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This meeting took place in 2014
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Metabolism and Angiogenesis (X5)
Organizer(s) Peter F. Carmeliet and Michael Simons
March 16—21, 2014
Whistler Conference Centre • Whistler, BC Canada
Discounted Abstract Deadline: Nov 18, 2013
Abstract Deadline: Dec 17, 2013
Scholarship Deadline: Nov 18, 2013
Discounted Registration Deadline: Jan 15, 2014
Supported by the Directors' Fund
Joint Meeting:
Tumor Metabolism (X6)
Summary of Meeting:
Endothelial cells are required to be quiescent in healthy conditions while having the capacity to actively proliferate and migrate during angiogenic sprouting. The transition from quiescence to rapid proliferation requires metabolic reprogramming that is very similar to that seen in rapidly growing tumor cells. Therefore, the integration of the fields of angiogenesis, metabolism and cancer biology has become a very hot topic in biomedical research. Since blood vessels arose in evolution to deliver nutrients and oxygen, it is not surprising that angiogenesis and metabolism are closely linked. The interface of these fields also offers unprecedented opportunities for pro- and anti-angiogenic therapies. This Keystone Symposia meeting on Metabolism and Angiogenesis will enhance cross-talk between researchers in the fields of angiogenesis (vascular biology) and cellular metabolism with a view of understanding the underlying biology and for identifying opportunities for new therapeutic strategies. Opportunities for cross-fertilization of ideas and interdisciplinary interactions will be further strengthened by joint keynote and plenary sessions with the concurrent meeting on “Tumor Metabolism.”
View Scholarships/Awards
Endothelial cells are required to be quiescent in healthy conditions while having the capacity to actively proliferate and migrate during angiogenic sprouting. The transition from quiescence to rapid proliferation requires metabolic reprogramming that is very similar to that seen in rapidly growing tumor cells. Therefore, the integration of the fields of angiogenesis, metabolism and cancer biology has become a very hot topic in biomedical research. Since blood vessels arose in evolution to deliver nutrients and oxygen, it is not surprising that angiogenesis and metabolism are closely linked. The interface of these fields also offers unprecedented opportunities for pro- and anti-angiogenic therapies. This Keystone Symposia meeting on Metabolism and Angiogenesis will enhance cross-talk between researchers in the fields of angiogenesis (vascular biology) and cellular metabolism with a view of understanding the underlying biology and for identifying opportunities for new therapeutic strategies. Opportunities for cross-fertilization of ideas and interdisciplinary interactions will be further strengthened by joint keynote and plenary sessions with the concurrent meeting on “Tumor Metabolism.”
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 16
MONDAY, MARCH 17
TUESDAY, MARCH 18
WEDNESDAY, MARCH 19
THURSDAY, MARCH 20
FRIDAY, MARCH 21
Conference Program Print | View meeting in 24 hr (international) time
SUNDAY, MARCH 16
8:00—9:30 AM
Keynote Session (Joint)
M. Celeste Simon,
University of Pennsylvania, USA
Oxygen, Lipids and Cancer Cell Metabolism
Oxygen, Lipids and Cancer Cell Metabolism
Steven L. McKnight,
University of Texas Southwestern Medical Center, USA
Acetate Consumption as a Potential Vulnerability of Certain Types of Human Tumors
Acetate Consumption as a Potential Vulnerability of Certain Types of Human Tumors
9:50 AM—12:30 PM
Novel Metabolic Pathways in Cancer I (Joint)
