University of Oxford Mathematical Institute Floorplan
This meeting took place in 2018
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Therapeutic Targeting of Hypoxia-Sensitive Pathways (V1)
Organizer(s) Chris W. Pugh, Pablo Wappner, Johanna Myllyharju and Moira K. Whyte
April 10—14, 2018
University of Oxford Mathematical Institute • Oxford, UK
Discounted Abstract Deadline: Dec 11, 2017
Abstract Deadline: Jan 10, 2018
Scholarship Deadline: Dec 11, 2017
Discounted Registration Deadline: Feb 13, 2018
Sponsored by Akebia Therapeutics
Summary of Meeting:
Tissue oxygen gradients contribute to morphogenesis and in health cells in different tissues function under differing ambient oxygen conditions. Diseases or environmental challenges can reduce oxygen supply or increase demand, resulting in tissue hypoxia. Adaptive mechanisms have evolved that range from almost instantaneous acute ventilatory changes, through transcriptional events entrained in hours, to epigenetic events with slower effects and genetic adaptations selected across species and over generations. The role of the 2-oxoglutarate dependent dioxygenase enzyme family in influencing many, but not all, of these pleiotropic processes is increasingly recognized, and drugs targeting these enzymes are being evaluated in both experimental and clinical settings. The conference aims to combine the Keystone Symposia brand with the European HypoxiaNET consortium to bring together experts in hypoxia biology from clinical, academic and industrial backgrounds, including trainees, to: 1) Address gaps in our knowledge of responses to hypoxia across these time-frames and in different tissues; 2) Benefit the field by sharing techniques and reagents to enhance therapeutic targeting of the hypoxic response in general, including via inhibition of oxygen-sensitive enzymes; 3) Consider the utility of harnessing these pathways in organ dysfunction, in regenerative medicine and to influence immune and inflammatory responses; and 4) Disseminate outcomes of ongoing clinical trials and enhance plans for future trials. The most important anticipated outcome from the conference is that, through sharing knowledge, enhancing collaborations and training participants from diverse backgrounds, the likelihood of successful manipulation of hypoxia pathways to produce clinical benefits in a variety of fields including, but not restricted to, renal anemia will be significantly enhanced.
View Scholarships/Awards
Tissue oxygen gradients contribute to morphogenesis and in health cells in different tissues function under differing ambient oxygen conditions. Diseases or environmental challenges can reduce oxygen supply or increase demand, resulting in tissue hypoxia. Adaptive mechanisms have evolved that range from almost instantaneous acute ventilatory changes, through transcriptional events entrained in hours, to epigenetic events with slower effects and genetic adaptations selected across species and over generations. The role of the 2-oxoglutarate dependent dioxygenase enzyme family in influencing many, but not all, of these pleiotropic processes is increasingly recognized, and drugs targeting these enzymes are being evaluated in both experimental and clinical settings. The conference aims to combine the Keystone Symposia brand with the European HypoxiaNET consortium to bring together experts in hypoxia biology from clinical, academic and industrial backgrounds, including trainees, to: 1) Address gaps in our knowledge of responses to hypoxia across these time-frames and in different tissues; 2) Benefit the field by sharing techniques and reagents to enhance therapeutic targeting of the hypoxic response in general, including via inhibition of oxygen-sensitive enzymes; 3) Consider the utility of harnessing these pathways in organ dysfunction, in regenerative medicine and to influence immune and inflammatory responses; and 4) Disseminate outcomes of ongoing clinical trials and enhance plans for future trials. The most important anticipated outcome from the conference is that, through sharing knowledge, enhancing collaborations and training participants from diverse backgrounds, the likelihood of successful manipulation of hypoxia pathways to produce clinical benefits in a variety of fields including, but not restricted to, renal anemia will be significantly enhanced.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Tuesday, April 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Sunday, April 15 in order to fully experience the meeting.
TUESDAY, APRIL 10
WEDNESDAY, APRIL 11
THURSDAY, APRIL 12
FRIDAY, APRIL 13
SATURDAY, APRIL 14
SUNDAY, APRIL 15
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Tuesday, April 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Sunday, April 15 in order to fully experience the meeting.
