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This meeting took place in 2016



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Axons: From Cell Biology to Pathology (J4)


Organizer(s) Giampietro Schiavo, Bruce D. Carter and Rejji Kuruvilla
January 24—27, 2016
Eldorado Hotel & Spa • Santa Fe, NM USA
Discounted Abstract Deadline: Sep 24, 2015
Abstract Deadline: Oct 27, 2015
Scholarship Deadline: Sep 24, 2015
Discounted Registration Deadline: Dec 18, 2015

Supported by the Directors' Fund


Summary of Meeting:
The development and maintenance of axons require efficient long-range communication in the nervous system. Axons extend distances ranging from a fraction of a millimeter to more than a meter in humans, lengths that require specialized mechanisms for formation, maintenance and regeneration. Given their extreme polarity and size, axons are particularly vulnerable to the risk of degeneration and dysfunction upon injury or disease. This Keystone Symposia meeting will bring together scientists from multiple disciplines interested in the common goal of addressing problems rooted in axonal cell biology, such as intracellular transport of organelles and guidance, with a view to accelerating progress in the field of axonal biology and pathology. This is a unique meeting that will cover a broad spectrum of the latest developments in axonal research, from development and maintenance, through to survival and repair, in both the central and peripheral nervous system. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of young researchers and those new to the field. The multidisciplinary theme and shared focus will facilitate communication from basic to clinical neuroscience, bridging these two communities and creating unique opportunities to synergize and collaborate.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, January 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 27 with a closing plenary session from 14:30 to 19:15, followed by a social hour and entertainment. We recommend return travel on Thursday, January 28 in order to fully experience the meeting.

SUNDAY, JANUARY 24

4:00—8:00 PM
Arrival and Registration

Eldorado Lounge
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Eldorado Lounge

MONDAY, JANUARY 25

7:00—8:00 AM
Breakfast

Anasazi Ballroom
7:30—8:00 AM
Poster Setup

Anasazi Ballroom
8:00 AM—5:00 PM
Poster Viewing

Anasazi Ballroom
8:00—9:00 AM
Welcome and Keynote Address

Eldorado B
* Giampietro Schiavo, University College London, UK

* Bruce D. Carter, Vanderbilt University School of Medicine, USA

* Rejji Kuruvilla, Johns Hopkins University, USA

Karl Deisseroth, Stanford University, USA
Structural and Molecular Interrogation of Intact Biological Systems

8:00—9:00 AM
Welcome and Keynote Address

Eldorado A
* Ann C. McKee, Boston University / VA Boston Healthcare System, USA

Maiken Nedergaard, University of Rochester, USA
The Glymphatic System and its Importance in Amyloid Clearance

9:00—11:15 AM
Axon Cytoskeleton and Specification

Eldorado B
Melissa Rolls, Pennsylvania State University, USA
Using Live Imaging of Dynamic Microtubules to Understand Axon Injury Responses

Erik Dent, University of Wisconsin-Madison, USA
Role of an F-BAR Protein in Inhibiting Axon Outgrowth

Francisca C. Bronfman, Catholic University, Chile
Short Talk: Axonal BDNF Promotes Local Axonal Synthesis and Retrograde Transport of the Transcription Factor PPARgamma in an mTOR-Dependent Manner

Christopher V. Gabel, Boston University School of Medicine, USA
Short Talk: The What, Where, and When of Activity Induced Calcium Signaling in Neuronal Regeneration

Jing Jin, Institute of Molecular Cell Biology, Germany
Short Talk: Ndr1/2 Kinases Regulate Neuronal Polarity through the Regulation of Par3

9:00—11:30 AM
What Are the Effects of TBI? Evidence from Human Observational Studies

Eldorado A
* Lee E. Goldstein, Boston University, USA

Ann C. McKee, Boston University / VA Boston Healthcare System, USA
Potential Long-Term Effects of Repetitive Concussive and Subconcussive Trauma

Alon Friedman, Ben-Gurion University of the Negev, Israel
Blood-Brain Barrier Dysfunction as a Biomarker and Target for Treatment in Brain Injuries

Alan Pearce, University of Melbourne, Australia
Using Transcranial Magnetic Stimulation to Measure Neurophysiological Responses Following Concussion

Jillian Urban, Wake Forest University, USA
Short Talk: Cumulative Head Impact Exposure in Youth Football Players

