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This meeting took place in 2013
Here are the related meetings in 2021:
Next Generation HIV Vaccines & Therapies (B4)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
HIV Vaccines (X2)
Organizer(s) Georgia D. Tomaras, Quentin J. Sattentau and Barbara L. Shacklett
February 10—15, 2013
Keystone Resort • Keystone, CO USA
Abstract Deadline: Oct 10, 2012
Late Abstract Deadline: Nov 12, 2012
Scholarship Deadline: Oct 10, 2012
Early Registration Deadline: Dec 10, 2012
Sponsored by Gilead Sciences, Inc. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.
Joint Meeting:
B Cell Development and Function (X1)
Summary of Meeting:
Recent data in both humans and non-human primates suggest that a clinically useful HIV-1 vaccine is possible and that the use of therapeutic interventions can be an efficacious prevention strategy. The path forward will require a detailed understanding of the correlates of protection to HIV-1/SIV and the development of better immunogens to induce specific and long lasting immunity. Moreover, the role of vaccine elicited immune responses to prevent the initial stages of HIV-1 infection at mucosal sites will be critical toward understanding protective immunity. Scientific expertise from vaccine trials and studies of long term immunity will help inform decisions in the path to the induction of immunity by an HIV-1 vaccine. Furthermore, a better understanding of how to target an efficacious vaccine in diverse populations will require more detailed studies of host genetics, innate immune responses, the effect of therapeutic interventions and other host factors (that can affect the development of robust immune responses and/or the analysis of HIV-1 vaccine trials. At this meeting, leading experts from both within and outside the HIV field will present findings from recent advances in human and non-human primate trials on immune mechanisms of protection as well as implementation of efficacious vaccines and other preventative strategies in diverse populations. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on B Cell Development and Function – which will share a keynote session and two plenary sessions with this meeting. This pairing is explicitly designed to enhance opportunities for exchanges between researchers who do not typically interact. In this regard, it must be emphasized that a major roadblock in our efforts to generate a successful HIV vaccine relates to our limited knowledge of the B cell subsets and signals required for the durable production of protective class-switched HIV-1 neutralizing and inhibitory antibodies systemically and at mucosal sites.
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Recent data in both humans and non-human primates suggest that a clinically useful HIV-1 vaccine is possible and that the use of therapeutic interventions can be an efficacious prevention strategy. The path forward will require a detailed understanding of the correlates of protection to HIV-1/SIV and the development of better immunogens to induce specific and long lasting immunity. Moreover, the role of vaccine elicited immune responses to prevent the initial stages of HIV-1 infection at mucosal sites will be critical toward understanding protective immunity. Scientific expertise from vaccine trials and studies of long term immunity will help inform decisions in the path to the induction of immunity by an HIV-1 vaccine. Furthermore, a better understanding of how to target an efficacious vaccine in diverse populations will require more detailed studies of host genetics, innate immune responses, the effect of therapeutic interventions and other host factors (that can affect the development of robust immune responses and/or the analysis of HIV-1 vaccine trials. At this meeting, leading experts from both within and outside the HIV field will present findings from recent advances in human and non-human primate trials on immune mechanisms of protection as well as implementation of efficacious vaccines and other preventative strategies in diverse populations. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on B Cell Development and Function – which will share a keynote session and two plenary sessions with this meeting. This pairing is explicitly designed to enhance opportunities for exchanges between researchers who do not typically interact. In this regard, it must be emphasized that a major roadblock in our efforts to generate a successful HIV vaccine relates to our limited knowledge of the B cell subsets and signals required for the durable production of protective class-switched HIV-1 neutralizing and inhibitory antibodies systemically and at mucosal sites.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 10
MONDAY, FEBRUARY 11
TUESDAY, FEBRUARY 12
WEDNESDAY, FEBRUARY 13
THURSDAY, FEBRUARY 14
FRIDAY, FEBRUARY 15
