Keystone Symposia

Fairmont Banff Springs Floorplan

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This meeting took place in 2016


Here are the related meetings in 2020:
Obesity and NAFLD: Mechanisms and Therapeutics (B3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Obesity and Adipose Tissue Biology (B2)


Organizer(s) Yu-Hua Tseng, Philipp E. Scherer and Deborah Clegg
February 15—19, 2016
Fairmont Banff Springs • Banff, AB Canada
Discounted Abstract Deadline: Oct 15, 2015
Abstract Deadline: Nov 17, 2015
Scholarship Deadline: Oct 15, 2015
Discounted Registration Deadline: Dec 15, 2015

Sponsored by MedImmune and Novo Nordisk A/S

Summary of Meeting:
Obesity is a growing pandemic and a major contributor to metabolic syndrome and disorders such as type 2 diabetes, cardiovascular disease, dyslipidemia, non-alcohol fatty liver and some cancers. Excess fat mass is the main characteristic of obesity, and adipocytes are the critical players in obesity-associated metabolic disorders. This symposium will focus on recent advances in our understanding of adipocyte biology and its related pathogenesis. These scientific breakthroughs include fundamental aspects of adipocyte development, heterogeneity of fat cells and their progenitors, fuel utilization in different types of adipocytes, environmental imprinting of adipose tissue, adipose tissue remodeling, brain-adipose communication and non-adipose tissue adipocytes. This meeting aims to unite interdisciplinary researchers, from basic and translational scientists to clinicians and industrial scientists, in order to integrate and synergize the diverse body of knowledge of adipose tissue, discuss cutting-edge technologies and foster collaborative interactions. Attendees will gain an in-depth knowledge of adipocyte biology and new insight into the role of adipose tissue in obesity and its related metabolic disorders.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Monday, February 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, February 19 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Saturday, February 20 in order to fully experience the meeting.

MONDAY, FEBRUARY 15

4:00—8:00 PM
Arrival and Registration

Van Horne Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

TUESDAY, FEBRUARY 16

7:00—8:00 AM
Breakfast

Van Horne B/C
8:00—9:00 AM
Welcome and Keynote Address

Van Horne A
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
New Dimensions in the Biology of Adipose Tissue and its Role in Insulin Resistance

9:00—11:30 AM
Brain-Adipose Communication

Van Horne A
* Yong Xu, Baylor College of Medicine, USA

Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
Astrocytes, Microglia, and Neurons in Body Weight Regulation

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Hypothalamic Regulation of Metabolism

Gary J. Schwartz, Albert Einstein College of Medicine, USA
CNS and SNS Control of Adipose Function

Atul Chopra, Case Western Reserve University, USA
Short Talk: Asprosin, a Fasting-Induced, Glucogenic and Orexigenic, Protein Hormone

Ana Domingos, University of Oxford, UK
Short Talk: Lean on Body Neurons

9:40—10:00 AM
Coffee Break

Van Horne Foyer
11:30 AM—1:00 PM
Poster Setup

Van Horne B/C
1:00—10:00 PM
Poster Viewing

Van Horne B/C
11:30 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Environmental Imprinting of Adipose Phenotype

Van Horne A
* Kevin L. Grove, Novo Nordisk, USA

Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Cold-Induced Dynamics in Brown, Beige and White Adipose Tissue

Matthias Blüher, University of Leipzig, Germany
Molecular Determinants of Adipose Tissue Health

Xin L. Ma, Thomas Jefferson University, USA
Novel Insight into Adiponectin Receptor Function

Kristen E. Boyle, University of Colorado School of Medicine, USA
Short Talk: DNA Hypermethylation of Metabolic Genes Corresponds to Lower Fatty Acid Oxidation in Mesenchymal Stem Cells from Infants of Obese Mothers: The Healthy Start BabyBUMP Project

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne B/C
7:30—10:00 PM
Poster Session 1

Van Horne B/C

WEDNESDAY, FEBRUARY 17

7:00—8:00 AM
Breakfast

Van Horne B/C
8:00—11:00 AM
Developmental Origin and Recruitment of Adipose Tissue

Van Horne A
* Stephen R. Farmer, Boston University School of Medicine, USA

Edward T. Chouchani, Dana-Farber Cancer Institute, USA
White, Brown and Beige Fat: Basic Biology and Novel Thermogenic Pathways