TUESDAY, APRIL 10
16:00—20:00
Arrival and Registration
South Mezzanine
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
South Mezzanine
08:30—09:30
Welcome and Keynote Address
Mathematical Institute, L1
*
Chris W. Pugh,
University of Oxford, UK
Session Chair
Session Chair
*
Pablo Wappner,
Fundacion Instituto Leloir, Argentina
Session Chair
Session Chair
*
Johanna Myllyharju,
University of Oulu, Finland
Session Chair
Session Chair
*
Moira K. Whyte,
University of Edinburgh, Queen's Medical Research Institute, UK
Session Chair
Session Chair
Peter J. Ratcliffe,
Francis Crick Institute, UK
New Horizons in Hypoxia Biology and Therapeutics
New Horizons in Hypoxia Biology and Therapeutics
09:30—12:00
Acute Oxygen-Sensing
Mathematical Institute, L1
*
Roland H. Wenger,
University of Zürich, Switzerland
Session Chair
Session Chair
Mark A. Krasnow,
Stanford University School of Medicine, USA
Acute Oxygen Sensing in the Lungs and Carotid Body
Acute Oxygen Sensing in the Lungs and Carotid Body
Coffee Break
Francesco Licausi,
Scuola Superiore Sant'Anna, Italy
Harnessing the Oxygen Sensing Mechanism of Plants
Harnessing the Oxygen Sensing Mechanism of Plants
Betty A. Eipper,
University of Connecticut Health Center, USA
Peptidylglycine alpha–Amidating Monooxygenase (PAM), a Conserved Secretory Pathway Enzyme, Is Sensitive to Physiologically Relevant Changes in Oxygen
Peptidylglycine alpha–Amidating Monooxygenase (PAM), a Conserved Secretory Pathway Enzyme, Is Sensitive to Physiologically Relevant Changes in Oxygen
David Macias,
University of Cambridge, UK
Short Talk: HIF-2α Is Essential for Carotid Body Development and Function
Short Talk: HIF-2α Is Essential for Carotid Body Development and Function
Christopher Turnbull,
University of Oxford, UK
Short Talk: Overnight Supplemental Oxygen Abolishes the Rise in Morning Blood Pressure Caused by CPAP withdrawal in OSA
Short Talk: Overnight Supplemental Oxygen Abolishes the Rise in Morning Blood Pressure Caused by CPAP withdrawal in OSA
12:00—17:00
On Own for Lunch
12:00—13:00
Poster Setup
South Mezzanine
13:00—22:00
Poster Viewing
South Mezzanine
14:00—16:30
Workshop 1: New Techniques for Oxygen Measurement
Mathematical Institute, L1
*
Joachim Fandrey,
University Duisburg-Essen, Germany
Session Chair
Session Chair
Giovanni E. Mann,
King's College London, UK
Defining Physiological Normoxia in vitro for Clinical Translation of Cell Physiology
Defining Physiological Normoxia in vitro for Clinical Translation of Cell Physiology
Christine Janz,
ibidi GmbH, Germany
Intra- and Extracellular Oxygen Measurement on a Live Cell Imaging System Using ibidi OPAL
Intra- and Extracellular Oxygen Measurement on a Live Cell Imaging System Using ibidi OPAL
Peter A. Robbins,
University of Oxford, UK
In-Airway Molecular Flow Sensing Using Laser Absorption Spectroscopy: What Is It and Why Is It Useful?
In-Airway Molecular Flow Sensing Using Laser Absorption Spectroscopy: What Is It and Why Is It Useful?
Andrew D. Farmery,
University of Oxford, UK
Polymer Fibre-Optic Oxygen Sensors
Polymer Fibre-Optic Oxygen Sensors
Margaret Ashcroft,
University of Cambridge, UK
CHCHD4 Confers Sensitivity to HIF Pathway Inhibitors
CHCHD4 Confers Sensitivity to HIF Pathway Inhibitors
16:30—17:00
Coffee Available
South Mezzanine
17:00—19:00
Hypoxia and Organ (dys)Function
Mathematical Institute, L1
*
Peppi Koivunen,
University of Oulu, Finland
Session Chair
Session Chair
Johanna Myllyharju,
University of Oulu, Finland
Transmembrane Prolyl 4-Hydroxylase (P4H-TM/PHD4) – Further Light into the Roles of this Enigmatic Enzyme
Transmembrane Prolyl 4-Hydroxylase (P4H-TM/PHD4) – Further Light into the Roles of this Enigmatic Enzyme
Dörthe M. Katschinski,
Georg August University, Germany
The HIF-PHD Pathway in the Cardiovascular System
The HIF-PHD Pathway in the Cardiovascular System
Joanne Holliday,
University of Nottingham, UK