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Metabolic Pathways Important for Tumor Growth and Survival
Metabolic Pathways Important for Tumor Growth and Survival
David M. Sabatini,
Whitehead Institute for Biomedical Research, USA
Amino Acids, Sugars and Cancer Metabolism
Amino Acids, Sugars and Cancer Metabolism
Ralph J. DeBerardinis,
University of Texas Southwestern Medical Center, USA
Metabolic Versatility in Cancer Cells
Metabolic Versatility in Cancer Cells
Douglas R. Green,
St. Jude Children's Research Hospital, USA
Balancing Act: Caspases and RIP Kinases in Cell Death and Development
Balancing Act: Caspases and RIP Kinases in Cell Death and Development
5:00—7:00 PM
Metabolism and Angiogenesis: Bidirectional Cross-Talk
*
Adrian L. Harris,
University of Oxford, Weatherall Institute of Molecular Medicine, UK
Zoltan P. Arany,
University of Pennsylvania, USA
Endothelial PGC-1alpha Mediates Vascular Dysfunction in Diabetes
Endothelial PGC-1alpha Mediates Vascular Dysfunction in Diabetes
Massimo Santoro,
Vesalius Research Center, Belgium
Novel Non-Mitochondrial Redox Regulator in Endothelial Cells
Novel Non-Mitochondrial Redox Regulator in Endothelial Cells
Luisa Iruela-Arispe,
University of California, Los Angeles, USA
Endothelial VEGFR2 Signaling in Diabetes
Endothelial VEGFR2 Signaling in Diabetes
Markus Jabs,
German Cancer Research Center, Germany
Short Talk: Notch Signaling Regulates Systemic Energy Metabolism
Short Talk: Notch Signaling Regulates Systemic Energy Metabolism
5:00—7:00 PM
Succinate Dehydrogenase and Fumarate Hydratase
*
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Patrick J. Pollard,
University of Edinburgh, UK
Oncometabolites: Linking Altered Metabolism With Cancer?
Oncometabolites: Linking Altered Metabolism With Cancer?
Eyal Gottlieb,
Technion - Israel Institute of Technology, Israel
Revealing New Metabolic Networks in FH-Deficient Tumors
Revealing New Metabolic Networks in FH-Deficient Tumors
Navdeep S. Chandel,
Northwestern University, USA
Targeting Mitochondrial Metabolism for Cancer Therapy
Targeting Mitochondrial Metabolism for Cancer Therapy
Paul-Joseph Penaflor Aspuria,
Atara Biotherapeutics, Inc., USA
Short Talk: Succinate Dehydrogenase Inhibition Leads to Epithelial-Mesenchymal Transition and Reprogrammed Carbon Metabolism
Short Talk: Succinate Dehydrogenase Inhibition Leads to Epithelial-Mesenchymal Transition and Reprogrammed Carbon Metabolism
8:00—11:15 AM
Metabolism and Vascular Branching
*
Luisa Iruela-Arispe,
University of California, Los Angeles, USA
Michael Potente,
Max Planck Institute for Heart and Lung Research, Germany
Linking Angiogenesis and Metabolism through FOXO Transcription Factors
Linking Angiogenesis and Metabolism through FOXO Transcription Factors
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
Targeting Endothelial Metabolism: Principles and Strategies
Targeting Endothelial Metabolism: Principles and Strategies
Annika Keller,
Zurich University Hospital, Switzerland
Endothelial-Pericyte Signaling and Brain Disease
Endothelial-Pericyte Signaling and Brain Disease
Kari K. Alitalo,
University of Helsinki, Finland
VEGF-B in Metabolic Reprogramming and Cardiovascular Disease
VEGF-B in Metabolic Reprogramming and Cardiovascular Disease
Hilary A. Coller,
University of California, Los Angeles, USA
Tumor Stromal Cells
Tumor Stromal Cells
Peter D. Westenskow,
The Scripps Research Institute, USA
Short Talk: Cone Photoreceptors Generate the Fatty Acid Amide Erucamide for Maintenance of the Ocular Vasculature
Short Talk: Cone Photoreceptors Generate the Fatty Acid Amide Erucamide for Maintenance of the Ocular Vasculature
Pengchun Yu,
