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This meeting took place in 2017
Here are the related meetings in 2021:
Tumor Metabolism and the Microenvironment (EK14)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Tumor Metabolism: Mechanisms and Targets (X3)
Organizer(s) Brendan D. Manning, Kathryn E. Wellen and Reuben J. Shaw
March 5—9, 2017
Whistler Conference Centre • Whistler, BC Canada
Discounted Abstract Deadline: Nov 8, 2016
Abstract Deadline: Dec 8, 2016
Scholarship Deadline: Nov 8, 2016
Discounted Registration Deadline: Jan 12, 2017
Sponsored by Bayer HealthCare Pharmaceuticals, Cell Research, Merck & Co., Inc. and Takeda Pharmaceutical Company Limited
Joint Meeting:
Adaptations to Hypoxia in Physiology and Disease (X4)
Summary of Meeting:
This conference is on the rapidly moving field of tumor metabolism and its implications in cancer development, progression and therapy. Experts from distinct fields of research will be brought together to present their latest discoveries on tumor metabolism, which is an inherently interdisciplinary field. Defining the diversity of metabolic strategies employed by cancer cells and how the genetic events underlying different types of cancer, as well as the tumor microenvironment, influence these metabolic properties is a major goal of this meeting. In addition, a combination of basic, translational and clinical studies will be presented, with the goal of identifying promising avenues in tumor metabolism that impact our understanding, diagnosis and treatment of cancer. In addition to a stellar line up of invited speakers, short talks and poster presentations will provide opportunities for researchers at all levels to discuss their most current work in this field. This meeting provides an excellent opportunity to share knowledge and methodology in tumor metabolism research in a collegial and social atmosphere.
View Scholarships/Awards
This conference is on the rapidly moving field of tumor metabolism and its implications in cancer development, progression and therapy. Experts from distinct fields of research will be brought together to present their latest discoveries on tumor metabolism, which is an inherently interdisciplinary field. Defining the diversity of metabolic strategies employed by cancer cells and how the genetic events underlying different types of cancer, as well as the tumor microenvironment, influence these metabolic properties is a major goal of this meeting. In addition, a combination of basic, translational and clinical studies will be presented, with the goal of identifying promising avenues in tumor metabolism that impact our understanding, diagnosis and treatment of cancer. In addition to a stellar line up of invited speakers, short talks and poster presentations will provide opportunities for researchers at all levels to discuss their most current work in this field. This meeting provides an excellent opportunity to share knowledge and methodology in tumor metabolism research in a collegial and social atmosphere.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 10 in order to fully experience the meeting.
SUNDAY, MARCH 5
MONDAY, MARCH 6
TUESDAY, MARCH 7
WEDNESDAY, MARCH 8
THURSDAY, MARCH 9
FRIDAY, MARCH 10
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Sunday, March 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 10 in order to fully experience the meeting.
SUNDAY, MARCH 5
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
8:00—9:00 AM
Welcome and Keynote Address (Joint)
*
M. Celeste Simon,
University of Pennsylvania, USA
Chi Van Dang,
University of Pennsylvania, USA
MYC as the Master Regulator of Proliferative Metabolism
MYC as the Master Regulator of Proliferative Metabolism
9:00—11:30 AM
Hypoxia and Tumor Metabolism (Joint)
