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This meeting took place in 2014
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Engineering Cell Fate and Function (Z3)
Organizer(s) Darrell J. Irvine, Sangeeta N. Bhatia and Christopher S. Chen
April 6—11, 2014
Resort at Squaw Creek • Olympic Valley, CA USA
Discounted Abstract Deadline: Dec 10, 2013
Abstract Deadline: Jan 15, 2014
Scholarship Deadline: Dec 10, 2013
Discounted Registration Deadline: Feb 6, 2014
Sponsored by Cell Research, Life Technologies Corporation and Sanofi US.
Joint Meeting:
Stem Cells and Reprogramming (Z4)
Summary of Meeting:
This Keystone symposium will bring together scientists and engineers to discuss key challenges in engineering biological systems across length and organizational scales: from single cells, collections of cells, to tissues and organs, with the goal of highlighting key advances being made at each of these length scales and to foster discussion of strategies for engineering biological systems across these scales. In accord with this goal, the meeting features talks starting at methods for engineering single cells and moving toward technologies shaping the function of entire multicellular tissues. The specific aims of the meeting are: (1) Highlight the latest advances in engineering cell fate and function across length scales; (2) Bring together researchers who may not typically engage one another– e.g., experts in engineering the function of single cells for cell therapy and those engaged in building entire tissues for in vivo or in vitro diagnostics/drug screening– with the goal of identifying common themes and spurring new collaborations; (3) Promote the training of young investigators in this highly interdisciplinary field, through interactions with the leaders of the field and colleagues from around the world. This meeting is timely and unique as it will serve as a platform to highlight the many exciting potential applications for cell & tissue engineering beyond regenerative medicine including cell therapy, diagnostics, and tissue models for drug screening and the study of disease pathology.
View Scholarships/Awards
This Keystone symposium will bring together scientists and engineers to discuss key challenges in engineering biological systems across length and organizational scales: from single cells, collections of cells, to tissues and organs, with the goal of highlighting key advances being made at each of these length scales and to foster discussion of strategies for engineering biological systems across these scales. In accord with this goal, the meeting features talks starting at methods for engineering single cells and moving toward technologies shaping the function of entire multicellular tissues. The specific aims of the meeting are: (1) Highlight the latest advances in engineering cell fate and function across length scales; (2) Bring together researchers who may not typically engage one another– e.g., experts in engineering the function of single cells for cell therapy and those engaged in building entire tissues for in vivo or in vitro diagnostics/drug screening– with the goal of identifying common themes and spurring new collaborations; (3) Promote the training of young investigators in this highly interdisciplinary field, through interactions with the leaders of the field and colleagues from around the world. This meeting is timely and unique as it will serve as a platform to highlight the many exciting potential applications for cell & tissue engineering beyond regenerative medicine including cell therapy, diagnostics, and tissue models for drug screening and the study of disease pathology.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 6
MONDAY, APRIL 7
