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This meeting took place in 2016
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Cellular Stress Responses and Infectious Agents (S4)
Organizer(s) Margo A. Brinton, Sandra K. Weller and Beth Levine
December 4—8, 2016
Eldorado Hotel & Spa • Santa Fe, NM USA
Discounted Abstract Deadline: Aug 4, 2016
Abstract Deadline: Sep 12, 2016
Scholarship Deadline: Aug 4, 2016
Discounted Registration Deadline: Oct 4, 2016
Supported by the Directors' Fund
Summary of Meeting:
This conference will bring together cell biologists studying various cellular stress responses and researchers interested in how various infectious agents activate and manipulate host cellular stress responses. Examples of cellular stress responses activated by infectious agents are: the stress granule response, the unfolded protein response, the DNA damage response, responses to oxidative stress and metabolic stress, autophagy, and other protein quality control responses. Many of these cellular homeostatic mechanisms function as part of innate and intrinsic defense mechanisms to counteract infections. Various infectious agents have evolved to subvert and manipulate many of these anti-pathogen mechanisms by utilizing, evading or inactivating components of these cellular pathways. The study of interactions between infectious agents and these pathways provides new insights about cellular stress responses and identifies new targets for the development of novel therapies for the treatment of infectious diseases.
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This conference will bring together cell biologists studying various cellular stress responses and researchers interested in how various infectious agents activate and manipulate host cellular stress responses. Examples of cellular stress responses activated by infectious agents are: the stress granule response, the unfolded protein response, the DNA damage response, responses to oxidative stress and metabolic stress, autophagy, and other protein quality control responses. Many of these cellular homeostatic mechanisms function as part of innate and intrinsic defense mechanisms to counteract infections. Various infectious agents have evolved to subvert and manipulate many of these anti-pathogen mechanisms by utilizing, evading or inactivating components of these cellular pathways. The study of interactions between infectious agents and these pathways provides new insights about cellular stress responses and identifies new targets for the development of novel therapies for the treatment of infectious diseases.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, December 4 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, December 8 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, December 9 in order to fully experience the meeting.
SUNDAY, DECEMBER 4
MONDAY, DECEMBER 5
TUESDAY, DECEMBER 6
WEDNESDAY, DECEMBER 7
THURSDAY, DECEMBER 8
FRIDAY, DECEMBER 9
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Sunday, December 4 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, December 8 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, December 9 in order to fully experience the meeting.
SUNDAY, DECEMBER 4
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
8:30—9:30 AM
Welcome and Keynote Address
*
Margo A. Brinton,
Georgia State University, USA
*
Beth Levine,
University of Texas Southwestern Medical Center, USA
David Ron,
University of Cambridge, UK
Protein-Folding Homeostasis in the Endoplasmic Reticulum – Some Lessons from Microbes
Protein-Folding Homeostasis in the Endoplasmic Reticulum – Some Lessons from Microbes
9:30 AM—12:00 PM
Unfolded Protein Response
*
Beth Levine,
University of Texas Southwestern Medical Center, USA
R. Luke Wiseman,
The Scripps Research Institute, USA
Regulating Secretory Proteostasis through the Unfolded Protein Response
Regulating Secretory Proteostasis through the Unfolded Protein Response
Coffee Break
Timothy A.J. Haystead,