Yale School of Medicine, USA
Short Talk: Regulation of Lymphangiogenesis by FGF Signaling
Short Talk: Regulation of Lymphangiogenesis by FGF Signaling
8:00—11:15 AM
Isocitrate Dehydrogenase
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
The von Hippel-Lindau Tumor Suppressor Protein: Insights into Oxygen Sensing and Cancer Metabolism
The von Hippel-Lindau Tumor Suppressor Protein: Insights into Oxygen Sensing and Cancer Metabolism
Craig B. Thompson,
Memorial Sloan Kettering Cancer Center, USA
Epigenetic Control by Mutant IDH
Epigenetic Control by Mutant IDH
Elizabeth Maher,
University of Texas Southwestern Medical Center, USA
Metabolic Imaging of IDH Mutant Brain Tumors
Metabolic Imaging of IDH Mutant Brain Tumors
Katharine Yen,
Auron Therapeutics, USA
AG-221 Offers a Survival Advantage in a Primary Human IDH2 Mutant AML Xenograft Model
AG-221 Offers a Survival Advantage in a Primary Human IDH2 Mutant AML Xenograft Model
Christian Metallo,
University of California, San Diego, USA
Short Talk: Exploiting Oncogenic IDH Mutations to Identify Therapeutic Targets and Annotate Compartmentalized Pathway Function
Short Talk: Exploiting Oncogenic IDH Mutations to Identify Therapeutic Targets and Annotate Compartmentalized Pathway Function
Yoko Ogawara,
National Cancer Center Research Institute, Japan
Short Talk: Critical Roles of the IDH2 Mutation in Development and Maintenance of Acute Myeloid Leukemia
Short Talk: Critical Roles of the IDH2 Mutation in Development and Maintenance of Acute Myeloid Leukemia
5:00—7:00 PM
Novel Metabolic Pathways in Cancer II
*
M. Celeste Simon,
University of Pennsylvania, USA
James M. Phang,
NCI at Frederick, National Institutes of Health, USA
The Proline Regulatory Axis: Metabolic Reprogramming in Cancer
The Proline Regulatory Axis: Metabolic Reprogramming in Cancer
Yury I. Miller,
University of California, San Diego, USA
Cholesterol Efflux and Angiogenesis
Cholesterol Efflux and Angiogenesis
Natalie Sheng Jie Lim†,
National University Singapore, Singapore
Short Talk: Strategy to Enhance Angiogenesis: A Prolyl Hydroxylase Inhibitor and Lysophospholipid Approach
Short Talk: Strategy to Enhance Angiogenesis: A Prolyl Hydroxylase Inhibitor and Lysophospholipid Approach
Hwee Ying Lim,
National University of Singapore, Singapore
Role of Lymphatic Vessels in Cholesterol Clearance and the Involvement of High-Density Lipoproteins in Regulating Lymphatic Function
Role of Lymphatic Vessels in Cholesterol Clearance and the Involvement of High-Density Lipoproteins in Regulating Lymphatic Function
Brian W. Wong,
Washington University School of Medicine, USA
Short Talk: Investigating the Metabolism of Venous and Lymphatic Endothelial Cells
Short Talk: Investigating the Metabolism of Venous and Lymphatic Endothelial Cells
5:00—7:00 PM
Lactate and Monocarboxylate Transporters
Ubaldo E. Martinez Outschoorn,
Thomas Jefferson University, USA
Talk Title to be Announced
Talk Title to be Announced
Jacques Pouysségur,
University of Nice, France
Targeting Lactate/H+ Symporters for Cancer Therapy
Targeting Lactate/H+ Symporters for Cancer Therapy
John Kurhanewicz,
University of California, San Francisco, USA
Using in Vivo Hyperpolarized 13C MR Imaging for Measuring Metabolic Fluxes Important to Prostate Cancer Progression and Therapeutic Response
Using in Vivo Hyperpolarized 13C MR Imaging for Measuring Metabolic Fluxes Important to Prostate Cancer Progression and Therapeutic Response
Sunghee Park,
Duke University Medical Center, USA
Short Talk: PGC-1alpha/ERRalpha Regulates Lactate-Fueled Mitochondrial Oxidative Metabolism in Breast Cancer
Short Talk: PGC-1alpha/ERRalpha Regulates Lactate-Fueled Mitochondrial Oxidative Metabolism in Breast Cancer