TUESDAY, APRIL 8
WEDNESDAY, APRIL 9
THURSDAY, APRIL 10
FRIDAY, APRIL 11
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 6
09:30—11:45
Engineering Cells and Cell-Mimetic Particles to Impact Fate in vivo
*
Jeffrey A. Hubbell,
University of Chicago, USA
Jeffrey Karp,
Brigham and Women's Hospital, Harvard Medical School, USA
Towards Bioengineered Control of Cell Fate Post-Transplantation
Towards Bioengineered Control of Cell Fate Post-Transplantation
Darrell J. Irvine,
Massachusetts Institute of Technology, USA
Engineering T Cells for Cancer and Infectious Disease
Engineering T Cells for Cancer and Infectious Disease
Ana I. Teixeira,
Karolinska Institutet, Sweden
Short Talk: Spatial Control of Membrane Receptor Function Using Ligand Nano-Calipers
Short Talk: Spatial Control of Membrane Receptor Function Using Ligand Nano-Calipers
Armon Sharei,
SQZ Biotech, USA
Short Talk: Engineering Immune Cell Function Using a Vector-Free Intracellular Delivery Platform
Short Talk: Engineering Immune Cell Function Using a Vector-Free Intracellular Delivery Platform
09:30—11:45
Regulation of Pluripotency I
*
Deepak Srivastava,
Gladstone Institutes, USA
John B. Gurdon,
University of Cambridge, UK
Transcriptional Reprogramming by Amphibian Eggs and Oocytes
Transcriptional Reprogramming by Amphibian Eggs and Oocytes
Shinya Yamanaka,
Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan and Gladstone Institutes, San Francisco
Recent Progress in iPS Cell Research and Application
Recent Progress in iPS Cell Research and Application
Bryce W. Carey,
Rockefeller University, USA
Short Talk: Metabolism Links Self-Renewal to Chromatin Regulation in Naïve Pluripotency
Short Talk: Metabolism Links Self-Renewal to Chromatin Regulation in Naïve Pluripotency
Carol F. Webb,
University of Oklahoma Health Sciences Center, USA
Short Talk: ARID3a Acts as a Barrier to Reprogramming by Repressing Human Oct4 Transcription
Short Talk: ARID3a Acts as a Barrier to Reprogramming by Repressing Human Oct4 Transcription
14:30—16:30
Workshop 1
*
Shinya Yamanaka,
Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan and Gladstone Institutes, San Francisco
Marina Bershteyn,
University of California, San Francisco, USA
Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells
Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells
Chulan Kwon,
Johns Hopkins University, USA
Precardiac Deletion of Numb and Numblike Reveals Renewal of Cardiac Progenitors
Precardiac Deletion of Numb and Numblike Reveals Renewal of Cardiac Progenitors
Wenze Niu,
University of Texas Southwestern Medical Center, USA
Stepwise Conversion of Striatal Astrocytes to Neuroblasts and Mature Neurons in vivo
Stepwise Conversion of Striatal Astrocytes to Neuroblasts and Mature Neurons in vivo
Siim Pauklin,
Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, UK
Cell Fate Propensity Depends on the Cell Cycle State of the Stem Cell
Cell Fate Propensity Depends on the Cell Cycle State of the Stem Cell
Abdenour Soufi,
University of Edinburgh, UK
Nucleosome-Binding Affinity as a Primary Determinant of the Pioneer Activity of Reprogramming Factors
Nucleosome-Binding Affinity as a Primary Determinant of the Pioneer Activity of Reprogramming Factors
Nadja Zeltner,
Memorial Sloan-Kettering Institute, USA
Modeling Disease Severity in an iPSC-Based in vitro Model of Familial Dysautonomia
Modeling Disease Severity in an iPSC-Based in vitro Model of Familial Dysautonomia
Joel W. Blanchard,
The Scripps Research Institute, USA
Induction of Somatic Sensory Neural Lineage from Human and Mouse Fibroblasts
Induction of Somatic Sensory Neural Lineage from Human and Mouse Fibroblasts
17:00—19:00
From Cells to Tissues (Assembly, Morphogenesis, Cell-Cell Interactions in Systems)
*
Jennifer Elisseeff,
