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This meeting took place in 2014
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RNA Silencing (A9)
Organizer(s) V. Narry Kim, David P. Bartel and Julius Brennecke
January 31—February 5, 2014
Sheraton Seattle Hotel • Seattle, WA USA
Discounted Abstract Deadline: Oct 10, 2013
Abstract Deadline: Nov 5, 2013
Scholarship Deadline: Oct 10, 2013
Discounted Registration Deadline: Dec 2, 2013
Supported by the Directors' Fund
Summary of Meeting:
Small regulatory RNAs have been implicated in virtually every developmental process and have key impacts on pathological pathways. Over the last 15 years, the field has rapidly discovered novel types of small RNAs and their associated silencing machineries in diverse species. Major gaps remain, however, in our understanding of the function and the molecular mechanisms of the diverse array of RNA silencing pathways. This meeting has been playing a central role in the field of small RNA silencing by mixing and synergizing expertise from diverse academic backgrounds. Since the beginning, it serves as an annual forum for researchers working on many different biological systems ranging from bacteria to plants and humans. The 2014 meeting will adhere to this tradition and puts an additional emphasis on translational research and therapeutics development, as well as emerging resources and technologies.
View Scholarships/Awards
Small regulatory RNAs have been implicated in virtually every developmental process and have key impacts on pathological pathways. Over the last 15 years, the field has rapidly discovered novel types of small RNAs and their associated silencing machineries in diverse species. Major gaps remain, however, in our understanding of the function and the molecular mechanisms of the diverse array of RNA silencing pathways. This meeting has been playing a central role in the field of small RNA silencing by mixing and synergizing expertise from diverse academic backgrounds. Since the beginning, it serves as an annual forum for researchers working on many different biological systems ranging from bacteria to plants and humans. The 2014 meeting will adhere to this tradition and puts an additional emphasis on translational research and therapeutics development, as well as emerging resources and technologies.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, JANUARY 31
SATURDAY, FEBRUARY 1
SUNDAY, FEBRUARY 2
MONDAY, FEBRUARY 3
TUESDAY, FEBRUARY 4
WEDNESDAY, FEBRUARY 5
Conference Program Print | View meeting in 24 hr (international) time
FRIDAY, JANUARY 31
8:30—9:30 AM
Keynote Address
*
V. Narry Kim,
Institute for Basic Science, South Korea
Phillip D. Zamore,
University of Massachusetts Medical School, USA
Germline and Somatic Small Silencing RNAs
Germline and Somatic Small Silencing RNAs
9:30—11:45 AM
Small RNAs in Microorganisms
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
RNA-Programmed Genome Defense by Bacterial CRISPRs
RNA-Programmed Genome Defense by Bacterial CRISPRs
Linfeng Huang,
Immune Disease Institute, Harvard University, USA
Short Talk: siRNA-Like RNAs in Bacteria
Short Talk: siRNA-Like RNAs in Bacteria
Yi Liu,
University of Texas Southwestern Medical Center, USA
Mechanisms of Small and Long Noncoding RNA Pathways in Fungi
Mechanisms of Small and Long Noncoding RNA Pathways in Fungi
Elisabetta Ullu,
Yale University, USA
Small RNA Machinery in Trypanosoma
Small RNA Machinery in Trypanosoma
2:30—4:30 PM
Workshop 1: Regulation of miRNA
*
Antonio J. Giraldez,
Yale University School of Medicine, USA
Haoquan Wu,
Texas Tech University Health Sciences Center, USA
The Lower and Upper Stem–ssRNA Junctions Together Determine the Drosha Cleavage Site
The Lower and Upper Stem–ssRNA Junctions Together Determine the Drosha Cleavage Site
Kristina M. Herbert,
Yale University, USA
