Keystone Symposia

Centro de Artes e Convenções (UFOP) Floorplan

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This meeting took place in 2013

Here are the related meetings in 2021:
Innate Immunity: Mechanisms and Modulation - RESCHEDULING IN PROGRESS (D1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Innate Immune Response in the Pathogenesis of Infectious Disease (E1)

Organizer(s) Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher
May 10—15, 2013
Centro de Artes e Convenções (UFOP) • Ouro Preto, Minas Gerais Brazil
Abstract Deadline: Jan 7, 2013
Late Abstract Deadline: Feb 4, 2013
Scholarship Deadline: Jan 7, 2013
Early Registration Deadline: Mar 5, 2013

Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation.

Summary of Meeting:
The rational development of immunological interventions that are effective for treating or preventing infectious diseases is still on its infancy. For decades, the majority of the studies on immunopathogenesis have dealt with physical damage and inflammation, primarily mediated by lymphocytes. The main focus of this Keystone Symposia meeting will be on the interface of the innate immune system and microbial pathogens and the role that it plays in protective versus deleterious immune responses and, thereby, of disease outcome. The program will promote discussions on fundamental concepts as well as new advances in the role of innate immunity in host resistance and pathogenesis of infectious diseases, with special emphasis on infections of the tropics. Investigators from different areas, such as biochemistry, cell biology, immunology, microbiology, parasitology, infectious diseases, tropical medicine and biotechnology will be included to encourage the discussion of interdisciplinary concepts and new directions for the field. This is the first of a series of Keystone Symposia meetings to be held in Brazil, and should also foster the participation of Latin American students and scientists. The close interaction of these participants with leading international experts in the field should lead to a stimulating atmosphere that we hope will promote the development of new South-North collaborations and research networks.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


Arrival and Registration


Welcome and Keynote Session

Teatro Ouro Preto
* Rodrigo Corrêa-Oliveira, FIOCRUZ, Brazil
Keystone Symposia Brazil and the Challenges of Global Tropical Diseases

Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases



Your Lodging
Poster Setup

Innate Immune Recognition

Teatro Ouro Preto
* Vishva M. Dixit, Genentech, Inc., USA
Non-Canonical Inflammasome Activation Targets Caspase-11

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammatory Gene Expression by Long Noncoding RNAs

Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Detecting and Responding to Microbial Viability

Egil Lien, University of Massachusetts Medical School, USA
Short Talk: Innate Immunity to Plague

Sun Hur, Harvard Medical School, USA
Short Talk: Molecular Mechanism for Viral dsRNA Detection by MDA5 Filaments

Jamie Lemon, University of Pennsylvania, USA
Short Talk: Cytosolic Access and Sensing of Components of Extracellular Bacteria by Macrophages

Coffee Break


Poster Session 1

Workshop 1: Innate Recognition and Signaling

Teatro Ouro Preto
* Marcelo T. Bozza, Universidade Federal do Rio de Janeiro, Brazil

* Koichi S. Kobayashi, Texas A&M Health Science Center, USA

Jiaxi Wu, Regeneron,Inc., USA
Identification of Cyclic-GMP-AMP (cGAMP) and Cyclic-GMP-AMP Synthase (cGAS) as Important Cytosolic DNA Sensing Mediators

Andrea Puhar, Umeå University, Sweden
Shigella Effector IpgD Dampens Inflammation by Securing Hemichannel Closing through Production of PdtIns5P, Thereby Inhibiting Extracellular ATP-Mediated Endogenous Danger Signaling

Rune Hartmann, Aarhus University, Denmark
The Oligoadenylate Synthetase Like Protein (OASL) Enhances Viral Recognition and Interferon Production by Infected Cells

Warrison A. Andrade, Faculdade de Medicina de Ribeirão Preto - FMRP-USP, Brazil
Combined Action of Nucleic Acid-Sensing Toll-Like Receptors (TLRs) and TLR11/TLR12 Heterodimers Imparts Host Resistance to Toxoplasma gondii

Jane Rasaiyaah, University College London, UK
Inhibition of HIV-1-Cofactor Interactions Triggers Innate Sensors and Interferon Secretion

Anamelia Lorenzetti Bocca, Universidade de Brasília, Brazil
Beta-Glucan Reverts the Macrophage Inability to Kill Cryptococcus neoformans in vitro

Sterling C. Eckard, University of Washington, USA
Intracellular Nucleic Acid Metabolism Limits the RIG-I-Mediated Antiviral Response

Felix Meissner, Max Planck Institute of Biochemistry, Germany
Secretomics Defines How Proximal Adaptors of TLRs Regulate Inflammation

Coffee Available

Innate Immunity in Vectors

Teatro Ouro Preto
* Elena A. Levashina, Max Planck Institute for Infection Biology, Germany
Mechanisms of Innate Resistance to Malaria Parasites in the Mosquito