Conference Program Print | View meeting in 24 hr (international) time
SUNDAY, FEBRUARY 10
7:15—9:30 PM
Welcome and Keynote Session (Joint)
*
Max D. Cooper,
Emory University, USA
*
Georgia D. Tomaras,
Duke University Medical Center, USA
Myron S. Cohen,
University of North Carolina at Chapel Hill, USA
HIV Prevention 2013: Preparing for a Vaccine
HIV Prevention 2013: Preparing for a Vaccine
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
The Human Antibody Response to HIV
The Human Antibody Response to HIV
8:00—11:15 AM
Protective Responses in Animal Models
*
James A. Hoxie,
University of Pennsylvania, USA
David H. O'Connor,
University of Wisconsin-Madison, USA
Understanding SIV Control in Macaques with Restricted Genetic Diversity
Understanding SIV Control in Macaques with Restricted Genetic Diversity
Genoveffa Franchini,
NCI, National Institutes of Health, USA
Innate and Adaptive Immune Correlate of Protection Against SIVmac251
Innate and Adaptive Immune Correlate of Protection Against SIVmac251
Kevin O. Saunders,
Duke University, USA
Short Talk: Lasting Protection Against SHIV by VRC01 Protein Immunoprophylaxis in Indian Rhesus Macaques
Short Talk: Lasting Protection Against SHIV by VRC01 Protein Immunoprophylaxis in Indian Rhesus Macaques
*
Jeffrey D. Lifson,
Leidos Biomedical Research, Inc., USA
Recent Developments in Non-human Primate Models for AIDS-related Vaccine Studies
Recent Developments in Non-human Primate Models for AIDS-related Vaccine Studies
Sallie R. Permar,
Duke University Medical Center, USA
Immune Protection against Postnatal HIV-1/SIV Transmission
Immune Protection against Postnatal HIV-1/SIV Transmission
David B. Weiner,
Wistar Institute, USA
Short Talk: Non-Human Primate Challenge Model to Study the Role of Serum and Vaginal IgA in Acquisition of Infection
Short Talk: Non-Human Primate Challenge Model to Study the Role of Serum and Vaginal IgA in Acquisition of Infection
8:00—11:15 AM
B Cell Genesis
*
Max D. Cooper,
Emory University, USA
Evolution of Adaptive Immunity in Vertebrates
Evolution of Adaptive Immunity in Vertebrates
Rudolf Grosschedl,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Mechanisms Underlying Transcriptional Control of B Cell Differentiation
Mechanisms Underlying Transcriptional Control of B Cell Differentiation
Tasuku Honjo,
Kyoto University Graduate School of Medicine, Japan
Acquired Immunity, Genome Instability, and Cancer
Acquired Immunity, Genome Instability, and Cancer
Frederick W. Alt,
Boston Children's Hospital, USA
V(D)J Recombination, IgH Class Switch Recombination, and Genomic Instability
V(D)J Recombination, IgH Class Switch Recombination, and Genomic Instability
Bao Q. Vuong,
City College of New York, CUNY, USA
Short Talk: A DNA Double Strand Break and Phosphorylation-Dependent Positive Feedback Loop Promotes Class Switch Recombination
Short Talk: A DNA Double Strand Break and Phosphorylation-Dependent Positive Feedback Loop Promotes Class Switch Recombination
Patricia J. Gearhart,
NIA, National Institutes of Health, USA
Short Talk: Transcriptional Stalling of RNA Polymerase II Gives AID Access to Immunoglobulin Variable Genes
Short Talk: Transcriptional Stalling of RNA Polymerase II Gives AID Access to Immunoglobulin Variable Genes
11:15 AM—12:45 PM
Hands On Computer Workshop on Los Alamos Sequence Database and Tools
Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructor: Brian Foley, Los Alamos National Laboratory
Instructor: Brian Foley, Los Alamos National Laboratory
2:30—4:30 PM
Workshop 1: Antibody Effector Functions and Env Based Immunogen Design
*
George K. Lewis,
University of Maryland, USA
*
Mark Connors,
NIAID, National Institutes of Health, USA
James E. Voss,
The Scripps Research Institute, USA
SIV Vaccine Induces Local AntibodyProduction and Delivery Correlate with Protection in Female Reproductive Tract Protection.
SIV Vaccine Induces Local AntibodyProduction and Delivery Correlate with Protection in Female Reproductive Tract Protection.
Justin Pollara,
Duke University, USA
Synergy between C1 Conformational and Anti-V2 Monoclonal Antibodies for Cell Surface Binding and ADCC
Synergy between C1 Conformational and Anti-V2 Monoclonal Antibodies for Cell Surface Binding and ADCC
Chiara Orlandi,
University of Maryland, USA
Potent ADCC Mediated by Human Monoclonal Antibodies (mAbs) Against Multiple Conserved Epitopes of HIV-Env
Potent ADCC Mediated by Human Monoclonal Antibodies (mAbs) Against Multiple Conserved Epitopes of HIV-Env
Ross W. Lindsay,
Stemline Therapeutics, USA
An Inactivated Viral Vaccine that Displays Conformationally Intact HIV-1 Envelope Trimers Elicits Neutralizing Antibodies
An Inactivated Viral Vaccine that Displays Conformationally Intact HIV-1 Envelope Trimers Elicits Neutralizing Antibodies
Andrew McGuire,
Fred Hutchinson Cancer Research Center, USA