Phosphorylation of DGCR8 Increases its Intracellular Stability and Induces a Pro-Growth miRNA Profile
Phosphorylation of DGCR8 Increases its Intracellular Stability and Induces a Pro-Growth miRNA Profile
Eran Hornstein,
Weizmann Institute of Science, Israel
Dicer Activity and microRNA Maturation Are Regulated by Stress Signaling in Neurodegeneration
Dicer Activity and microRNA Maturation Are Regulated by Stress Signaling in Neurodegeneration
Dimitris Lagos,
University of York, UK
The Cytoplasmic microRNA Biogenesis Assembly as a Determinant of Primary Cell Activation and Survival
The Cytoplasmic microRNA Biogenesis Assembly as a Determinant of Primary Cell Activation and Survival
Xuhang Liu,
Rockefeller University, USA
A Precursor MicroRNA Surveillance System in Quality Control of MicroRNA Synthesis
A Precursor MicroRNA Surveillance System in Quality Control of MicroRNA Synthesis
Corinna Speth,
University of Tübingen, Germany
RACK1 Scaffold Proteins Influence miRNA Abundance in Arabidopsis
RACK1 Scaffold Proteins Influence miRNA Abundance in Arabidopsis
Martin J. Simard,
CRCHU de Québec-Université Laval, Canada
Identification of a New Modulator of microRNA Function
Identification of a New Modulator of microRNA Function
Manuel de la Mata,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Target-Mediated microRNA Decay in Neurons
Target-Mediated microRNA Decay in Neurons
5:00—7:00 PM
Structure and Mechanism I
*
Julius Brennecke,
IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
Dinshaw J. Patel,
Memorial Sloan Kettering Cancer Center, USA
Structural Insights into Silencing Machineries
Structural Insights into Silencing Machineries
Leemor Joshua-Tor,
HHMI/Cold Spring Harbor Laboratory, USA
Slicer and the Argonautes
Slicer and the Argonautes
Elisa Izaurralde,
Max Planck Institute for Developmental Biology, Germany
Structural Insight into the Interaction of GW182 Proteins with Deadenylase Complexes
Structural Insight into the Interaction of GW182 Proteins with Deadenylase Complexes
Jinbiao Ma,
Fudan University, China
Short Talk: Structural and Functional Insights into NRPD4/7 Subcomplex of Plant Specific RNA Polymerase IV
Short Talk: Structural and Functional Insights into NRPD4/7 Subcomplex of Plant Specific RNA Polymerase IV
8:30—11:45 AM
Structure and Mechanism II
*
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
Ian MacRae,
The Scripps Research Institute, USA
Structure of Dicer and Argonaute
Structure of Dicer and Argonaute
Antonio J. Giraldez,
Yale University School of Medicine, USA
Silencing Mechanism in Zebrafish
Silencing Mechanism in Zebrafish
Takashi Fukaya,
, Japan
Short Talk: microRNAs Block eIF4F Assembly during Translation Initiation in Drosophila
Short Talk: microRNAs Block eIF4F Assembly during Translation Initiation in Drosophila
V. Narry Kim,
Institute for Basic Science, South Korea
MicroRNA Regulation via 3' End Modifications
MicroRNA Regulation via 3' End Modifications
Xuemei Chen,
University of California, Riverside, USA
Mechanisms of MicroRNA Turnover in Plants
Mechanisms of MicroRNA Turnover in Plants
Ivan Martinez,
West Virginia University, USA
Short Talk: TMG-Capped Primary MicroRNAs are XPO1 Dependent and XPO5 Independent during Cellular Quiescence
Short Talk: TMG-Capped Primary MicroRNAs are XPO1 Dependent and XPO5 Independent during Cellular Quiescence
2:30—4:30 PM
Workshop 2: Biology of Small RNAs
*
Julie M. Claycomb,
University of Toronto, Canada
Amelia F. Alessi,
University of Michigan, USA
CEY-1 Attenuates let-7 MicroRNA-Mediated gene Silencing in C. elegans
CEY-1 Attenuates let-7 MicroRNA-Mediated gene Silencing in C. elegans
Hervé Seitz,
CNRS, France
MicroRNA Titration by Pseudo-Targets: An Alternative Explanation to Seed Match Conservation
MicroRNA Titration by Pseudo-Targets: An Alternative Explanation to Seed Match Conservation
Hyun Yong Jin,
The Scripps Research Institute, USA
