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Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2014

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Mobile Genetic Elements and Genome Evolution (C2)

Organizer(s) Nancy L. Craig, Henry L. Levin and Cedric Feschotte
March 9—14, 2014
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, NM USA
Discounted Abstract Deadline: Nov 6, 2013
Abstract Deadline: Dec 9, 2013
Scholarship Deadline: Nov 6, 2013
Discounted Registration Deadline: Jan 8, 2014

Supported by the Directors' Fund

Summary of Meeting:
Transposable elements are powerful engines of evolution. They constitute the majority of genomic DNA in many eukaryotes, and they dramatically shape genetic content by causing mutations, rearrangements and sequence duplications. Of increasing significance is the link of these transposon-mediated mutations to disease. Sequencing of human populations demonstrates that active transposons are substantially more prevalent than previously appreciated. The aims of this conference are to: 1) Apply recent innovations in high-throughput sequencing and genome analysis to the study of transposon biology and genome evolution; 2) Discuss the discovery of cellular systems that inhibit transposon activity as examples of the evolutionary arms race that exists between mobile DNA and their hosts; and 3) Describe active transposition during neurogenesis and in tumor cells and raise fundamental questions about the role of mobile DNA in brain development and cancer. The symposium is designed to foster ties between leaders in the field of transposon biology and the pioneers of genome analysis. Discussions of transposon activity and genome evolution will focus on mechanistic models. Methods applied to these problems include molecular structures, biochemistry, expression studies and bioinformatic analyses. The transposons and hosts represented in this meeting include diverse examples from eubacteria, archaea, protists, plants and mammals.

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Conference Program    Print  |   View meeting in 24 hr (international) time


4:00—8:00 PM
Arrival and Registration



7:00—8:00 AM

8:00—9:40 AM
Keynote Session

Mesa A-B
Allan C. Spradling, HHMI/Carnegie Institute, USA
Transposon Regulation and Genome Evolution

Haig H. Kazazian, Johns Hopkins University School of Medicine, USA
Biology of Human Retrotransposons: A Potential Role for Retrotransposition in Tumorigenesis?

9:40—10:00 AM
Coffee Break

10:00—11:30 AM
Transposon Applications and Human Health

Mesa A-B
Gerald G. Schumann, Paul-Ehrlich-Institute, Germany
Short Talk: Reprogramming Triggers Mutagenic Endogenous L1, Alu and SVA Retrotransposition in Human Induced Pluripotent Stem Cells

Frederic D. Bushman, University of Pennsylvania, USA
Viral Metagenomes

Shawn M. Burgess, NHGRI, National Institutes of Health, USA
Short Talk: MLV Integration Site Selection Is Driven by Strong Enhancers and Active Promoters: Implications for Genome Evolution and Gene Therapy

* Kevin L. Gunderson, Illumina, Inc., USA
In vitro Transposition Assays for Next Generation Sequencing Library Preparation

11:30 AM—1:00 PM
Poster Setup

Mesa C
1:00—10:00 PM
Poster Viewing

Mesa C
11:30 AM—5:00 PM
On Own for Lunch and Recreation

4:30—5:00 PM
Coffee Available

5:00—7:00 PM
A Transposon-Eye View of Primate Evolution

Mesa A-B
Mark A. Batzer, Louisiana State University, USA
Mobile Elements and Genomic Variation

Geoffrey J. Faulkner, Queensland Brain Institute, Australia
L1 Mobilization in the Mammalian Hippocampus

David B. Greenberg, University of California, Santa Cruz, USA
Short Talk: ZNF91 and ZNF93 Evolved to Restrict SVA and L1 Mobile Elements in Ape Genomes

Pam Cook, NIDDK, National Institutes of Health, USA
Short Talk: Phosphorylation of ORF1p on Conserved MAPK Target and Docking Motifs Regulates L1 Retrotransposition

* John V. Moran, University of Michigan Medical School, USA
The L1 Poly (A) Tail is Required for Efficient Retrotransposition

7:00—8:00 PM
Social Hour with Lite Bites

7:30—10:00 PM
Poster Session 1

Mesa C


7:00—8:00 AM

7:30—8:00 AM
Poster Setup

Mesa C
8:00 AM—7:00 PM
Poster Viewing

Mesa C
8:00—11:00 AM
Mechanisms of Genome Evolution I

Mesa A-B
Marlene Belfort, University of Albany, SUNY, USA
How Intron Retro-Elements Shape Genomes in Bacteria and Yeast