Sheila Collins, Vanderbilt University Medical Center, USA
Integrating Signaling Mechanisms for Adipocyte 'Browning'

Aaron M. Cypess, NIDDK, National Institutes of Health, USA
Short Talk: Mild Intermittent Cooling of Mice is Sufficient to Increase the Thermogenic Capacity of the Adipose Tissue Depots

Rana K. Gupta, University of Texas Southwestern Medical Center, USA
Establishment and Maintenance of the White Adipose Lineage by Zfp423

Ajay Chawla, Merck and University of California, San Francisco, USA
Innate Immunity and Beige Fat Thermogenesis

Dwight J. Klemm, University of Colorado Denver Anschutz Medical Center, USA
Short Talk: Integrin Beta1 Regulates Production of Adipocytes and Other Mesenchymal Lineages from Adipose Tissue Stromal Myeloid Cells

9:40—10:00 AM
Coffee Break

Van Horne Foyer
11:00 AM—1:00 PM
Poster Setup

Van Horne B/C
1:00—10:00 PM
Poster Viewing

Van Horne B/C
11:00 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Cross-Talk between Adipose Tissue and Other Organs

Van Horne A
* Jacqueline M. Stephens, Louisiana State University, USA

Domenico Accili, Columbia University, USA
Cross-Talk between Adipose Tissue and Pancreatic Beta Cells

Michael P. Czech, University of Massachusetts Medical School, USA
Adipose Tissue and Hepatic Glucose Metabolism

Anthony M. Heagerty, University of Manchester, UK
The Role of Adipose Tissue in Cardiovascular Function

Iichiro Shimomura, Osaka University, Japan
Short Talk: Adiponectin, Fat-Derived Abundant Secretory Factor, Accumulates in Vasculature and Exhibits Vascular Protective Action, via T-Cadherin

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne B/C
7:30—10:00 PM
Poster Session 2

Van Horne B/C

THURSDAY, FEBRUARY 18

7:00—8:00 AM
Breakfast

Van Horne B/C
8:00—11:15 AM
Regulation of Fuel Utilization in Adipose Tissue

Van Horne A
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Lipogenesis in Adipose Tissue

Stephan Herzig, Helmholtz Zentrum München, Germany
Molecular Control of Lipid Handling in Adipocytes

Denis P. Blondin, University of Sherbrooke, Canada
Short Talk: Inhibition of Intracellular Triglyceride Lipolysis Significantly Impairs BAT Oxidative Metabolism in Humans

Chih-Hao Lee, Harvard University School of Public Health, USA
Mitochondrial Remodeling and Metabolic Flexibility

Barbara Cannon, Stockholm University, Sweden
Mitochondrial Uncoupling and Fuel Utilization

Violeta I. Gallardo Montejano, University of Texas Southwestern Medical Center, USA
Short Talk: Perilipin 5 Expression in Mouse Brown Adipose Tissue Regulates Systemic Glucose and Lipid Metabolism

9:40—10:00 AM
Coffee Break

Van Horne Foyer
11:15 AM—1:00 PM
Poster Setup

Van Horne B/C
1:00—10:00 PM
Poster Viewing

Van Horne B/C
11:15 AM—2:30 PM
On Own for Lunch

2:30—4:30 PM
Workshop: New Therapeutic Approaches for Obesity and Related Metabolic Disorders

Van Horne A
* Patrick Seale, University of Pennsylvania, USA

* Christopher D. Church, MedImmune, UK

Andres Andres Contreras, Michigan State University, USA
Perivascular Adipose Tissue Adipocyte Progenitor Distribution Is Influenced by Gender and Anatomical Site

Lei Sun, Duke-NUS Graduate Medical School Singapore, Singapore
De novo Reconstruction of Adipose Tissue Transcriptomes Reveals Novel Long Noncoding RNAs that Regulate Brown Adipocyte Development

Eric S. Muise, Merck & Co., Inc., USA
Acute Treatment of Mice with Potent AMPK Activators Mimics Acute Exercise-Induced Transcriptional Effects in White and Brown Adipose Tissues