*
Amato J. Giaccia,
Stanford University, USA
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
2-Oxoglutarate-Dependent Dioxygenases and Cancer
2-Oxoglutarate-Dependent Dioxygenases and Cancer
Coffee Break
Nicholas Denko,
Ohio State University, USA
Hypoxic Regulation of Mitochondrial Function
Hypoxic Regulation of Mitochondrial Function
Andrew M. Intlekofer,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Acidification Enhances Production of L-2-Hydroxyglutarate through Alternative Substrate use by Dehydrogenase Enzymes
Short Talk: Acidification Enhances Production of L-2-Hydroxyglutarate through Alternative Substrate use by Dehydrogenase Enzymes
James A. Nathan,
Cambridge Institute for Medical Research, UK
Short Talk: Oxygen Sensing and Metabolism: The Role of the 2-Oxoglutarate Dehydrogenase Complex and Mitochondrial Protein Lipoylation
Short Talk: Oxygen Sensing and Metabolism: The Role of the 2-Oxoglutarate Dehydrogenase Complex and Mitochondrial Protein Lipoylation
Karen H. Vousden,
Francis Crick Institute, UK
A Role for p53 in the Adaptation to Metabolic Stress
A Role for p53 in the Adaptation to Metabolic Stress
2:30—4:30 PM
Workshop 1
*
Costas A. Lyssiotis,
University of Michigan, USA
Sumin Kang,
Emory University, USA
Phosphorylation-Mediated Activation of Lactate Dehydrogenase A Promotes Cancer Cell Invasion and Tumor Metastasis
Phosphorylation-Mediated Activation of Lactate Dehydrogenase A Promotes Cancer Cell Invasion and Tumor Metastasis
Atsuo T. Sasaki,
University of Cincinnati, USA
SSK2 Couples Nucleolar Transcription and Anabolic GTP Metabolism for Gliomagenesis
SSK2 Couples Nucleolar Transcription and Anabolic GTP Metabolism for Gliomagenesis
Isaac Spencer Harris,
University of Rochester, USA
Understanding the Vulnerabilities in Cancer Cells Upon Inhibition of Glutathione Synthesis
Understanding the Vulnerabilities in Cancer Cells Upon Inhibition of Glutathione Synthesis
Won Dong Lee,
Princeton University, USA
Inferring Compartmentalized Mitochondrial, Nuclear, and Cytosolic Metabolic Fluxes via Isotope Tracing with Cell Fractionation
Inferring Compartmentalized Mitochondrial, Nuclear, and Cytosolic Metabolic Fluxes via Isotope Tracing with Cell Fractionation
Lauren E. Drake,
University of Chicago, USA
BNip3 Loss Promotes Hepatocellular Carcinoma Growth through Increased Lipogenesis
BNip3 Loss Promotes Hepatocellular Carcinoma Growth through Increased Lipogenesis
Salvador Aznar Benitah,
ICREA and Institute for Research in Biomedicine, Spain
Identifying and Targeting Metastatic-Initiating Cells through the Fatty Acid Receptor CD36
Identifying and Targeting Metastatic-Initiating Cells through the Fatty Acid Receptor CD36
Jing Chen,
Winship Cancer Institute, Emory University, USA
Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth
Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth
5:00—7:00 PM
Oncogenic Control of Metabolism
*
Heather Christofk,
University of California, Los Angeles, USA
Lewis C. Cantley,
Weill Cornell Medicine, USA
PI3K Signaling and Glucose Metabolism in Tumors
PI3K Signaling and Glucose Metabolism in Tumors
Almut Schulze,
University of Würzburg/Theodor-Boveri Institute, Germany
Targeting Glucose and Lipid Metabolism in Cancer
Targeting Glucose and Lipid Metabolism in Cancer
Brendan D. Manning,
Harvard School of Public Health, USA
A Coordinated Anabolic Program Downstream of mTOR
A Coordinated Anabolic Program Downstream of mTOR
Alejo Efeyan,
Spanish National Cancer Research Institute, Spain
Short Talk: Oncogenic Mutations in the Nutrient Sensing Pathway Upstream of mTORC1 Alter B Lymphocyte Functions in Novel Genetically-engineered Mice
Short Talk: Oncogenic Mutations in the Nutrient Sensing Pathway Upstream of mTORC1 Alter B Lymphocyte Functions in Novel Genetically-engineered Mice
