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This meeting took place in 2014
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Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine (A1)
Organizer(s) Peter J. Ratcliffe, L. Eric Huang, Michael Ohh and Cynthia M. Beall
January 7—12, 2014
Beaver Run Resort • Breckenridge, CO USA
Discounted Abstract Deadline: Oct 2, 2013
Abstract Deadline: Oct 24, 2013
Scholarship Deadline: Oct 2, 2013
Discounted Registration Deadline: Nov 7, 2013
Supported by the Directors' Fund
Summary of Meeting:
Hypoxia is an important component of most human diseases. This meeting will focus on advances in our understanding of the biochemistry and biology of hypoxia signaling and their impact on cell biology, physiology and medicine. Specific emphasis will be placed on the emerging interfaces of hypoxia biology with new areas of scientific progress including metabolic regulation, epigenetic signaling, stem cell biology, inflammation, immunity, tissue repair and cancer. The meeting will also aim to link these processes to the integrative physiology of hypoxia and act as a forum for interfacing reductionist molecular approaches with medical physiology. Key objectives are to: 1) Report key emerging research findings in hypoxia biology across a range of biomedical research fronts; 2) Promote and extend new areas of research into the impact of hypoxia on biological systems; and 3) Foster interdisciplinary research aimed at linking molecular and integrated physiology and defining therapeutic opportunities.
View Scholarships/Awards
Hypoxia is an important component of most human diseases. This meeting will focus on advances in our understanding of the biochemistry and biology of hypoxia signaling and their impact on cell biology, physiology and medicine. Specific emphasis will be placed on the emerging interfaces of hypoxia biology with new areas of scientific progress including metabolic regulation, epigenetic signaling, stem cell biology, inflammation, immunity, tissue repair and cancer. The meeting will also aim to link these processes to the integrative physiology of hypoxia and act as a forum for interfacing reductionist molecular approaches with medical physiology. Key objectives are to: 1) Report key emerging research findings in hypoxia biology across a range of biomedical research fronts; 2) Promote and extend new areas of research into the impact of hypoxia on biological systems; and 3) Foster interdisciplinary research aimed at linking molecular and integrated physiology and defining therapeutic opportunities.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, JANUARY 7
WEDNESDAY, JANUARY 8
THURSDAY, JANUARY 9
FRIDAY, JANUARY 10
SATURDAY, JANUARY 11
SUNDAY, JANUARY 12
Conference Program Print | View meeting in 24 hr (international) time
TUESDAY, JANUARY 7
8:00—9:00 AM
Keynote Address
*
Peter J. Ratcliffe,
University of Oxford, UK
M. Celeste Simon,
University of Pennsylvania, USA
Hypoxia, Metabolism and Tumor Progression
Hypoxia, Metabolism and Tumor Progression
9:00—11:15 AM
Hypoxia Signaling
*
Roland H. Wenger,
University of Zürich, Switzerland
L. Eric Huang,
University of Utah, USA
Non-Canonical HIF Signaling to Malignant Progression-Associated Genetic Alteration
Non-Canonical HIF Signaling to Malignant Progression-Associated Genetic Alteration
Michael Ohh,
University of Toronto, Canada
Mechanistic Insight into the E3 Ligase Activity of VHL Complex
Mechanistic Insight into the E3 Ligase Activity of VHL Complex
Cheng-Jun Hu,
University of Colorado Denver, USA
Short Talk: Role of HIF in Regulating RNA Splicing of HIF Target Genes
Short Talk: Role of HIF in Regulating RNA Splicing of HIF Target Genes
2:00—4:00 PM
Workshop 1: Junior Investigators and Late-Breaking News
*
Max Gassmann,
University of Zürich, Switzerland
Roland H. Wenger,
University of Zürich, Switzerland
Second But Not Last: HIF-2 Regulated Gene Expression
Second But Not Last: HIF-2 Regulated Gene Expression
Sarah Taylor,
University of Liverpool, UK
HIF-2alpha Tracking in Living Cells Using Gold Nanoparticle Functionalisation and Photothermal Microscopy
