Keystone Symposia

Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2014

Here are the related meetings in 2021:
Diabetes: Many Faces of the Disease (EK18)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Challenges and Opportunities in Diabetes Research and Treatment (J1)

Organizer(s) Domenico Accili, Masato Kasuga and Morris F. White
January 12—17, 2014
Fairmont Hotel Vancouver • Vancouver, BC Canada
Discounted Abstract Deadline: Oct 4, 2013
Abstract Deadline: Oct 29, 2013
Scholarship Deadline: Oct 4, 2013
Discounted Registration Deadline: Nov 14, 2013

Sponsored by MedImmune, Novo Nordisk A/S, Pfizer Inc. and Takeda Pharmaceutical Company Limited

Summary of Meeting:
Type 2 diabetes affects more than 250 million people worldwide, and available therapeutic options for its treatment fall short of reversing its progressive course, let alone preventing it. This conference is focused on bringing together scientists from academia, government, and industry, to assess the state of medical discovery in areas that are likely to yield therapeutic advances for the prevention, treatment, and reversal of type 2 diabetes. The organizers have identified the following areas, among many deserving to be highlighted, for in-depth analyses and discussions: increasing energy dispersal through "browning" of white fat; metabolic effects of bariatric surgery; hormonal of hepatic lipid and glucose metabolism; integration of omics-based findings to identify biomarkers of disease predisposition and outcomes; insulin signaling and impaired beta cell function; diabetes and cancer; circadian regulation of metabolism and predisposition to diabetes; mechanisms of insulin signaling in the heart and their relationship to heart disease; and emerging therapeutic concepts in counterregulatory systems. The pace of discovery has been especially brisk in these areas, and it's likely to yield exciting new information and therapeutic advances in the foreseeable future. The conference will act as a catalyst for further progress by bringing together leaders in the academic and pharmaceutical communities to present the latest developments in their research.

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Conference Program    Print  |   View meeting in 24 hr (international) time


4:00—8:00 PM
Arrival and Registration

British/Columbia Foyer


7:30—8:30 AM

Pacific Ballroom
8:30—9:30 AM
Keynote Session (Joint)

British/Columbia Ballroom
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
An Increasing Web of Interactions in Diabetes and Obesity

9:30—10:00 AM
Coffee Break

British/Columbia Foyer
10:00 AM—12:30 PM
Metabolic Control in Liver

British Ballroom
* Masato Kasuga, National Center for Global Health and Medicine, Japan

Rebecca A. Haeusler, Columbia University, USA
Regulation of Metabolic Flux by FoxOs during the Fasting–Refeeding Transition

Morris J. Birnbaum, Pfizer Inc., USA
The Control of Hepatic Metabolism by Insulin

Kei Sakamoto, Nestlé Institute of Health Sciences, Switzerland
LKB1-SIK Signaling Pathway in the Control of Hepatic Gluconeogenesis

David J. Lloyd, Amgen, Inc., USA
Short Talk: Small Molecule Disruption of the GKRP-GK Interaction Accompanied with Glucose Lowering Efficacy

Hans-Ulrich Häring, Eberhard-Karls University Tübingen, Germany
Subphenotypes in Prediabetes: Role of Fatty Liver and Brain Insulin Resistance

Following Session is for Obesity: A Multisystems Perspective (J2)

10:00 AM—12:15 PM
Development of Adipose Tissue

Columbia Ballroom
* Christian Wolfrum, ETH Zürich, Switzerland

Jonathan M. Graff, University of Texas Southwestern Medical Center, USA
Adipose Stem Cells: Give Me a Pill Not a Treadmill

Peter Arner, Karolinska Institutet, Sweden
Bone Marrow as a Source of Adipocytes in Adult Humans

Matt Rodeheffer, Yale University, USA
Cellular Mechanisms of Adipogenesis in vivo

David A. Guertin, University of Massachusetts Medical School, USA
Short Talk: New Insights into the Origins and Programming of Adipocyte Development

Dwight J. Klemm, University of Colorado Denver Anschutz Medical Center, USA
Short Talk: De Novo Generation of Adipocytes from Bone Marrow in Human Adipose Tissue