5:00—7:00 PM
Hypoxic Influences on Intracellular and Tissue Homeostasis
*
Richard K. Bruick,
University of Texas Southwestern Medical Center, USA
Young Il Yeom,
Korea Research Institute of Bioscience and Biotechnology, South Korea
Lactate-Induced Responses to Hypoxia
Lactate-Induced Responses to Hypoxia
Geert Carmeliet,
KU Leuven, Belgium
Glutamine, Glycogen and Bioenergetics
Glutamine, Glycogen and Bioenergetics
Othon Iliopoulos,
Massachusetts General Hospital Cancer Center, USA
Glutaminase and PARP Inhibitors Synergistically Suppress ROS and Pyrimidine Dependent Growth of VHL-Deficient Renal Cell Cancer: A Novel Strategy for Treatment of Hypoxia-Driven and HIF-Expressing Tumors
Glutaminase and PARP Inhibitors Synergistically Suppress ROS and Pyrimidine Dependent Growth of VHL-Deficient Renal Cell Cancer: A Novel Strategy for Treatment of Hypoxia-Driven and HIF-Expressing Tumors
Thomas Markus Leissing,
University of Oxford, UK
Short Talk: Structural Basis for the Inhibition of Prolyl-Hydroxylase Domain Containing Proteins (PHDs) by Clinical Candidates for Anaemia Treatment
Short Talk: Structural Basis for the Inhibition of Prolyl-Hydroxylase Domain Containing Proteins (PHDs) by Clinical Candidates for Anaemia Treatment
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:15 AM
Metabolic Strategies in Cancer
*
Jared Rutter,
University of Utah, USA
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Metabolic Adaptations to Allow Tumor Cell Proliferation
Metabolic Adaptations to Allow Tumor Cell Proliferation
Jurre J. Kamphorst,
Rheos Medicines, USA
Triglycerides Buffer Membrane Phospholipid Saturation during Hypoxic Stress
Triglycerides Buffer Membrane Phospholipid Saturation during Hypoxic Stress
Coffee Break
Ralph J. DeBerardinis,
University of Texas Southwestern Medical Center, USA
Heterogeneous Metabolic Phenotypes and Liabilities in Human Cancer
Heterogeneous Metabolic Phenotypes and Liabilities in Human Cancer
Cosimo Commisso,
Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Not Dying of Starvation: Nutrient Stress Controls Macropinocytosis in Tumor Cells
Short Talk: Not Dying of Starvation: Nutrient Stress Controls Macropinocytosis in Tumor Cells
Elizabeth Petri Henske,
Brigham and Women's Hospital, USA
Short Talk: Therapeutic Targeting of mTORC1-Dependent Metabolic Vulnerabilities in TSC and LAM
Short Talk: Therapeutic Targeting of mTORC1-Dependent Metabolic Vulnerabilities in TSC and LAM
8:00—11:15 AM
Physiological Responses to Hypoxia
*
Maria F. Czyzyk-Krzeska,
University of Cincinnati, USA
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
Metabolic Adaptations of Tumor Blood Vessels
Metabolic Adaptations of Tumor Blood Vessels
Frank S. Lee,
University of Pennsylvania School of Medicine, USA
Short Talk: Studies on the Zinc Finger of Prolyl Hydroxylase Domain Protein 2 (PHD2), a Hypoxia Inducible Factor-alpha Hydroxylase
Short Talk: Studies on the Zinc Finger of Prolyl Hydroxylase Domain Protein 2 (PHD2), a Hypoxia Inducible Factor-alpha Hydroxylase
Francisco J. Quintana,
Harvard Medical School, USA
Regulation of CNS Inflammation by Hypoxia-Responsive Signaling
Regulation of CNS Inflammation by Hypoxia-Responsive Signaling
Coffee Break
Mark R. Boothby,
Vanderbilt University Medical Center, USA
Short Talk: Germinal Center Hypoxia and Regulation of mTORC1 Activity in B Cells Shape Antibody Response Qualities
Short Talk: Germinal Center Hypoxia and Regulation of mTORC1 Activity in B Cells Shape Antibody Response Qualities
Janine T. Erler,
University of Copenhagen, Denmark
Hypoxia-Driven ECM Remodelling during Cancer Progression
Hypoxia-Driven ECM Remodelling during Cancer Progression
Navdeep S. Chandel,
Northwestern University, USA
Why Mammalian Cells Respire?
Why Mammalian Cells Respire?