Duke University, USA
Hsp90 Promotes HIV and Chikungunya Virus Replication, Hsp90 Inhibitors are Antiviral
Hsp90 Promotes HIV and Chikungunya Virus Replication, Hsp90 Inhibitors are Antiviral
Claudio Soto,
University of Texas Medical School at Houston, USA
The Unfolded Protein Response after Prion Infection
The Unfolded Protein Response after Prion Infection
Timothy E. Audas,
Simon Fraser University, Canada
Short Talk: Adaptation to Stressors by Systemic Protein Amyloidogenesis
Short Talk: Adaptation to Stressors by Systemic Protein Amyloidogenesis
Ross Buchan,
University of Arizona, USA
Short Talk: Endocytosis is a Key Regulator of TDP-43 Aggregation, Toxicity and Turnover
Short Talk: Endocytosis is a Key Regulator of TDP-43 Aggregation, Toxicity and Turnover
2:30—4:30 PM
Workshop 1: Unfolded Protein Response and ER Stress
*
Timothy A.J. Haystead,
Duke University, USA
Mitali Adlakha,
University of Connecticut Health Center, USA
HSV-1 Immediate Early Proteins ICP0 and ICP22 Manipulate the Cellular Protein Homeostatic Machinery
HSV-1 Immediate Early Proteins ICP0 and ICP22 Manipulate the Cellular Protein Homeostatic Machinery
Vikas Anathy,
University of Vermont, Larner College of Medicine, USA
Activation of UPR Transducer ATF6alpha and Increases in PDIA3 is Required for Influenza Propagation and Development of Lung Pathology
Activation of UPR Transducer ATF6alpha and Increases in PDIA3 is Required for Influenza Propagation and Development of Lung Pathology
Ben P. Johnston,
Dalhousie University, Canada
KSHV Modulates the IRE1-XBP1 Axis of the Unfolded Protein Response during Lytic Replication
KSHV Modulates the IRE1-XBP1 Axis of the Unfolded Protein Response during Lytic Replication
Kimberly Kline,
Nanyang Technological University, Singapore
Streptolysin-Induced Endoplasmic Reticulum Stress Controls in vivo Biofilm Formation by Group A Streptococcus
Streptolysin-Induced Endoplasmic Reticulum Stress Controls in vivo Biofilm Formation by Group A Streptococcus
Charles Grose,
University of Iowa, USA
Cellular Stress, Autophagosomes, Amphisomes and Virus Trafficking during Varicella Infection
Cellular Stress, Autophagosomes, Amphisomes and Virus Trafficking during Varicella Infection
Abagail Rosen,
University of Virginia, USA
A Novel, IRE1-Dependent Role for Sigma-1 Receptor in Control of Inflammatory Cytokine Production
A Novel, IRE1-Dependent Role for Sigma-1 Receptor in Control of Inflammatory Cytokine Production
5:00—7:00 PM
Stress Granule Response, Modulation of Translation and Innate Immunity
*
Margo A. Brinton,
Georgia State University, USA
Richard E. Lloyd,
Baylor College of Medicine, USA
Cross-Talk between RNA Granules and Innate Immunity
Cross-Talk between RNA Granules and Innate Immunity
Craig McCormick,
Dalhousie University, Canada
Control of Protein Synthesis in Influenza Virus-Infected Cells
Control of Protein Synthesis in Influenza Virus-Infected Cells
Mena Abdel-Nour,
University of Toronto, Canada
Short Talk: The eIF2 alpha Kinase HRI Senses Protein Aggregation and Facilitates Signaling of Cytosolic Innate Immune Receptors
Short Talk: The eIF2 alpha Kinase HRI Senses Protein Aggregation and Facilitates Signaling of Cytosolic Innate Immune Receptors
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:30—11:45 AM
Regulation of Stress Responses
*
James C. Alwine,
University of Pennsylvania School of Medicine, USA
Carolyn-Ann Robinson,
Dalhousie University, Canada
Activation of LXRalpha Inhibits Kaposi’s Sarcoma-Associated Herpesvirus Replication
Activation of LXRalpha Inhibits Kaposi’s Sarcoma-Associated Herpesvirus Replication
Carmen Rivas,
Centro Nacional de Biotecnología, Spain
Regulation of Stress Responses by SUMOylation
Regulation of Stress Responses by SUMOylation
Coffee Break
Robert H. Silverman,
Cleveland Clinic Foundation, USA
The Role of 2’,5’-Oligoadenylate Synthetases in Cellular Responses to Stress
The Role of 2’,5’-Oligoadenylate Synthetases in Cellular Responses to Stress
Peter D. Nagy,