Johns Hopkins University, USA
Shulamit Levenberg,
Technion - Israel Institute of Technology, Israel
Cell Organization into 3D Tissue Structures
Cell Organization into 3D Tissue Structures
Peter W. Zandstra,
University of British Columbia, Canada
Engineering Pluripotent Stem Cell Fate to Enable Human Cell- and Tissue-Based Drug Screening and Development
Engineering Pluripotent Stem Cell Fate to Enable Human Cell- and Tissue-Based Drug Screening and Development
Nathan Palpant,
University of Queensland, Australia
Short Talk: In vitro Titration of Wnt/beta-Catenin Signaling Enables Efficient Fate Specification of Lateral Plate Mesoderm Derivatives
Short Talk: In vitro Titration of Wnt/beta-Catenin Signaling Enables Efficient Fate Specification of Lateral Plate Mesoderm Derivatives
Helen M. Blau,
Stanford University, USA
Synergy of Biochemical and Biophysical Cues Rejuvenates the Aged Stem Cell Population which Restores Strength to Aged Muscles
Synergy of Biochemical and Biophysical Cues Rejuvenates the Aged Stem Cell Population which Restores Strength to Aged Muscles
17:00—19:00
Regulation of Pluripotency II
*
Austin Smith,
University of Cambridge, UK
Rudolf Jaenisch,
Whitehead Institute for Biomedical Research, USA
iPS Cell Technology, Gene Editing and Disease Research
iPS Cell Technology, Gene Editing and Disease Research
Robert H. Blelloch,
University of California, San Francisco, USA
Alternative Paths to Induced Pluripotency as Defined by Two MicroRNA Loci
Alternative Paths to Induced Pluripotency as Defined by Two MicroRNA Loci
Kathrin Plath,
University of California, Los Angeles, USA
Insights into Reprogramming to Pluripotency
Insights into Reprogramming to Pluripotency
Ori Bar-Nur,
Harvard university, USA
Short Talk: Small Compounds Facilitate Rapid and Synchronous Reprogramming of Somatic Cells into iPS Cells by Defined Factors
Short Talk: Small Compounds Facilitate Rapid and Synchronous Reprogramming of Somatic Cells into iPS Cells by Defined Factors
08:00—11:15
Redirecting Natural Processes
*
Samuel I. Stupp,
Northwestern University, USA
David J. Mooney,
Harvard University, USA
Biomaterials to Control Immune Cell Trafficking and Activation
Biomaterials to Control Immune Cell Trafficking and Activation
Jeffrey A. Hubbell,
University of Chicago, USA
Molecular Engineering of Growth Factor – ECM Interactions
Molecular Engineering of Growth Factor – ECM Interactions
Eric Lagasse,
University of Pittsburgh, USA
Growing a Surrogate Organ in Lymph Node: From an Experimental Approach to Potential Cinical Applications
Growing a Surrogate Organ in Lymph Node: From an Experimental Approach to Potential Cinical Applications
Jennifer Elisseeff,
Johns Hopkins University, USA
Biomaterial Approaches for Controlling Cell Function and Healing Processes
Biomaterial Approaches for Controlling Cell Function and Healing Processes
Zhen Ma,
University of California, Berkeley, USA
Short Talk: Biophysical Cues for Spatially Differentiating Human Induced Pluripotent Stem Cells into Cardiac Lineage
Short Talk: Biophysical Cues for Spatially Differentiating Human Induced Pluripotent Stem Cells into Cardiac Lineage
Gustavo P. Garlet,
São Paulo University, Brazil
Short Talk: Tregs Chemoattraction Triggers the Redirecting of MSCs Toward a Pro-Reparative and Pro-Immunosuppressive Phenotype that Actively Contributes to Experimental Periodontitis Attenuation
Short Talk: Tregs Chemoattraction Triggers the Redirecting of MSCs Toward a Pro-Reparative and Pro-Immunosuppressive Phenotype that Actively Contributes to Experimental Periodontitis Attenuation
08:00—11:15
Direct Reprogramming (Transdifferentiation)
*
Helen M. Blau,
Stanford University, USA
Deepak Srivastava,
Gladstone Institutes, USA
