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This meeting took place in 2014
Here are the related meetings in 2021:
MEETING CHANGE TO VIRTUAL: Autophagy: Mechanisms and Disease (S6)
Autophagy: Mechanisms and Disease (EK7)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Autophagy: Fundamentals to Disease (E2)
Organizer(s) Christina H. Eng, Daniel J. Klionsky, Guido Kroemer and Li Yu
May 23—28, 2014
Hyatt Regency Austin • Austin, TX USA
Discounted Abstract Deadline: Jan 23, 2014
Abstract Deadline: Feb 27, 2014
Scholarship Deadline: Jan 23, 2014
Discounted Registration Deadline: Mar 24, 2014
Sponsored by AbbVie Inc., Cell Research and Shire Human Genetic Therapies
Summary of Meeting:
Autophagy is a fundamental cellular process that orchestrates the degradation of proteins, lipids and organelles during both basal and cellular or environmental stress conditions. Once thought to occur only during times of nutrient limitation, autophagy clearly plays major roles in both developmental and pathological situations. As the importance of autophagy in a variety of diseases is emerging, an in-depth knowledge of primary and alternative autophagic pathways is required to fully understand and effectively modulate it. The forefront of autophagy research will be highlighted at this meeting, from basic mechanistic insights and signaling to the role autophagy plays in multiple disease areas and prospects for therapeutic targeting. Key areas of discussion will include the source of the autophagosomal membrane, new mechanistic insights into both macroautophagy and mitophagy, and the critical roles of autophagy in normal and disease situations such as cancer, neurodegenerative diseases, Crohn’s disease, lysosomal storage diseases, cardiomyopathy and aging. Examining the role of autophagy in disease will enable us to understand in contexts in which modulation of autophagy may be beneficial, and identifying the core processes that control autophagy will enable us to identify tools to modulate the pathway. This meeting will bring together a variety of investigators exploring different facets of autophagy, and their interactions will expand our knowledge of fundamental autophagic mechanisms in different contexts and their critical functions in physiological and pathological settings.
View Scholarships/Awards
Autophagy is a fundamental cellular process that orchestrates the degradation of proteins, lipids and organelles during both basal and cellular or environmental stress conditions. Once thought to occur only during times of nutrient limitation, autophagy clearly plays major roles in both developmental and pathological situations. As the importance of autophagy in a variety of diseases is emerging, an in-depth knowledge of primary and alternative autophagic pathways is required to fully understand and effectively modulate it. The forefront of autophagy research will be highlighted at this meeting, from basic mechanistic insights and signaling to the role autophagy plays in multiple disease areas and prospects for therapeutic targeting. Key areas of discussion will include the source of the autophagosomal membrane, new mechanistic insights into both macroautophagy and mitophagy, and the critical roles of autophagy in normal and disease situations such as cancer, neurodegenerative diseases, Crohn’s disease, lysosomal storage diseases, cardiomyopathy and aging. Examining the role of autophagy in disease will enable us to understand in contexts in which modulation of autophagy may be beneficial, and identifying the core processes that control autophagy will enable us to identify tools to modulate the pathway. This meeting will bring together a variety of investigators exploring different facets of autophagy, and their interactions will expand our knowledge of fundamental autophagic mechanisms in different contexts and their critical functions in physiological and pathological settings.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, MAY 23