HIF-2alpha Tracking in Living Cells Using Gold Nanoparticle Functionalisation and Photothermal Microscopy
Jolene Caifeng Ho,
National University of Singapore, Singapore
Hypoxia Mediates Tumourigenesis Epigenetically via the H3K9 Methylation Regulators G9a and Jmjd1a
Hypoxia Mediates Tumourigenesis Epigenetically via the H3K9 Methylation Regulators G9a and Jmjd1a
Kathryn E. Hacker,
University of North Carolina at Chapel Hill, USA
The Interplay between VHL Inactivation and Chromatin Modifiers in ccRCC: How a Distinct Profile of Genetic Alterations Contributes to Tumorigenesis
The Interplay between VHL Inactivation and Chromatin Modifiers in ccRCC: How a Distinct Profile of Genetic Alterations Contributes to Tumorigenesis
Pardeep Heir,
University of Toronto, Canada
Oxygen-Dependent Regulation of JAK/STAT Signal Transduction
Oxygen-Dependent Regulation of JAK/STAT Signal Transduction
Yihua Wang,
Ludwig Institute for Cancer Research, UK
Regulation of FIH Function by Hypoxia and Ankyrin Repeats Containing Protein ASPP2
Regulation of FIH Function by Hypoxia and Ankyrin Repeats Containing Protein ASPP2
Karim Ullah,
University of Oulu, Finland
Inactivation or Deletion of PHD1 Suppresses Inflammatory Response in Mice through p53 Mediated Apoptosis
Inactivation or Deletion of PHD1 Suppresses Inflammatory Response in Mice through p53 Mediated Apoptosis
Sonia Rocha,
University of Liverpool, UK
Role of PHD Enzymes in the Control of the Cell Cycle Machinery
Role of PHD Enzymes in the Control of the Cell Cycle Machinery
4:30—6:45 PM
Hypoxia Signaling in Inflammation and Immunity
*
Michael Ohh,
University of Toronto, Canada
Joaquín M. Espinosa,
Linda Crnic Institute for Down Syndrome, USA
Mechanisms of Transcriptional Regulation in the HIF Network
Mechanisms of Transcriptional Regulation in the HIF Network
Yael Nevo-Caspi,
Safra Children's Hospital, Sheba Medical Center, Israel
Short Talk: F11R Expression upon Hypoxia Is Regulated by RNA Editing
Short Talk: F11R Expression upon Hypoxia Is Regulated by RNA Editing
Randall S. Johnson,
University of Cambridge, UK
Diverse Roles of Hypoxia Signaling in Inflammation
Diverse Roles of Hypoxia Signaling in Inflammation
Drew M. Pardoll,
Johns Hopkins University School of Medicine, USA
HIF-1, Metabolism and T Cell Differentiation
HIF-1, Metabolism and T Cell Differentiation
Romain Vuillefroy de Silly,
Centre of Oncology, Switzerland
Short Talk: Oxygen Tension as a Regulator of CD8+ T Cell Expansion and Function
Short Talk: Oxygen Tension as a Regulator of CD8+ T Cell Expansion and Function
8:00—11:00 AM
Genetic Adaption to Hypoxia
*
Nanduri R. Prabhakar,
University of Chicago, USA
Cynthia M. Beall,
Case Western Reserve University, USA
Human Population Adaptation to Hypoxia at Altitude
Human Population Adaptation to Hypoxia at Altitude
Jay F. Storz,
University of Nebraska, USA
Mechanisms of Hemoglobin Adaptation to Hypoxia in High-Altitude Vertebrates
Mechanisms of Hemoglobin Adaptation to Hypoxia in High-Altitude Vertebrates
Aashish R. Jha,
University of Chicago, USA
Short Talk: Convergent Evolution of Hypoxia Adaptation in Laboratory Selected Drosophila melanogaster and in High Altitude Human Populations
Short Talk: Convergent Evolution of Hypoxia Adaptation in Laboratory Selected Drosophila melanogaster and in High Altitude Human Populations
Tatum S. Simonson,
University of California, San Diego, USA
Genetic Selection of Hypoxia-Related Traits at Altitude
Genetic Selection of Hypoxia-Related Traits at Altitude
Choongwon Jeong,
University of Chicago, USA
Short Talk: Admixture Facilitated Genetic Adaptations to High-Altitude in Tibet
Short Talk: Admixture Facilitated Genetic Adaptations to High-Altitude in Tibet
Nimrat Chatterjee,
Baylor College of Medicine, USA
Short Talk: Environmental Stress Induces Trinucleotide Repeat Instability in Human Cells
Short Talk: Environmental Stress Induces Trinucleotide Repeat Instability in Human Cells
4:30—7:00 PM
Oxygen and Nutrient Signaling in Model Organisms
*
Volker H. Haase,
Vanderbilt University, USA
Utpal Banerjee,
University of California, Los Angeles, USA