Daniel Daneshvar, Boston University, USA
Short Talk: Examining Repetitive Head Impact Exposure Metrics and Risk of Chronic Traumatic Encephalopathy in American Football Players

9:40—10:00 AM
Coffee Break

Concourse
11:15 AM—12:15 PM
Lunch

Anasazi Ballroom
12:00—2:30 PM
Poster Session 1

Anasazi Ballroom
2:30—4:30 PM
Axonal Degeneration and Regeneration

Eldorado B
* Valeria Cavalli, Washington University, USA

Marc Hammarlund, Yale University School of Medicine, USA
Neuronal Regulation of Axon Regeneration

Trent A. Watkins, Baylor College of Medicine, USA
DLK-Dependent Regulation of the Degenerative and Regenerative Responses to Axonal Injury

Richard E. Zigmond, Case Western Reserve University, USA
Macrophages in Dorsal Root Ganglia (drgs) Promote Nerve Regeneration through a Stat3-Dependent Mechanism

Peter Walter, HHMI/University of California, San Francisco, USA
Inhibition of the Integrated Stress Response Restores Cognition After Brain Injury

2:30—4:30 PM
Workshop 1: TBI, Neuroinflammation and Microvasculopathy

Eldorado A
* Maiken Nedergaard, University of Rochester, USA

Rita H. Nguyen, University of Calgary, Canada
Understanding the Role of Microglia Following Repetitive Mild Traumatic Brain Injury using Intravital Microscopy

Jon D. Cherry, Boston University School of Medicine, USA
Repetitive Head Injury Results in Neuroinflammation that Precedes Chronic Traumatic Encephalopathy Pathology and Scales with Disease Severity

Barry W. Festoff, University of Kansas Medical School, Phlogistix LLC, USA
TBI Effects on BBB Neuro-Gliovascular (N-GVU) Units Modeled by Inflammo-Coag Factors In Vitro

Susanna Rosi, University of California, San Francisco, USA
In vivo Metabolic Imaging of Neuroinflammation after TBI

Bertrand Russell Huber, VA Boston Healthcare, USA
Assessing Long-Term Vascular Dysfunction in Chronic Traumatic Encephalopathy with Fibrinogen Immunohistochemistry

Dara Bree, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Characterisation of Headache-Related Behaviours in a Clinically Relevant Rat Model of Posttraumatic Headache

4:30—5:00 PM
Coffee Available

Concourse
5:00—7:00 PM
RNA Targeting and Local Translation

Eldorado B
* Michael Fainzilber, Weizmann Institute of Science, Israel

* Christopher V. Gabel, Boston University School of Medicine, USA

Jeffery L. Twiss, University of South Carolina, USA
Molecular Determinants for mRNA Transport into Axons

Dianna E. Willis, Burke-Cornell Medical Research Institute, USA
Altered RNA Binding Protein Regulation and Axonal RNA Transport in Diabetic Peripheral Neuropathy

Ulrich Hengst, Columbia University, USA
Short Talk: Regulation of Retrograde Transport in Axons through Local Synthesis of Dynein Adaptor Proteins

Alexander Jaworski, Brown University, USA
Short Talk: Operational Redundancy in Axon Guidance through the Multifunctional Receptor Robo3 and its Ligand NELL2

5:00—7:00 PM
What Are the Effects of TBI? Evidence from Neuroimaging Studies

Eldorado A
* Alon Friedman, Ben-Gurion University of the Negev, Israel

Jeffrey J. Bazarian, University of Rochester Medical Center, USA
DTI Coupled with Helmet Impact Sensors Provides Insight into the Relationship between Repetitive Head Hits and Traumatic Axonal Injury

Rami Burstein, Harvard Medical School, USA
The Pathophysiology of Trauma Induced Headache

Ramon Diaz-Arrastia, Uniformed Services University of the Health Sciences, USA
Overview of Neuroimaging

7:00 PM
On Own for Dinner

8:00—10:00 PM
OPTIONAL - Poster Session for Down Syndrome

Hilton Santa Fe - Mesa C

TUESDAY, JANUARY 26

7:00—8:00 AM
Breakfast

Anasazi Ballroom
8:00—11:15 AM
Axonal Signaling Mechanisms

Eldorado B
* Marc Hammarlund, Yale University School of Medicine, USA

* Alexander Jaworski, Brown University, USA

Steven J. Burden, New York University Medical Center, USA
Bi-Directional Signaling to Form and Preserve Neuromuscular Synapses