SATURDAY, MAY 24
SUNDAY, MAY 25
MONDAY, MAY 26
TUESDAY, MAY 27
WEDNESDAY, MAY 28
Conference Program Print | View meeting in 24 hr (international) time
FRIDAY, MAY 23
8:30—9:30 AM
Keynote Address
*
Christina H. Eng,
Pfizer, USA
9:30—11:45 AM
Autophagosome Biogenesis and Trafficking
*
Li Yu,
Tsinghua University, China
Zvulun Elazar,
Weizmann Institute of Science, Israel
Atg8 in Health and Disease
Atg8 in Health and Disease
Fulvio Reggiori,
University Medical Centre Groningen, Netherlands
Roles of phosphatidylinositol-3-phosphate in autophagy
Roles of phosphatidylinositol-3-phosphate in autophagy
Sharon A. Tooze,
Francis Crick Institute, UK
The Role of PI3P and WIPI2 in Autophagy
The Role of PI3P and WIPI2 in Autophagy
Liang Ge,
Tsinghua University, China
Short Talk: A Functional Approach Identifies the ER-Golgi Intermediate Compartment as a Key Membrane Source for Autophagosome Biogenesis
Short Talk: A Functional Approach Identifies the ER-Golgi Intermediate Compartment as a Key Membrane Source for Autophagosome Biogenesis
3:00—5:00 PM
Workshop 1: Autophagy at the Single Cell and Molecular Level
*
David C. Rubinsztein,
Cambridge Institute for Medical Research, UK
*
Sharon A. Tooze,
Francis Crick Institute, UK
Ben Loos,
Stellenbosch University, South Africa
Defining and Measuring Autophagic Flux at Single Cell Level
Defining and Measuring Autophagic Flux at Single Cell Level
Jiajie Diao,
Stanford University, USA
Single-Vesicle Analysis of SNARE-Mediated Membrane Fusion Involved in Autophagy
Single-Vesicle Analysis of SNARE-Mediated Membrane Fusion Involved in Autophagy
Sangita C. Sinha,
North Dakota State University, USA
Intrinsically Disordered Regions in Autophagy Proteins
Intrinsically Disordered Regions in Autophagy Proteins
Takanori Otomo,
The Scripps Research Institute, USA
Structural Basis of ATG3 Recognition by the Autophagic Ubiquitin-Like Protein ATG12
Structural Basis of ATG3 Recognition by the Autophagic Ubiquitin-Like Protein ATG12
Daric J. Wible,
University of Texas MD Anderson Science Park, USA
ATG16L1 Interaction with ATG5 Forms a Molecular Switch that Controls the Competing Conjugation Reactions of Ubiquitin and the Ubiquitin-Like (Ubl) Protein, ATG12
ATG16L1 Interaction with ATG5 Forms a Molecular Switch that Controls the Competing Conjugation Reactions of Ubiquitin and the Ubiquitin-Like (Ubl) Protein, ATG12
Calvin Yip,
University of British Columbia, Canada
Molecular Architecture of the Saccharomyces cerevisiae Autophagy Regulatory Complex Atg17-Atg31-Atg29
Molecular Architecture of the Saccharomyces cerevisiae Autophagy Regulatory Complex Atg17-Atg31-Atg29
5:30—7:30 PM
Mitochondrial Autophagy
*
Richard J. Youle,
NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin Pathway can Regulate Removal of Impaired Mitochondria by Autophagy
Damage Control - How the Pink1/Parkin Pathway can Regulate Removal of Impaired Mitochondria by Autophagy
Mondira Kundu,
St. Jude Children's Hospital, USA
Mitochondrial (Dys)Function and Autophagy - A “Chicken or Egg?” Conundrum
Mitochondrial (Dys)Function and Autophagy - A “Chicken or Egg?” Conundrum
Charleen T. Chu,
University of Pittsburgh, USA
Mitophagy and Parkinson’s Disease: Hanging in the Balance
Mitophagy and Parkinson’s Disease: Hanging in the Balance
Iain Scott,
University of Pittsburgh, USA
Short Talk: GCN5L1 – Holding the Balance between Mitochondrial Biogenesis and Degradation