Drosophila as a Model System for Analyzing Hif Function
Drosophila as a Model System for Analyzing Hif Function
Christopher M. West,
University of Oklahoma, USA
Ancient Roles of Prolyl Hydroxylases and Glycosyltransferases in Protist O2-Signaling
Ancient Roles of Prolyl Hydroxylases and Glycosyltransferases in Protist O2-Signaling
Peter J. Espenshade,
Johns Hopkins University School of Medicine, USA
Regulation of the Hypoxic Response by the Ofd1 Prolyl Hydroxylase in Fission Yeast
Regulation of the Hypoxic Response by the Ofd1 Prolyl Hydroxylase in Fission Yeast
Pablo Wappner,
Fundacion Instituto Leloir, Argentina
Short Talk: The Drosophila FKBP38 Homologue ZONDA Is Involved in Autophagy
Short Talk: The Drosophila FKBP38 Homologue ZONDA Is Involved in Autophagy
Yi-Hsien Su,
Academia Sinica, Taiwan
Short Talk: Asymmetrical Stabilization of Hypoxia Inducible Factor alpha Regulates Dorsoventral Patterning in the Sea Urchin Embryo
Short Talk: Asymmetrical Stabilization of Hypoxia Inducible Factor alpha Regulates Dorsoventral Patterning in the Sea Urchin Embryo
John Flibotte,
Children's Hospital of Philadelphia, USA
Short Talk: Neural Oxygen Sensing and Neuropeptide Signaling Influence Survival after Anoxia in C. elegans
Short Talk: Neural Oxygen Sensing and Neuropeptide Signaling Influence Survival after Anoxia in C. elegans
8:00—11:00 AM
Signaling of Hypoxia in Health and Disease
*
Cynthia M. Beall,
Case Western Reserve University, USA
Rubin M. Tuder,
University of Ciolorado Hospital - Anschutz, USA
New Insights into Hypoxia and Pulmonary Vascular Biology
New Insights into Hypoxia and Pulmonary Vascular Biology
Nanduri R. Prabhakar,
University of Chicago, USA
Gasotransmitter Signaling: A Key Step in O2 Sensing by the Carotid Body
Gasotransmitter Signaling: A Key Step in O2 Sensing by the Carotid Body
Lorna G. Moore,
University of Colorado, Denver, USA
Trans-Generational Adaptation to Hypoxia at Altitude
Trans-Generational Adaptation to Hypoxia at Altitude
Josef Prchal,
University of Utah, USA
Short Talk: The Mechanisms Responsible for Neocytolysis in the Erythron
Short Talk: The Mechanisms Responsible for Neocytolysis in the Erythron
Kou-Juey Wu,
China Medical University, Taiwan
Short Talk: Post-Translational Regulation of Hypoxia-Induced Epithelial-Mesenchymal Transition
Short Talk: Post-Translational Regulation of Hypoxia-Induced Epithelial-Mesenchymal Transition
Lital Bentovim,
Weizmann Institute of Science, Israel
Short Talk: A Metabolic Switch Turns ON Bone Development
Short Talk: A Metabolic Switch Turns ON Bone Development
2:00—4:00 PM
Workshop 2: Translational: Linking Molecular and Integrative Physiology
*
Johanna Myllyharju,
University of Oulu, Finland
Dörthe M. Katschinski,
Georg August University, Germany
Overlapping and Non-Redundant Functions of PHD Isoforms
Overlapping and Non-Redundant Functions of PHD Isoforms
F. Aisha Chow,
FibroGen Inc., USA
Therapeutic Benefit of HIF Prolyl Hydroxylase Inhibitors in Experimental Autoimmune Encephalomyelitis (EAE), a T-Cell Mediated Model of Multiple Sclerosis
Therapeutic Benefit of HIF Prolyl Hydroxylase Inhibitors in Experimental Autoimmune Encephalomyelitis (EAE), a T-Cell Mediated Model of Multiple Sclerosis
Antonio Heras-Garvín,
Instituto de Biomedicina de Sevilla, Spain
Microglia and Hypoxia: Implications in Alzheimer's Disease
Microglia and Hypoxia: Implications in Alzheimer's Disease
Peppi Koivunen,
University of Oulu, Finland
HIF Prolyl-4-Hydroxylase-2 Inhibition Protects Mice against Obesity and Metabolic Dysfunction
HIF Prolyl-4-Hydroxylase-2 Inhibition Protects Mice against Obesity and Metabolic Dysfunction
Waihay J. Wong,
University of Pennsylvania, USA
Hypoxia Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Formation
Hypoxia Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Formation
Ben Wielockx,
Technical University of Dresden, Germany
Loss of Epithelial HIF Prolyl Hydroxylase-2 (PHD2) Accelerates Skin Wound Healing in Mice
Loss of Epithelial HIF Prolyl Hydroxylase-2 (PHD2) Accelerates Skin Wound Healing in Mice
Pinelopi P. Kapitsinou,
Northwestern University, USA