University of Kentucky, USA
A Small Plant Virus Co-opts Heat Shock Protein and the Actin Cytoskeleton and Rewires Glycolytic Pathway during Infection
A Small Plant Virus Co-opts Heat Shock Protein and the Actin Cytoskeleton and Rewires Glycolytic Pathway during Infection
Walid A. Houry,
University of Toronto, Canada
Short Talk: Systematic Characterization of the Chaperone Networks Required for Cellular Protein Homeostasis
Short Talk: Systematic Characterization of the Chaperone Networks Required for Cellular Protein Homeostasis
Sebastian Aguirre,
Mount Sinai School of Medicine, USA
Short Talk: The DNA Sensor cGAS Detects Dengue Virus Infection Collateral Damage
Short Talk: The DNA Sensor cGAS Detects Dengue Virus Infection Collateral Damage
2:30—4:30 PM
Workshop 2: RNA Granules and Regulation of Translation
*
Paul J. Anderson,
Harvard Medical School, USA
Wei-Chih Tsai,
Baylor College of Medicine, USA
Arginine Demethylation of G3BP1 Promotes Stress Granules Assembly
Arginine Demethylation of G3BP1 Promotes Stress Granules Assembly
Bruce W. Banfield,
Queen's University, Canada
Herpes Simplex Virus Type 2 Promotes Stress Granule Disassembly Via the Endoribonuclease Activity of Virion Host Shutoff Protein
Herpes Simplex Virus Type 2 Promotes Stress Granule Disassembly Via the Endoribonuclease Activity of Virion Host Shutoff Protein
Jason Mackenzie,
University of Melbourne, Australia
Norovirus Translation: Control at the Stress Granule-PKR-p-elf2alpha Axis
Norovirus Translation: Control at the Stress Granule-PKR-p-elf2alpha Axis
Huib Rabouw,
Utrecht University, Netherlands
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses
Ji-Young Youn,
Lunefeld Tanenbaum Research Institute, Canada
Identification of Novel Protein Components of Stress Granules and Processing Bodies using BioID Approach
Identification of Novel Protein Components of Stress Granules and Processing Bodies using BioID Approach
Alessia Ruggieri,
University of Heidelberg, Germany
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses
5:00—7:00 PM
Infectious Agents and Oxidative Stress
*
Robert H. Silverman,
Cleveland Clinic Foundation, USA
Sandra K. Weller,
University of Connecticut School of Medicine, USA
Herpes Simplex Virus Manipulates Cellular Oxidative Stress Responses to Promote Lytic Infection
Herpes Simplex Virus Manipulates Cellular Oxidative Stress Responses to Promote Lytic Infection
Christopher F. Basler,
Georgia State University, USA
Marburg Virus VP24 Protein Interacts with Keap1 to Engage the Antioxidant Response Pathway
Marburg Virus VP24 Protein Interacts with Keap1 to Engage the Antioxidant Response Pathway
Margo A. Brinton,
Georgia State University, USA
Resistance of Flavivirus-infected Cells to Arsenite-induced Stress Granule Formation is Mediated by Activation of the Cell Antioxidant Pathway.
Resistance of Flavivirus-infected Cells to Arsenite-induced Stress Granule Formation is Mediated by Activation of the Cell Antioxidant Pathway.
Eric Skaar,
Vanderbilt University, USA
Short Talk: Dietary Manganese Supplementation Influences the Oxidative Stress Response to Staphylococcus Aureus during Infection of the Heart
Short Talk: Dietary Manganese Supplementation Influences the Oxidative Stress Response to Staphylococcus Aureus during Infection of the Heart
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:30—11:45 AM
Autophagy and Host Defense Against Infectious Agents
*
Sara R. Cherry,
University of Pennsylvania, USA
Beth Levine,
University of Texas Southwestern Medical Center, USA
Conserved Mechanisms for Autophagic Removal of Mitochondria and Microbes
Conserved Mechanisms for Autophagic Removal of Mitochondria and Microbes
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Regulation of Tissue Inflammation by Autophagy Genes through Multiple Mechanisms
Regulation of Tissue Inflammation by Autophagy Genes through Multiple Mechanisms
Coffee Break
Felix Randow,
Medical Research Council, UK
How Autophagy Defends the Cytosol Against Bacterial Invasion
