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This meeting took place in 2016
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Systems Immunology: From Molecular Networks to Human Biology (A1)
Organizer(s) Ronald N. Germain, Aviv Regev, Nir Hacohen and Dana Pe'er
January 10—14, 2016
Big Sky Resort • Big Sky, MT USA
Discounted Abstract Deadline: Sep 21, 2015
Abstract Deadline: Oct 20, 2015
Scholarship Deadline: Sep 21, 2015
Discounted Registration Deadline: Nov 10, 2015
Sponsored by Cell Signaling Technology, Inc., Roche and Takeda Pharmaceutical Company Limited
Summary of Meeting:
This meeting on “Systems Immunology” will constitute a unique opportunity for the field to transition from reductionist studies that have been the focus of past meetings on lymphocyte activation to a more integrated approach to the study of immune physiology and pathology from the molecular (signal transduction) to the medical (human clinical studies) scales. It will highlight the latest advances in large-scale, quantitative data collection and computational analysis as applied to biochemical aspects of immune cell activation and function, multicellular behavior in tissues and model organisms, and human immune function in health and disease. Emphasis will be placed on understanding how biological function emerges from the interaction of multiple components in networks and pathways, on the construction of quantitative models that permit predictions about systems behavior that can be tested experimentally, and on identification of reliable biomarkers and insight into disease pathogenesis that can be acquired from deep analysis of large-scale, multi-parameter data collection in humans. The speakers hail from various areas in systems immunology, ranging from those modeling discrete biochemical pathways and cell activation processes, to those developing new tools for measurement of such molecular events, to imagers studying immune cells in situ, to those doing omic-scale studies on humans in response to vaccines or in patients suffering from autoimmune or immunodeficiency syndromes. The meeting should attract participants across the range of immunological disciplines, from the most basic to the clinical, and be of interest to systems biologists in general.
View Scholarships/Awards
This meeting on “Systems Immunology” will constitute a unique opportunity for the field to transition from reductionist studies that have been the focus of past meetings on lymphocyte activation to a more integrated approach to the study of immune physiology and pathology from the molecular (signal transduction) to the medical (human clinical studies) scales. It will highlight the latest advances in large-scale, quantitative data collection and computational analysis as applied to biochemical aspects of immune cell activation and function, multicellular behavior in tissues and model organisms, and human immune function in health and disease. Emphasis will be placed on understanding how biological function emerges from the interaction of multiple components in networks and pathways, on the construction of quantitative models that permit predictions about systems behavior that can be tested experimentally, and on identification of reliable biomarkers and insight into disease pathogenesis that can be acquired from deep analysis of large-scale, multi-parameter data collection in humans. The speakers hail from various areas in systems immunology, ranging from those modeling discrete biochemical pathways and cell activation processes, to those developing new tools for measurement of such molecular events, to imagers studying immune cells in situ, to those doing omic-scale studies on humans in response to vaccines or in patients suffering from autoimmune or immunodeficiency syndromes. The meeting should attract participants across the range of immunological disciplines, from the most basic to the clinical, and be of interest to systems biologists in general.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 15 in order to fully experience the meeting.
SUNDAY, JANUARY 10
MONDAY, JANUARY 11
TUESDAY, JANUARY 12
WEDNESDAY, JANUARY 13
THURSDAY, JANUARY 14
FRIDAY, JANUARY 15
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 15 in order to fully experience the meeting.
