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This meeting took place in 2011



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Stem Cells in Development, Tissue Homeostasis and Disease (B3)


Organizer(s) Ronald D. McKay, Elaine Fuchs and Thea D. Tlsty
January 30—February 4, 2011
Eldorado Hotel & Spa • Santa Fe, NM USA
Abstract Deadline: Sep 30, 2010
Late Abstract Deadline: Nov 2, 2010
Scholarship Deadline: Sep 30, 2010
Early Registration Deadline: Nov 30, 2010

Sponsored by Novartis Institutes for BioMedical Research, Pfizer Inc. and Sangamo BioSciences, Inc.

Summary of Meeting:
This meeting is focussed on the mechanisms controlling stem cells throughout life. The presentations will define the different pluripotent cells in the early embryo and the signals that lead them into the many distinct cell types that co-operate to form an adult organism. An exciting aspect of the field is that as we define the shared mechanisms controlling different tissues, we will generate an integrated view of human development. This symposium is designed to present key advances that are leading to a systematic understanding of the biology of human tissues throughout life. In this program, we strive to balance recognized problems in the stem cell field and new ideas that will functionalize human genetic and cellular diversity providing a new understanding of developmental decisions and tissue repair. The presentations will form a strong platform for all the participants to discuss new technologies that identify the central regulators of development and treat disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


SUNDAY, JANUARY 30

3:00—7:30 PM
Registration

Zia Concourse
6:15—7:15 PM
Refreshments

Zia Concourse
7:15—8:30 PM
Welcome and Keynote Address

Anasazi Ballroom
* Gordon M. Keller, University Health Network, MaRS Centre, Canada

Elizabeth J. Robertson, University of Oxford, UK
Pathways Regulating Specification of Progenitor Populations during Gastrulation


MONDAY, JANUARY 31

7:00—8:00 AM
Breakfast

Eldorado Court
8:00—11:00 AM
Pluripotent Cells and the Primitive Streak

Anasazi Ballroom
Austin Smith, University of Cambridge, UK
Maintaining the Pluripotent State

Azim Surani, University of Cambridge, UK
Genetic and Epigenetic Regulators of the Germline and Pluripotency

Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA
Genetic Control of Cell Fate and Behavior in the Mouse Primitive Streak

* Peter W. Reddien, Whitehead Institute, USA
An Adult Pluripotent Stem Cell Drives Planarian Regeneration

Masayo Sakaki-Yumoto, University of California San Francisco, USA
Short Talk: Differential Roles of Smad2 and Smad3 in Human Embryonic Stem Cell Pluripotency

9:20—9:40 AM
Coffee Break

Zia Concourse
11:00 AM—1:00 PM
Poster Setup

Sunset Room/Eldorado Court
1:00—10:00 PM
Poster Viewing

Sunset Room/Eldorado Court
11:00 AM
On Own for Lunch and Recreation

4:30—5:00 PM
Coffee Available

Zia Concourse
5:00—7:00 PM
Cell Lineages and Disease

Anasazi Ballroom
* Elaine V. Fuchs, Rockefeller University, USA

* Valentina Greco, Yale School of Medicine, USA

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Modeling Human Neural Development and Disease in Pluripotent Stem Cells

Elly M. Tanaka, IMP - Research Institute of Molecular Pathology, Austria
Applying Regenerative Concepts for the CNS from the Salamander to Mammalian Neural Stem Cells

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Transcriptional Control, Chromosome Structure and Disease

Fredrik Lanner, Karolinska Institutet, Sweden
Short Talk: Cell Surface Proteomics of Blastocyst-Derived Cells Enables Flow-Cytometric Isolation of Blastocyst Lineages

7:00—8:00 PM
Social Hour with Lite Bites

Eldorado Court/Sunset Room
7:30—10:00 PM
Poster Session 1

Sunset Room/Eldorado Court

TUESDAY, FEBRUARY 1

7:00—8:00 AM
Breakfast

Eldorado Court
8:00—11:00 AM
Self-Renewal through the Life-Span

Anasazi Ballroom
* Margaret A. Goodell, Baylor College of Medicine, USA

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Developmental Changes in the Regulation of PI3 Kinase Signaling Lead to Developmental Changes in HSC Self-Renewal and Leukemogenesis mechanisms

Amy J. Wagers, Harvard University, USA
Skeletal Muscle Regeneration

Peter M. Lansdorp, BC Cancer Research Center, Canada
Telomeres, Stem Cells and Bone Marrow Failure

Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Telomeres in Cancer and Aging

Tudorita (Doina) Tumbar, Cornell University, USA
Short Talk: Runx1 is a Master Regulator of Adult Hair Follicle Stem Cells Activation, Emergence, and Maintenance, and Promotes Skin Tumorigenesis

9:20—9:40 AM
Coffee Break

Zia Concourse
11:00 AM—1:00 PM
Poster Setup

Sunset Room/Eldorado Court
1:00—10:00 PM
Poster Viewing

Sunset Room/Eldorado Court
11:00 AM
On Own for Lunch and Recreation

4:30—5:00 PM
Coffee Available

Zia Concourse
5:00—7:00 PM
Global Genetic and Epigenetic Data Sets

Anasazi Ballroom
* Peter M. Lansdorp, BC Cancer Research Center, Canada

Ronald D. McKay, Lieber Institute for Brain Development, USA
Controlling Mouse and Human Stem Cells