George Dimopoulos, Johns Hopkins University, USA
Innate and Microbiota-Mediated Control of Dengue Virus in Mosquitoes

Simona Paro, IBMC-CNRS/Université de Strasbourg, France
Short Talk: Sensing Viral Nucleic Acids by the Innate Immune System: Lessons from Drosophila

David L. Sacks, NIAID, National Institutes of Health, USA
Influence of Vector Transmission on the Innate Immune Response to Leishmania major

On Own for Dinner



Your Lodging
Innate Lymphoid Cells (ILC) and Mucosal Immunity

Teatro Ouro Preto
* Fiona M. Powrie, University of Oxford, UK
IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal Inflammation and Colon Cancer

David Artis, Weill Cornell Medical College, USA
Regulation of Innate and Adaptive Immunity at Barrier Surfaces

Dan R. Littman, HHMI/New York University School of Medicine, USA
Microbiota-Host Interactions in T Cell Homeostasis and Autoimmune Disease

Marco Colonna, Washington University School of Medicine, USA
Innate Lymphoid Cells in Mucosal Immunity

Lucille Rankin, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: T-bet Is Required for the Development of NKp46+ Innate Lymphoid Cells via a Notch Dependent Pathway

Kevin J. Maloy, University of Oxford, UK
Nlrp3 Inflammasome Activation in the Intestinal Epithelium Protects Against a Mucosal Pathogen

Coffee Break

Poster Setup

On Own for Lunch and Recreation

Coffee Available

Effector Mechanisms

Teatro Ouro Preto
* Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
NETs – From Infection to Autoimmunity

Judith E. Allen, University of Manchester, UK
Macrophages in Helminth Infection

Jonathan Howard, Instituto Gulbenkian de Ciência, Portugal
Genetic Basis of Innate Immune Control of a Parasitic Disease

Dario S. Zamboni, University of São Paulo, Brazil
Short Talk: Inflammasome-Mediated Innate Immune Responses to Leishmania

Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Short Talk: Activation of Caspase-1 by the NLRP3 Inflammasome Regulates NOX2 to Control Phagosome Function

Social Hour with Lite Bites

Poster Session 2




Your Lodging
Innate Cytokines Influencing Adaptive Immunity and Inflammation

Teatro Ouro Preto
* Alan Sher, NIAID, National Institutes of Health, USA
TLR12: A New Player in Innate Recognition and Host Resistance to Protozoan Infection

Robert L. Coffman, Dynavax Technologies, USA
Clinical Applications of Innate Immune Signals

Kingston H.G. Mills, Trinity College Dublin, Ireland
Innate Determinates of Th1/Th17 versus Treg Cells

Edgar M. Carvalho, Universidade Federal da Bahia, Brazil
Innate Determinants in the Control and Pathology of Human Tegumentary Leishmaniasis

Katrijn Neyt, VIB, Ghent University, Belgium
Short Talk: The Innate Cytokine IL-1alpha Is Necessary and Sufficient for Formation of Tertiary Lymphoid Tissues following Influenza A Virus Infection

Andreas Wack, Francis Crick Institute, UK
Short Talk: Pathogenic Potential of Type I IFN in Influenza Infection

Coffee Break

Poster Setup


Poster Session 3

Workshop 2: Cytokines, Inflammation and Pathogenesis

Teatro Ouro Preto
* Sergio Costa Oliveira, Universidade Federal de Minas Gerais, Brazil

* Kevin J. Maloy, University of Oxford, UK

David Sancho, CNIC-Fundación Centro Nacional de Investigaciones Cardiovasculares, Spain
Recognition of Leishmania Parasites by the Macrophage-Inducible C-Type Lectin Mincle Subverts Adaptive Immunity and Promotes Susceptibility to Infection

Jennifer Palomo, CNRS - INEM - UMR7355, France
Type I Interferons Contribute to Orchestrate IFNgamma Dependent Development of Experimental Cerebral Malaria

Maria Bellio, Universidade Federal do Rio de Janeiro, Brazil
Intrinsic IL-18R1 Signaling Pathway Plays a Crucial Role in Th1 Cell Expansion in Mice Infected with Trypanosoma cruzi

Catalina D. Alba Soto, Universidad de Buenos Aires, Argentina
Impairment of Natural Killer (NK) Cells Editing of Immature Dendritic Cells (DC) by Infection with a Virulent Trypanosoma cruzi Population

Gregory F. Sonnenberg, Weill Cornell Medicine, USA
Innate Lymphoid Cells Are Critical Regulators of Host Immune Responses to Bacteria and Intestinal Homeostasis

Shie-Liang Hsieh, Academia Sinica, Taiwan
C-Type Lectin 5A (CLEC5A) Is Critical for the Pathogenesis of Flaviviral Infections