Short Talk: GCN5L1 – Holding the Balance between Mitochondrial Biogenesis and Degradation
8:30—11:45 AM
Mechanisms of Autophagy
*
Fulvio Reggiori,
University Medical Centre Groningen, Netherlands
Meiyan Jin,
University of Michigan, USA
Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome Formation
Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome Formation
Adi Kimchi,
Weizmann Institute of Science, Israel
Discovering Novel Protein-Protein Interactions in Autophagy and in its Cross-Talk with Apoptosis
Discovering Novel Protein-Protein Interactions in Autophagy and in its Cross-Talk with Apoptosis
Beat Nyfeler,
Novartis Institutes for BioMedical Research, Switzerland
Genetic and Pharmacological Tools to Modulate Autophagy
Genetic and Pharmacological Tools to Modulate Autophagy
Virginie M. Betin,
University of Bristol, UK
Short Talk: Investigating the Role of Sorting Nexin-4 (SNX4) in Autophagosome Biogenesis
Short Talk: Investigating the Role of Sorting Nexin-4 (SNX4) in Autophagosome Biogenesis
Guang-Chao Chen,
Academia Sinica, Taiwan
Short Talk; The Transmembrane Protein Atg9 Coordinates with dTRAF2/TRAF6 in the Regulation of JNK Signaling and Autophagy Under Oxidative Stress Conditions
Short Talk; The Transmembrane Protein Atg9 Coordinates with dTRAF2/TRAF6 in the Regulation of JNK Signaling and Autophagy Under Oxidative Stress Conditions
5:00—7:00 PM
Role of Autophagy in Neurodegeneration
*
Charleen T. Chu,
University of Pittsburgh, USA
Albert R. La Spada,
Duke University, USA
Defining a Transcriptional Regulatory Network for Autophagy Activation
Defining a Transcriptional Regulatory Network for Autophagy Activation
Patricia Boya,
Centro de Investigaciones Biológicas, CSIC, Spain
Lysosome Dysfunction and Neurodegeneration
Lysosome Dysfunction and Neurodegeneration
David C. Rubinsztein,
Cambridge Institute for Medical Research, UK
ATG16L1 Meets mATG9 in Recycling Endosomes - Additional Roles for the Plasma Membrane and Endocytosis in Autophagosome Biogenesis
ATG16L1 Meets mATG9 in Recycling Endosomes - Additional Roles for the Plasma Membrane and Endocytosis in Autophagosome Biogenesis
Veronika Redmann,
Washington University, USA
Short Talk: Clec16A Plays a Critical Role in Autophagy and the Survival of Purkinje Cells
Short Talk: Clec16A Plays a Critical Role in Autophagy and the Survival of Purkinje Cells
8:30—11:45 AM
Impact of Autophagy in Cancer
*
Beth Levine,
University of Texas Southwestern Medical Center, USA
Guido Kroemer,
Cordeliers Research Center, France
Autophagy and Anticancer Immune Responses
Autophagy and Anticancer Immune Responses
Ravi K. Amaravadi,
University of Pennsylvania, USA
Targeting Autophagy for Cancer Therapy
Targeting Autophagy for Cancer Therapy
Eileen P. White,
Rutgers Cancer Institute of New Jersey, USA
Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
Xian-De Liu,
University of Texas MD Anderson Cancer Center, USA
Short Talk: Autophagy Mediates HIF2alpha Degradation and Suppresses Renal Tumorigenesis
Short Talk: Autophagy Mediates HIF2alpha Degradation and Suppresses Renal Tumorigenesis
David L. Boone,
Indiana University School of Medicine, USA
Short Talk: The Thr300Ala Variant in ATG16L1 Is Associated with Improved Survival in Human Colorectal Cancer and Enhanced Production of Type I Interferon
Short Talk: The Thr300Ala Variant in ATG16L1 Is Associated with Improved Survival in Human Colorectal Cancer and Enhanced Production of Type I Interferon
5:00—7:00 PM
Pharmacological Manipulation of Autophagy
*
Ravi K. Amaravadi,
University of Pennsylvania, USA
Christina H. Eng,
Pfizer, USA
Are Atgs Good Oncology Drug Targets?
Are Atgs Good Oncology Drug Targets?
