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This meeting took place in 2015
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Beige and Brown Fat: Basic Biology and Novel Therapeutics (D5)
Organizer(s) Bruce M. Spiegelman and Sven Enerbäck
April 17—22, 2015
Snowbird Resort • Snowbird, UT USA
Discounted Abstract Deadline: Dec 16, 2014
Abstract Deadline: Jan 15, 2015
Scholarship Deadline: Dec 16, 2014
Discounted Registration Deadline: Feb 18, 2015
Sponsored by AstraZeneca
Summary of Meeting:
The epidemic of obesity and diabetes has become a world-wide health risk. These metabolic disorders are a direct threat to the health and economic well-being of many nations. Unfortunately, education about diet and exercise are not sufficient to meet this emergency and new therapies are badly needed. Brown fat has emerged as one of the few genuinely new approaches to these problems. Brown fat exists in most or all adult humans and can dissipate caloric energy and improve both obesity and diabetes in experimental animals. This meeting will focus on new pathways controlling brown fat development and thermogenesis. We will delve into the types of brown fat cells, beige, classical brown and others. We will also put a special emphasis on emerging approaches, both biological and chemical, that can manipulate these cells for therapeutic purposes. It is our hope and belief that this meeting can nucleate expanded efforts in both academia and pharma to explore this promising research area. There has not been a Keystone Symposia conference dedicated to brown fat. While there has been a session here and there at the Obesity meeting, the science and the biomedical needs warrant this new and focused conference. Of course, this will also bridge the Obesity and Diabetes communities, and lead to pharma/academic collaborations.
View Scholarships/Awards
The epidemic of obesity and diabetes has become a world-wide health risk. These metabolic disorders are a direct threat to the health and economic well-being of many nations. Unfortunately, education about diet and exercise are not sufficient to meet this emergency and new therapies are badly needed. Brown fat has emerged as one of the few genuinely new approaches to these problems. Brown fat exists in most or all adult humans and can dissipate caloric energy and improve both obesity and diabetes in experimental animals. This meeting will focus on new pathways controlling brown fat development and thermogenesis. We will delve into the types of brown fat cells, beige, classical brown and others. We will also put a special emphasis on emerging approaches, both biological and chemical, that can manipulate these cells for therapeutic purposes. It is our hope and belief that this meeting can nucleate expanded efforts in both academia and pharma to explore this promising research area. There has not been a Keystone Symposia conference dedicated to brown fat. While there has been a session here and there at the Obesity meeting, the science and the biomedical needs warrant this new and focused conference. Of course, this will also bridge the Obesity and Diabetes communities, and lead to pharma/academic collaborations.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, APRIL 17
SATURDAY, APRIL 18
SUNDAY, APRIL 19
MONDAY, APRIL 20
TUESDAY, APRIL 21
WEDNESDAY, APRIL 22
Conference Program Print | View meeting in 24 hr (international) time
FRIDAY, APRIL 17
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
8:00—8:15 AM
Welcome Remarks
Bruce M. Spiegelman,
Harvard Medical School, USA
Sven Enerbäck,
University of Gothenburg, Sweden
8:15—9:15 AM
Keynote Address
*
Bruce M. Spiegelman,
Harvard Medical School, USA
Vamsi K. Mootha,
Massachusetts General Hospital, USA
A Systems Approach to Mitochondrial Bioenergetics
A Systems Approach to Mitochondrial Bioenergetics
9:15—11:30 AM
Brown and Beige: Lineage and Development I
Lineage and development of brown fat cells.
Patrick Seale,
University of Pennsylvania, USA
Transcriptional Control of Brown and Beige Fat Cell Fate
Transcriptional Control of Brown and Beige Fat Cell Fate
James G. Granneman,
Wayne State University School of Medicine, USA
Mechanisms of Brown Adipocyte Recruitment by Adrenergic Receptor Activation in Vivo
Mechanisms of Brown Adipocyte Recruitment by Adrenergic Receptor Activation in Vivo
*
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
De Novo Birth of Beige Fat Cells
De Novo Birth of Beige Fat Cells
Jacob M. McGlashon,
University of Iowa, USA
Short Talk: Pet-1+ Serotonin Neurons Induce White Adipose Browning, Activate Brown Adipose and Are Required for Metabolic Homeostasis
Short Talk: Pet-1+ Serotonin Neurons Induce White Adipose Browning, Activate Brown Adipose and Are Required for Metabolic Homeostasis
5:00—7:00 PM
Brown and Beige: Lineage and Development II
Lineage and development of brown fat cells.