2:30—4:30 PM
Workshop 1: Fundamental Processes of Oxygen Sensing
James A. Smythies,
University of Oxford, UK
Utilisation of Next Generation Sequencing Technologies to Identify Novel Contributors to Hypoxia Inducible Factor Binding Site Selectivity
Utilisation of Next Generation Sequencing Technologies to Identify Novel Contributors to Hypoxia Inducible Factor Binding Site Selectivity
*
Luis del Peso,
Universidad Autonoma, Spain
Transcriptional Repression in Hypoxia is Mediated by the Sin3A Histone Deacetylase Complex
Transcriptional Repression in Hypoxia is Mediated by the Sin3A Histone Deacetylase Complex
Johannes Schödel,
Universitätsklinikum Erlangen, Germany
Complex Regulation of Glucose Transporter 3 Expression by HIF
Complex Regulation of Glucose Transporter 3 Expression by HIF
Andrew Fraser,
University of Toronto, Canada
How Worms Hold Their Breath: The Unusual Metabolic Response of Nematodes to Hypoxia and the Importance for 2 Billion Humans
How Worms Hold Their Breath: The Unusual Metabolic Response of Nematodes to Hypoxia and the Importance for 2 Billion Humans
Roman Vozdek,
University of California, San Francisco, USA
Novel Uncharacterized Protein Tyrosine Kinase Senses Hypoxia to Mediate HIF-1 Independent Transcriptional Response in C. elegans
Novel Uncharacterized Protein Tyrosine Kinase Senses Hypoxia to Mediate HIF-1 Independent Transcriptional Response in C. elegans
Austin Gabel,
University of Maryland, Baltimore County, USA
Understanding Induction of Suspended Animation In Zebrafish
Understanding Induction of Suspended Animation In Zebrafish
Farhad B. Imam,
Bill & Melinda Gates Foundation, USA
Cellular and Metabolic Studies of Hypoxia-Sensitive Mutants in irs2 and ctrc3, Key Regulators of Glucose and Fatty Acid Metabolism
Cellular and Metabolic Studies of Hypoxia-Sensitive Mutants in irs2 and ctrc3, Key Regulators of Glucose and Fatty Acid Metabolism
5:00—7:00 PM
Metabolic Adaptations of Cells within the Tumor Microenvironment (Joint)
*
Erika L. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Raghu Kalluri,
University of Texas MD Anderson Cancer Center, USA
The Functional Contribution of Exosomes in Cancer Metabolism and Metastasis
The Functional Contribution of Exosomes in Cancer Metabolism and Metastasis
Randall S. Johnson,
University of Cambridge, UK
The Metabolic Role of Hypoxic Response in T Cell Activation
The Metabolic Role of Hypoxic Response in T Cell Activation
Shannon J. Turley,
Genentech, Inc., USA
Leukocyte Function and Positioning in Diverse Stromal Niches
Leukocyte Function and Positioning in Diverse Stromal Niches
Hong Xie,
University of Pennsylvania, USA
Short Talk: Balancing Anabolic Metabolism with Homeostatic Stress Responses in Myc-Transformed Cancer Cells
Short Talk: Balancing Anabolic Metabolism with Homeostatic Stress Responses in Myc-Transformed Cancer Cells
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:15 AM
Metabolism, Signaling and Epigenetics
*
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Aimee L. Edinger,
University of California, Irvine, USA
Macropinocytosis Drives Cancer Cell Growth in Both Nutrient-Limiting and-Replete Conditions
Macropinocytosis Drives Cancer Cell Growth in Both Nutrient-Limiting and-Replete Conditions
Coffee Break
Joshua D. Rabinowitz,
Princeton University, USA
Multiple Functions of Mitochondrial Folate Metabolism
Multiple Functions of Mitochondrial Folate Metabolism
Kathryn E. Wellen,
University of Pennsylvania, USA
Acetyl-CoA at the Crossroads of Metabolism and Epigenetics
Acetyl-CoA at the Crossroads of Metabolism and Epigenetics
Christian C. Dibble,
Beth Israel Deaconess Medical Center, USA
Short Talk: PI3K Signaling Controls de novo Biosynthesis of Coenzyme A from Vitamin B5
Short Talk: PI3K Signaling Controls de novo Biosynthesis of Coenzyme A from Vitamin B5