Engaging of the Germline BCRs of Anti-HIV bNAbs with Modified Recombinant Env Immunogens
Engaging of the Germline BCRs of Anti-HIV bNAbs with Modified Recombinant Env Immunogens
Andrew B. Ward,
The Scripps Research Institute, USA
Evaluating HIV Envelope Trimers as Structural Scaffolds and Immunogens
Evaluating HIV Envelope Trimers as Structural Scaffolds and Immunogens
Joseph R. Francica,
Vaccine Research Center, National Institutes of Health, USA
Genetic Assessment of B Cell Responses in NHP following HIV Env Immunization
Genetic Assessment of B Cell Responses in NHP following HIV Env Immunization
2:30—4:30 PM
Workshop 1: B Cell Development and Signaling
*
David J. Rawlings†,
University of Washington, Seattle Children's Hospital Research Institute, USA
Anupam Banerjee,
University of Pennsylvania, USA
Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment
Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment
Matteo Villa,
MPI Immunobiology and Epigenetics, Germany
The Role of Aryl Hydrocarbon Receptor in B Cell-Mediated Immunity
The Role of Aryl Hydrocarbon Receptor in B Cell-Mediated Immunity
*
Mary Ellen Conley,
University of Tennessee College of Medicine
A Dominant Negative Mutation in the Transcription Factor E2A in Patients with Agammaglobulinemia
A Dominant Negative Mutation in the Transcription Factor E2A in Patients with Agammaglobulinemia
Stéphane J. C. Mancini,
INSERM, France
The Development of the Pro-B and Pre-B Cell Subsets Depends on Distinct Bone Marrow Stromal Cell Niches
The Development of the Pro-B and Pre-B Cell Subsets Depends on Distinct Bone Marrow Stromal Cell Niches
Thomas Beck,
Yale University, USA
Molecular Mechanisms of Developing B Cell Egress from the Bone Marrow
Molecular Mechanisms of Developing B Cell Egress from the Bone Marrow
Andre Limnander,
Regeneron, USA
Unraveling the Molecular Mechanisms of Developmental Checkpoints during B Cell Selection in the Bone Marrow
Unraveling the Molecular Mechanisms of Developmental Checkpoints during B Cell Selection in the Bone Marrow
Marc Schwartz,
Dana Farber Cancer Institute / Broad Institute, USA
The Role of CD40 in Peripheral B Cell Development
The Role of CD40 in Peripheral B Cell Development
2:30—4:30 PM
Workshop 2: Molecular Basis of Antibody Diversification
*
Patrick C. Wilson,
University of Chicago, USA
*
George Georgiou,
University of Texas at Austin, USA
Robert W. Maul,
NIA, National Institutes of Health, USA
B Cell Receptor Stimulation Induces Uracil DNA Glycosylase and Inhibits Class Switch Recombination
B Cell Receptor Stimulation Induces Uracil DNA Glycosylase and Inhibits Class Switch Recombination
Leng-Siew Yeap,
Boston Children's Hospital, USA
Mechanisms by which DNA Sequences Influence Activation Induced Cytidine Deaminase (AID) Activity in Somatic Hypermutation and Class Switch Recombination
Mechanisms by which DNA Sequences Influence Activation Induced Cytidine Deaminase (AID) Activity in Somatic Hypermutation and Class Switch Recombination
Jeroen E. Guikema,
Academic Medical Center Amsterdam, Netherlands
Genome-Wide Analysis of RAG-Induced DNA Breaks in Developing B Cells
Genome-Wide Analysis of RAG-Induced DNA Breaks in Developing B Cells
Stephen P. Methot,
Institut de Recherches Cliniques de Montreal, Canada
Differentiating the Roles of Activation Induced Deaminase Cytoplasmic Retention and Nuclear Export
Differentiating the Roles of Activation Induced Deaminase Cytoplasmic Retention and Nuclear Export
Menno C. van Zelm,
Monash University, Australia
B Cell Antigen Receptor and CD40 Signaling Together Direct Human Antibody Maturation and Selection
B Cell Antigen Receptor and CD40 Signaling Together Direct Human Antibody Maturation and Selection
Maria A. Curotto de Lafaille,
New York University School of Medicine, USA
How the Failure-to-Thrive of IgE Germinal Centers Cells Paves the Way for the Unique Role of Sequential Switching in Generating IgE Plasma Cells
How the Failure-to-Thrive of IgE Germinal Centers Cells Paves the Way for the Unique Role of Sequential Switching in Generating IgE Plasma Cells
5:00—7:00 PM
Potentially Protective Responses in Human Clinical Trials
*
Georgia D. Tomaras,
Duke University Medical Center, USA
*
Lawrence Corey,
Fred Hutchinson Cancer Research Center, USA
Merlin L. Robb,
Walter Reed Army Institute of Research, USA
Military HIV Research Program Clinical Studies and the Search for Correlates
Military HIV Research Program Clinical Studies and the Search for Correlates
Glenda E. Gray,
South African Medical Research Council, South Africa
Efficacy Trials in South Africa: Factors Affecting Vaccine Induced Immune Response in HIV Clinical Trials
Efficacy Trials in South Africa: Factors Affecting Vaccine Induced Immune Response in HIV Clinical Trials
Susan Zolla-Pazner,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: RV144-Induced V1V2 Antibodies Reactive with Multiple Subtypes Correlated with Decreased Risk of HIV-1 Infection
