William T. Pu,
Children's Hospital, Harvard Medical School, USA
More than a Cover: Epicardial Function in Heart Development and Disease
More than a Cover: Epicardial Function in Heart Development and Disease
Paul H. Goldspink,
Medical College of Wisconsin, USA
Short Talk: The E-Domain of MGF Preserves Cardiac Function and Mobilizes Cardiac Progenitor Cell Populations following Myocardial Infarction
Short Talk: The E-Domain of MGF Preserves Cardiac Function and Mobilizes Cardiac Progenitor Cell Populations following Myocardial Infarction
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
8:00—11:00 AM
Intercellular and Intracellular Communication
*
Joseph M. Metzger,
University of Minnesota Medical School, USA
Kenneth Walsh,
University of Virginia School of Medicine, USA
Signaling between Cardiac Myocytes and Endothelial Cells
Signaling between Cardiac Myocytes and Endothelial Cells
Gerald W. Dorn, II,
Washington University School of Medicine, USA
Cross-Talk between ER and Mitochondria
Cross-Talk between ER and Mitochondria
Yibin Wang,
University of California, Los Angeles, David Geffen School of Medicine, USA
A Mitochondrial Protein Phosphatase in Cardiac Regulation
A Mitochondrial Protein Phosphatase in Cardiac Regulation
Daniela C. Tirziu,
Yale University School of Medicine, USA
Short Talk: Role of Nitric Oxide-G Protein Axis in Endothelium to Cardiomyocyte Crosstalk
Short Talk: Role of Nitric Oxide-G Protein Axis in Endothelium to Cardiomyocyte Crosstalk
5:00—7:00 PM
Cardiac Rebirth and Renewal
Loren J. Field,
Indiana University, School of Medicine, USA
Cell Cycle Induction and Stem Cell Mobilization for Cardiomyocyte Repopulation
Cell Cycle Induction and Stem Cell Mobilization for Cardiomyocyte Repopulation
Michael A. Laflamme,
University Health Network, Canada
Human Embryonic Stem Cell-Derived Cardiomyocytes and the Risk of Graft-Related Arrhythmias
Human Embryonic Stem Cell-Derived Cardiomyocytes and the Risk of Graft-Related Arrhythmias
Doris A. Taylor,
Texas Heart Institute, USA
Cells, Molecules and Matrix: New Tools for Regeneration
Cells, Molecules and Matrix: New Tools for Regeneration
Hesham A. Sadek,
University of Texas Southwestern Medical Center, USA
Short Talk: Heart Regeneration in Neonatal Mice
Short Talk: Heart Regeneration in Neonatal Mice
Following Session is for Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)
5:00—7:00 PM
Bench to Bedside: Experimental Therapeutics
Eva van Rooij,
Hubrecht Institute, Netherlands
Oligo-Based Modulation of miRNAs to Control Cardiovascular Disease
Oligo-Based Modulation of miRNAs to Control Cardiovascular Disease
Roger J. Hajjar,
Mount Sinai School of Medicine, USA
Manipulating SERCA2a in Heart Failure: Basic Mechanisms to Clinical Applications
Manipulating SERCA2a in Heart Failure: Basic Mechanisms to Clinical Applications
Bruce E. Markham,
Phrixus Pharmaceuticals, USA
Membrane Repair, Triblock Co-Polymers and Heart Failure
Membrane Repair, Triblock Co-Polymers and Heart Failure
Yang Xiang,
University of California, Davis, USA
Short Talk: Spatiotemporal Regulation of beta Adrenergic Receptor Signaling in Cardiac Myocytes
Short Talk: Spatiotemporal Regulation of beta Adrenergic Receptor Signaling in Cardiac Myocytes
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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American Heart Association's Council on Basic Cardiovascular Sciences |
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