Reprogramming Approaches for Cardiovascular Disease
Reprogramming Approaches for Cardiovascular Disease
Marius Wernig,
Stanford University, USA
Direct Lineage Reprogramming toward the Neural Lineage
Direct Lineage Reprogramming toward the Neural Lineage
Sheng Ding,
Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
A Chemical Approach to Controlling Cell Fate
A Chemical Approach to Controlling Cell Fate
Eva C. Thoma,
, Switzerland
Short Talk: Chemical Conversion of Human Fibroblasts into Functional Schwann Cells
Short Talk: Chemical Conversion of Human Fibroblasts into Functional Schwann Cells
Yi-Ju Chen,
, USA
Short Talk: De novo Formation of Insulin-Producing “Neo-Beta-Cell Islets” from Intestinal Crypts
Short Talk: De novo Formation of Insulin-Producing “Neo-Beta-Cell Islets” from Intestinal Crypts
17:00—19:15
Models of Human Tissues - Healthy and Diseased
*
Jason A. Burdick,
University of Pennsylvania, USA
Melody A. Swartz,
University of Chicago, USA
Manipulating Lymphatic Endothelial Cells for Immunomodulation
Manipulating Lymphatic Endothelial Cells for Immunomodulation
Donald E. Ingber,
Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Microengineered Human Organs on Chips
Microengineered Human Organs on Chips
Claudia Fischbach-Teschl,
Cornell University, USA
Engineering Meets Cancer Biology: Experimental Models of Tumor Angiogenesis and Metastasis
Engineering Meets Cancer Biology: Experimental Models of Tumor Angiogenesis and Metastasis
Fiona M. Watt,
King's College London School of Medicine, UK
Examining the Interactions between Keratinocytes and their Niche in Normal Epidermis and in Tumors
Examining the Interactions between Keratinocytes and their Niche in Normal Epidermis and in Tumors
17:00—19:00
Epigenetics of Reprogramming and Differentiation.
Session sponsored by Development.
Support for these organizer-selected speakers generously provided by this journal.
*
Rudolf Jaenisch,
Whitehead Institute for Biomedical Research, USA
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Epigenetic Landscape of Pluripotent Stem Cells
Epigenetic Landscape of Pluripotent Stem Cells
Joanna Wysocka,
Stanford University, USA
Enhancer Landscapes in Pluripotency and Differentiation
Enhancer Landscapes in Pluripotency and Differentiation
Benoit G. Bruneau,
Gladstone Institutes, USA
Epigenetic Regulation of Cardiac Lineage Development
Epigenetic Regulation of Cardiac Lineage Development
Alessandro Bertero,
University of Washington, USA
Short Talk: Activin Signaling Controls the Epigenetic Landscape of Human Pluripotent Stem Cells
Short Talk: Activin Signaling Controls the Epigenetic Landscape of Human Pluripotent Stem Cells
08:00—11:00
In vivo Integration/Tolerance/Scaleup/Delivery of Cells and Tissues
*
David J. Mooney,
Harvard University, USA
Daniel G. Anderson,
Massachusetts Institute of Technology, USA
Combinatorial Development of Biomaterials for Cellular Delivery
Combinatorial Development of Biomaterials for Cellular Delivery
Jason A. Burdick,
University of Pennsylvania, USA
Engineering Cardiac Tissue Response Post-Infarction through Biomaterial Design
Engineering Cardiac Tissue Response Post-Infarction through Biomaterial Design
Samuel I. Stupp,
Northwestern University, USA
Signaling and Targeting Cells with Extracellular Supramolecular Structures
Signaling and Targeting Cells with Extracellular Supramolecular Structures
Joseph T. Rodgers,
University of Southern California Keck School of Medicine, USA
Short Talk: Harnessing Physiologic Responses by Quiescent Stem Cells to Improve Wound Repair and Tissue Regeneration
Short Talk: Harnessing Physiologic Responses by Quiescent Stem Cells to Improve Wound Repair and Tissue Regeneration
Yubing Sun,
University of Michigan, Ann Arbor, USA