SUNDAY, JANUARY 10
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Nir Hacohen,
Massachusetts General Hospital, USA
Genes, Networks and Variations of the Immune Response
Genes, Networks and Variations of the Immune Response
09:00—11:00
Immunoreceptor Signaling I: Receptors and Pathways
*
Grégoire Altan-Bonnet,
NCI, National Institutes of Health, USA
Smita Krishnaswamy,
Yale School of Medicine, USA
Tracking the Impact of Immunotherapy Across the Phenotypic Landscape
Tracking the Impact of Immunotherapy Across the Phenotypic Landscape
Suzanne Gaudet,
Dana-Farber Cancer Institute/Harvard Medical School, USA
NF-kappaB Signaling Dynamics and the Control of Transcription and Cell Fate
NF-kappaB Signaling Dynamics and the Control of Transcription and Cell Fate
Bridget S. Wilson,
University of New Mexico Health Science Center, USA
Short Talk: Dynamic Interactions of Pre-BCR Homodimers Provide Finely-Tuned Tonic Signals for Survival
Short Talk: Dynamic Interactions of Pre-BCR Homodimers Provide Finely-Tuned Tonic Signals for Survival
13:00—14:00
Publishing Forum
*
Angela Colmone,
Science Immunology, USA
*
Craig Mak,
Cell Press, USA
*
Thomas Lemberger,
Molecular Systems Biology, Germany
*
Corinne Williams,
Journal of Clinical Investigation, JCI Insight, USA
14:30—16:30
Workshop 1: Signaling
Mary H. Young,
Celgene, USA
T Cell Receptor Signaling and Toll-Like Receptor Signaling Converge to Amplify T Cell Responses
T Cell Receptor Signaling and Toll-Like Receptor Signaling Converge to Amplify T Cell Responses
Arnon Arazi,
Broad Institute, USA
Th17 Differentiation is an Emergent Collective Behavior, Driven by Cellular Heterogeneity
Th17 Differentiation is an Emergent Collective Behavior, Driven by Cellular Heterogeneity
*
Rachel A. Gottschalk,
NIAID, National Institutes of Health, USA
Contextual Control of TLR-Induced Responses by Divergent Signaling Thresholds
Contextual Control of TLR-Induced Responses by Divergent Signaling Thresholds
Michael J.T. Stubbington,
European Bioinformatics Institute, UK
Simultaneously Inferring T Cell Fate and Clonality from Single Cell Transcriptomes
Simultaneously Inferring T Cell Fate and Clonality from Single Cell Transcriptomes
Wenji Ma,
Columbia University, USA
Single Cell and Bulk Transcriptome Analysis Reveals Differentiation Mechanism of Human Dendritic Cell
Single Cell and Bulk Transcriptome Analysis Reveals Differentiation Mechanism of Human Dendritic Cell
Ricardo Noel Ramirez,
University of California, Irvine, USA
High-Resolution Epigenomic Analysis of Human Myeloid Differentiation Reveals Temporal and Cell-Specific Patterns of the Immune Regulatory Network
High-Resolution Epigenomic Analysis of Human Myeloid Differentiation Reveals Temporal and Cell-Specific Patterns of the Immune Regulatory Network
17:00—19:00
Immunoreceptor Signaling II: New Methods for Probing Cell Signaling
*
Nir Hacohen,
Massachusetts General Hospital, USA
Veit Hornung,
Ludwig-Maximilians-University Munich, Germany
CRISPR/Cas Approaches to Analysis of Immune Cell Signaling
CRISPR/Cas Approaches to Analysis of Immune Cell Signaling
Bernard Malissen,
Centre d'Immunologie de Marseille-Luminy, France
Engineered Systems for Analysis of Signaling Pathways in Primary Lymphocytes Using Quantitative Proteomics
Engineered Systems for Analysis of Signaling Pathways in Primary Lymphocytes Using Quantitative Proteomics
Iain D.C. Fraser,
NIAID, National Institutes of Health, USA
Interrogating Immune Signaling Systems with High-Throughput/High-Content Screening
Interrogating Immune Signaling Systems with High-Throughput/High-Content Screening
Felix Meissner,
Max Planck Institute of Biochemistry, Germany
Short Talk: Proteome Atlas of Circulating Human Immune Cells Reveals Intercellular Communication Structures
Short Talk: Proteome Atlas of Circulating Human Immune Cells Reveals Intercellular Communication Structures
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Modeling Signaling Pathways and Transcriptional Networks
*
Dana Pe'er,
Memorial Sloan Kettering Cancer Center, USA
Alan Aderem,
Center for Infectious Disease Research, USA
Dissecting the Innate Immune System Using Tools of Systems Biology
Dissecting the Innate Immune System Using Tools of Systems Biology
Aviv Regev,
Genentech, USA
Signaling Networks in Th17 CD4 T Cells