Lynne E. Maquat, University of Rochester Medical Center, USA
Control of Gene Expression via SINE-Containing lncRNAs and mRNAs

Scott Waddell, University of Oxford, UK
Short Talk: Transposition Driven Genomic Heterogeneity in the Drosophila Brain

Kazufumi Mochizuki, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria
Two Types of Eliminated Sequences Express Different Classes of siRNAs during Programmed DNA Elimination in Tetrahymena

Guillaume Cornelis, Stanford University, USA
Short Talk: Syncytin Env Gene Capture: Taming of Endogenous Retroviruses Involved in Placenta Formation and Diversity in Mammals

* Guillaume Bourque, McGill University, Canada
Transposable Elements: Innovation and Biochemical Noise in the Human Genome

9:20—9:40 AM
Coffee Break

11:00 AM—12:00 PM

Mesa C
12:00—2:30 PM
Poster Session 2

Mesa C
2:30—4:30 PM
Workshop 1: Transposition Mechanisms and Regulation

Mesa A-B
Stuart F.J. Le Grice, NCI, National Institutes of Health, USA
Ty3 Reverse Transcriptase Complexed with an RNA/DNA Hybrid Shows Structural and Functional Asymmetry

Jake Z. Jacobs, Rutgers University, USA
Sap1 Replication Fork Barrier Activity Guides the Integration of LTR Retrotransposons in Fission Yeast

Orsolya Barabas, European Molecular Biology Laboratory, Germany
Crystal Structure of a Conjugative Transposon Integrase: Insights into Tyrosine Recombination without Homology

Bao Ton-Hoang, Laboratoire de Microbiologie et de Génétique Moléculaire, LMGM, France
Single Strand Transposases and Genome Dynamics

Antoine Molaro, Fred Hutchinson Cancer Research Center, USA
Multiple Waves of de novo Methylation during Mouse Germ Cell Development

Sergey G. Shpiz, Institute of Molecular Genetics, Russia
Transposon-Induced piRNA Cluster Formation

* R. Keith Slotkin, Ohio State University, USA
Transposable Element Small Interfering RNAs Regulate Genic mRNAs and Inhibit Host TE Silencing

4:30—5:00 PM
Coffee Available

5:00—7:00 PM
Mechanisms of Genome Evolution II

Mesa A-B
David M. Kingsley, Stanford University, USA
Fishing for the Secrets of Vertebrate Evolution

Daniel A. Barbash, Cornell University, USA
How Species Cope with Genomic Cancer

Anne-Marie Dion-Côté, University Laval, Canada
Short Talk: Fast-Forward Speciation: Investigating the Role of Transposable Elements in Reproductive Isolation

David R. Kelley, Harvard University, USA
Short Talk: RNA Binding Proteins Interact Specifically with Transposable Element Sequence in Human Genes

* Cedric Feschotte, Cornell University, USA
Flexible Genomes for Better Flyers: Evolution of the Bat Genome

7:00 PM
On Own for Dinner


7:00—8:00 AM

8:00—11:00 AM
The Contribution of Host Factors to DNA Mobility

Mesa A-B
Suzanne B. Sandmeyer, University of California, Irvine, USA
Ty3 Promoters: Making Sense from the Change

Jef D. Boeke, New York University Langone Medical Center, USA
Affinity Proteomics Reveals Human Host Factors for L1 Retrotransposition

Axel V. Horn, Tulane University, USA
Short Talk: The ESCRT Cargo-Sorting Pathway Is Involved in LINE Retrotransposition

Alan N. Engelman, Dana-Farber Cancer Institute, USA
Host Factors and Multimodal HIV-1 Integrase Inhibitors

Pascale Lesage, Institut Universitaire d'Hématologie, France
Short Talk: An Essential Role of Pol III Subunit AC40 in Ty1 Integration Targeting

Mireille Bétermier, CNRS UPR 3404, France
Short Talk: Ku-Mediated Coupling of DNA Cleavage and Repair during Programmed Genome Rearrangements in Paramecium

* Nancy L. Craig, Johns Hopkins University School of Medicine, USA
Transposon Mechanism and Regulation