*
Barbara Cannon,
Stockholm University, Sweden
White, Beige/Brite and Brown Adipocytes
White, Beige/Brite and Brown Adipocytes
Stephan Herzig,
Helmholtz Zentrum München, Germany
Transcriptional Co-Factor Loops in BAT Activation and Systemic Energy Balance
Transcriptional Co-Factor Loops in BAT Activation and Systemic Energy Balance
Saverio Cinti,
University of Ancona, Italy
White, Brown and Pink Adipocytes: The Extraordinary Plasticity of the Adipose Organ
White, Brown and Pink Adipocytes: The Extraordinary Plasticity of the Adipose Organ
Jeremie Boucher,
AstraZeneca, Sweden
Short Talk: Identification of Compounds Inducing UCP1 in Differentiating Human White Preadipocytes
Short Talk: Identification of Compounds Inducing UCP1 in Differentiating Human White Preadipocytes
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:15 AM
Transcriptional Control of Brown Fat I
Transcriptional control of brown fat and the thermogenic gene program.
Bruce M. Spiegelman,
Harvard Medical School, USA
Regulation of Heat Production by Various Shades of Fat: A Novel Thermogenic Pathway in Beige Fat
Regulation of Heat Production by Various Shades of Fat: A Novel Thermogenic Pathway in Beige Fat
*
Stephen R. Farmer,
Boston University School of Medicine, USA
Novel Signaling/Transcriptional Pathways Regulating Conversion of Progenitors to Beige/Brite Adipocytes
Novel Signaling/Transcriptional Pathways Regulating Conversion of Progenitors to Beige/Brite Adipocytes
Ann Marie Hammarstedt,
Lundberg Laboratory for Diabetes Research, Sweden
Short Talk: BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis
Short Talk: BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis
Carol Renfrew Haft,
NIDDK, National Institutes of Health, USA
Short Talk: Funding Opportunities
Short Talk: Funding Opportunities
5:00—7:00 PM
Transcriptional Control of Brown Fat II
Transcriptional control of brown fat and the thermogenic gene program.
*
Ajay Chawla,
Merck and University of California, San Francisco, USA
Innate Control of Thermogenesis
Innate Control of Thermogenesis
Laurie J. Goodyear,
Joslin Diabetes Center, Harvard Medical School, USA
Exercise Regulation of Beige and Brown Fat
Exercise Regulation of Beige and Brown Fat
Matthew T. Andrews,
University of Minnesota, USA
Short Talk: Integrating Molecular and Functional Analysis of Brown Adipose Tissue across the Physiological Extremes of Natural Hibernation
Short Talk: Integrating Molecular and Functional Analysis of Brown Adipose Tissue across the Physiological Extremes of Natural Hibernation
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:00 AM
Human BAT and Therapeutic Modulation I
The types of human BAT and how their functions and amounts can be modulated.
*
Yu-Hua Tseng,
Joslin Diabetes Center/Harvard Medical School, USA
Sven Enerbäck,
University of Gothenburg, Sweden
Human Brown Adipose Tissue
Human Brown Adipose Tissue
Aaron M. Cypess,
NIDDK, National Institutes of Health, USA
The Responses of Human Brown, Beige and White Fat to Pharmacological Stimulation
The Responses of Human Brown, Beige and White Fat to Pharmacological Stimulation
Steven A. Kliewer,
University of Texas Southwestern Medical Center, USA
FGF21: Regulating the Fuel and the Fire of Metabolism
FGF21: Regulating the Fuel and the Fire of Metabolism
Wouter D. van Marken Lichtenbelt,
Maastricht University, Netherlands
Recruitment of Human Brown and Beige Fat
Recruitment of Human Brown and Beige Fat
Kirsi A. Virtanen,
Turku University Hospital, University of Turku, Finland
Short Talk: Fatty Acids Taken Up by Activated Human Brown Adipose Tissue Are Mainly Oxidized
Short Talk: Fatty Acids Taken Up by Activated Human Brown Adipose Tissue Are Mainly Oxidized
5:00—7:00 PM
Human BAT and Therapeutic Modulation II
The types of human BAT and how their functions and amounts can be modulated.