Short Talk: Biophysical Regulation of Functional Motor Neuron Generation from Human Pluripotent Stem Cells
Short Talk: Biophysical Regulation of Functional Motor Neuron Generation from Human Pluripotent Stem Cells
08:00—11:15
Modeling of Disease
*
Hideyuki Okano,
Keio University School of Medicine, Japan
Fred H. Gage,
The Salk Institute for Biological Studies, USA
Modeling of Complex Neurologic Disease
Modeling of Complex Neurologic Disease
Adam Rosenthal,
Bioverativ, USA
iPSC Models of Alzheimer's Disease: From Platform to Therapeutic Candidate
iPSC Models of Alzheimer's Disease: From Platform to Therapeutic Candidate
Clive N. Svendsen,
Cedars-Sinai Regenerative Medicine Institute, USA
Modeling Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS) and Huntington’s Disease (HD) Using iPS Cells
Modeling Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS) and Huntington’s Disease (HD) Using iPS Cells
Lior Gepstein,
Technion-Israel Institute of Technology, Israel
Modeling of Inherited Cardiac Disorders Using Induced Pluripotent Stem Cells
Modeling of Inherited Cardiac Disorders Using Induced Pluripotent Stem Cells
A. Sophie de Boer,
Harvard University, USA
Short Talk: Genetic Validation of a Therapeutic Target Derived from a Stem Cell Model of ALS
Short Talk: Genetic Validation of a Therapeutic Target Derived from a Stem Cell Model of ALS
Chun-Li Zhang,
University of Texas Southwestern Medical Center, USA
Short Talk: Modeling Human Disease by Using Fibroblast-Converted Functional Motor Neurons
Short Talk: Modeling Human Disease by Using Fibroblast-Converted Functional Motor Neurons
14:30—16:30
Workshop 2: Clinical Progress for Stem Cell Therapies. Organized in collaboration with California Institute for Regenerative Medicine (CIRM)
*
Ellen G. Feigal,
, USA
Eva L. Feldman,
University of Michigan, USA
Intraspinal Stem Cell Transplantation in ALS: Results of a Phase I Clinical Trial
Intraspinal Stem Cell Transplantation in ALS: Results of a Phase I Clinical Trial
Philip D. Gregory,
Bluebird Bio, USA
Genome Editing with Zinc Finger Nucleases: A Novel Apporach to HIV Therapy
Genome Editing with Zinc Finger Nucleases: A Novel Apporach to HIV Therapy
Kevin A. D'Amour,
ViaCyte, Inc., USA
Development of an Encapsulated Stem Cell-Based Therapy for Diabetes
Development of an Encapsulated Stem Cell-Based Therapy for Diabetes
Tracy C. Grikscheit,
Children's Hospital Los Angeles, USA
Defining the Function of Tissue-Engineered Intestine Generated from Human Postnatal Progenitor Cells in a Murine Model
Defining the Function of Tissue-Engineered Intestine Generated from Human Postnatal Progenitor Cells in a Murine Model
17:00—19:15
iPS Models of Disease (Joint)
*
Christopher S. Chen,
Boston University, USA
Lorenz Studer,
Memorial Sloan Kettering Cancer Center, USA
Modeling Disease Severity in an iPSC-Based in vitro Model of Familial Dysautonomia
Modeling Disease Severity in an iPSC-Based in vitro Model of Familial Dysautonomia
George Q. Daley,
HHMI/Boston Children's Hospital, USA
Dissecting Reprogramming, Differentiation and Conversion with Network Biology
Dissecting Reprogramming, Differentiation and Conversion with Network Biology
Sangeeta N. Bhatia,
Massachusetts Institute of Technology, USA
Disease Modeling of Human Hepatotropic Infections in iPS Cells
Disease Modeling of Human Hepatotropic Infections in iPS Cells
Mo Mandegar,
Tenaya Therapeutics, USA
Short Talk: Cardiac Disease Modeling Using Engineered Human iPS Cell-Derived Cardiomyocytes
Short Talk: Cardiac Disease Modeling Using Engineered Human iPS Cell-Derived Cardiomyocytes
Michela Deleidi,
German Center for Neurodegenerative Diseases, Germany
Short Talk: Modeling GBA1-Associated Parkinson's Disease Using Patient iPSCs Reveals Defects in the Lysosomal Machinery and Calcium Homeostasis
