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This meeting took place in 2014
Here are the related meetings in 2020:
Tissue Immunity (A6)
T Cell Memory (X2)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Tissue-Resident Memory T Cells (A4)
Organizer(s) Cornelia L. Trimble, Rachael A. Clark, Leo Lefrançois (in memoriam) and David Masopust
January 12—16, 2014
Snowbird Resort • Snowbird, UT USA
Discounted Abstract Deadline: Oct 3, 2013
Abstract Deadline: Oct 28, 2013
Scholarship Deadline: Oct 3, 2013
Discounted Registration Deadline: Nov 13, 2013
Sponsored by BioLegend, Inc. Supported by an educational donation provided by Amgen.
Summary of Meeting:
Infections that are encountered through epithelial barrier tissues such as the skin, gut, lung and genitourinary tract generate a population of tissue-resident T cells that remain sessile long-term in the affected tissue, and are protective against re-infection. Indeed, most effector memory T cells reside in non-sterile barrier epithelial tissues, as opposed to the circulation. While tissue-resident T cells play a critical role in defending against infections and cancer, aberrant activation of these cells gives rise to inflammatory and autoimmune conditions, including psoriasis, multiple sclerosis and inflammatory bowel disease. Tissue-resident T cells are not simply T cells in an unexpected location; these cells have many phenotypic and functional differences that distinguish them from circulating T cells. This conference will bring together basic and translational immunologists to discuss tissue-localized mechanisms of immune cell recruitment, retention, activation and homeostasis. The major objectives will be to: 1) Explore the roles that tissue immune cells play in immune surveillance, including recall responses to infectious pathogens, and mechanisms of dysregulation leading to autoimmune disease; 2) Examine the mechanisms by which immune responses can be shaped by the local tissue microbiome; 3) Investigate the mechanisms by which immune responses can be subverted by chronic infections or early neoplastic lesions; and 4) Discuss the rationale for immunotherapeutic strategies targeting specific tissue sites. A better understanding of the biology of tissue-resident T cells will inform vaccination strategies for both infections and cancer, as well as novel therapies for inflammatory and autoimmune diseases.
View Scholarships/Awards
Infections that are encountered through epithelial barrier tissues such as the skin, gut, lung and genitourinary tract generate a population of tissue-resident T cells that remain sessile long-term in the affected tissue, and are protective against re-infection. Indeed, most effector memory T cells reside in non-sterile barrier epithelial tissues, as opposed to the circulation. While tissue-resident T cells play a critical role in defending against infections and cancer, aberrant activation of these cells gives rise to inflammatory and autoimmune conditions, including psoriasis, multiple sclerosis and inflammatory bowel disease. Tissue-resident T cells are not simply T cells in an unexpected location; these cells have many phenotypic and functional differences that distinguish them from circulating T cells. This conference will bring together basic and translational immunologists to discuss tissue-localized mechanisms of immune cell recruitment, retention, activation and homeostasis. The major objectives will be to: 1) Explore the roles that tissue immune cells play in immune surveillance, including recall responses to infectious pathogens, and mechanisms of dysregulation leading to autoimmune disease; 2) Examine the mechanisms by which immune responses can be shaped by the local tissue microbiome; 3) Investigate the mechanisms by which immune responses can be subverted by chronic infections or early neoplastic lesions; and 4) Discuss the rationale for immunotherapeutic strategies targeting specific tissue sites. A better understanding of the biology of tissue-resident T cells will inform vaccination strategies for both infections and cancer, as well as novel therapies for inflammatory and autoimmune diseases.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 12
MONDAY, JANUARY 13
TUESDAY, JANUARY 14
WEDNESDAY, JANUARY 15
THURSDAY, JANUARY 16
Conference Program Print | View meeting in 24 hr (international) time
SUNDAY, JANUARY 12
8:00—9:00 AM
Keynote Address
Peter C. Doherty,
University of Melbourne, Australia
Thinking about Memory
Thinking about Memory
9:00—11:30 AM
Tissue-Resident T Cells: What Are the Questions?