*
Sven Enerbäck,
University of Gothenburg, Sweden
Masayuki Saito,
Tenshi College, Japan
Brown Adipose Tissue as a Therapeutic Target for Human Obesity
Brown Adipose Tissue as a Therapeutic Target for Human Obesity
Yu-Hua Tseng,
Joslin Diabetes Center/Harvard Medical School, USA
Deciphering Human Brown Adipogenesis by Functional and Clonal Analyses
Deciphering Human Brown Adipogenesis by Functional and Clonal Analyses
Francesc Villarroya,
Universidad de Barcelona, Spain
BAT as Endocrine Organ: Identification of New Brown Adipokines
BAT as Endocrine Organ: Identification of New Brown Adipokines
Denis P. Blondin,
University of Sherbrooke, Canada
Short Talk: Postprandial Energy Metabolism of Brown Adipose Tissue in Cold-Acclimated Humans
Short Talk: Postprandial Energy Metabolism of Brown Adipose Tissue in Cold-Acclimated Humans
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:00 AM
Novel Pathways of Energy Expenditure
New findings related to control of BAT amounts and function that work through the nervous system, immune cells and blood vessels.
Sheila Collins,
Vanderbilt University Medical Center, USA
Signaling Mechanisms Activating Brown Adipocytes and Thermogenesis by cAMP and cGMP from Mice to Humans
Signaling Mechanisms Activating Brown Adipocytes and Thermogenesis by cAMP and cGMP from Mice to Humans
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
Nuclear Receptors in Vagal Sensory Neurons Regulate Adipose Tissue and Energy Expenditure
Nuclear Receptors in Vagal Sensory Neurons Regulate Adipose Tissue and Energy Expenditure
*
Antonio J. Vidal-Puig,
University of Cambridge, UK
BMP 8b and Brown Fat Thermogenesis
BMP 8b and Brown Fat Thermogenesis
Alexander Pfeifer,
University of Bonn, Germany
CyclicGMP Signaling Enhances Brown Fat Function - Pharmacological Studies
CyclicGMP Signaling Enhances Brown Fat Function - Pharmacological Studies
Aaron P. Frank,
Cedars-Sinai Medical Center, USA
Short Talk: Roux-en-Y Gastric Bypass Induces Browning of Gonadal Adipose Tissues
Short Talk: Roux-en-Y Gastric Bypass Induces Browning of Gonadal Adipose Tissues
5:00—7:00 PM
Biochemistry and Bioenergetics of BAT
Bioenergetic findings related to BAT function.
Yuriy Kirichok,
University of California, San Francisco, USA
Mitochondrial Uncoupling and Thermogenesis in Brown Fat
Mitochondrial Uncoupling and Thermogenesis in Brown Fat
Leslie P. Kozak,
Polish Academy of Sciences, Poland
The Genetics of Brown Adipocyte Induction in White Fat Depots
The Genetics of Brown Adipocyte Induction in White Fat Depots
*
Mary-Ellen Harper,
University of Ottawa, Canada
Redox, ROS and the Control of UCP1
Redox, ROS and the Control of UCP1
Egor Akimov,
Center of Sports Innovation Technologies and Teams Management, Russia
Short Talk: Participation of Brown Adipose Tissue in Lactate Utilization during Muscular Work
Short Talk: Participation of Brown Adipose Tissue in Lactate Utilization during Muscular Work
7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
*
Sven Enerbäck,
University of Gothenburg, Sweden
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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