12:30 AM—1:00 PM
Poster Setup

Pacific Ballroom
1:00—10:00 PM
Poster Viewing

Pacific Ballroom
12:30—2:30 PM
On Own for Lunch and Recreation

2:30—4:30 PM
Workshop 1: Inflammation and Insulin Sensitivity

British Ballroom
* Anna Krook, Karolinska Institutet, Sweden

Tine Hannibal, University of Copenhagen, Denmark
Investigating the Role of Plasmacytoid Dendritic Cells in Inflammation Associated with Diabetes

Jan Mauer, Max Planck Institute for Neurological Research, Germany
Novel Aspects of Macrophage IL-6-Signaling in Obesity-Associated Inflammation

Tadasuke Komori, Wakayama Medical University, Japan
Oncostatin M Protects against Obesity and Related Metabolic Disorders in Mice

Aurele Besse-Patin, Montreal Neurological Institute, Canada
Loss of Pgc-1alpha Expression in Aging Mouse Muscle Potentiates Glucose Intolerance and Systemic Inflammation

Yan-Shan Dai, Central South University, China
NFATc3 Is Required for Pancreatic beta-Cell Function and Adipose Tissue Inflammation

Darren C. Henstridge, Baker IDI Heart and Diabetes Institute, Australia
HSP72 Prevents Peripheral Tissue Lipotoxicity and Preserves Insulin Sensitivity by Increasing Oxidative Metabolism in Skeletal Muscle

Following Session is for Obesity: A Multisystems Perspective (J2)

2:30—4:30 PM
Workshop 1: Obesity Drug Discovery

Columbia Ballroom
* Minmin Wang, Eli Lilly and Company, USA

Lex H.T. Van der Ploeg, VDP LLC, USA
Melanocortin 4 Receptor Agonists for the Treatment of Obesity

David Maggs, Fractyl Labs, USA
Endobarrier Therapy for Obesity and Diabetes

Lotte Bjerre Knudsen, Novo Nordisk A/S, Denmark
Liraglutide Lowers Body Weight through CART, NPY and AgRP

Yong Xu, Baylor College of Medicine, USA
Targeting Hypothalamic Steroid Receptor Co-Activator-1 to Treat Diet-Induced Obesity

Zachary R. Patterson, Carleton University, Canada
Novel GOAT Inhibitor, CF801, Reduces Acylated Ghrelin and Body Weight in C57/BL6J Male Mice: A Potential Treatment for Obesity Related Disorders

Susan Cellitti, Genomics Institute of the Novartis Research Foundation, USA
A Novel GLP-1-FGF21 Fusion Protein for the Treatment of Diabetes and Obesity

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:15 PM
Role of Brown Adipose Tissue in Thermogenesis and Glucose Uptake (Joint)

British/Columbia Ballroom
* Jan Nedergaard, Stockholm University, Sweden

* Alexander S. Banks, Harvard Medical School, USA

Barbara Cannon, Stockholm University, Sweden
Brown adipose tissue and thermogenesis

Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Brown Adipose Tissue and a Potential Role in Resolution of the Metabolic Syndrome

Masayuki Saito, Tenshi College, Japan
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fatness in Humans

Antonio J. Vidal-Puig, University of Cambridge, UK
BMP8b and Thermogenesis

7:15—8:15 PM
Social Hour with Lite Bites

Pacific Ballroom
7:30—10:00 PM
Poster Session 1

Pacific Ballroom


7:30—8:30 AM

Pacific Ballroom
8:00—8:30 AM
Poster Setup

Pacific Ballroom
8:30 AM—7:00 PM
Poster Viewing

Pacific Ballroom
8:30—11:45 AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joint)

British/Columbia Ballroom
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

* Laurent Gautron, University of Texas Southwestern Medical Center, USA

Lee M. Kaplan, Massachusetts General Hospital, USA
Molecular Mechanisms of Response to Roux-en-Y Gastric Bypass

Blandine Laferrère, St. Luke's-Roosevelt, Columbia University, USA
Mechanism of Diabetes Remission after Gastric Bypass Surgery: Not Just Weight Loss

Carel Le Roux, University College Dublin, Ireland
Gastro Intestinal Regulation of Appetitive Drives

Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Neural Mechanisms of Gastric Bypass

Nicholas Stylopoulos, Harvard Medical School and Boston Children's Hospital, USA
Short Talk: Bypassing Diabetes by Reprogramming Intestinal Metabolism