Natalie D'Amore,
Takeda Boston, USA
Targeting Autophagy for Cancer Therapy
Targeting Autophagy for Cancer Therapy
Junying Yuan,
Harvard Medical School, USA
Chaperone-Mediated Autophagy Degrades Mutant p5
Chaperone-Mediated Autophagy Degrades Mutant p5
Xiaojun Tan,
University of Wisconsin-Madison, USA
Short Talk: A Kinase Independent Role for EGF Receptor in Autophagy Initiation
Short Talk: A Kinase Independent Role for EGF Receptor in Autophagy Initiation
8:30—11:45 AM
Autophagy and Disease
*
Junying Yuan,
Harvard Medical School, USA
Beth Levine,
University of Texas Southwestern Medical Center, USA
Autophagy and Immunity
Autophagy and Immunity
Andrea Ballabio,
Telethon Institute of Genetics and Medicine, Italy
The Transcriptional Control of Autophagy in Health and Disease
The Transcriptional Control of Autophagy in Health and Disease
Ken H. Cadwell,
New York University School of Medicine, USA
Anti-Inflammatory Functions of Autophagy in Crohn’s Disease and Beyond
Anti-Inflammatory Functions of Autophagy in Crohn’s Disease and Beyond
Qingjun Wang,
University of Kentucky, USA
Short Talk: Novel Role of Juvenile Neuronal Ceroid Lipofuscinosis (Batten) Disease Gene CLN3 in Autophagy
Short Talk: Novel Role of Juvenile Neuronal Ceroid Lipofuscinosis (Batten) Disease Gene CLN3 in Autophagy
Neng-Yu Lin,
Friedrich Alexander University, Germany
Short Talk: Inhibition of Autophagy Ameliorates Inflammatory and Non-Inflammatory Bone Loss
Short Talk: Inhibition of Autophagy Ameliorates Inflammatory and Non-Inflammatory Bone Loss
2:30—4:30 PM
Workshop 2: Novel Functions of Autophagy
*
Christina H. Eng,
Pfizer, USA
*
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Hong Dou,
University of Texas MD Anderson Cancer Center, USA
SUMO-Driven Autophagy Regulates DNA Replication
SUMO-Driven Autophagy Regulates DNA Replication
Seungmin (Sam) Hwang,
University of Chicago, USA
Vesicle-Like Endomembrane Structures of Pathogens Are Targeted for Disruption by the Ubiquitin-Like Conjugation Systems of Macroautophagy Pathway
Vesicle-Like Endomembrane Structures of Pathogens Are Targeted for Disruption by the Ubiquitin-Like Conjugation Systems of Macroautophagy Pathway
Wen-Xing Ding,
University of Kansas Medical Center, USA
Excess Endoplasmic Reticulum Is Degraded by SQSTM1/p62-Mediated Selective Autophagy in Mammals
Excess Endoplasmic Reticulum Is Degraded by SQSTM1/p62-Mediated Selective Autophagy in Mammals
Taras Nazarko,
Georgia State University, USA
Atg37/ACBD5 Is a New Important Component of the Pexophagic Receptor Protein Complex
Atg37/ACBD5 Is a New Important Component of the Pexophagic Receptor Protein Complex
Jon Sin,
Heart Institute, Cedars-Sinai Medical Center, USA
Coxsackievirus B3 Escapes the Host Cell via Ejected Autophagosomes
Coxsackievirus B3 Escapes the Host Cell via Ejected Autophagosomes
Chengyu Liang,
University of Southern California, USA
A Coordinator of Golgi-ER Transport and Atg9-Mediated Autophagy Trafficking
A Coordinator of Golgi-ER Transport and Atg9-Mediated Autophagy Trafficking
Michelangelo Campanella,
RVC and UCL Consortium for Mitochondrial Research, UK
The 18kDa Translocator Protein Triggers a ROS-Mediated Inhibition of Mitochondrial Autophagy
The 18kDa Translocator Protein Triggers a ROS-Mediated Inhibition of Mitochondrial Autophagy
Zaiming Tang,
University of Texas Southwestern Medical Center, USA
Autophagy Promotes Primary Ciliogenesis
Autophagy Promotes Primary Ciliogenesis
5:00—7:00 PM
Interplay between Autophagy, Metabolism and Aging
*
Guido Kroemer,
Cordeliers Research Center, France
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Selective Autophagy and Metabolism in Aging
Selective Autophagy and Metabolism in Aging
Frank Madeo,
University of Graz, Austria
Spermidine Induced Autophagy for the Avoidance of Age-Associated Diseases
Spermidine Induced Autophagy for the Avoidance of Age-Associated Diseases
Myung-Shik Lee,
Yonsei University College of Medicine, South Korea
Role of Autophagy in Obesity and Diabetes
Role of Autophagy in Obesity and Diabetes
Louis R. Lapierre,
Brown University, USA
Short Talk: HLH-30/TFEB Is a Conserved Regulator of Autophagy and Modulates Longevity in C. elegans
Short Talk: HLH-30/TFEB Is a Conserved Regulator of Autophagy and Modulates Longevity in C. elegans
*Session Chair †Invited, not yet responded.
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