*
Philip D. Greenberg,
University of Washington, USA
Wolf-Hervé Fridman,
Cordeliers Research Centre, France
Role of Tumor-Associated Tertiary Lymphoid Structures in the Generation and Shaping of Cancer-Controlling T Lymphocytes
Role of Tumor-Associated Tertiary Lymphoid Structures in the Generation and Shaping of Cancer-Controlling T Lymphocytes
Harlan Robins,
Adaptive Biotechnologies, USA
Immunosequencing Tumor-Infiltrating Lymphocytes in Ovarian and Colon Tumors
Immunosequencing Tumor-Infiltrating Lymphocytes in Ovarian and Colon Tumors
Nelson Glennie,
University of Pennsylvania, USA
Short Talk: The Role of Skin-Localized Memory CD4 T Cells in Protection against Leishmania major
Short Talk: The Role of Skin-Localized Memory CD4 T Cells in Protection against Leishmania major
Jenny Thom,
ETH Zürich, Switzerland
Short Talk: Cytomegalovirus Infection Results in the Formation of CD8+ and CD4+ Tissue Resident Memory T Cells in the Salivary Glands
Short Talk: Cytomegalovirus Infection Results in the Formation of CD8+ and CD4+ Tissue Resident Memory T Cells in the Salivary Glands
Thomas S. Kupper,
Brigham and Women's Hospital, USA
Barrier Epithelial Tissues as Immune Organs
Barrier Epithelial Tissues as Immune Organs
11:30—12:30 AM
Navigating NIAID: Funding Priorities, Processes and Resources
*
Cheryl Lapham†,
NIAID, National Institutes of Health, USA
*
Halonna Kelly,
Division of Allergy, Immunology, and Transplantation, National Institutes of Health, USA
2:30—4:30 PM
Workshop 1
Joshua T. Schiffer,
Fred Hutchinson Cancer Research Center, USA
Contribution of Decay and Movement to CD8+ T-Cell Decline from Genital Tract Micro-Regions following Clearance of HSV-2 Infected Cells: Predictions from a Mathematical Model
Contribution of Decay and Movement to CD8+ T-Cell Decline from Genital Tract Micro-Regions following Clearance of HSV-2 Infected Cells: Predictions from a Mathematical Model
Georg Stary,
Harvard Medical School, USA
Induction of Tissue-Resident Memory CD4+ T Cells in the Genital Tract by Intranasal Application of a Nanoparticle-Based Chlamydia Vaccine
Induction of Tissue-Resident Memory CD4+ T Cells in the Genital Tract by Intranasal Application of a Nanoparticle-Based Chlamydia Vaccine
Elizabeth L. Frost,
Pennsylvania State University College of Medicine, USA
Requirements for the Development and Maintenance of Mouse Polyomavirus-Specific Brain Resident Memory CD8+ T Cells
Requirements for the Development and Maintenance of Mouse Polyomavirus-Specific Brain Resident Memory CD8+ T Cells
Tyler A. Landrith,
University of California, Riverside, USA
Characterization of CD103+ CD8+ T Cell Populations Present in the Brain during Chronic Toxoplasma gondii Infection
Characterization of CD103+ CD8+ T Cell Populations Present in the Brain during Chronic Toxoplasma gondii Infection
Jennifer M. Lund,
Fred Hutchinson Cancer Research Center, USA
Regulatory T Cells Shape the Resident Memory T Cell Response to Virus Infection in the Tissues
Regulatory T Cells Shape the Resident Memory T Cell Response to Virus Infection in the Tissues
Pablo A. Romagnoli,
University of Connecticut Health Center, USA
Memory gammadelta T Cells Orchestrate Response to Secondary Oral Lm Infection
Memory gammadelta T Cells Orchestrate Response to Secondary Oral Lm Infection
*
Marion Pepper,
University of Washington, USA
Visualizing Allergen-Specific Lung-Resident CD4+ Th2 Memory Cells in Asthma
Visualizing Allergen-Specific Lung-Resident CD4+ Th2 Memory Cells in Asthma
Kristin Anderson,
University of Washington, USA
Recirculation and Residence of Memory CD8 T Cells in the Murine Lung
Recirculation and Residence of Memory CD8 T Cells in the Murine Lung
5:00—7:00 PM
Site-Specific: Reproductive Tract Mucosa
*
Cornelia Liu Trimble,
Johns Hopkins University School of Medicine, USA
Tissue T Cells in Preinvasive HPV Disease
Tissue T Cells in Preinvasive HPV Disease