Thomas Alexander Lutz, University of Zürich, Switzerland
Short Talk: GLP-1 Contributes to Improved Vascular Reactivity after Roux-en-Y Gastric Bypass Surgery (RYGB)

9:50—10:10 AM
Coffee Break

British/Columbia Foyer
11:45 AM—12:30 PM

Pacific Ballroom
12:00—2:30 PM
Poster Session 2

Pacific Ballroom
2:30—4:30 PM
Workshop 2: Advances in the Diabetes Drug Pipeline

British Ballroom
Avirup Bose, Novartis Institutes for Biomedical Research Inc., USA
FGF21 Pharmacology: Implications for T2D and Beyond?

Philip J. Larsen, Bayer Pharmaceuticals, Germany
Diabetes Therapy of Tomorrow: Beyond Glycemic Control

Anish Konkar, Eli Lilly and Company, Germany
Leveraging Gut Peptides for the Treatment of Type 2 Diabetes

* Cristina M. Rondinone, Cellarity Inc., USA
Biologics: The Future of Cardiometabolic Medicines?

Alessandro Pocai, Janssen, Pharmaceutical Companies of Johnson & Johnson, USA
Glucagon Agonism to Treat Diabetes

Yoshiyuki Tsujihata, Takeda Pharmaceutical Company, Ltd., Japan
Efficacy of Mono and Combination Therapy with GPR40/FFAR1 Agonist Fasiglifam in Animal Models Suggest Potential New Treatment for Type 2 Diabetes

* Bei B. Zhang, Pfizer Inc., USA
Challenges and Opportunities in Diabetes Drug Discovery

Following Session is for Obesity: A Multisystems Perspective (J2)

2:30—4:30 PM
Workshop 2: Hypothalamic Development and Maternal Effects

Columbia Ballroom
Richard B. Simerly, Vanderbilt University, USA
Hypothalamic Development

Kevin L. Grove, Novo Nordisk, USA
Effects of Maternal Overnutrition

Lori M. Zeltser, Columbia University, USA
Early Intervention in a Mouse Model of Childhood Obesity

* William F. Colmers, University of Alberta, Canada
Talk Title Unknown

Sebastien G. Bouret, Inserm U1172, France
Molecular Mechanisms Involved in Hypothalamic Development

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—6:45 PM
Diabetes and Neurodegenerative Disorders

British Ballroom
* Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
IRS Signaling Balances Metabolic Homeostasis and Neurodegeneration

Linda Partridge, Max Planck Institute for Biology of Ageing, Germany
Nutrient-Sensing Pathways and Aging

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
The Dual Function of Autophagy in Aging and Age-Related Disorders

Following Session is for Obesity: A Multisystems Perspective (J2)

5:00—6:45 PM
Role of the Gut Microbiota in Obesity and Metabolic Disorders

Columbia Ballroom
* Helen Cox, King's College London, UK

Frank J. Gonzalez, National Institutes of Health, USA
Microbiome and Intestinal Farnesoid X Receptor in the Control of Obesity

Martin J. Blaser, New York University School of Medicine, USA
Effects of Early Life Antibiotics on Developmental Phenotypes

Patrice D. Cani, Université Catholique de Louvain, Belgium
Cross-Talks between Host Intestinal Epithelial Cells and Gut Microbes Controls Energy Homeostasis

6:45 PM
On Own for Dinner


7:30—8:30 AM

Pacific Ballroom
8:30—11:30 AM

British Ballroom
* Simeon Taylor, University of Maryland School of Medicine, USA

Christopher B. Newgard, Duke University Medical Center, USA
Intermediary Metabolism and Insulin Resistance

Murielle M. Veniant, Amgen Inc., USA
FGF21, a Potential Therapeutic for Type 2 Diabetes

Feifan Guo, Institute for Nutritional Sciences, China
Branched Chain Amino Acids and Metabolic Signaling

Wataru Ogawa, Kobe University, Japan
Novel Variants of PGC1alpha and Muscle Energy Efficiency

Alexander S. Banks, Harvard Medical School, USA
Short Talk: Both Erk and Cdk5 Kinases Control the Diabetogenic Actions of PPARgamma