MiR-17~92 and Lymphomagenesis: Functions and Mechanistic Insights into MiRNA-Mediated Gene Regulation
MiR-17~92 and Lymphomagenesis: Functions and Mechanistic Insights into MiRNA-Mediated Gene Regulation
Alex S. So,
California Institute of Technology, USA
Dual Mechanisms by which MiR-125b Represses IRF4 to Induce Myeloid and B Cell Leukemias
Dual Mechanisms by which MiR-125b Represses IRF4 to Induce Myeloid and B Cell Leukemias
Rui Zhou,
Johns Hopkins University School of Medicine, USA
Core snRNP Splicing Factor SmD1 Modulates RNAi in Drosophila
Core snRNP Splicing Factor SmD1 Modulates RNAi in Drosophila
Anastasios Vourekas,
University of Pennsylvania, USA
Direct Roles of MOV10L1 in Primary piRNA Precursor Processing Revealed by Transcriptome-Wide Target RNA Identification
Direct Roles of MOV10L1 in Primary piRNA Precursor Processing Revealed by Transcriptome-Wide Target RNA Identification
Colin Dean Malone,
Columbia University College of Physicians and Surgeons, USA
The Exon Junction Complex Controls Transposon Mobilization in Drosophila Gonads by Ensuring Faithful Splicing of Piwi Transcripts
The Exon Junction Complex Controls Transposon Mobilization in Drosophila Gonads by Ensuring Faithful Splicing of Piwi Transcripts
5:00—7:00 PM
Small RNAs in Disease and Therapeutics
*
David P. Bartel,
Massachusetts Institute of Technology and Whitehead Institute, USA
Joshua T. Mendell,
University of Texas Southwestern Medical Center, USA
Mammalian MicroRNA Functions in Normal Physiology and Cancer
Mammalian MicroRNA Functions in Normal Physiology and Cancer
Sonya D. Zabludoff,
Regulus Therapeutics, USA
Targeting the Pathways of Human Disease with MicroRNA Therapeutics
Targeting the Pathways of Human Disease with MicroRNA Therapeutics
Christopher L. Daige,
Mirna Therapeutics, USA
Short Talk: Development of a miR34-Based Cancer Therapy
Short Talk: Development of a miR34-Based Cancer Therapy
Rachel E. Meyers,
Third Rock Ventures, USA
Developing RNAi Therapeutics for the Treatment of Rare Diseases
Developing RNAi Therapeutics for the Treatment of Rare Diseases
8:30—11:45 AM
Function of MicroRNA
*
Gregory J. Hannon,
University of Cambridge, UK
David P. Bartel,
Massachusetts Institute of Technology and Whitehead Institute, USA
MicroRNAs and their Regulatory Effects
MicroRNAs and their Regulatory Effects
Eric C. Lai,
Sloan Kettering Institute, USA
Genetic Analysis of Neural miRNA Functions
Genetic Analysis of Neural miRNA Functions
Katherine McJunkin,
NIDDK, National Institutes of Health, USA
Short Talk: An Essential MicroRNA Family Prevents Precocious Expression of the Sex Determination Program in C. elegans
Short Talk: An Essential MicroRNA Family Prevents Precocious Expression of the Sex Determination Program in C. elegans
Robert H. Blelloch,
University of California, San Francisco, USA
MicroRNA Destabilization and Stabilization of Cell Fates
MicroRNA Destabilization and Stabilization of Cell Fates
Jia L. Song,
University of Delaware, USA
Short Talk: Functional Analysis of MicroRNAs in Cell Specification and Morphogenesis
Short Talk: Functional Analysis of MicroRNAs in Cell Specification and Morphogenesis
5:00—7:00 PM
Small Interfering RNAs
*
Xuemei Chen,
University of California, Riverside, USA
Andrew Fire,
Stanford University, USA
Triggers and Limits to Amplification in RNAi
Triggers and Limits to Amplification in RNAi
Kazufumi Mochizuki,
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria
Transgenerational Epigenetic Inheritance of DNA Elimination in Tetrahymena
Transgenerational Epigenetic Inheritance of DNA Elimination in Tetrahymena
Blake C. Meyers,
Donald Danforth Plant Science Center, USA
Short Talk: Plant PhasiRNAs in Male Reproductive Tissues, as Analogs of Mammalian piRNAs
Short Talk: Plant PhasiRNAs in Male Reproductive Tissues, as Analogs of Mammalian piRNAs
8:30—11:45 AM
Piwi-Interacting RNAs and Genome Control
*
Phillip D. Zamore,
University of Massachusetts Medical School, USA