Short Talk: RV144-Induced V1V2 Antibodies Reactive with Multiple Subtypes Correlated with Decreased Risk of HIV-1 Infection
5:00—7:15 PM
Early Events in B Cell Activation
*
Facundo D. Batista,
Massachusetts Institute of Technology and Harvard University, USA
Dynamic Imaging of Lymphocyte Activation - From Single Molecule to Living Tissue
Dynamic Imaging of Lymphocyte Activation - From Single Molecule to Living Tissue
Michael Reth,
Albert-Ludwigs University Freiburg, Germany
Role of Protein Islands for the Activation of B Cells
Role of Protein Islands for the Activation of B Cells
Michael C. Carroll,
Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Binding and Activation
Short Talk: Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Binding and Activation
Victor L.J. Tybulewicz,
Francis Crick Institute, UK
Short Talk: The B Cell Antigen Receptor Transduces Signals from the BAFF Receptor Required for B Cell Survival
Short Talk: The B Cell Antigen Receptor Transduces Signals from the BAFF Receptor Required for B Cell Survival
8:00—11:00 AM
Quality of Immune Response (Immune Geography and Memory)
*
Barbara L. Shacklett,
University of California, Davis, USA
*
Daniel C. Douek,
NIAID, National Institutes of Health, USA
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Imaging Immune Cell Dynamics and Function
Imaging Immune Cell Dynamics and Function
Jacob D. Estes,
Oregon Health and Science University, USA
Early Events following SIV Mucosal Challenge
Early Events following SIV Mucosal Challenge
Shane Crotty,
La Jolla Institute for Immunology, USA
Designing Vaccines: The Role of CD4 follicular T-helper Cells
Designing Vaccines: The Role of CD4 follicular T-helper Cells
Mario Roederer,
NIAID, National Institutes of Health, USA
Single Cell Transcriptomics: Measuring Quality and Quantity
Single Cell Transcriptomics: Measuring Quality and Quantity
Qingsheng Li,
University of Nebraska Center for Virology, USA
Short Talk: Distribution and Dissemination of Transmitted SIV Viruses in the Early Infection of Rhesus macaques via Anal/Rectal Route
Short Talk: Distribution and Dissemination of Transmitted SIV Viruses in the Early Infection of Rhesus macaques via Anal/Rectal Route
8:00—11:15 AM
B Cell Evolution and Repertoire Selection
Michael S. Neuberger,
Medical Research Council, UK
The AID/APOBEC Family of DNA Deaminases: Balancing Immunity versus Cancer
The AID/APOBEC Family of DNA Deaminases: Balancing Immunity versus Cancer
Garnett H. Kelsoe,
Duke University and Medical Center, USA
Genetic Control of the First Tolerance Checkpoint in B Cells
Genetic Control of the First Tolerance Checkpoint in B Cells
Hedda Wardemann,
German Cancer Research Center, Germany
An Atlas of the Murine B Cell Repertoire: From Immunoglobulin Sequence to B Cell Differentiation State and Histo-Anatomical Localization
An Atlas of the Murine B Cell Repertoire: From Immunoglobulin Sequence to B Cell Differentiation State and Histo-Anatomical Localization
Ziv Shulman,
Weizmann Institute, Israel
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers
Christopher D. C. Allen,
University of California, San Francisco, USA
Short Talk: IgE-Expressing B Cells Are Restrained by an Intrinsic Cell Fate Predisposition
Short Talk: IgE-Expressing B Cells Are Restrained by an Intrinsic Cell Fate Predisposition
11:00 AM—12:30 PM
Hands On Computer Workshop on Los Alamos Immunology Database and Tools
Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructor: Brian Foley, Los Alamos National Laboratory
Instructor: Brian Foley, Los Alamos National Laboratory
2:30—4:30 PM
Joint Workshop: B Cell Responses to Vaccines and HIV
*
Leonidas Stamatatos,
Fred Hutchinson Cancer Research Center, USA
*
Jonathan W. Yewdell,
NIAID, National Institutes of Health, USA
David Nemazee,
The Scripps Research Institute, USA
Knock-In Mice Expressing Broadly Neutralizing HIV Antibodies b12 and 4E10
Knock-In Mice Expressing Broadly Neutralizing HIV Antibodies b12 and 4E10
Katherine Nicholas,
Vanderbilt University Medical Center, USA
The Effect of Chronic HIV-1 Infection on pTFH Cells
The Effect of Chronic HIV-1 Infection on pTFH Cells
Josiane Chagnon-Choquet,
Université de Montréal, Canada
Maintenance of Breg Capacity and Increased LT-alpha Expression by First Line MZ-Like B Cells Is Associated with Control of HIV Disease Progression
Maintenance of Breg Capacity and Increased LT-alpha Expression by First Line MZ-Like B Cells Is Associated with Control of HIV Disease Progression
Adam K. Wheatley,
University of Melbourne, Australia
Prime-Boost Vaccination Against Influenza H5N1 Elicits the Expansion of Potentially Neutralizing H5/H1 Cross-Reactive Memory B Cells
Prime-Boost Vaccination Against Influenza H5N1 Elicits the Expansion of Potentially Neutralizing H5/H1 Cross-Reactive Memory B Cells
Hongyan Liao,
University of Nebraska Medical Center, USA