8:00—11:15 AM
Metabolism and Anti-Angiogenic Therapy
Dai Fukumura,
Massachusetts General Hospital, USA
Vascular Normalization and Metabolic Microenvironment
Vascular Normalization and Metabolic Microenvironment
Patrizia Agostinis,
KU Leuven, Belgium
Tumor Vessel Normalization by Chloroquine Independent on Autophagy Blockage
Tumor Vessel Normalization by Chloroquine Independent on Autophagy Blockage
Olivier Feron,
Université Catholique de Louvain, Belgium
Targeting Lactate and Glutamine Metabolism in Endothelial Cells
Targeting Lactate and Glutamine Metabolism in Endothelial Cells
Adrian L. Harris,
University of Oxford, Weatherall Institute of Molecular Medicine, UK
Metabolic Response to Anti-Angiogenic Therapy
Metabolic Response to Anti-Angiogenic Therapy
Guy Eelen,
Vesalius Research Center, KU Leuven, Belgium
Short Talk: Deletion of Glutamine Synthetase in Endothelial Cells Leads to Vessel Branching Defects
Short Talk: Deletion of Glutamine Synthetase in Endothelial Cells Leads to Vessel Branching Defects
Stephanie M. Cossette,
Medical College of Wisconsin, USA
Short Talk: Sucrose Non-Fermenting Related Kinase (SNRK) Is an AMPK Family Member that Is Essential for Cardiac Metabolism in vivo
Short Talk: Sucrose Non-Fermenting Related Kinase (SNRK) Is an AMPK Family Member that Is Essential for Cardiac Metabolism in vivo
8:00—11:15 AM
Metabolism and Epigenetic Enzymes
Lucy A. Godley,
University of Chicago, USA
Regulation of Hematopoiesis by 5-Hydroxymethylcytosine
Regulation of Hematopoiesis by 5-Hydroxymethylcytosine
Chuan He,
University of Chicago, USA
Epigenetic DNA and RNA Demethylation in Mammalian Regulation
Epigenetic DNA and RNA Demethylation in Mammalian Regulation
Paul Guilhamon,
University College London Cancer Institute, UK
Short Talk: Meta-Analysis of IDH-Mutant Cancers Identifies a New Interaction Partner for TET2
Short Talk: Meta-Analysis of IDH-Mutant Cancers Identifies a New Interaction Partner for TET2
Hong-Wu Chen,
University of California, Davis, USA
Short Talk: Reprogramming Metabolism for Cancer Therapeutic Resistance by Histone Methylases
Short Talk: Reprogramming Metabolism for Cancer Therapeutic Resistance by Histone Methylases
2:30—4:30 PM
Workshop: Monitoring Metabolism
Hilary A. Coller,
University of California, Los Angeles, USA
Metabolism of Quiescent Cells
Metabolism of Quiescent Cells
Linda C. Hsieh-Wilson,
California Institute of Technology, USA
The Interplay of Protein Glycosylation and Cancer Metabolism
The Interplay of Protein Glycosylation and Cancer Metabolism
Alan Saghatelian,
The Salk Institute for Biological Studies, USA
Protein-Metabolite Interactions
Protein-Metabolite Interactions
Sakino Toue,
Ajinomoto Co., Inc, Japan
Short Talk: MALDI-Imaging Mass Spectrometry Assisted by On-Tissue Chemical Derivatization for Visualizing Multiple Amino Acids in Human Colon Cancer Xenografts
Short Talk: MALDI-Imaging Mass Spectrometry Assisted by On-Tissue Chemical Derivatization for Visualizing Multiple Amino Acids in Human Colon Cancer Xenografts
5:00—7:00 PM
Metabolism and Pathological Angiogenesis
Massimiliano Mazzone,
KU Leuven – VIB, Belgium
Influence of Macrophage Metabolism on Vessel Shape: Implications for Cancer
Influence of Macrophage Metabolism on Vessel Shape: Implications for Cancer
Tony Walshe,
Novartis, USA
Short Talk: Mitochondrial Oxidative Phosphorylation and Redox Signaling Govern Endothelial Cell Fate Decisions
Short Talk: Mitochondrial Oxidative Phosphorylation and Redox Signaling Govern Endothelial Cell Fate Decisions
5:00—7:00 PM
Lipid Metabolism
Daniel K. Nomura,
University of California, Berkeley, USA