Short Talk: Ablation of Factor Inhibiting HIF (FIH1) Modulates Cardiac Function and Improves Hypoxic Tolerance
Short Talk: Ablation of Factor Inhibiting HIF (FIH1) Modulates Cardiac Function and Improves Hypoxic Tolerance
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
South Mezzanine
19:30—22:00
Poster Session 1
South Mezzanine
08:30—11:45
Hypoxia and Development
Mathematical Institute, L1
*
Cormac Taylor,
University College Dublin, Ireland
Session Chair
Session Chair
Dino A. Giussani,
University of Cambridge, UK
Heart Disease Link to Fetal Hypoxia: An Intergenerational Perspective
Heart Disease Link to Fetal Hypoxia: An Intergenerational Perspective
Josh Bonkowsky,
University of Utah, USA
Hypoxia and Connectivity in the Developing Vertebrate Nervous System
Hypoxia and Connectivity in the Developing Vertebrate Nervous System
Coffee Break
Ernestina Schipani,
University of Pennsylvania, USA
Impairment of Mitochondrial Respiration Promotes Survival of HIF-1alpha Deficient Chondrocytes in vivo
Impairment of Mitochondrial Respiration Promotes Survival of HIF-1alpha Deficient Chondrocytes in vivo
Pablo Wappner,
Fundacion Instituto Leloir, Argentina
Novel Mechanisms of HIF Regulation: Genetic Lessons from Drosophila
Novel Mechanisms of HIF Regulation: Genetic Lessons from Drosophila
Emma U. Hammarlund,
Lund University, Sweden
Short Talk: Pseudohypoxia-Activated Pathways Were Essential for Vertebrate Evolution in Earth's Oxic Niche
Short Talk: Pseudohypoxia-Activated Pathways Were Essential for Vertebrate Evolution in Earth's Oxic Niche
Tiffany M. Bernardo,
University of Pittsburgh, USA
Short Talk: Hypoxia, PPARγ, and Lactate Metabolism in Placental Development and Injury
Short Talk: Hypoxia, PPARγ, and Lactate Metabolism in Placental Development and Injury
11:45—17:00
On Own for Lunch
11:45—13:00
Poster Setup
South Mezzanine
13:00—22:00
Poster Viewing
South Mezzanine
16:30—17:00
Coffee Available
South Mezzanine
17:00—19:00
Clinical Inhibitors of HIF Hydroxylases and HIFs
Mathematical Institute, L1
*
Sarah R. Walmsley,
University of Edinburgh, Queen's Medical Research Institute, UK
Session Chair
Session Chair
Martin Richard Späth,
University Hospital of Cologne, Germany
Short Talk: Molecular Correlates of Hypoxic Preconditioning and PHD-Inhibition in Renal Ischemia Reperfusion Injury
Short Talk: Molecular Correlates of Hypoxic Preconditioning and PHD-Inhibition in Renal Ischemia Reperfusion Injury
Christopher J. Schofield,
University of Oxford, UK
Inhibiting 2-Oxogluterate Oxygenases for Therapeutic Benefit
Inhibiting 2-Oxogluterate Oxygenases for Therapeutic Benefit
Chris W. Pugh,
University of Oxford, UK
Inducible Phd2 Knockdown in the Mouse Reveals Immunological Effects that Warrant Consideration in the Context of Pharmacological Inhibition of this Enzyme in the Clinic
Inducible Phd2 Knockdown in the Mouse Reveals Immunological Effects that Warrant Consideration in the Context of Pharmacological Inhibition of this Enzyme in the Clinic
Kyoji Yamaguchi,
Vanderbilt University Medical Center, USA
Short Talk: DS-1093a, A Novel HIF Prolyl Hydroxylase Inhibitor, Has Therapeutic Potential in a Wide Range of Diseases
Short Talk: DS-1093a, A Novel HIF Prolyl Hydroxylase Inhibitor, Has Therapeutic Potential in a Wide Range of Diseases
Thomas Kietzmann,
University of Oulu, Finland
Short Talk: The Epidermal Growth Factor Receptor (EGFR) Adaptor Protein CIN85 Is a Novel Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2 (PHD2)
Short Talk: The Epidermal Growth Factor Receptor (EGFR) Adaptor Protein CIN85 Is a Novel Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2 (PHD2)
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
South Mezzanine
19:30—22:00
Poster Session 2
South Mezzanine
08:30—11:30
Immune and Inflammatory Effects of Hypoxia
Mathematical Institute, L1
*
Edurne Berra,
CIC bioGUNE, Spain
Session Chair
Session Chair
Moira K. Whyte,