Dominant Production of Polyreactive Antibodies by Circulating Plasmablasts in HIV-Infected Individuals
Dominant Production of Polyreactive Antibodies by Circulating Plasmablasts in HIV-Infected Individuals
Sarah F. Andrews,
National Institutes of Health, USA
Adaptibility of the Human Influenza-specific Antibody Response
Adaptibility of the Human Influenza-specific Antibody Response
Sean P. McBurney,
Oregon Health Sciences University, USA
Elicitation of MPER-Specific Neutralizing Antibodies following Vaccination with an MPER-Targeted Vaccine Strategy
Elicitation of MPER-Specific Neutralizing Antibodies following Vaccination with an MPER-Targeted Vaccine Strategy
John B. Schell,
Yale School of Medicine, USA
An Env-Only Vaccine Does Not Provide Sterilizing Protection of Rhesus macaques Against High-Dose SIVsmE660 Challenge
An Env-Only Vaccine Does Not Provide Sterilizing Protection of Rhesus macaques Against High-Dose SIVsmE660 Challenge
2:30—4:30 PM
Workshop 4: Mucosal B Cell Responses
*
Sidonia Fagarasan,
RIKEN Research Center for Allergy and Immunology, Japan
Samuel K. Lai,
University of North Carolina at Chapel Hill, USA
Mucosal Immunity Mediated by Antibody-Mucin Crosslinking
Mucosal Immunity Mediated by Antibody-Mucin Crosslinking
Georg F. Weber,
University Hospital Erlangen, Germany
Protective Function of Pleural B Cells in Pneumonia
Protective Function of Pleural B Cells in Pneumonia
Mats Bemark,
Gothenburg University, Sweden
Oral Immunization Induces Long-Lived Intestinal and Bone Marrow Plasma Cells and Memory B Cells Destined for Mucosal Homing
Oral Immunization Induces Long-Lived Intestinal and Bone Marrow Plasma Cells and Memory B Cells Destined for Mucosal Homing
Øyvind Steinsbø,
Oslo University Hospital - Rikshospitalet, Norway
Limited Somatic Hypermutation in IgA of Transglutaminase 2 Specific as well as Gluten Specific Plasma Cells of Celiac Disease Intestinal Lesions
Limited Somatic Hypermutation in IgA of Transglutaminase 2 Specific as well as Gluten Specific Plasma Cells of Celiac Disease Intestinal Lesions
Giuliana Magri,
Institut Hospital del Mar d'Investigacions Médiques, Spain
A Novel Subset of GM-CSF-Producing Innate Lymphoid Cells Links Splenic B Cell-Helper Neutrophils with Marginal Zone B Cells
A Novel Subset of GM-CSF-Producing Innate Lymphoid Cells Links Splenic B Cell-Helper Neutrophils with Marginal Zone B Cells
5:00—7:15 PM
Mucosal Antibody Responses (Joint)
*
Barton F. Haynes,
Duke University Medical Center, USA
*
Andrea Cerutti,
Mount Sinai School of Medicine, USA
Mucus and Goblet Cells : New Insights in Intestinal Homeostasis Homeostasis
Mucus and Goblet Cells : New Insights in Intestinal Homeostasis Homeostasis
Sidonia Fagarasan,
RIKEN Research Center for Allergy and Immunology, Japan
IgA Synthesis: A Form of Functional Immune Adaptation Extending Beyond Gut
IgA Synthesis: A Form of Functional Immune Adaptation Extending Beyond Gut
Andrew J.S. Macpherson,
University of Bern, Switzerland
Mucosal and Systemic Antibody Responses to Commensal Microbes – Induction and Function
Mucosal and Systemic Antibody Responses to Commensal Microbes – Induction and Function
Duane R. Wesemann,
Harvard Medical School, USA
Short Talk: Early B Lineage Cell Develompment in the Gut Lamina Propria
Short Talk: Early B Lineage Cell Develompment in the Gut Lamina Propria
Olga Malykhina,
Northwestern University, USA
Short Talk: Cervical and Cervicovaginal Mucus Show Differential Retention of IgA But Similar Retention of IgG -- Implication for HIV Vaccine
Short Talk: Cervical and Cervicovaginal Mucus Show Differential Retention of IgA But Similar Retention of IgG -- Implication for HIV Vaccine
8:00—11:15 AM
CD8 and CD4 T Cell Immunity
*
Douglas F. Nixon,
Weill Cornell Medicine, USA
*
Stephen A. Migueles,
NIAID, National Institutes of Health, USA
Olivier Lambotte,
University Paris South, France
T-cells in HIV Controllers and the Perspectives for HIV Cure Strategies
T-cells in HIV Controllers and the Perspectives for HIV Cure Strategies
Bruce D. Walker,
Ragon Institute of MGH, MIT and Harvard, USA
Properties of Protective CD8 T Cell Responses
Properties of Protective CD8 T Cell Responses
Barbara L. Shacklett,
University of California, Davis, USA
Mucosal T-Cell Responses and HIV Infection
Mucosal T-Cell Responses and HIV Infection
Brenna J. Hill,
Frederick National Laboratories, USA
Short Talk: Characterization of SIV-Specific T Cells after Heterologous Mucosal Vaccination
Short Talk: Characterization of SIV-Specific T Cells after Heterologous Mucosal Vaccination
Tomas Hanke,
University of Oxford, UK
Short Talk: Targeting HIV-1 Where It Hurts: Phase I/ IIa Clinical Trials
Short Talk: Targeting HIV-1 Where It Hurts: Phase I/ IIa Clinical Trials
8:00—11:15 AM
Germinal Center, Plasma Cell and Memory B Cell Differentiation
*
Carola G. Vinuesa,
Australian National University, Australia