Catherine L. Kennedy, University of Melbourne, Australia
Fas Signaling in Immune Defense Against the Intestinal Pathogen, Citrobacter rodentium

Monica Macal, Five Prime Therapeutics, Inc, USA
TLR7 Is Required for Both Plasmacytoid Dendritic Cell IFN-I Production and Subsequent Exhaustion during Chronic Viral Infection

Coffee Available

Innate Signals in Disease Pathogenesis

Teatro Ouro Preto
Zhijian "James" Chen, University of Texas Southwestern Medical Center, USA
Innate Immune Sensing and Signaling of Cytosolic DNA through a Cyclic Dinucleotide Pathway

Douglas Golenbock, University of Massachusetts Medical School, USA
DNA Sensing Drives the Innate Immune Response in Malaria

* Anne O'Garra, Francis Crick Institute, UK
The Immune Response in Tuberculosis: From Mouse Models to Human Disease

Corey A. Balinsky, NIAID, National Institutes of Health, USA
Short Talk: NF45 Interacts with Dengue Virus Capsid Protein and Modulates Induction of Interferon Beta

Sergio Costa Oliveira, Universidade Federal de Minas Gerais, Brazil
Short Talk: Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection

On Own for Dinner



Your Lodging
Cell Death in Host Resistance and Pathogenesis of Infectious Diseases

Teatro Ouro Preto
Douglas R. Green, St. Jude Children's Research Hospital, USA
Dead on Arrival: How Caspases Promote and Prevent Cell Death

* Ricardo T. Gazzinelli, Fundação Oswaldo Cruz-CPqRR, Brazil
NLRP12/NLRP3-Dependent Caspase-1 Driven Inflammation in Malaria

Maya Saleh, McGill University, Canada
cIAP2 Protects Mice from Alveolar Epithelial Injury during Influenza A Virus Infection

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Inflammasome-Dependent and -Independent Regulation of IL-1 Cytokines in Inflammatory Disease

Karina R. Bortoluci, Federal University of São Paulo, Brazil
Short Talk: Inflammasome-Independent Cell Death Induced by Cytosolic flagellin

Edward A. Miao, University of North Carolina at Chapel Hill, USA
Non-Canonical Inflammasome Activation of Caspase-11 Protects Against Cytosolic Bacteria

Mohamed Lamkanfi, Ghent University, Belgium
Short Talk: Regulation of Nlrp3 Inflammasome Activation by the Ubiquitin-Editing Enzyme A20

Coffee Break

On Own for Lunch and Recreation

Workshop 3: Cell Death and Pathogenesis

Teatro Ouro Preto
* Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil

* Clare E. Bryant, University of Cambridge, UK
A Critical Link between Innate Immunity and Cellular Mechanics to Control Bacterial Load in Macrophages

Petr Broz, University of Lausanne, Switzerland
Caspase-11 Increases Susceptibility to Salmonella Infection in the Absence of Caspase-1

William J. Kaiser, Emory University School of Medicine, USA
Virus Inhibition of Caspase 8 Restricts Pathogenesis via RIP3-Dependent Programmed Necrosis

Marco A. Ataíde, Universidade Federal de Minas Gerais, Brazil
CD14dimCD16+ Monocytes Are a Main Source of Active Caspase-1 and IL-1beta Release during Plasmodium vivax Malaria

Vijay Pancholi, Ohio State University College of Medicine, USA
Group A Streptococcus Ser/Thr Phosphatase-Mediated Apoptosis of Human Respiratory Cells

Mordechay Gerlic, Sackler Faculty of Medicine, Tel Aviv University, Israel
EBV-miR-BART15 Regulates the Nlrp3 Inflammasome and IL-1beta Production

Ivan Tattoli, University of Toronto, Canada
mTOR Signaling and Metabolic Stress Response Pathways in the Host Response to Intracellular Bacteria

Larissa D. Cunha, Ribeirao Preto Medical School, University of Sao Paulo, Brazil
Coxiella burnetii Inhibits Inflammasome Activation through a Dot/Icm-Dependent Effector Protein

Coffee Available

Immunological Adjuvants and Vaccines

Teatro Ouro Preto
* Jorge Kalil, Instituto Butantan, Brazil
Dengue Vaccine Candidates

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Harnessing Human Dendritic Cell Subsets and Follicular Helper T Cell Subsets for Next Generation Vaccines

Closing Keynote Address

Teatro Ouro Preto
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Targeting Dendritic Cells in Malaria Vaccine

Social Hour with Lite Bites





*Session Chair †Invited, not yet responded.

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Bill & Melinda Gates Foundation CNPq - the National Council for Scientific and Technological Development, Brazil
FAPEMIG - Minas Gerais State Agency for Development Research

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AI106140-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Dynavax Technologies Corporation

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Journal of Innate Immunity

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email:,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email:,
Phone:+1 970-262-1179