Christian Bjorbaek, Beth Israel Deaconess Medical Center, USA
Short Talk: Hypothalamic AgRP Neurons and the Central Melanocortin System are Mediators of Leptin’s Anti-Diabetic Actions

Following Session is for Obesity: A Multisystems Perspective (J2)

8:30—11:45 AM
Genetics of Obesity and Metabolic Traits

Columbia Ballroom
* Elizabeth K. Speliotes, University of Michigan, USA

Struan F. A. Grant, Children’s Hospital of Philadelphia Research Institute, USA
Genetics of Common Paediatric Obesity

Cristen J. Willer, University of Michigan, USA
Genetic Architecture of Obesity: Lessons Learned from Lipids

Sadaf Farooqi, University of Cambridge, UK
Genetic Basis of Severe Obesity

Abhimanyu Garg, University of Texas Southwestern Medical Center, USA
Genetic Basis of Lipodystrophies

Marcelo Nobrega, University of Chicago, USA
Short Talk: Obesity-Associated Variants within FTO Form Long-Range Functional Connections with IRX3

Christopher Lelliott, Wellcome Trust Sanger Institute, UK
Short Talk: Discovery of Novel Genes Relevant for Metabolic Homeostasis by the Sanger Mouse Genetics Project

9:50—10:10 AM
Coffee Break

British/Columbia Foyer
11:30 AM—1:00 PM
Poster Setup

Pacific Ballroom
1:00—10:00 PM
Poster Viewing

Pacific Ballroom
11:30 AM—5:00 PM
On Own for Lunch and Recreation

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Insulin Sensitivity in the CV System

British Ballroom
* Juleen R. Zierath, Karolinska Institutet, Sweden

Alan R. Tall, Columbia University, USA
Diabetes and Obesity Promote Myelopoiesis and Atherogenesis

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Myocardial Insulin Signaling, Hyperinsulinemia and Heart Failure

Sekar Kathiresan, Verve Therapeutics, USA
Diabetes and Cardiovascular Disease: Is there a Causal Link in Humans?

In-Kyu Lee, Kyungpook National University Hospital, South Korea
Short Talk: The Role of PDK4 in Vascular Calcification

Following Session is for Obesity: A Multisystems Perspective (J2)

5:00—7:00 PM
CNS Control of Energy Homeostasis

Columbia Ballroom
* Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany

Scott M. Sternson, HHMI/Janelia Research Campus, USA
Neural Circuits that Control Feeding Behavior

Roger D. Cone, University of Michigan, USA
Novel Allosteric Modulators and Signaling Modalities of the Melanocortin-4 Receptor

Michael Rosenbaum, Columbia University Medical College, USA
Leptin Depletion and Repletion

Peter K. Jackson, Stanford University, USA
Short Talk: Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndromepathway to Signal in Neuronal Primary Cilia

7:00—8:00 PM
Social Hour with Lite Bites

Pacific Ballroom
7:30—10:00 PM
Poster Session 3

Pacific Ballroom


7:30—8:30 AM

Pacific Ballroom
8:30—11:30 AM
Diabetes and Cancer

British Ballroom
* Lily Q. Dong, University of Texas Health Science Center, USA

Derek Leroith, Mount Sinai School of Medicine, USA
Diabetes and Cancer: The Role of Insulin and IGFs

Timothy E. McGraw, Weill Medical College of Cornell University, USA
Cancer Metabolism

Kathryn E. Wellen, University of Pennsylvania, USA
Metabolic Reprogramming in Cancer Cells: Links to the Epigenome

Li Qiang, Columbia University Medical Center, USA
Short Talk: Deficiency of Deleted in Breast Cancer 1 Increases Risks for Metabolic Disorders through Activation of Stearoyl-Coenzyme A Desaturase 1

Following Session is for Obesity: A Multisystems Perspective (J2)

8:30—11:45 AM
Circadian Rhythms, Obesity and Metabolic Disorders

Columbia Ballroom
Joseph T. Bass, Northwestern University, USA
Circadian Integration of Mitochondrial Oxidative Function and Behavior

Eve Van Cauter, University of Chicago, USA
Sleep Disturbances and Obesity

* Satchidananda Panda, The Salk Institute for Biological Studies, USA
Rhythmic Feeding and Fasting Prevents Metabolic Diseases in Mice

Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA
Molecular Mechanisms of the Mammalian Circadian Clock