Regulation of Tfh Cell-Mediated Selection in Germinal Centers
Regulation of Tfh Cell-Mediated Selection in Germinal Centers
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Lipid Cues and Cell Migration during the Humoral Immune Response
Lipid Cues and Cell Migration during the Humoral Immune Response
Jacques F. Banchereau,
The Jackson Laboratory for Genomic Medicine, USA
Dendritic Cells and Macrophages Help the Generation of Human Plasma Cells
Dendritic Cells and Macrophages Help the Generation of Human Plasma Cells
Tomohiro Kurosaki,
Osaka University, Japan
B Cell Intrinsic and Extrinsic Mechanisms for Rapid Responsiveness of IgG1 Type Memory B Cells
B Cell Intrinsic and Extrinsic Mechanisms for Rapid Responsiveness of IgG1 Type Memory B Cells
Christopher C. Goodnow,
Garvan Institute of Medical Research, Australia
Short Talk: Clonal Anergy, the Function of IgD, and Redemption of Self-Reactive Antibodies in Germinal Centers
Short Talk: Clonal Anergy, the Function of IgD, and Redemption of Self-Reactive Antibodies in Germinal Centers
Hai Qi,
Tsinghua University, China
Short Talk: Parenchymal Bystander B Cells Control ICOS-Dependent Follicular Recruitment of Helper T Cells
Short Talk: Parenchymal Bystander B Cells Control ICOS-Dependent Follicular Recruitment of Helper T Cells
2:30—4:30 PM
Workshop 5: Germinal Center B Cell Response
*
Ulf Klein,
Columbia University, USA
Alexander Dent,
Indiana University School of Medicine, USA
Dissecting the Role of BCL6 in Normal B Cells
Dissecting the Role of BCL6 in Normal B Cells
Lisa G. Barnett,
Genomics Institute of the Novartis Research Foundation, USA
Temporally Defined Cognate T Cell-B Cell Interactions Regulate Germinal Center Development
Temporally Defined Cognate T Cell-B Cell Interactions Regulate Germinal Center Development
Gabriel D. Victora,
Rockefeller University, USA
c-MYC Is Required for Germinal Center Selection and Cyclic Re-Entry
c-MYC Is Required for Germinal Center Selection and Cyclic Re-Entry
Zahra Sabouri,
Australian National University, Australia
Antibody Redemption: Removal of Self-Reactivity from IgD+ Anergic B Cells by Purifying Selection in Germinal Centers
Antibody Redemption: Removal of Self-Reactivity from IgD+ Anergic B Cells by Purifying Selection in Germinal Centers
Kai-Michael Toellner,
University of Birmingham, UK
Asymmetric B Cell Division Optimises Information Processing in Germinal Centres
Asymmetric B Cell Division Optimises Information Processing in Germinal Centres
*
Carol E. Schrader,
University of Massachusetts, USA
AP Endonuclease 2 (APE2) Regulates the Expansion of Germinal Center B Cells by Protecting Against Oxidative Damage
AP Endonuclease 2 (APE2) Regulates the Expansion of Germinal Center B Cells by Protecting Against Oxidative Damage
Alberto Martin,
University of Toronto, Canada
Caspase 8 Activity Regulates Germinal Center B Cell Homeostasis and the Generation of High Affinity Antibodies
Caspase 8 Activity Regulates Germinal Center B Cell Homeostasis and the Generation of High Affinity Antibodies
Luise Humpert,
Roche, Switzerland
Functional Role of CXCR7 Expression on Late Germinal Center B Cells
Functional Role of CXCR7 Expression on Late Germinal Center B Cells
2:30—4:30 PM
Workshop 6: Plasma Cell and Memory B Cell Responses
*
John C. Cambier,
University of Colorado, USA
Wei Xu,
Roche Innovation Center Zurich, Switzerland
Identification of Human Granzyme B-Expressing Plasma Cells
Identification of Human Granzyme B-Expressing Plasma Cells
Ignacio Sanz,
Emory University, School of Medicine, USA
Heterogeneity of Antibody Secreting Cell Subsets in Blood after Vaccination and Bone Marrow in Healthy Adults: Identification of Human Long-Lived Plasma Cells
Heterogeneity of Antibody Secreting Cell Subsets in Blood after Vaccination and Bone Marrow in Healthy Adults: Identification of Human Long-Lived Plasma Cells
Laura Ann George,
University of Birmingham, UK
Differential Regulation of IRF4 during Extrafollicular B Cell Differentiation, and its Role for Ig Class Switching
Differential Regulation of IRF4 during Extrafollicular B Cell Differentiation, and its Role for Ig Class Switching
Mark Wright,
Monash University, Australia
Plasma Cells Require CD37-Dependent Integrin Signaling for Long-Term Survival
Plasma Cells Require CD37-Dependent Integrin Signaling for Long-Term Survival
*
Lynn M. Corcoran,
Walter and Eliza Hall Institute of Medical Research, Australia
The BTB-ZF Transcription Factor Zbtb20 Is Driven by Irf4 and Promotes Plasma Cell Differentiation
The BTB-ZF Transcription Factor Zbtb20 Is Driven by Irf4 and Promotes Plasma Cell Differentiation
Deepta Bhattacharya,
Washington University School of Medicine, USA
Adjuvant-Specific Regulation of Long-Term Antibody Responses by Zbtb20
Adjuvant-Specific Regulation of Long-Term Antibody Responses by Zbtb20
Daniel Radtke,
University of Erlangen, Germany