Jordan Meier,
NCI, National Institutes of Health, USA
Short Talk: Defining Metabolic Mechanisms of Epigenetic Signaling using Chemoproteomics
Short Talk: Defining Metabolic Mechanisms of Epigenetic Signaling using Chemoproteomics
8:00—11:15 AM
Biochemical and Epigenetic Responses to Hypoxia
*
Frank S. Lee,
University of Pennsylvania School of Medicine, USA
Peter J. Ratcliffe,
University of Oxford, UK
Genome Wide Studies of the Hypoxia Transcriptome
Genome Wide Studies of the Hypoxia Transcriptome
Daniel Cooper,
Duke University School of Medicine, USA
Short Talk: Hypoxia and Radiation Regulate HIF1alpha Gene Targets in a Context-Dependent manner
Short Talk: Hypoxia and Radiation Regulate HIF1alpha Gene Targets in a Context-Dependent manner
Fraydoon Rastinejad,
University of Oxford, UK
Structures and Drug-Binding Potentials of HIF-alpha-ARNT Heterodimers
Structures and Drug-Binding Potentials of HIF-alpha-ARNT Heterodimers
Coffee Break
Isha Jain,
University of California, San Francisco, USA
Short Talk: Hypoxia as a Therapy for Mitochondrial Disease
Short Talk: Hypoxia as a Therapy for Mitochondrial Disease
Eli M. Wallace,
Merck, USA
Small Molecule HIF-2a Antagonists and Their Therapeutic Applications
Small Molecule HIF-2a Antagonists and Their Therapeutic Applications
Maria F. Czyzyk-Krzeska,
University of Cincinnati, USA
Oncogenic and Tumor Suppressive Autophagic Programs in Renal Cell Carcinoma
Oncogenic and Tumor Suppressive Autophagic Programs in Renal Cell Carcinoma
2:30—4:30 PM
Workshop 2
*
Aimee L. Edinger,
University of California, Irvine, USA
Liron Bar-Peled,
The Scripps Research Institute, USA
A Druggable Transcriptional Vulnerability in NRF2-Dependent Lung Cancers
A Druggable Transcriptional Vulnerability in NRF2-Dependent Lung Cancers
Volkan I. Sayin,
Sahlgrenska Cancer Center, Sweden
Somatic Editing of Keap1/Nrf2 Antioxidant Response is Pro-Tumorigenic and Promotes a Targetable Genotype-Dependent Metabolic Switch in KRAS-Driven Lung Cancer
Somatic Editing of Keap1/Nrf2 Antioxidant Response is Pro-Tumorigenic and Promotes a Targetable Genotype-Dependent Metabolic Switch in KRAS-Driven Lung Cancer
Valeria Santoro,
Bayer Pharma AG, Germany
Mitochondrial Folate Transporter (SLC25A32) Protects Against ROS-Mediated Cancer Cell Death
Mitochondrial Folate Transporter (SLC25A32) Protects Against ROS-Mediated Cancer Cell Death
Zhimin Lu,
University of Texas MD Anderson Cancer Center, USA
Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
Boyi Gan,
MD Anderson Cancer Center, USA
LncRNA NBR2 Regulates AMPK-Mediated Energy Stress Response and Modulates Cancer Cell Sensitivity to Biguanides
LncRNA NBR2 Regulates AMPK-Mediated Energy Stress Response and Modulates Cancer Cell Sensitivity to Biguanides
Bin Zheng,
Harvard Medical School, USA
Targeting Metabolic Vulnerabilities of MDSCs to Enhance the Anti-Tumor Activity of PD-1 Blockade
Targeting Metabolic Vulnerabilities of MDSCs to Enhance the Anti-Tumor Activity of PD-1 Blockade
Giulia Agnello,
Aeglea BioTherapeutics, USA
Therapeutic Depletion of Arginine via Arginase I (AEB1102, Pegzilarginase) Administration Inhibits Tumor Growth and Further Sensitizes the Tumor to Immunotherapy with Anti-PD1 and Anti-PD-L1
Therapeutic Depletion of Arginine via Arginase I (AEB1102, Pegzilarginase) Administration Inhibits Tumor Growth and Further Sensitizes the Tumor to Immunotherapy with Anti-PD1 and Anti-PD-L1
Prasenjit Dey,
MD Anderson Cancer Center, USA
Collateral Lethality as a Therapeutic Target in Cancer
Collateral Lethality as a Therapeutic Target in Cancer
5:00—7:00 PM
Interplay with Other Cell Types and Tissues
*
Ralph J. DeBerardinis,
University of Texas Southwestern Medical Center, USA