How Autophagy Defends the Cytosol Against Bacterial Invasion
Jae U. Jung,
Keck School of Medicine of University of Southern California, USA
Viral Manipulation of Autophagy for Viral Lifecycle
Viral Manipulation of Autophagy for Viral Lifecycle
Chiara Calabrese,
University of Cologne, Germany
Short Talk: Salmonella Typhimurium Disrupts Sirt1/AMPK Signaling Network to Impair Autophagy
Short Talk: Salmonella Typhimurium Disrupts Sirt1/AMPK Signaling Network to Impair Autophagy
Elena Muscolino,
Heinrich Pette Institute, Germany
Short Talk: Murine Cytomegalovirus Recruits the Retromer Complex to Promote NEMO Degradation by Autophagy
Short Talk: Murine Cytomegalovirus Recruits the Retromer Complex to Promote NEMO Degradation by Autophagy
2:30—4:30 PM
Workshop 3: Autophagy, Regulation of Stress and Metabolic Stress
*
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Jennifer Corcoran,
Dalhousie University, Canada
Viral Control of Autophagy to Reprogram the Host Cell Secretome
Viral Control of Autophagy to Reprogram the Host Cell Secretome
Alexandra Boeske,
Forschungszentrum Jülich, Germany
GABARAPs Mediate Anterograde Transport and Secretion of HIV-1 Nef via Mechanisms Related to Unconventional Protein Secretion
GABARAPs Mediate Anterograde Transport and Secretion of HIV-1 Nef via Mechanisms Related to Unconventional Protein Secretion
Nazira El-Hage,
Florida International University, USA
Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in vitro
Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in vitro
Elizabeth Figueroa-Juárez,
Instituto Nacional de Ciencias Médicas y Nutrición, S.Z., Mexico
Renal Endoplasmic Reticulum Stress and its Modulation by Resveratrol
Renal Endoplasmic Reticulum Stress and its Modulation by Resveratrol
Julien Moretti,
Mount Sinai School of Medicine, USA
Vita-PAMP Sensing by STING Orchestrates Stress-Induced ER-phagy Apical to a Type-I Interferon Response
Vita-PAMP Sensing by STING Orchestrates Stress-Induced ER-phagy Apical to a Type-I Interferon Response
Jessica Tsalikis,
University of Toronto, Canada
The Role of U snRNA Maturation and mRNA Splicing Regulation in Response to Metabolic Stress and Bacterial Infection
The Role of U snRNA Maturation and mRNA Splicing Regulation in Response to Metabolic Stress and Bacterial Infection
Teresa S. Wiley,
Wiley Systems, Inc, USA
Autophagy Pathways and the Effects of Steroid Hormones
Autophagy Pathways and the Effects of Steroid Hormones
Angela M. Phillips,
Massachusetts Institute of Technology, USA
Host Proteostasis Network-Mediated Modulation of Influenza Evolution
Host Proteostasis Network-Mediated Modulation of Influenza Evolution
5:00—7:00 PM
Intracellular Infectious Agents and Metabolic Stress
*
Craig McCormick,
Dalhousie University, Canada
Joshua C. Munger,
University of Rochester Medical Center, USA
Harnessing Small Molecule Stress Pathways to Support Viral Infection
Harnessing Small Molecule Stress Pathways to Support Viral Infection
Stephen E. Girardin,
University of Toronto, Canada
A Cytosolic Unfolded Protein Response Controls Innate Immune Signaling
A Cytosolic Unfolded Protein Response Controls Innate Immune Signaling
James C. Alwine,
University of Pennsylvania School of Medicine, USA
The Masterful Manipulation of Host Cell Stress Responses, Signaling and Metabolism by Human Cytomegalovirus
The Masterful Manipulation of Host Cell Stress Responses, Signaling and Metabolism by Human Cytomegalovirus
Andrew Timmons,
Johns Hopkins Hospital, USA
Short Talk: Small Molecule Inhibition of Intrinsic Stress Pathways Substantially Reduces HIV Transcription upon T Cell Activation
Short Talk: Small Molecule Inhibition of Intrinsic Stress Pathways Substantially Reduces HIV Transcription upon T Cell Activation
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:30—11:45 AM
Integrated Stress Responses and Infectious Agents
Sara R. Cherry,
University of Pennsylvania, USA
Systems Approaches to Study Antiviral Immunity
Systems Approaches to Study Antiviral Immunity