Signaling Networks in Th17 CD4 T Cells
Harinder Singh,
Cincinnati Children's Hospital Medical Center, USA
Gene Regulatory Networks Orchestrating Cell Fate Dynamics of Activated B Cells
Gene Regulatory Networks Orchestrating Cell Fate Dynamics of Activated B Cells
Ellen V. Rothenberg,
California Institute of Technology, USA
Transcriptional Networks in Developing Lymphocytes
Transcriptional Networks in Developing Lymphocytes
Aaron J. Arvey,
Gilead, USA
Short Talk: Genetic and Epigenetic Variation in the Lineage Specification of Regulatory T Cells
Short Talk: Genetic and Epigenetic Variation in the Lineage Specification of Regulatory T Cells
Vladimir Litvak,
Sanofi US, USA
Short Talk: Decoding Transcriptional and Epigenetic Regulatory Networks in Macrophages
Short Talk: Decoding Transcriptional and Epigenetic Regulatory Networks in Macrophages
14:30—16:30
Workshop 2: Human Systems Immunology
Lisa Marie Kronstad,
Stanford University, USA
Human Natural Killer Cell Sensing of Influenza A Viruses
Human Natural Killer Cell Sensing of Influenza A Viruses
John P. Barton,
University of California, Riverside, USA
Intra-Host HIV Evolution to Evade Cellular Immunity is Predictable
Intra-Host HIV Evolution to Evade Cellular Immunity is Predictable
*
Brittany A. Goods,
Massachusetts Institute of Technology, USA
Functional Inflammatory Profiles Distinguish Myelin-Reactive T Cells from Patients with Multiple Sclerosis
Functional Inflammatory Profiles Distinguish Myelin-Reactive T Cells from Patients with Multiple Sclerosis
Andrew Fiore-Gartland,
Fred Hutchinson Cancer Research Institute, USA
Modular Cytokine Analysis Reveals Innate Correlates of Influenza Outcome in a Multicenter Study
Modular Cytokine Analysis Reveals Innate Correlates of Influenza Outcome in a Multicenter Study
Ning Jenny Jiang,
University of Texas at Austin, USA
Accurate and High-Coverage Immune Repertoire Sequencing Reveals Characteristics of Antibody Repertoire Diversification in Young Children
Accurate and High-Coverage Immune Repertoire Sequencing Reveals Characteristics of Antibody Repertoire Diversification in Young Children
Irit Gat-Viks,
Tel-Aviv University, Israel
Modeling the Genetic and Immunological Basis of in vivo Phenotypes
Modeling the Genetic and Immunological Basis of in vivo Phenotypes
17:00—19:00
Single Cell Analysis Modeling I
*
Aviv Regev,
Genentech, USA
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Imaging Immunity: Creating a Quantitative Spatiotemporal Understanding of Host Defense
Imaging Immunity: Creating a Quantitative Spatiotemporal Understanding of Host Defense
Catherine A. Blish,
Stanford University School of Medicine, USA
Defining Protective Immunologic Signatures
Defining Protective Immunologic Signatures
Michael Meyer-Hermann,
Helmholtz Centre for Infection Research, Germany
Germinal Centres in vivo and in silico
Germinal Centres in vivo and in silico
Kelly Wen Li Chen,
Massachusetts Institute of Technology, USA
Short Talk: Investigation of Cytokine-Mediated Intercellular Crosstalk in Normal and Inflammatory Conditions
Short Talk: Investigation of Cytokine-Mediated Intercellular Crosstalk in Normal and Inflammatory Conditions
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Single Cell Analysis Modeling II
*
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Dana Pe'er,
Memorial Sloan Kettering Cancer Center, USA
Modeling Cellular Responses
Modeling Cellular Responses
Grégoire Altan-Bonnet,
NCI, National Institutes of Health, USA
Modeling the Spatio-Temporal Heterogeneity of Cell-to-Cell Communications
Modeling the Spatio-Temporal Heterogeneity of Cell-to-Cell Communications
Martin Meier-Schellersheim,
NIAID, National Institutes of Health, USA
Computational Modelling Elucidates How MAPK Crosstalk Regulates Sensitivity of Macrophages Toward TLR4 Stimulation
Computational Modelling Elucidates How MAPK Crosstalk Regulates Sensitivity of Macrophages Toward TLR4 Stimulation
Sayak Mukherjee,
Ohio State University, USA
Short Talk: Reconstruction of Single Cell Signaling Trajectories using Snapshot Cytometry Data
Short Talk: Reconstruction of Single Cell Signaling Trajectories using Snapshot Cytometry Data
17:00—19:00
Systems Analysis of Cancer and Model Organisms
*
Suzanne Gaudet,
Dana-Farber Cancer Institute/Harvard Medical School, USA