University of Edinburgh, Queen's Medical Research Institute, UK
Hypoxia and Regulation of Inflammatory Cell Migration
Hypoxia and Regulation of Inflammatory Cell Migration
Yun-Cai Liu,
La Jolla Institute for Allergy and Immunology, USA
VHL-HIF-Glycolytic Pathway in Immune Regulation
VHL-HIF-Glycolytic Pathway in Immune Regulation
Coffee Break
Sarah R. Walmsley,
University of Edinburgh, Queen's Medical Research Institute, UK
Hypoxia and Regulation of Inflammation and Anti-Microbial Responses
Hypoxia and Regulation of Inflammation and Anti-Microbial Responses
Randall S. Johnson,
University of Cambridge, UK
Hypoxia and its Role in the Interaction of the Innate and Adaptive Immune Systems
Hypoxia and its Role in the Interaction of the Innate and Adaptive Immune Systems
Einav Gross,
Hebrew University of Jerusalem, Israel
Short Talk: Innate Immunity Regulation by Neuronal Oxygen Sensors in the Nematode Caenorhabditis elegans
Short Talk: Innate Immunity Regulation by Neuronal Oxygen Sensors in the Nematode Caenorhabditis elegans
11:30—17:00
On Own for Lunch
11:30—13:00
Poster Setup
South Mezzanine
13:00—22:00
Poster Viewing
South Mezzanine
14:30—16:30
Workshop 2: Chromatin and Epigenetics
Mathematical Institute, L1
*
Moira K. Whyte,
University of Edinburgh, Queen's Medical Research Institute, UK
Session Chair
Session Chair
Sophie Cowman,
University of Liverpool, UK
Alteration of DNA Repair Activity in Hypoxic Brain Tumours Underlies Treatment Resistance
Alteration of DNA Repair Activity in Hypoxic Brain Tumours Underlies Treatment Resistance
Minoru Kobayashi,
Kyoto University, Japan
A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of its Downstream Genes
A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of its Downstream Genes
Tamas Ordog,
Mayo Clinic, USA
Hypoxia-Inducible Factor 1 alpha (HIF1A) Stimulates Neuronal Nitric Oxide Synthase (Nos1) Transcription by Modifying Spatial Chromatin Organization
Hypoxia-Inducible Factor 1 alpha (HIF1A) Stimulates Neuronal Nitric Oxide Synthase (Nos1) Transcription by Modifying Spatial Chromatin Organization
Ilaria Maria Cristina Orlando,
University of Fribourg, Switzerland
Regulatory DNA Elements Modulating Oxygen-Regulated Erythropoietin Gene Expression
Regulatory DNA Elements Modulating Oxygen-Regulated Erythropoietin Gene Expression
Catherine Turgeon,
Université Laval, Canada
PRMT1-Mediated DOCK6 Arginine Methylation Represses Hypoxia-Inducible Factor-1 (HIF-1) Expression
PRMT1-Mediated DOCK6 Arginine Methylation Represses Hypoxia-Inducible Factor-1 (HIF-1) Expression
Michael Batie,
University of Liverpool, UK
The Role of Chromatin Structure and JmjC Histone Demethylases in the Hypoxic Response
The Role of Chromatin Structure and JmjC Histone Demethylases in the Hypoxic Response
16:30—17:00
Coffee Available
South Mezzanine
17:00—19:00
Hypoxia and Stem Cell Function
Mathematical Institute, L1
*
Pablo Wappner,
Fundacion Instituto Leloir, Argentina
Session Chair
Session Chair
Kamil R. Kranc,
Institute of Cancer Research, UK
Hypoxia Signaling in Normal and Malignant Haematopoiesis
Hypoxia Signaling in Normal and Malignant Haematopoiesis
Paul R. Riley,
University of Oxford, UK
The Role of Hypoxia and HIF-Signaling in Epicardial Activation during Neonatal Cardiac Regeneration
The Role of Hypoxia and HIF-Signaling in Epicardial Activation during Neonatal Cardiac Regeneration
Edurne Berra,
CIC bioGUNE, Spain
Harnessing the Intricate Crosstalk in Hypoxia Signaling Pathways
Harnessing the Intricate Crosstalk in Hypoxia Signaling Pathways
Jong Park,
University of Maryland, Baltimore County, USA
Short Talk: Role of Lactate-NDRG1 Signaling in Low Oxygen Tolerance
Short Talk: Role of Lactate-NDRG1 Signaling in Low Oxygen Tolerance
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
South Mezzanine
19:30—22:00
Poster Session 3
South Mezzanine
08:30—11:30
Tissue Degeneration, Regeneration and Programming
Mathematical Institute, L1