Hugo Snippert, Hubrecht Institute, Netherlands
Short Talk : Intestinal Stem Cell Self-Renewal

Angie Rizzino, University of Nebraska Medical Center, USA
Short Talk: SOX2 Protein Levels Regulate the Fate of Embryonic Stem (ES) Cells

7:00—8:00 PM
Social Hour with Lite Bites

Eldorado Court/Sunset Room
7:30—10:00 PM
Poster Session 2

Sunset Room/Eldorado Court

WEDNESDAY, FEBRUARY 2

7:00—8:00 AM
Breakfast

Eldorado Court
8:00—11:00 AM
Stem Cells Interactions in the Niche

Anasazi Ballroom
* Elly M. Tanaka, IMP - Research Institute of Molecular Pathology, Austria

Tannishtha Reya, University of California, San Diego, USA
Control of Cell Fate by Developmental Signals

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Signaling Pathways and Transcriptional Control of Hematopoiesis

Elaine V. Fuchs, Rockefeller University, USA
Skin Stem Cells in Silence and Action

Sergei Y. Sokol, Mount Sinai School of Medicine, USA
Short Talk: Canonical Wnt Signaling

Thea D. Tlsty, University of California, San Francisco, USA
Human Cells with Extensive Plasticity

9:20—9:40 AM
Coffee Break

Zia Concourse
11:00 AM—1:00 PM
Poster Setup

Sunset Room/Eldorado Court
1:00—10:00 PM
Poster Viewing

Sunset Room/Eldorado Court
11:00 AM
On Own for Lunch and Recreation

4:30—5:00 PM
Coffee Available

Zia Concourse
5:00—7:00 PM
Systems Approaches to Stem Cell Fate Choice

Anasazi Ballroom
* Elizabeth J. Robertson, University of Oxford, UK

Jürgen A. Knoblich, IMBA, Institute of Molecular Biotechnology, Austria
Asymmetric Cell Division and Tumorigenesis in Neural Stem Cell Lineages

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Potential of Pluripotent Stem Cells

Simon Fortier, Institute for Research in Immunology and Cancer (IRIC), Canada
Short Talk: Identification of Embryonic Stem Cell Fate Determinants

Ian Chambers, University of Edinburgh, UK
Short Talk: The Developmental Dismantling of Pluripotency and its Reversal

7:00—8:00 PM
Social Hour with Lite Bites

Eldorado Court/Sunset Room
7:30—10:00 PM
Poster Session 3

Sunset Room/Eldorado Court

THURSDAY, FEBRUARY 3

7:00—8:00 AM
Breakfast

Eldorado Court
8:00—11:00 AM
The Lineage Origin of Cancer

Anasazi Ballroom
* Thea D. Tlsty, University of California, San Francisco, USA

Cédric Blanpain, Universite Libre de Bruxelles, Belgium
EMBO Young Investigator Lecture: Uncovering the Cell Lineages at the Origin of Skin Cancers

Margaret A. Goodell, Baylor College of Medicine, USA
Regulation of Hematopoietic Stem Cells

Irving L. Weissman, Stanford University, USA
Normal and Neoplastic Stem Cells

Irina M. Conboy, University of California, Berkeley, USA
Signal Transduction in Adult Stem Cells or how to Reverse Stem Cell Aging

Patricia K. Donahoe, Massachusetts General Hospital, USA
Short Talk: Müllerian Inhibiting Substance and its Anthrapyrazolone Mimetic Preferentially Inhibit a Stem/Progenitor Cell Enriched Population in Human Ovarian Cancer Cell Lines Compared to Chemotherapeutic Agents

9:00—9:20 AM
Coffee Break

Zia Concourse
11:00 AM
On Own for Lunch and Recreation

5:30—6:00 PM
Coffee Available

Zia Concourse
6:00—6:45 PM
Using Stem Cell Biology to Model and Treat Disease

Anasazi Ballroom
* Ronald D. McKay, Lieber Institute for Brain Development, USA

Shahin Rafii, Weill Cornell Medical College, USA
Instructive Endothelial-Derived Angiocrine Signals in Stem Cell Self-Renewal and Organ Regeneration

7:00—8:00 PM
Social Hour with Lite Bites

Eldorado Court/Sunset Room
8:00—11:00 PM
Entertainment

Eldorado Court/Sunset Room

FRIDAY, FEBRUARY 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD068073-01




We gratefully acknowledge additional support for this conference from:

Aastrom Biosciences, Inc. Biospherix, Ltd.
Cell Signaling Technology, Inc. March of Dimes Foundation
Novartis Institutes for BioMedical Research Pfizer Inc.
Sangamo BioSciences, Inc. STEMCELL Technologies, Inc.
Stemgent The Company of Biologists Ltd
The Rockefeller University Press - The Journal of Cell Biology The Rockefeller University Press - The Journal of Experimental Medicine

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Cells Tissues Organs

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179