Nicolas Cuburu,
NCI, National Institutes of Health, USA
Intravaginal Vaccination with Human Papillomavirus Vectors Against Herpes Simplex Virus 2 Infection
Intravaginal Vaccination with Human Papillomavirus Vectors Against Herpes Simplex Virus 2 Infection
Norifumi Iijima,
Yale University School of Medicine, USA
Short Talk: A Local Chemokine Network Sustains Tissue-Resident Memory T Cells Crucial for Antiviral Protection
Short Talk: A Local Chemokine Network Sustains Tissue-Resident Memory T Cells Crucial for Antiviral Protection
Lawrence Corey,
Fred Hutchinson Cancer Research Center, USA
8:00—11:15 AM
Imprinting and Plasticity
Kenneth M. Murphy,
HHMI/Washington University School of Medicine, USA
Transcriptional Basis of Dendritic Cell Diversity in T Cell Priming
Transcriptional Basis of Dendritic Cell Diversity in T Cell Priming
David B. Masopust,
University of Minnesota, USA
Characterization of Tissue-Resident Memory CD8 T Cells in Mice: Distribution, Differentiation, and Function
Characterization of Tissue-Resident Memory CD8 T Cells in Mice: Distribution, Differentiation, and Function
Brian J. Laidlaw,
University of California, San Francisco, USA
Short Talk: CD4 Help Is Critical for the Formation of Tissue Resident Memory T Cells following Influenza Infection
Short Talk: CD4 Help Is Critical for the Formation of Tissue Resident Memory T Cells following Influenza Infection
Naomi A. Yudanin,
Weill Cornell Medical College, USA
Short Talk: Mechanisms of Lung-Resident Memory CD4 T Cell Migration and Retention
Short Talk: Mechanisms of Lung-Resident Memory CD4 T Cell Migration and Retention
Stephen C. Jameson,
University of Minnesota Medical School, USA
Putting T Cells in their Place
Putting T Cells in their Place
*
Marc K. Jenkins,
University of Minnesota Medical School, USA
Origins of CD4+ Memory T Cells
Origins of CD4+ Memory T Cells
5:00—7:15 PM
Site-Specific: GI Tract
*
David B. Masopust,
University of Minnesota, USA
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Compartmentalized and Systemic Control of Tissue Immunity by Commensals
Compartmentalized and Systemic Control of Tissue Immunity by Commensals
Hilde Cheroutre,
La Jolla Institute for Allergy and Immunology, USA
From Transcription Factors to Defense Mechanisms: Different Rules Apply for Mucosal Effector Memory T Cells
From Transcription Factors to Defense Mechanisms: Different Rules Apply for Mucosal Effector Memory T Cells
Livija Deban,
Prokarium Ltd., UK
Short Talk: RGS1 Is a Major Regulator of Intestinal TRM Cell Responsiveness
Short Talk: RGS1 Is a Major Regulator of Intestinal TRM Cell Responsiveness
Charisse Petersen,
University of Utah, USA
Short Talk: Direct Recognition of Commensals by T Cells Promotes Microbiota Selection by IgA to Prevent Dysbiosis
Short Talk: Direct Recognition of Commensals by T Cells Promotes Microbiota Selection by IgA to Prevent Dysbiosis
Gregory F. Sonnenberg,
Weill Cornell Medicine, USA
Regulation of Host-Commensal Bacteria Relationships in Human Health and Disease
Regulation of Host-Commensal Bacteria Relationships in Human Health and Disease
8:00—11:15 AM
Site-Specific: Skin
*
Rachael A. Clark,
Brigham and Women's Hospital, Harvard Medical School, USA
Unique Features of Human Skin Resident T Cells
Unique Features of Human Skin Resident T Cells
Wendy L. Havran,
The Scripps Research Institute, USA
Crosstalk between Skin-Resident T Cells and their Neighbors
Crosstalk between Skin-Resident T Cells and their Neighbors
Shruti Naik,
New York University, USA
Short Talk: Specific Commensal-Dendritic Cell Crosstalk Promotes Cutaneous IL-17A+ CD8 T Effectors
Short Talk: Specific Commensal-Dendritic Cell Crosstalk Promotes Cutaneous IL-17A+ CD8 T Effectors
Erika J. Crosby,
Duke University, USA
Short Talk: Bystander CD8 T Cells in the Skin Promote Increased Disease Severity during Leishmania Major Infection