Zach Gerhart-Hines, University of Copenhagen, Denmark
Short Talk: The Nuclear Receptor Rev-erb? Controls Circadian Thermogenic Plasticity

Rosa van den Berg, Leiden University Medical Center, Netherlands
Short Talk: Circadian Rhythm Modulates Body Fat Mass through Regulation of Brown Adipose Tissue Function

11:45 AM—12:30 PM
Joint Workshop: NIH Funding Opportunities through NIDDK

Columbia Ballroom
Carol Renfrew Haft, NIDDK, National Institutes of Health, USA

Aaron Pawlyk, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA

9:50—10:10 AM
Coffee Break

British/Columbia Foyer
12:30—5:00 PM
On Own for Lunch and Recreation

Following Session is for Obesity: A Multisystems Perspective (J2)

2:30—4:30 PM
Workshop 3: Late Breaking Results

Columbia Ballroom
* Lora K. Heisler, Rowett Institute, University of Aberdeen, UK

Brian Finan, Novo Nordisk, USA
Molecular Cold Mimicry via TRPM8 Modulation Amplifies Thermogenesis by Influencing the Adrenergic Axis

Diego V. Bohórquez, Duke University, USA
A Gut-Brain Neurocircuit Unveiled

Jayne F. Martin Carli, Columbia University Medical Center, USA
Functional Analysis of Potential Modifiers of Leptin Production Identified by GWAS

Chen Liu, University of Texas Southwestern Medical Center, USA
A Paradoxical Orexigenic 5HT2CR Circuit in Forebrain Sim1 Neurons

Joseph H. Nadeau, Maine Medical Center Research Institute, USA
Fractal Genetics, Gene Interactions and Systems Properties of Diet Induced Metabolic Conditions

Maja Storm Engelstoft, Kallyope, USA
Identical Nutrient Metabolite Sensors Stimulate GLP-1 Release and Inhibit Ghrelin Release through Differential, Cell-Specific G Protein Coupling

Eugenia Morselli, University of Texas Southwestern Medical Center, USA
Hypothalamic PGC-1alpha Protects against High Fat Diet Exposure by Regulating ER alpha

Arian F. Baquero, Novo Nordisk Inc., USA
ATP-Sensitive Potassium Channels (KATP) Are Essential for the Switch in Leptin Signaling to its Inhibitory Actions on NPY/AgRP Neurons during Development

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Approaches to Beta Cell Failure in Type 2 Diabetes

British Ballroom
Susumu Seino, Kobe University Graduate School of Medicine, Japan
Cell Signaling in Insulin Secretion: Novel Mechanisms of cAMP Action

Domenico Accili, Columbia University, USA
beta-Cell Dedifferentiation and beta-Cell Failure

* Andrew F. Stewart, Mount Sinai School of Medicine, USA
Beta Cell Expansion Strategies

Tsai-Hsiu Tess Lu, Max-Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: PRC2 Stabilizes Functional Beta-Cell Transcriptional Program and Prevents Terminal Dedifferentiation

Following Session is for Obesity: A Multisystems Perspective (J2)

5:00—7:15 PM
All Kinds of -kines

Columbia Ballroom
* Sheila Collins, Vanderbilt University Medical Center, USA

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
FGF21: From Feast to Famine to Pharmacology

Ruth E. Gimeno, Eli Lilly and Company, USA
Secreted Proteins as Therapeutic Targets for Metabolic Disorders

Jaemyoung Suh, Korea Advanced Institute of Science & Technology, South Korea
New Roles for FGF1 in Metabolic Homeostasis and Insulin Sensitization

Rajesh R. Rao, Genomics Institute of Novartis Research Foundation, USA
Short Talk: Identification of a Novel PGC-1alpha4-Dependent Myokine that Regulates Adipose Tissue Thermogenesis, Energy Homeostasis and Inflammation

Nicholas Douris, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Short Talk: The Sympathetic Nervous System Mediates Systemic Adaptation to the Ketogenic Diet

7:00—8:00 PM
Social Hour with Lite Bites

Pacific Ballroom
8:00—11:00 PM

Pacific Ballroom



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

MedImmune Novo Nordisk A/S
Pfizer Inc. Takeda Pharmaceutical Company Limited

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 5R13DK084688-05

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email:,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-1179