Hypoxia-Inducible Factor-2 in Endothelial Cells Mediates Protection and Recovery from Ischemic Kidney Injury
Hypoxia-Inducible Factor-2 in Endothelial Cells Mediates Protection and Recovery from Ischemic Kidney Injury
Bing Zhou,
University of Carolina at Chapel Hill, USA
Erythropoietin Promotes Breast Tumorigenesis through Tumor Initiating Cell Self-Renewal
Erythropoietin Promotes Breast Tumorigenesis through Tumor Initiating Cell Self-Renewal
4:30—7:00 PM
Metabolic Regulation and Hypoxia
*
Lorenz Poellinger,
Karolinska Institutet, Sweden
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Metabolic Fluxes and Growth Control in Cancer
Metabolic Fluxes and Growth Control in Cancer
Wilhelm Krek,
Institute of Molecular Health Sciences, ETH Zürich, Switzerland
The Role of Hypoxia Inducible Factors in Cardiac and Adipose Metabolism
The Role of Hypoxia Inducible Factors in Cardiac and Adipose Metabolism
Navdeep S. Chandel,
Northwestern University, USA
Metabolic Signaling to and from the Mitochondrion
Metabolic Signaling to and from the Mitochondrion
Tak W. Mak,
Campbell Family Institute for Breast Cancer, Canada
Epigenetic Regulation of Hematopoiesis by 2-HG and TET Oxygenases
Epigenetic Regulation of Hematopoiesis by 2-HG and TET Oxygenases
Lucy A. Godley,
University of Chicago, USA
Short Talk: TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
Short Talk: TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
8:00—11:00 AM
Cell Differentiation and Stem Cell Biology
*
Dörthe M. Katschinski,
Georg August University, Germany
Toshio Suda,
Keio University, Japan
Metabolic Regulation of Hematopoietic Function
Metabolic Regulation of Hematopoietic Function
Emin Maltepe,
University of California, San Francisco, USA
Short Talk: Non-Canonical HIF-2 Activity Can Regulate Stem Cell Fate in the Placenta
Short Talk: Non-Canonical HIF-2 Activity Can Regulate Stem Cell Fate in the Placenta
Lorenz Poellinger,
Karolinska Institutet, Sweden
Short Talk: Regulation of the Cell Differentation Status by Hypoxia
Short Talk: Regulation of the Cell Differentation Status by Hypoxia
Hannele Ruohola-Baker,
University of Washington, USA
Role of Hypoxia Inducible Factors in Stem Cell Transitions
Role of Hypoxia Inducible Factors in Stem Cell Transitions
Amato J. Giaccia,
Stanford University, USA
Unique Roles of the HIF/PHD Pathway in Normal Tissue Homeostasis and Protection against Stress
Unique Roles of the HIF/PHD Pathway in Normal Tissue Homeostasis and Protection against Stress
Bradly G. Wouters,
University Health Network, Canada
Short Talk: Hypoxia Promotes Stemness and Poor Prognosis through Epigenetic Regulation of DICER
Short Talk: Hypoxia Promotes Stemness and Poor Prognosis through Epigenetic Regulation of DICER
4:30—7:00 PM
New Horizons for Hypoxia Signaling
*
L. Eric Huang,
University of Utah, USA
Gregg L. Semenza,
Johns Hopkins University School of Medicine, USA
Targeting HIFs for the Treatment of Cardiovascular Disease and Cancer
Targeting HIFs for the Treatment of Cardiovascular Disease and Cancer
Stephen Lee,
University of Ottawa, Canada
The Hypoxic Translation Machinery and Cellular Adaptation to Low Oxygen Tension
The Hypoxic Translation Machinery and Cellular Adaptation to Low Oxygen Tension
Ze'ev A. Ronai,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Linking the UPR and Hypoxia by the Ubiquitin Ligases Siah1/2
Short Talk: Linking the UPR and Hypoxia by the Ubiquitin Ligases Siah1/2
Christopher J. Schofield,
University of Oxford, UK
Implications of the Expanding Biology of 2 Oxoglutarate-Dependent Oxygenases
Implications of the Expanding Biology of 2 Oxoglutarate-Dependent Oxygenases
Richard K. Bruick,
University of Texas Southwestern Medical Center, USA
Selective Regulation of HIF-2alpha
Selective Regulation of HIF-2alpha
7:00—7:15 PM
Closing Remarks
Peter J. Ratcliffe,
University of Oxford, UK
Concluding Remarks
Concluding Remarks
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
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Hypoxia journal – Dove Medical Press |
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
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