Short Talk: Bystander CD8 T Cells in the Skin Promote Increased Disease Severity during Leishmania Major Infection
Laura K. Mackay,
University of Melbourne, Australia
Generation of Epithelial Resident Memory T Cells
Generation of Epithelial Resident Memory T Cells
Frank Oliver Nestle,
Sanofi, USA
Regulation of Skin T Cells in Skin Homeostasis and Pathology
Regulation of Skin T Cells in Skin Homeostasis and Pathology
2:30—4:30 PM
Workshop 2
*
Donna L. Farber,
Columbia University Medical Center, USA
Marcia A. Blackman,
Trudeau Institute, USA
Effect of Aging on Tissue-Resident Memory to Influenza Virus
Effect of Aging on Tissue-Resident Memory to Influenza Virus
Shiki Takamura,
Kinki University Faculty of Medicine, Japan
CD69 Enhances the Recruitment of Memory CD8+ T Cells to the Lung Airways by Inhibiting S1P-Mediated Lymphocyte Egression from the Lung Parenchyma
CD69 Enhances the Recruitment of Memory CD8+ T Cells to the Lung Airways by Inhibiting S1P-Mediated Lymphocyte Egression from the Lung Parenchyma
Shalini Sharma,
St. Jude Children's Research Hospital, USA
mCMV Alters the Airway Inflammatory Milieu Regulating Protective and Pathogenic Heterologous Immunity to Influenza A Virus Infection
mCMV Alters the Airway Inflammatory Milieu Regulating Protective and Pathogenic Heterologous Immunity to Influenza A Virus Infection
Silvia Ariotti,
Netherlands Cancer Institute, Netherlands
Induction of a Local Anti-Pathogen State by Tissue-Resident Memory CD8+ T Cells
Induction of a Local Anti-Pathogen State by Tissue-Resident Memory CD8+ T Cells
Carmen Gerlach,
Harvard Medical School, USA
Transitional Memory Cells (Ttm) – A Novel Subset of CD8+ Memory T Cells
Transitional Memory Cells (Ttm) – A Novel Subset of CD8+ Memory T Cells
Chang Hoon Lee,
Korea Research Institute of Chemical Technology, South Korea
Human CCR2+ MAIT Cells Demonstrate Efficient Transendothelial Migration that Depends on the Expression of Glycosyltransferases and Non-redundant Chemokine Receptors
Human CCR2+ MAIT Cells Demonstrate Efficient Transendothelial Migration that Depends on the Expression of Glycosyltransferases and Non-redundant Chemokine Receptors
Charles L. Dulberger,
University of Chicago, USA
The Molecular Basis for MAIT Cell Recognition of Microbial Antigens Bound to MR1
The Molecular Basis for MAIT Cell Recognition of Microbial Antigens Bound to MR1
Yujun Huang,
La Jolla Institute for Allergy and Immunology, USA
Driving Pre-Existing Immunity at the Mucosal Borders of the Intestine
Driving Pre-Existing Immunity at the Mucosal Borders of the Intestine
5:00—6:25 PM
Site-Specific: Pulmonary
*
David L. Woodland,
Keystone Symposia on Molecular and Cellular Biology, USA
Linda S. Cauley,
University of Connecticut Health Center, USA
Protection by Tissue-Resident Memory CD8 T Cells in the Lungs
Protection by Tissue-Resident Memory CD8 T Cells in the Lungs
Jie Liu,
NIAID, National Institutes of Health, USA
Short Talk: Pre-Existing Subdominant CD8 T Effectors Control Respiratory Syncytial Virus Lung Infection with Limited Immunopathology
Short Talk: Pre-Existing Subdominant CD8 T Effectors Control Respiratory Syncytial Virus Lung Infection with Limited Immunopathology
Jacob E. Kohlmeier,
Emory University, USA
Generation, Maintenance and Recall of Airway-Resident Memory T Cells
Generation, Maintenance and Recall of Airway-Resident Memory T Cells
6:25—7:00 PM
Closing Remarks
Peter C. Doherty,
University of Melbourne, Australia
Closing Remarks with Acknowledgement of Leo Lefrançois
Closing Remarks with Acknowledgement of Leo Lefrançois
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
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We gratefully acknowledge additional support for this conference from:
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Mucosal Immunology Studies Team (MIST), in memory of Dr. Leo LeFrancois |
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