Short Talk: Modeling GBA1-Associated Parkinson's Disease Using Patient iPSCs Reveals Defects in the Lysosomal Machinery and Calcium Homeostasis
08:00—11:15
Engineering Mammalian Cells with Synthetic Biology
*
Darrell J. Irvine,
Massachusetts Institute of Technology, USA
Ron Weiss,
Massachusetts Institute of Technology, USA
Synthetic Biology: From Parts to Modules to Therapeutic Systems
Synthetic Biology: From Parts to Modules to Therapeutic Systems
Patrick D. Hsu,
The Salk Institute for Biological Studies, USA
Genome Engineering: Technologies and Applications
Genome Engineering: Technologies and Applications
Wendell A. Lim,
University of California, San Francisco, USA
Exploring and Exploiting the Design Principles of Cell Signaling Networks
Exploring and Exploiting the Design Principles of Cell Signaling Networks
Martin Fussenegger,
ETH Zürich, Switzerland
Prosthetic Networks – Synthetic Biology-Inspired Treatment Strategies for Metabolic Disorders
Prosthetic Networks – Synthetic Biology-Inspired Treatment Strategies for Metabolic Disorders
Victor D. Fedorov,
Memorial Sloan-Kettering Cancer Center, USA
Short Talk: iCARs: Novel Engineered Cell-Intrinsic Safety Switches for Prevention of Immunotherapy Toxicities
Short Talk: iCARs: Novel Engineered Cell-Intrinsic Safety Switches for Prevention of Immunotherapy Toxicities
Samantha A. Morris,
Washington University in St Louis, USA
Short Talk: Enhancing Cellular Engineering through Network Biology
Short Talk: Enhancing Cellular Engineering through Network Biology
08:00—11:15
Translational Applications of Stem Cells
*
Fred H. Gage,
The Salk Institute for Biological Studies, USA
Hideyuki Okano,
Keio University School of Medicine, Japan
Modeling Neurological and Psychiatric Disorders Using iPSCs Technologies and Transgenic Non-Human Primates
Modeling Neurological and Psychiatric Disorders Using iPSCs Technologies and Transgenic Non-Human Primates
Masayo Takahashi,
RIKEN Center for Developmental Biology, Japan
Retinal Cell Therapy Using iPS Cells
Retinal Cell Therapy Using iPS Cells
Leonard I. Zon,
HHMI/Boston Children's Hospital, USA
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment
Lei (Stanley) Qi,
Stanford University, USA
Short Talk: Engineering of the Genome Using CRSPR Technology
Short Talk: Engineering of the Genome Using CRSPR Technology
Christina V. Theodoris,
University of California, San Francisco, USA
Short Talk: iPSC-based Modeling of Human NOTCH1 Mutations Reveals Novel Pathways Regulating Calcific Aortic Valve Disease
Short Talk: iPSC-based Modeling of Human NOTCH1 Mutations Reveals Novel Pathways Regulating Calcific Aortic Valve Disease
17:00—19:15
Cellular Microenvironments/Synthetic Niches to Control Cell Fate (Joint)
*
Sangeeta N. Bhatia,
Massachusetts Institute of Technology, USA
Christopher S. Chen,
Boston University, USA
Mechanoregulation: Linking Adhesion, Force, Form and Function
Mechanoregulation: Linking Adhesion, Force, Form and Function
Jennifer A. Lewis,
Harvard University, SEAS, USA
3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs
3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs
Helen M. Blau,
Stanford University, USA
Short Talk: Rejuvenated Muscle Stem Cell Population Increases Strength in Aged Muscles
Short Talk: Rejuvenated Muscle Stem Cell Population Increases Strength in Aged Muscles
Haiyang Chen,
Carnegie Institution for Science, USA
Short Talk: Nuclear Lamina Regulates Stem-Cell Niche Organization through Integration Nuclear Structure and EGFR Signaling
Short Talk: Nuclear Lamina Regulates Stem-Cell Niche Organization through Integration Nuclear Structure and EGFR Signaling
*Session Chair †Invited, not yet responded.
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