9:20—9:40 AM
Coffee Break

11:00 AM—1:00 PM
Poster Setup

Mesa C
1:00—10:00 PM
Poster Viewing

Mesa C
11:00 AM—5:00 PM
On Own for Lunch and Recreation

4:30—5:00 PM
Coffee Available

5:00—7:00 PM
The Biological Impact of Mobile DNA, Friend or Foe I

Mesa A-B
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Nuclear RNA Processing Network and Cryptic Introns Target RNAi to Silence Retrotransposons

Michelle S. Longworth, Cleveland Clinic Lerner Research Institute, USA
Short Talk: Condensin II Subunit dCAP-D3 Prevents Retrotransposon Destabilization in Drosophila Somatic Cells

Damon R. Lisch, University of California, Berkeley, USA
Causes and Consequences of MuDR Transposon Silencing in Maize

Axel Imhof, Ludwig Maximilians University of Munich, Germany
Short Talk: A Pair of Centromeric Proteins Mediates Reproductive Isolation in Drosophila Species

* Henry L. Levin, NIH, USA
The Biological Impact of Mobile DNA

7:00—8:00 PM
Social Hour with Lite Bites

7:30—10:00 PM
Poster Session 3

Mesa C


7:00—8:00 AM

8:00—11:00 AM
The Biological Impact of Mobile DNA, Friend or Foe II

Mesa A-B
William Theurkauf, University of Massachusetts Medical Center, USA
A Role for Germline Transposition in Adaptation to Genetic Stress

Luciano A. Marraffini, Rockefeller University, USA
Tolerance during CRISPR-Cas Immunity: Domesticating the Virus

Grace A. Wyngaard, James Madison University, USA
Short Talk: Billions of Basepairs of Recently Expanded, Repetitive Sequences Are Eliminated from the Somatic Genome during Copepod Development

Todd S. Macfarlan, NICHD, National Institutes of Health, USA
Short Talk: KRAB-ZNF Proteins Function as Species-Specific Pro-Viral Silencers

Vasavi Sundaram, Washington University in St. Louis, USA
Short Talk: Characterization of Transposable Elements’ Contribution to the Innovation of Gene Regulatory Networks in Human and Mouse

* Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Genetic Conflicts between Host and Viral Genomes

9:20—9:40 AM
Coffee Break

11:00 AM—2:30 PM
On Own for Lunch and Recreation

2:30—4:30 PM
Workshop 2: Genetic Variation and Evolution

Mesa A-B
Peter W. Atkinson, University of California, Riverside, USA
The Muta1 Transposon from the Mosquito Aedes aegypti Is Active in its Host Insect and a Range of Organisms

Csaba Miskey, Paul Ehrlich Institut, Germany
Search for the Primate-Specific Functions of SETMAR, a Domesticated, Transposase-Derived Protein in Apes and Humans

Keizo Tomonaga, Kyoto University, Japan
Endogenous Bornavirus-Like Elements: Cellular Co-Option and Impact on Genome Evolution

Josefa González, Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, Spain
A Transposable Element Insertion Confers Xenobiotic Resistance in Drosophila

Inigo Narvaiza, Takeda, USA
Differential L1 Regulation in Induced Pluripotent Stem Cells between Humans and Great Apes

Liana Fasching, Wallenberg Neuroscience Center, Lund University, Sweden
Transcriptional Co-Repressor TRIM28 controls Endogenous Retroviruses in Neural Progenitor Cells

* Josh Dubnau, Stony Brook University, USA
The Transposon Storm Hypothesis of Neurodegeneration

4:30—5:00 PM
Coffee Available

5:00—7:00 PM
The Interface between Mobile DNA, DNA Replication and DNA Repair/The Molecular Face of Transposition

Mesa A-B
Rasika M. Harshey, University of Texas at Austin, USA
Repair of Mu DNA Insertions

Fred Dyda, NIDDK, National Institutes of Health, USA
The Architecture of Hermes, a hAT Family DNA Transposase

Phoebe A. Rice, University of Chicago, USA
Why Are Two Recombinases Better than One: The Large S Recombinases of MRSA

* Joseph E. Peters, Cornell University, USA
Heterologous Expression Reveals a Mechanism for Transposon Tn7 Host Specificity through Adaptation to Replication Processivity Factor

8:00—9:00 PM
Social Hour with Lite Bites

Promenade/Mesa Ballroom
8:00—11:00 PM

Mesa Ballroom



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge additional support for this conference from:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

March of Dimes Foundation Grant No. 4-FY14-469

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Illumina, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

PLOS Genetics

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email:,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

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Phone:+1 970-262-1179