Michael Fainzilber, Weizmann Institute of Science, Israel
From Retrograde Injury Signaling to Axon Growth Control

Valeria Cavalli, Washington University, USA
Activating a Regeneration Program with Hypoxia

Bruce D. Carter, Vanderbilt University School of Medicine, USA
Mechanisms of Retrograde Apoptotic Signaling by the p75 Neurotrophin Receptor

Eva Klinman, University of Pennsylvania, USA
Short Talk: Regulation of Neuronal Trafficking and Transport by CDK5

Patti Murphy, University of Pennsylvania, USA
Short Talk: Roundabout2 and Exotosin-like 3 Promote Target Specific Peripheral Nerve Regeneration in vivo

8:00—11:00 AM
Mechanistic Insights from Animal Studies

Eldorado A
* John M. Lee, North Shore University Health System, USA

Lee E. Goldstein, Boston University, USA
Acute and Chronic Neuronal Injury: Insights from Murine Models of Blast and Impact TBI

Matt Russo, National Institutes of Health, USA
Short Talk: Role of Resident vs. Peripherally-Derived Myeloid Cells in the Immune Response to Mild Traumatic Brain Injury

Karen Duff, Columbia University, USA
Propagation of Tau Pathology: Lessons Learned from Neurodegenerative Diseases

Andrew Fisher, Boston University, USA
Short Talk: Comparative Modeling of Blast- and Impact-Induced Traumatic Brain Injury

Mark Walter Wojnarowicz, Boston University, USA
Short Talk: Microvasculopathy, Blood-Brain Barrier Dysfunction, and Early Chronic Traumatic Encephalopathy-Linked Neuropathology In a Mouse Model of Concussive Impact Neurotrauma

9:20—9:40 AM
Coffee Break

Concourse
11:15 AM—1:00 PM
Poster Setup

Anasazi Ballroom
1:00—10:00 PM
Poster Viewing

Anasazi Ballroom
11:15 AM—12:30 PM
On Own for Lunch

12:30—2:30 PM
OPTIONAL - Poster Session for Down Syndrome

Hilton Santa Fe - Mesa C
4:30—5:00 PM
Coffee Available

Concourse
5:00—7:15 PM
Axonal Membrane Dynamics and Axonal Transport

Eldorado B
* Subhojit Roy, University of Wisconsin Madison, USA

Yoshio Goshima, Yokohama City University Graduate School of Medicine, Japan
Axonal Transport Elicited by Axon Guidance Molecules

Rejji Kuruvilla, Johns Hopkins University, USA
Endocytic Trafficking of Neurotrophins in Neural Development

Casper Hoogenraad, Genentech, Inc., USA
Mechanisms of Axon Formation: Microtubule Remodeling and Motor Activity

Karen Duff, Columbia University, USA
Tau Proteinopathy, Neuronal Dyshomeostasis and Neurodegeneration

5:00—7:00 PM
Mechanistic Insights from Human Studies

Eldorado A
* Lee E. Goldstein, Boston University, USA

T. Blaine Hoshizaki, University of Ottawa, Canada
The Relationship between Impact Characteristics and Brain Tissue Strain Distributions

Susan Margulies, University of Pennsylvania, USA
Mechanisms of Pediatric TBI - Integrating Human and Animal Studies

Tsang-Wei Tu, National Institutes of Health, USA
Short Talk: GlucoCEST Correlates with 2DG Autoradiography in Monitoring Glucose Metabolism in Mild Traumatic Brain Injury

Ramon Diaz-Arrastia, Uniformed Services University of the Health Sciences, USA
Short Talk: DTI and MAP-MRI Abnormalities in the Closed Head Injury Model of Engineered Rotational Acceleration (CHIMERA) Mouse Model of Diffuse Axonal Injury

Cheryl Wellington, University of British Columbia, Canada
Short Talk: Traumatic Brain Injury and Steroids

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
7:30—10:00 PM
Poster Session 2

Anasazi Ballroom

WEDNESDAY, JANUARY 27

7:00—8:00 AM
Breakfast

Anasazi Ballroom
8:00—11:00 AM
Axons and Disease

Eldorado B
* James Shorter, University of Pennsylvania, USA

* Patti Murphy, University of Pennsylvania, USA

Sung O.K. Yoon, Ohio State University, USA
Role of JNK3 in Development of Alzheimer's