George A. Belov,
University of Maryland, USA
Membrane Metabolism of Picornavirus-Infected Cells: A Little Virus Makes A Big Mess
Membrane Metabolism of Picornavirus-Infected Cells: A Little Virus Makes A Big Mess
Coffee Break
Denise A. Galloway,
Fred Hutchinson Cancer Research Center, USA
Human Papillomaviruses dampen the Response to DNA Damage
Human Papillomaviruses dampen the Response to DNA Damage
*
Ralph Isberg,
Tufts University School of Medicine, USA
Bacterial Community Behavior in Deep Tissue Sites during Microbial Disease
Bacterial Community Behavior in Deep Tissue Sites during Microbial Disease
Scott Espenschied,
Duke University, USA
Short Talk: In vivo Analysis of Intestinal Epithelial Damage Responses in a Zebrafish Model of NSAID-Induced Enteropathy
Short Talk: In vivo Analysis of Intestinal Epithelial Damage Responses in a Zebrafish Model of NSAID-Induced Enteropathy
Adam R. Renslo,
University of California, San Francisco, USA
Short Talk: Discovery and Optimization of Small Molecule Antagonists of the Integrated Stress Response
Short Talk: Discovery and Optimization of Small Molecule Antagonists of the Integrated Stress Response
2:30—4:30 PM
Workshop 4: Integrated Stress Responses and the DNA Damage Response
*
Denise A. Galloway,
Fred Hutchinson Cancer Research Center, USA
Wolfram Brune,
Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Germany
Activation and Inhibition of Caspase-2 by Human Cytomegalovirus
Activation and Inhibition of Caspase-2 by Human Cytomegalovirus
Christopher Fisher,
University of Florida College of Medicine, USA
HSV-1 Infection Activates ATR and Chk1, Mislocalizes the Phosphorylated Proteins, and Utilizes their Activity to Promote Viral Replication
HSV-1 Infection Activates ATR and Chk1, Mislocalizes the Phosphorylated Proteins, and Utilizes their Activity to Promote Viral Replication
Terri Edwards,
University of Florida, USA
Rebound of Human Papillomavirus (Hpv) Dna Episomes Following Antiviral Treatment Shares Fundamental Features with Genome Amplification During the HPV Life Cycle
Rebound of Human Papillomavirus (Hpv) Dna Episomes Following Antiviral Treatment Shares Fundamental Features with Genome Amplification During the HPV Life Cycle
Priya Luthra,
Georgia State University, USA
The Crosstalk Between DNA Damage and Innate Immune Responses Circumvents Ebola Virus Immune Evasion Mechanisms
The Crosstalk Between DNA Damage and Innate Immune Responses Circumvents Ebola Virus Immune Evasion Mechanisms
Michael P. Sheetz,
Mechanobiology Institute, National University of Singapore, Singapore
DNA Damage Causes Rapid Accumulation of Phosphoinositides to Recruit ATR but not ATM
DNA Damage Causes Rapid Accumulation of Phosphoinositides to Recruit ATR but not ATM
Rong Tan,
University of Pittsburgh, USA
Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
Alexander Zaika,
Vanderbilt University Medical Center, USA
Bacterial Pathogen Helicobacter Pylori Modulates Cellular Responses to DNA Damage and Oncogenic Stress by Inducing Degradation of p53 Protein and Altering Expression of p53 Isoforms
Bacterial Pathogen Helicobacter Pylori Modulates Cellular Responses to DNA Damage and Oncogenic Stress by Inducing Degradation of p53 Protein and Altering Expression of p53 Isoforms
5:00—6:45 PM
Infectious Agents and the DNA Damage Response
*
Sandra K. Weller,
University of Connecticut School of Medicine, USA
Matthew D. Weitzman,
Children's Hospital of Philadelphia, USA
DNA Damage Responses to DNA Virus Infection
DNA Damage Responses to DNA Virus Infection
Richard I. Morimoto,
Northwestern University, USA
Regulation of the Heat Shock Response and Proteostasis Networks
Regulation of the Heat Shock Response and Proteostasis Networks
Hugues de Thé,
Hopital St. Louis, France
In vivo Sumoylation Control by PML Nuclear Bodies under Oxidative Stress
In vivo Sumoylation Control by PML Nuclear Bodies under Oxidative Stress
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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