Cecile Vernochet, Pfizer, USA
Lysophospholipase-like 1 (LYPLAL1) Inhibition Impacts Adipocyte Biology and Impairs Insulin Mediated Glucose Uptake

Christina Camell, University of Minnesota, USA
NLRP3 Inflammasome Controls Adipose Tissue Leukocytosis and Inflammation During Aging

Mathieu Laplante, Laval University, Canada
The Pre-Adipokine EMPRD Promotes the Commitment and the Development of White Adipocytes

Hedi Soussi, University Pierre and Marie Curie, France
DAPK2 Down-Regulation Associates with Attenuated Adipocyte Autophagic Clearance in Human Obesity

Jin Shang, , USA
Dysmetabolic Obese Rhesus Monkeys Exhibit Insulin Resistance that is Similar But Not Identical to Obese Humans

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Non-Adipose Tissue Adipocytes

Van Horne A
* Victor Leonard Schuster, Albert Einstein College of Medicine, USA

Clifford J. Rosen, Maine Medical Center, USA
Adipocytes in Bone

Maksim Plikus, University of California, Irvine, USA
The Role of Adipocytes in Skin Biology and Regeneration

Saswata Talukdar, Merck Sharp & Dohme, USA
Short Talk: FGF21 Regulates Sweet and Alcohol Preference

Silvia Corvera, University of Massachusetts Medical School, USA
Short Talk: Human Brite/Beige Adipocytes Derived from Human Capillary Networks Improve Glucose Disposal in Humanized Mice

Alexander Bartelt, Ludwig-Maximilians-University, Germany
Short Talk: A Central Role for Nfe2l1 in ER Adaptation and Mitochondrial Health in Brown Fat

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne B/C
7:30—10:00 PM
Poster Session 3

Van Horne B/C

FRIDAY, FEBRUARY 19

7:00—8:00 AM
Breakfast

Van Horne B/C
8:00—11:15 AM
Adipose Tissue Remodeling

Van Horne A
* Jan Nedergaard, Stockholm University, Sweden

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipose Tissue Fibrosis and Metabolic Dysfunction

Andreas Stahl, University of California, Berkeley, USA
Engineering Brown Adipose Tissue

Tim Julius Schulz, German Institute of Human Nutrition, Germany
Short Talk: Age-Related Changes in Bioactive Lipids Regulate Brown Adipocyte Formation and Function

Karine Clément, INSERM / Sorbonne Universite, France
Adipose Tissue Stiffness, Cell Size and Metabolic Function

Ruth E. Gimeno, Eli Lilly and Company, USA
Pharmacological Approaches to Diabetes and Metabolic Disorders

Peter K. Jackson, Stanford University, USA
Short Talk: The Asymmetric Cell Division Regulator Ags3/Pins Couples Primary Cilia to Insulin/IGF1 Signaling and Reprogramming of CD34+ Preadipocytes to Differentiate

9:20—9:40 AM
Coffee Break

Van Horne Foyer
11:15 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:15 PM
Novel CNS Pathways in Metabolic Regulation

Van Horne A
* Deborah Clegg, Cedars-Sinai Medical Center, USA
Hypothalamic Autophagy, Mitophagy and Lipophagy: Estrogens Regulate Them ALL!

Xiaoyong Yang, Yale University School of Medicine, USA
Dialog Between Brain and Fat via O-GlcNAc Signaling

* Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Searching for Mechanisms of Weight Loss and Diabetes Resolution after Bariatric Surgery: Are We Ready to Ditch the Knife?

John Garretson, Albert Einstein College of Medicine, USA
Short Talk: Lipolysis Activates Sensory Nerves in White Fat

Candice B. Herber, University of California, San Francisco, USA
Short Talk: In Vivo Imaging of a New Highly Sensitive ThermoMouse (Ucp1-Luc) Line Reveals Marked Sex-Differences in BAT Thermogenesis

7:15—7:30 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Van Horne A
7:30—8:30 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne B/C
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Van Horne B/C

SATURDAY, FEBRUARY 20

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

MedImmune Novo Nordisk A/S

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK104611-01




National Institutes of Health

Grant No. 5R13DK104611-02

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

Adipogen International ALPCO Diagnostics
Educational grant from Lilly
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Eli Lilly and Company

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179