Grb2 Regulates B Cell Maturation, B Cell Memory Responses and Inhibits B Cell Ca2+ Signaling
Grb2 Regulates B Cell Maturation, B Cell Memory Responses and Inhibits B Cell Ca2+ Signaling
Boaz Tirosh,
Hebrew University, Israel
mTORC1 Activation Promotes Plasma Cell Differentiation and Bypasses the Unfolded Protein Response for Immunoglobulin Secretion
mTORC1 Activation Promotes Plasma Cell Differentiation and Bypasses the Unfolded Protein Response for Immunoglobulin Secretion
2:30—4:30 PM
Workshop 7: Autoimmunity and Neoplasia
*
Ann Marshak-Rothstein,
University of Massachusetts Medical School, USA
*
Michael P. Cancro,
University of Pennsylvania, USA
Joseph D. Dekker,
University of Texas at Austin, USA
Pathways and Mechanisms by which FOXP1 and BCL11A Contribute to Activated B Cell Diffuse Large B Cell Lymphoma (ABC-DLBCL)
Pathways and Mechanisms by which FOXP1 and BCL11A Contribute to Activated B Cell Diffuse Large B Cell Lymphoma (ABC-DLBCL)
Carel J. M. van Noesel,
Academic Medical Center, Netherlands
Antigen-Driven Lymphoma Growth: A Novel Mutated B-Cell Chronic Lymphocytic Leukemia Subset that Recognizes and Responds to Fungi
Antigen-Driven Lymphoma Growth: A Novel Mutated B-Cell Chronic Lymphocytic Leukemia Subset that Recognizes and Responds to Fungi
Saravanan Yuvaraj,
Erasmus Medical Centrum, Netherlands
The Role of Antigenic Stimulation in the Pathogenesis of Chronic Lymphocytic Leukemia
The Role of Antigenic Stimulation in the Pathogenesis of Chronic Lymphocytic Leukemia
Simone Bürgler,
Rikshospitalet and University of Oslo, Norway
A Chronic Immune Response between B Cells and T Helper Cells Drives Chronic Lymphocytic Leukemia
A Chronic Immune Response between B Cells and T Helper Cells Drives Chronic Lymphocytic Leukemia
Nataliya Yeremenko,
Academic Medical Center, Netherlands
The Role of Bob1 in Rheumatoid Arthritis: Potential Implications for Autoimmunity
The Role of Bob1 in Rheumatoid Arthritis: Potential Implications for Autoimmunity
Simanta Pathak,
University of Texas Southwestern Medical Center, USA
Overexpression of Fatty Acid Amide Hydrolase Promotes Peripheral B Cell Receptor Revision and Emergence of Polyreactive Antibodies in Lupus Prone Mice
Overexpression of Fatty Acid Amide Hydrolase Promotes Peripheral B Cell Receptor Revision and Emergence of Polyreactive Antibodies in Lupus Prone Mice
Nancy L. Monson,
University of Texas Southwestern Medical Center, USA
B Cells that Display a Particular Somatic Hypermutation Pattern in their Antibody Genes Are Unique to Patients with Multiple Sclerosis and Recognize Neurons and Astrocytes
B Cells that Display a Particular Somatic Hypermutation Pattern in their Antibody Genes Are Unique to Patients with Multiple Sclerosis and Recognize Neurons and Astrocytes
5:00—7:00 PM
Protective Antibody Responses Against HIV (Joint)
*
Christiane Moog,
INSERM and Université of Strasbourg, France
*
Diane L. Bolton,
US Military HIV Research Program
Barton F. Haynes,
Duke University Medical Center, USA
Antibody Virus Co-evolution in Acutely Infected Patients Followed to Broadly Neutralizing Antibody Induction
Antibody Virus Co-evolution in Acutely Infected Patients Followed to Broadly Neutralizing Antibody Induction
Peter D. Kwong,
NIAID, National Institutes of Health, USA
Structural Biology of Sites of HIV-1 Vulnerability to Neutralizing Antibody
Structural Biology of Sites of HIV-1 Vulnerability to Neutralizing Antibody
Dennis R. Burton,
The Scripps Research Institute, USA
Antibody Protection Against HIV: Broadly Neutralizing MAb PGT121
Antibody Protection Against HIV: Broadly Neutralizing MAb PGT121
Georgia D. Tomaras,
Duke University Medical Center, USA
Spectrum of Vaccine-Elicited Humoral Responses
Spectrum of Vaccine-Elicited Humoral Responses
8:00—11:00 AM
New Concepts in Innate Immunity and Stimulation
*
Robert A. Seder,
NIAID, National Institutes of Health, USA
*
Gregg A. Dean,
Colorado State University, USA
Peter Johannes Holst,
BioInnovation Institute, Denmark
Short Talk: MHC Class II Associated Invariant Chain as a Genetic Adjuvant in Virus Vectored Vaccines
Short Talk: MHC Class II Associated Invariant Chain as a Genetic Adjuvant in Virus Vectored Vaccines
Nina Bhardwaj,
Icahn School of Medicine at Mount Sinai, USA
HIV-DC interactions
HIV-DC interactions
Karin Loré,
Karolinska Institutet, Sweden
Innate mechanisms by which Vaccine Adjuvants Influence HIV Env Immunity in Non-Human Primates
Innate mechanisms by which Vaccine Adjuvants Influence HIV Env Immunity in Non-Human Primates
Xu Yu,
Massachusetts General Hospital, USA
Short Talk: LILRB2 Interaction with HLA Class I Correlates with Outcomes of HIV-1 Infection
Short Talk: LILRB2 Interaction with HLA Class I Correlates with Outcomes of HIV-1 Infection
8:00—11:00 AM
MicroRNAs and B Cell Neoplasias
*
Klaus Rajewsky,
Max Delbrück Center for Molecular Medicine, Germany