Gregory J. Hannon,
University of Cambridge, UK
Small RNAs in Mammalian Germline
Small RNAs in Mammalian Germline
Haruhiko Siomi,
Keio University School of Medicine, Japan
Small RNAs in the Adult Testes of the Common Marmoset, a Model Primate
Small RNAs in the Adult Testes of the Common Marmoset, a Model Primate
Julius Brennecke,
IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
The Involvement of Chromatin in the Drosophila piRNA Pathway
The Involvement of Chromatin in the Drosophila piRNA Pathway
Zhao Zhang,
Carnegie Institution for Science, USA
Short Talk: Organization of a Transposon Silencing Machine
Short Talk: Organization of a Transposon Silencing Machine
Alexei A. Aravin,
California Institute of Technology, USA
Short Talk: The Role of Chromatin and Trans-Generational Inheritance in piRNA Biogenesis
Short Talk: The Role of Chromatin and Trans-Generational Inheritance in piRNA Biogenesis
Julie M. Claycomb,
University of Toronto, Canada
Short Talk: The C. elegans Argonaute CSR-1 Licenses Germline Gene Expression
Short Talk: The C. elegans Argonaute CSR-1 Licenses Germline Gene Expression
Colin C. Conine,
University of Massachusetts Medical School, USA
Short Talk: Argonautes Promote Transcription in the Male Germline and Provide a Paternal Memory of Germline Gene Expression in C. elegans
Short Talk: Argonautes Promote Transcription in the Male Germline and Provide a Paternal Memory of Germline Gene Expression in C. elegans
2:30—4:30 PM
Workshop 3: Technology, Disease and Therapeutics
*
Eric C. Lai,
Sloan Kettering Institute, USA
Jerome E. Lee,
University of Colorado, USA
High-Efficiency RNA Cloning Enables Accurate Quantification of miRNA Expression by Deep Sequencing
High-Efficiency RNA Cloning Enables Accurate Quantification of miRNA Expression by Deep Sequencing
Sung Wook Chi,
Korea University, South Korea
Modification of Seed Regions Harness Target Specificity of RNA Interference
Modification of Seed Regions Harness Target Specificity of RNA Interference
Christopher J. Cheng,
Yale University, USA
AntimiRs Targeted to the Tumor Microenvironment to Exploit OncomiR Addiction in Lymphoma
AntimiRs Targeted to the Tumor Microenvironment to Exploit OncomiR Addiction in Lymphoma
Soon-Tae Lee,
Seoul National University Hospital, South Korea
Development of Antagomir-Based Drug for Alzheimer's Disease
Development of Antagomir-Based Drug for Alzheimer's Disease
Dongli Pan,
Harvard Medical School, USA
A Neuron-Specific Host MicroRNA Targets Herpes Simplex Virus-1 ICP0 Expression and Promotes Establishment of Latency
A Neuron-Specific Host MicroRNA Targets Herpes Simplex Virus-1 ICP0 Expression and Promotes Establishment of Latency
Eva H. Gottwein,
Northwestern University, USA
Role of a Partial Viral Mimic of Cellular miR-142-3p in Transformation by the Kaposin Locus
Role of a Partial Viral Mimic of Cellular miR-142-3p in Transformation by the Kaposin Locus
5:00—7:00 PM
Resources and Emerging Technologies
*
Elisa Izaurralde,
Max Planck Institute for Developmental Biology, Germany
Feng Zhang,
Broad Institute of MIT and Harvard University, USA
Genome Engineering: Technologies and Applications
Genome Engineering: Technologies and Applications
Peyton Greenside,
Stanford University, USA
Short Talk: Consequences and Solutions for Widespread RNAi Off-Target Effects Detected at Genome Scale
Short Talk: Consequences and Solutions for Widespread RNAi Off-Target Effects Detected at Genome Scale
Michael T. McManus,
University of California, San Francisco, USA
A Resource for the Conditional Ablation of miRNAs
A Resource for the Conditional Ablation of miRNAs
Sam Griffiths-Jones,
University of Manchester, UK
miRBase, High Quality MicroRNAs and Community Annotation
miRBase, High Quality MicroRNAs and Community Annotation
*Session Chair †Invited, not yet responded.
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