Erika L. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Biosynthetic Needs of Immune Cells and Effects on Immunotherapy
Biosynthetic Needs of Immune Cells and Effects on Immunotherapy
Nada Y. Kalaany,
Boston Children's Hospital at Harvard Medical School, USA
Metabolic Dependencies in Obesity-Associated Pancreatic Cancer
Metabolic Dependencies in Obesity-Associated Pancreatic Cancer
Scott Bultman,
University of North Carolina at Chapel Hill, USA
Regulation of Tumor Metabolism by the Microbiome
Regulation of Tumor Metabolism by the Microbiome
Costas A. Lyssiotis,
University of Michigan, USA
Short Talk: Stromal Support of Pancreatic Tumor Metabolism
Short Talk: Stromal Support of Pancreatic Tumor Metabolism
5:00—7:00 PM
Hypoxia and the Tumor Stroma
*
Ester M. Hammond,
University of Oxford, UK
M. Celeste Simon,
University of Pennsylvania, USA
HIFs and Metabolic Adaptations in Renal Cancer
HIFs and Metabolic Adaptations in Renal Cancer
Mia J. Phillipson,
Uppsala University, Sweden
Contribution of Immune Cells in Restoration of Hypoxic Tissues
Contribution of Immune Cells in Restoration of Hypoxic Tissues
Sonia Rocha,
University of Liverpool, UK
PBRM1, a Highly Mutated Member of the SWI/SNF Complex in Renal Cancer, has an Unconventional Role in the Control of the Hypoxia Response
PBRM1, a Highly Mutated Member of the SWI/SNF Complex in Renal Cancer, has an Unconventional Role in the Control of the Hypoxia Response
Jong Park,
University of Maryland, Baltimore County, USA
Short Talk: Role of Lactate-NDRG Signaling in Low Oxygen Tolerance
Short Talk: Role of Lactate-NDRG Signaling in Low Oxygen Tolerance
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:15 AM
Tumor Progression and Suppression by Metabolic Enzymes
*
Sarah-Maria Fendt,
VIB-KU Leuven, Belgium
David M. Sabatini,
Whitehead Institute for Biomedical Research, USA
CRISPR Screening for Metabolic Dependencies in Cancer Cells
CRISPR Screening for Metabolic Dependencies in Cancer Cells
Coffee Break
Heather Christofk,
University of California, Los Angeles, USA
Metabolic Transitions in Cancer: Lessons from Viral Infection
Metabolic Transitions in Cancer: Lessons from Viral Infection
Eyal Gottlieb,
Technion - Israel Institute of Technology, Israel
Metabolic Dependencies of Leukemic Stem Cells
Metabolic Dependencies of Leukemic Stem Cells
Oliver Maddocks,
University of Glasgow, UK
Short Talk: MTAP Deletion and Polyamine Pathway Activity Combine to Confer Cysteine Essentiality in Cancer Cells
Short Talk: MTAP Deletion and Polyamine Pathway Activity Combine to Confer Cysteine Essentiality in Cancer Cells
Susan Demo,
Calithera Biosciences, USA
Short Talk: CB-839, a Selective Glutaminase Inhibitor, has Anti-Tumor Activity in Renal Cell Carcinoma and Synergizes with Everolimus and Cabozantinib
Short Talk: CB-839, a Selective Glutaminase Inhibitor, has Anti-Tumor Activity in Renal Cell Carcinoma and Synergizes with Everolimus and Cabozantinib
8:00—11:15 AM
Hypoxia, Inflammation and Tumor Progression
*
Emin Maltepe,
University of California, San Francisco, USA
Amato J. Giaccia,
Stanford University, USA
Clear Cell Renal Cancers: Lipid Droplets
Clear Cell Renal Cancers: Lipid Droplets
Cormac Taylor,
University College Dublin, Ireland
The Role of Hypoxia in Immunity and Inflammation
The Role of Hypoxia in Immunity and Inflammation
G-One Ahn,
Pohang University of Science and Technology, South Korea
Short Talk: Tumor-Associated Macrophages Can Exacerbate Tumor Hypoxia and Glycolysis
Short Talk: Tumor-Associated Macrophages Can Exacerbate Tumor Hypoxia and Glycolysis
Coffee Break
Gregg L. Semenza,
Johns Hopkins University School of Medicine, USA
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis
Christian Metallo,
University of California, San Diego, USA
Reprogramming of Amino Acid Metabolism by Hypoxia