MicroRNAs in Normal and Neoplastic B Cells
MicroRNAs in Normal and Neoplastic B Cells
Maryaline Coffre,
New York University School of Medicine, USA
Short Talk: Role of RNAi in B Cell Development and Maturation
Short Talk: Role of RNAi in B Cell Development and Maturation
Louis M. Staudt,
NCI, National Institutes of Health, USA
Therapeutic Efficacy of B Cell Receptor Signaling Inhibitors in Lymphoma
Therapeutic Efficacy of B Cell Receptor Signaling Inhibitors in Lymphoma
David Baltimore,
California Institute of Technology, USA
MicroRNAs, Inflammation and Cancer
MicroRNAs, Inflammation and Cancer
2:30—4:30 PM
Workshop 3: CD4+ T Cell Help
*
Nicole Frahm,
Bill & Melinda Gates Medical Research Institute, USA
*
Spyros A. Kalams,
Vanderbilt University Medical Center, USA
Kristin L. Boswell,
NIAID, National Institutes of Health, USA
Characterization of Peripheral TFH-like Cells in HIV Infection
Characterization of Peripheral TFH-like Cells in HIV Infection
Rafael Cubas,
Genentech, USA
Impaired Peripheral Tfh-mediated B-cell Function Affects Humoral Defenses in Chronic HIV Infected Individuals
Impaired Peripheral Tfh-mediated B-cell Function Affects Humoral Defenses in Chronic HIV Infected Individuals
Colin Havenar-Daughton,
Vir Biotechnology, USA
Ability to Generate HIV-1 Neutralizing Antibodies Is Correlated with Increases in Activated Memory B Cells and Peripheral T Follicular Helper Cells
Ability to Generate HIV-1 Neutralizing Antibodies Is Correlated with Increases in Activated Memory B Cells and Peripheral T Follicular Helper Cells
Antje Heit,
Fred Hutchinson Cancer Research Center, USA
HVTN-Tested Candidate HIV Vaccines Induce Early Plasmablast and Tfh-Like Responses in Peripheral Blood
HVTN-Tested Candidate HIV Vaccines Induce Early Plasmablast and Tfh-Like Responses in Peripheral Blood
Kristin Hollister,
Indiana University School of Medicine, USA
Enhanced Expansion of Follicular T Helper Cells following Vaccination with gp120-Encoding DNA
Enhanced Expansion of Follicular T Helper Cells following Vaccination with gp120-Encoding DNA
Patricia Bourguignon,
GlaxoSmithKline Vaccines, Belgium
Co-Administration of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein (F4/AS01) and Adenovirus-35 Gag-RT-Int-Nef (Ad35-GRIN) Induces Potent, Polyfunctional CD4 and CD8 T-Cell Responses
Co-Administration of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein (F4/AS01) and Adenovirus-35 Gag-RT-Int-Nef (Ad35-GRIN) Induces Potent, Polyfunctional CD4 and CD8 T-Cell Responses
5:00—7:00 PM
Antibody Genomics and Immunogen Design
*
Marie Pancera,
Fred Hutchinson Cancer Research Center, USA
Ruth M. Ruprecht,
Texas Biomedical Research Institute, USA
Passive Immunization against Mucosal R5 SHIV Transmission with Different Isotypes of Human Neutralizing Monoclonal Antibodies
Passive Immunization against Mucosal R5 SHIV Transmission with Different Isotypes of Human Neutralizing Monoclonal Antibodies
John R. Mascola,
NIAID, National Institutes of Health, USA
Genetics of Antibody Elicitation
Genetics of Antibody Elicitation
Nicole A. Doria-Rose,
NIAID, National Institutes of Health, USA
Short Talk: Highly Potent V2-Directed Antibodies with Exceptionally Long CDRH3 that Neutralize HIV-1 Subtype C Viruses
Short Talk: Highly Potent V2-Directed Antibodies with Exceptionally Long CDRH3 that Neutralize HIV-1 Subtype C Viruses
Rebecca M. Lynch,
George Washington University, USA
Short Talk: Effective HIV-1 Neutralization at the CD4-Binding Site through Loop-Based Modes of Antibody Recognition
Short Talk: Effective HIV-1 Neutralization at the CD4-Binding Site through Loop-Based Modes of Antibody Recognition
William Schief,
International AIDS Vaccine Initiative and The Scripps Research Institute, USA
Epitope-Focused HIV Vaccine Design
Epitope-Focused HIV Vaccine Design
*
Quentin J. Sattentau,
Sir William Dunn School of Pathology, UK
Chemical Modification of Env for HIV-1 Vaccine Design
Chemical Modification of Env for HIV-1 Vaccine Design
5:00—7:00 PM
Autoimmunity and Regulatory B Cells
*
Betty Diamond,
Feinstein Institute for Medical Research, USA
Negative Regulation of Peripheral Autoreactive B Cells
Negative Regulation of Peripheral Autoreactive B Cells
Robert Brink,
Garvan Institute of Medical Research, Australia
Censoring Self-Reactive B Cells in the Germinal Center Reaction
Censoring Self-Reactive B Cells in the Germinal Center Reaction
Edgar G. Engleman,
Stanford University School of Medicine, USA
B Cells and Insulin Resistance
B Cells and Insulin Resistance
Claude-Agnès Reynaud,
Necker-Paris Medical School, France
Short Talk: B-Cell Depletion in Immune Thrombocytopenia Induces the Settlement of Splenic Long-Lived Plasma Cells
Short Talk: B-Cell Depletion in Immune Thrombocytopenia Induces the Settlement of Splenic Long-Lived Plasma Cells
*Session Chair †Invited, not yet responded.
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