Vincenzo De Paola, Imperial College London, UK
Long-Term Imaging of Axon Growth and Calcium Activity in Human iPSC- Derived Neurons from Healthy and Down Syndrome Donors Grafted in the Adult Mouse Brain

Ralph A. Nixon, New York University, Langone Medical Center, USA
Autophagy in Neurological Disorders

Swetha Gowrishankar, University of Illinois at Chicago, USA
Short Talk: Contributions of Amyloid Plaque-Associated Axonal Lysosome Transport and Maturation Defects to Alzheimer’s Disease Pathology

Eran Perlson, Tel Aviv University, Israel

8:00—11:45 AM
From Precision Medicine to Therapies

Eldorado A
* Cheryl Wellington, University of British Columbia, Canada

Ramon Diaz-Arrastia, Uniformed Services University of the Health Sciences, USA
Endophenotypes of Traumatic Brain Injury: What We Need to Know for the Next Generation of TBI Clinical Trials

Kaj Blennow, University of Gothenburg, Sweden
Fluid Biomarkers for TBI – Research and Clinical Applications

Michael Chopp, Henry Ford Hospital, USA
Novel Neurorestorative Therapies for Remodeling the CNS and Enhancing Neurological Recovery Post TBI

Dallas C. Hack, , USA
TBI Clinical Trials: The Path Forward

Vivian Y.H. Hook, University of California, San Diego, USA
Short Talk: Cathepsin B is a Validated Drug Target for Traumatic Brain Injury

Tatyana Gudz, Medical University of South Carolina, USA
Short Talk: Targeting Sphingosine to Protect Mitochondria after Traumatic Brain Injury

9:20—9:40 AM
Coffee Break

Concourse
11:00 AM—2:30 PM
On Own for Lunch

2:30—4:30 PM
Axon-Glia-Blood Vessel Interactions

Eldorado B
* Jeffery L. Twiss, University of South Carolina, USA

* Eva Klinman, University of Pennsylvania, USA

Mary A. Logan, Oregon Health & Science University, USA
Age-Dependent Changes in Glial Responses to Axon Injury and Disease

Patrizia Casaccia, Advanced Science Research Center, USA
Epigenetic Mechanisms Modulating Oligodendroglial Development and Function

Chenghua Gu, Harvard Medical School, USA
Interactions between Nervous and Vascular Systems in the CNS

Subhojit Roy, University of Wisconsin Madison, USA
Short Talk: A Two-Tier Assembly of F-actin in Axons: "Actin Rings" and "Actin Trails"

4:30—5:00 PM
Coffee Available

Concourse
5:00—7:00 PM
Axon, Pathogens and Prion-Like Proteins

Eldorado B
* Francisca C. Bronfman, Catholic University, Chile

Giampietro Schiavo, University College London, UK
Inhibition of Specific Protein Kinases Rescues Retrograde Axonal Transport Defects in Amyotrophic Lateral Sclerosis

James Shorter, University of Pennsylvania, USA
Potentiated Protein Disaggregates to Counter Neurodegenerative Disease

Andres Couve, Universidad de Chile, Chile
Short Talk: The Endoplasmic Reticulum and Protein Trafficking in Axons

Lauren Walker, University of Pennsylvania, USA
Short Talk: Axon Self-Destruction: Integrating Sarm1 Activation, NAD+ Depletion, and MAPK Signaling

5:00—6:45 PM
Therapeutic Approaches to TBI

Eldorado A
* Ramon Diaz-Arrastia, Uniformed Services University of the Health Sciences, USA

Peter Walter, HHMI/University of California, San Francisco, USA
Short Talk: Inhibition of the Integrated Stress Response Restores Cognition after Brain Injury

Ciaran Hill, University of Cambridge, UK
Short Talk: A Novel Organotypic Brain Slice Model of Traumatic Stretch Injury

Richard M. Ransohoff, Third Rock Ventures, USA
Microglia: A Reintroduction

David K. Menon, University of Cambridge, UK
What Do We Know About TBI? Where Do We Need To Go?

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions

Eldorado B
* Giampietro Schiavo, University College London, UK

* Bruce D. Carter, Vanderbilt University School of Medicine, USA

* Rejji Kuruvilla, Johns Hopkins University, USA

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Eldorado A
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Anasazi Ballroom

THURSDAY, JANUARY 28

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge additional support for this conference from:

Chroma Technology Corporation
Integra Foundation

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

NeuroscientistNews

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations

If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179