Reprogramming of Amino Acid Metabolism by Hypoxia
Erinn B. Rankin,
Stanford University, USA
Short Talk: Hypoxic Signaling in the Tumor-Mesothelial Niche
Short Talk: Hypoxic Signaling in the Tumor-Mesothelial Niche
2:30—4:30 PM
Workshop 2: Hypoxia and Disease Processes
*
Peppi Koivunen,
University of Oulu, Finland
Notch Downregulation and Extramedullary Erythrocytosis in HIF Prolyl 4-Hydroxylase-2-Deficient Mice
Notch Downregulation and Extramedullary Erythrocytosis in HIF Prolyl 4-Hydroxylase-2-Deficient Mice
*
Qing Zhang,
UT Southwestern Medical Center, USA
ZHX2 Promotes ccRCC as a Potential pVHL Target by Activating NF-kB
ZHX2 Promotes ccRCC as a Potential pVHL Target by Activating NF-kB
Jason Boehme,
University of California, San Francisco, USA
Preservation of Myocardial Contractility during Acute Hypoxia with OMX—A Novel Oxygen Delivery Biotherapeutic
Preservation of Myocardial Contractility during Acute Hypoxia with OMX—A Novel Oxygen Delivery Biotherapeutic
Sara M. Timpano,
University of Guelph, Canada
Human Cells Cultured Under Physiological Oxygen Utilize a Different Mode of Translation Initiation, Have Higher Proliferation Rates, Less Oxidized DNA and More Tubular Mitochondria
Human Cells Cultured Under Physiological Oxygen Utilize a Different Mode of Translation Initiation, Have Higher Proliferation Rates, Less Oxidized DNA and More Tubular Mitochondria
Norihiko Takeda,
University of Tokyo, Japan
HIF-1-PDK1 Axis Induced Active Glycolysis Plays an Essential Role in Macrophage Migratory Capacity
HIF-1-PDK1 Axis Induced Active Glycolysis Plays an Essential Role in Macrophage Migratory Capacity
Merve Erdem,
RWTH Aachen University Hospital, Germany
HIF-1alpha in Myeloid Cells Affects Peripheral Lipid Metabolism in Cancer Cachexia
HIF-1alpha in Myeloid Cells Affects Peripheral Lipid Metabolism in Cancer Cachexia
Jamie D. Weyandt,
Vanderbilt University Medical Center, USA
Loss of Fumarate Hydratase Upregulates Glycolytic Metabolism in a Mouse Renal Carcinoma Cell Line
Loss of Fumarate Hydratase Upregulates Glycolytic Metabolism in a Mouse Renal Carcinoma Cell Line
5:00—6:45 PM
Metabolic Vulnerabilities in Cancer
*
Almut Schulze,
University of Würzburg/Theodor-Boveri Institute, Germany
Eileen P. White,
Rutgers Cancer Institute of New Jersey, USA
Inhibiting Autophagy as a Cancer Therapy
Inhibiting Autophagy as a Cancer Therapy
Katya Marjon,
Agios Pharmaceuticals, USA
Metabolic Collateral Vulnerabilities of MTAP-Deleted Cancers as Therapeutic Opportunities
Metabolic Collateral Vulnerabilities of MTAP-Deleted Cancers as Therapeutic Opportunities
Reuben J. Shaw,
The Salk Institute for Biological Studies, USA
The AMPK Pathway: Cancer Fighter, Cancer Promoter
The AMPK Pathway: Cancer Fighter, Cancer Promoter
5:00—6:45 PM
O2 Availability and Stress Responses
*
Randall S. Johnson,
University of Cambridge, UK
Constantinos Koumenis,
University of Pennsylvania, USA
Genome-Wide Analysis of Hypoxic Responses in Cells and Tumors Reveals Novel Splicing Pathways Impacting Macromolecular Synthesis
Genome-Wide Analysis of Hypoxic Responses in Cells and Tumors Reveals Novel Splicing Pathways Impacting Macromolecular Synthesis
Bradly G. Wouters,
University Health Network, Canada
ULK1 Regulates Oxygen Metabolism, Hypoxia Tolerance and Is a Therapeutic Target in Pancreatic Cancer
ULK1 Regulates Oxygen Metabolism, Hypoxia Tolerance and Is a Therapeutic Target in Pancreatic Cancer
Ester M. Hammond,
University of Oxford, UK
Ribonucleotide Reductase Favors the RRM2B Subunit to Maintain DNA Replication in Hypoxia
Ribonucleotide Reductase Favors the RRM2B Subunit to Maintain DNA Replication in Hypoxia
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka,
Director of Corporate Relations, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org, Phone:+1 970-262-1179 |