Andrea Califano,
Columbia University, USA
Systematic Elucidation of Druggable Dependencies in Human Malignancies: A New Take on Precision Medicine
Systematic Elucidation of Druggable Dependencies in Human Malignancies: A New Take on Precision Medicine
Kathryn Miller-Jensen,
Yale University, USA
Discovering Macrophage Paracrine Signaling Networks from Single-Cell Data
Discovering Macrophage Paracrine Signaling Networks from Single-Cell Data
Catherine A.A. Beauchemin,
Ryerson University, Canada
Modelling Viral Infection in vivo and in vitro
Modelling Viral Infection in vivo and in vitro
Edward S. Lee,
University of Glasgow, UK
Short Talk: Novel Computational Approaches to TCR Repertoire Analysis
Short Talk: Novel Computational Approaches to TCR Repertoire Analysis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Human Systems Immunology: Methods
*
David Furman,
Buck Institute for Research on Aging, USA
Damien Chaussabel,
Sidra Medical and Research Center, Qatar
Systems Approaches to Health Maintenance and Immunological Knowledge Discovery
Systems Approaches to Health Maintenance and Immunological Knowledge Discovery
Alexandra-Chloé Villani,
Broad Institute of MIT and Harvard, USA
Short Talk: Talk Title to be Announced
Short Talk: Talk Title to be Announced
Linas Mazutis,
Vilnius University, Lithuania
Short Talk: Barcoding and Sequencing Thousands of Individual Cells using Droplet Microfluidics
Short Talk: Barcoding and Sequencing Thousands of Individual Cells using Droplet Microfluidics
Matthew H. Spitzer,
Stanford University, USA
Modeling Systems-Wide Immunity Reveals Coordinated Responses in Health and Cancer
Modeling Systems-Wide Immunity Reveals Coordinated Responses in Health and Cancer
John Tsang,
NIAID, National Institutes of Health, USA
From Single Cells to Networks to Human Populations: Assessing and Utilizing Heterogeneity of the Immune System
From Single Cells to Networks to Human Populations: Assessing and Utilizing Heterogeneity of the Immune System
Ayelet Alpert,
Technion-Israel Institute of Technology, Israel
Short Talk: Baseline Matters: The Effect of Initial Immune State on Outcome of Septic Patients
Short Talk: Baseline Matters: The Effect of Initial Immune State on Outcome of Septic Patients
14:30—16:30
Workshop 3: Methodological Advances in Systems Immunology
*
Matthew H. Spitzer,
Stanford University, USA
Nathan Paul Manes,
National Institutes of Health, USA
Targeted Proteomics-Driven Computational Modeling of the Chemotaxis and Toll-like Receptor Signaling Pathways in Macrophages
Targeted Proteomics-Driven Computational Modeling of the Chemotaxis and Toll-like Receptor Signaling Pathways in Macrophages
Andriy Morgun,
Oregon State University, USA
Transkingdom Networks as a Model of Host-Microbiota Interactions
Transkingdom Networks as a Model of Host-Microbiota Interactions
Denis Schapiro,
University of Zurich, Switzerland
Imaging Mass Cytometry Reveals Neighboring Cell Interactions Amongst the Heterogeneity of Breast Cancer
Imaging Mass Cytometry Reveals Neighboring Cell Interactions Amongst the Heterogeneity of Breast Cancer
Brian Kidd,
Icahn School of Medicine at Mount Sinai, USA
Mapping the Effects of Drugs on the Immune System
Mapping the Effects of Drugs on the Immune System
Nienke Moret,
Harvard University, USA
Controlling Regulatory T Cell Heterogeneity by Chemical Modification of Signaling Pathways
Controlling Regulatory T Cell Heterogeneity by Chemical Modification of Signaling Pathways
17:00—18:45
Human Systems Immunology: Biomedical Applications
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Long-term Consequences of Infection for Tissue Immunity and Metabolism
Long-term Consequences of Infection for Tissue Immunity and Metabolism
*
Anne O'Garra,
Francis Crick Institute, UK
Systems Studies of Human Immune Responses to Infection
Systems Studies of Human Immune Responses to Infection
Arup K. Chakraborty,
Massachusetts Institute of Technology, USA
How to Hit HIV Where it Hurts by Integrating Sequencing, Statistical Inference, Mechanistic Models and Human Data
How to Hit HIV Where it Hurts by Integrating Sequencing, Statistical Inference, Mechanistic Models and Human Data
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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