Mapping Dyregulated Metabolic Pathways in Cancer Using Functional Proteomic and Metabolomic Platforms
Mapping Dyregulated Metabolic Pathways in Cancer Using Functional Proteomic and Metabolomic Platforms
Gerald Hoefler,
Medical University of Graz, Austria
Adipose Triglyceride Lipase (ATGL) is a Metabolic Tumor Suppressor Gene
Adipose Triglyceride Lipase (ATGL) is a Metabolic Tumor Suppressor Gene
Ernst R. Lengyel,
University of Chicago, USA
Crosstalk between Cancer Cells and Adipocytes
Crosstalk between Cancer Cells and Adipocytes
Jurre J. Kamphorst,
CR-UK Beatson Institute and University of Glasgow, UK
Short Talk: Hypoxic and Ras-Transformed Cells Support Growth by Scavenging Fatty Acids from Lysophospholipids
Short Talk: Hypoxic and Ras-Transformed Cells Support Growth by Scavenging Fatty Acids from Lysophospholipids
8:00—11:00 AM
Novel Cancer Metabolic Targets (Joint)
Almut Schulze,
University of Würzburg/Theodor-Boveri Institute, Germany
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells
Jonathan Hurov,
Agios Pharmaceuticals, USA
Investigation of Glutaminase (GLS1) Dependency in Cancer Cells
Investigation of Glutaminase (GLS1) Dependency in Cancer Cells
Thomas O'Brien,
Pfizer, USA
and
and
Peter K. Jackson,
Stanford University, USA
Inhibiting Glycolysis with a New LDHA Inhibitor
Inhibiting Glycolysis with a New LDHA Inhibitor
Brooke M. Emerling,
Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Deletion of Phosphatidylinositol-5-Phosphate 4-Kinases Results in Impaired Growth of p53 Deficient Tumors by Mediating Changes in Metabolism
Short Talk: Deletion of Phosphatidylinositol-5-Phosphate 4-Kinases Results in Impaired Growth of p53 Deficient Tumors by Mediating Changes in Metabolism
Kristen E.N. Scott,
H. Lee Moffitt Cancer Center & Research Institute, USA
Short Talk: De Novo Fatty Acid Synthesis Is Regulated by Myc and Is Required for B-Lymphoma Survival
Short Talk: De Novo Fatty Acid Synthesis Is Regulated by Myc and Is Required for B-Lymphoma Survival
5:00—7:00 PM
Metabolism and Angiogenesis: Therapeutic Implications
*
Massimiliano Mazzone,
KU Leuven – VIB, Belgium
Sara Zanivan,
CRUK Beatson Institute, UK
Elucidating Endothelial Metabolism Using Quantitative Proteomics
Elucidating Endothelial Metabolism Using Quantitative Proteomics
Ulrike Harjes,
University of Oxford, UK
Dll4-Notch and Foxo1 Co-Regulate Endothelial Fatty Acid Binding Protein 4
Dll4-Notch and Foxo1 Co-Regulate Endothelial Fatty Acid Binding Protein 4
Miguel Quintela-Fandino,
Spanish National Cancer Research Centre, Spain
Short Talk: Metabolic Synthetic Lethality: Antiangiogenic Treatment Plus Phenformin in Breast Cancer
Short Talk: Metabolic Synthetic Lethality: Antiangiogenic Treatment Plus Phenformin in Breast Cancer
Anuradha Doddaballapur,
Institute of Cardiovascular Regeneration, Germany
Short Talk: Shear Stress and Krüppel-Like Factor 2 Regulate Endothelial Metabolism by Repressing PFKFB3
Short Talk: Shear Stress and Krüppel-Like Factor 2 Regulate Endothelial Metabolism by Repressing PFKFB3
5:00—7:00 PM
Novel Cancer Metabolic Targets II
Benjamin F. Cravatt III,
The Scripps Research Institute, USA
Crosstalk between Metabolic and Signaling Pathways in Cancer
Crosstalk between Metabolic and Signaling Pathways in Cancer
Sandaruwan Geeganage,
Eli Lilly and Company, USA
Targeting Metabolic Reprogramming for Cancer – A Pharma Perspective
Targeting Metabolic Reprogramming for Cancer – A Pharma Perspective
Nissim Hay,
University of Illinois at Chicago, USA
Targeting Glucose Metabolism for Cancer Therapy
Targeting Glucose Metabolism for Cancer Therapy
*Session Chair †Invited, not yet responded.
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