*
Johanna Myllyharju,
University of Oulu, Finland
Session Chair
Session Chair
Peppi Koivunen,
University of Oulu, Finland
HIF Prolyl 4-Hydroxylase Inhibition in Fatty Liver Diseases
HIF Prolyl 4-Hydroxylase Inhibition in Fatty Liver Diseases
Sean P. Colgan,
University of Colorado Denver, USA
Hypoxia and HIF as Regulators of Barrier Function in the Mucosa
Hypoxia and HIF as Regulators of Barrier Function in the Mucosa
Coffee Break
Hesham A. Sadek,
University of Texas Southwestern Medical Center, USA
Redox Regulation of Cardiomyocyte Renewal
Redox Regulation of Cardiomyocyte Renewal
Tracey A. Rouault,
NICHD, National Institutes of Health, USA
Translational Regulation of HIF2 alpha and Erythropoiesis by the IRE-IRP System
Translational Regulation of HIF2 alpha and Erythropoiesis by the IRE-IRP System
James A. Nathan,
Cambridge Institute of Therapeutic Immunology & Infectious Disease, UK
Short Talk: The Endolysosomal Vacuolar-ATPase Complex Controls HIF Signaling by Restricting Iron Availability
Short Talk: The Endolysosomal Vacuolar-ATPase Complex Controls HIF Signaling by Restricting Iron Availability
11:30—12:30
Keynote Address
Mathematical Institute, L1
*
Chris W. Pugh,
University of Oxford, UK
Session Chair
Session Chair
*
Pablo Wappner,
Fundacion Instituto Leloir, Argentina
Session Chair
Session Chair
*
Johanna Myllyharju,
University of Oulu, Finland
Session Chair
Session Chair
*
Moira K. Whyte,
University of Edinburgh, Queen's Medical Research Institute, UK
Session Chair
Session Chair
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
Do Histone Demethylases Directly Sense Oxygen to Control Chromatin Structure and Cell Fate?
Do Histone Demethylases Directly Sense Oxygen to Control Chromatin Structure and Cell Fate?
12:30—17:00
On Own for Lunch
14:30—16:30
Workshop 3: Physiology and Metabolism
Mathematical Institute, L1
*
Thomas Kietzmann,
University of Oulu, Finland
Session Chair
Session Chair
Franziska Dengler,
University of Leipzig, Germany
Hypoxia in Jejunum Epithelium: Fast Adaptation of Glucose Transport
Hypoxia in Jejunum Epithelium: Fast Adaptation of Glucose Transport
Paul Grevitt,
Barts Cancer Institute, UK
Identification of Novel Regulators of HIFs
Identification of Novel Regulators of HIFs
Amalia Ruiz-Serrano,
University of Zürich, Switzerland
Deletion of the FIH Substrate OTUB1 in Mice Affects Viability, Energy Metabolism and Oxygen Physiology
Deletion of the FIH Substrate OTUB1 in Mice Affects Viability, Energy Metabolism and Oxygen Physiology
Julián Aragonés Lopez,
Research Institute Princesa, Spain
Role of Hif2α-Epo Pathway in Airway Response to Oxygen FluctuatioNS
Role of Hif2α-Epo Pathway in Airway Response to Oxygen FluctuatioNS
Gijsbert Jacob van Belle,
Universitätsmedizin Göttingen, Germany
Hypoxia-Stimulated Membrane Trafficking Requires T-Plastin
Hypoxia-Stimulated Membrane Trafficking Requires T-Plastin
16:30—17:00
Coffee Available
South Mezzanine
17:00—18:45
Epigenetic and Pan-Genomic Effects of Hypoxia
Mathematical Institute, L1
*
Chris W. Pugh,
University of Oxford, UK
Session Chair
Session Chair
Raul Mostoslavsky,
Harvard Medical School, USA
Linking Epigenetics, Metabolism and Cancer: Lessons from SIRT6
Linking Epigenetics, Metabolism and Cancer: Lessons from SIRT6
Skirmantas Kriaucionis,
University of Oxford, UK
TET Proteins and 5-Hydroxymethylcytosine in Transcription
TET Proteins and 5-Hydroxymethylcytosine in Transcription
Joaquín M. Espinosa,
Linda Crnic Institute for Down Syndrome, USA
Mechanisms of Transcriptional Regulation during the Hypoxic Response
Mechanisms of Transcriptional Regulation during the Hypoxic Response
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Mathematical Institute, L1
19:00—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
South Mezzanine
11:00—11:00
Departure
*Session Chair †Invited, not yet responded.
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