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This meeting took place in 2020



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Hypoxia: Molecules, Mechanisms and Disease (A3)


Organizer(s) José López-Barneo, Sarah R. Walmsley, Hesham A. Sadek and Jacques Pouysségur
January 19—23, 2020
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Sep 25, 2019
Abstract Deadline: Oct 16, 2019
Scholarship Deadline: Sep 25, 2019
Discounted Registration Deadline: Nov 19, 2019

Sponsored by Akebia Therapeutics and Merck & Co., Inc.

Summary of Meeting:
Hypoxia research reflects a dynamic and rapidly expanding field with growing implications ranging from basic molecular biology to medicine. Changes in cellular oxygen availability secondary to environmental challenges or diseases, trigger a broad array of adaptive responses that can be rapid (seconds) or more protracted (weeks to months). The molecules and mechanisms involved in these versatile hypoxia signaling pathways are fundamental to the pathogenesis of highly prevalent medical conditions, among which are respiratory depression, hypertension, tumor progression and inflammation. Moreover, oxygen regulates cellular processes, which are essential to cell reprogramming, development and tissue/organ regeneration. In this conference on Hypoxia, the tenth in the series of Keystone Symposia, experts from basic, clinical and industrial backgrounds will gather to update the status of the field, to discuss the most relevant discoveries and their applications, and to envision the conceptual and technological trends for upcoming years. The conference is designed to provide a broad coverage of the hypoxia field, with emphasis in translational strategies and perspectives. It will also promote multidisciplinary collaborations between scientists from different research backgrounds and the interaction between new graduate students and postdocs with leaders in this discipline.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, January 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 23 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 24 in order to fully experience the meeting.

SUNDAY, JANUARY 19

4:00—8:00 PM
Arrival and Registration

Longs Peak Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, JANUARY 20

7:00—8:00 AM
Breakfast

Longs/Quandary Peaks
8:00—9:00 AM
Welcome and Keynote Address

Grays Peak
* José López-Barneó, University of Seville, Spain

Randall S. Johnson, University of Cambridge, UK
Hypoxic Response is not Pathological: Oxygen Flux, Physiology, and HIF

9:00—11:15 AM
Hypoxia Signaling: Acute Oxygen Sensing

Grays Peak
* Sonia Rocha, University of Liverpool, UK

José López-Barneó, University of Seville, Spain
Acute Oxygen Sensing by Arterial Chemoreceptors: A Mix of Metabolism, Mitochondrial Signaling and Ion Channels

Coffee Break

Alexander Gourine, University College London, UK
Acute Oxygen Sensing in the Brain

Natascha Sommer, Justus Liebig University, Germany
Oxygen Sensing in the Lung Vasculature: Role in Pulmonary Hypertension

Emma J. Hodson, Francis Crick Institute, UK
Short Talk: HIF-2α in the Carotid Body

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Longs/Quandary Peaks
1:00—10:00 PM
Poster Viewing

Longs/Quandary Peaks
2:30—4:30 PM
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis. Maximum attendance: 60.

Castle Peaks I & II
Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK

Michaela Frye, Deutsches Krebsforschungszentrum, Germany

Christopher Sinz, Merck South San Francisco, USA

Cormac Taylor, University College Dublin, Ireland

Silvia V. Conde, Centro de Estudos de Doenças Crónicas, Portugal

Elyse Dankoski, Journal of Clinical Investigation, USA

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Pathophysiology of Hypoxia and Ischemia

Grays Peak
* Paul T. Schumacker, Northwestern University, USA

Thomas Park, University of Illinois at Chicago, USA
Mechanisms of Extreme Tolerance to Anoxia in the African Naked Mole-Rat

Silvia V. Conde, Centro de Estudos de Doenças Crónicas, Portugal
Novel Therapies in Carotid Body-Mediated Sympathetic Over-Activation Syndromes

Jennifer V.F. Potter, University of Virginia, USA
Pharmacology of Peripheral and Central Chemoreceptors: The Respiratory Depression and Opioid Epidemics

Jong Park, University of Maryland, Baltimore County, USA
Short Talk: Role of Lactate-NDRG1 Signaling in Low Oxygen Tolerance

Nathaniel Berg, University of Texas Health Science Center, USA
Short Talk: Hif1a-Dependent Expression of miR-147 in Myeloid Cells Promotes Resolution of Acute Lung Injury

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 1

Longs/Quandary Peaks

TUESDAY, JANUARY 21

7:00—8:00 AM
Breakfast

Longs/Quandary Peaks
8:00—8:20 AM
Special Session: Tribute to William G. Kaelin, Peter J. Ratcliffe and Gregg L. Semenza (2019 Nobel Laureates)

Grays Peak
8:20—11:30 AM
Hypoxia Signaling: Hydroxylases and the Hypoxia Inducible Factors

Grays Peak
* Roland H. Wenger, University of Zürich, Switzerland

Peter J. Ratcliffe, University of Oxford, UK
Signalling Oxygen Levels in Cells by Enzymatic Protein Oxidation

Joseph A. Garcia, Columbia University Medical Center, USA
An Acetate Switch Links Dynamic Changes in Intermediary Metabolism with Stress Signaling by HIF-2 in Mammals

Coffee Break

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
New Therapeutic Strategies Based on the Functions of the VHL Tumor Suppressor and HIF

Erquan Zhang, National Institute of Biological Sciences, China
Towards Understanding the Mutual Regulation of Hypoxia Signaling and the Circadian Clock

Stephanie Naas, Universitätsklinikum Erlangen, Germany
Short Talk: Transcriptional Auto-Regulation of Hypoxia-Inducible Factor-2α in Renal Cells

Brian M.W. Ortmann, University of Cambridge, UK
Short Talk: How is the Hypoxia Inducible Factor Response Efficiently Activated?

11:30 AM—12:30 PM
Climate Crisis - As Scientists We Have a Moral Duty to Act (Optional)
Objectives: To hear peoples thoughts/concerns, to plan ways we can act, and to connect within our community and with other global organizations.

Grays Peak
* Isabel N. Christie, University College London, UK

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Longs/Quandary Peaks
1:00—10:00 PM
Poster Viewing

Longs/Quandary Peaks
3:00—4:30 PM
Workshop 1

Grays Peak
Alejandro Moreno, Instituto de Biomedicina de Sevilla, Spain
Acute Oxygen Sensing by Ca2+ Channels in Vascular Smooth Muscle Depends on Mitochondrial Complex I Signaling

Andrew Cowburn, Imperial College London, UK
Targeting HIF2α Hetero-Dimerisation as a Novel Therapeutic Strategy for PAH

Mariia Burdyniuk, Stanford University, USA
Human 3D Cellular Model of Hypoxic Brain Injury of Prematurity: Alterations in GABAergic Interneurons

* Josef Prchal, University of Utah, USA
Augmented HIF and Thrombosis

Charandeep Singh, Cleveland Clinic, USA
Is Metabolism in Hyperoxia Opposite to that in Hypoxia?

Joona Tapio, University of Oulu, Finland
Lower Hemoglobin Levels Associate with Lower Body Mass Index and Healthier Metabolic Profile

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
Redox Signaling in Hypoxia Responses

Grays Peak
* Cormac Taylor, University College Dublin, Ireland

Paul T. Schumacker, Northwestern University, USA
Mitochondrial Regulation of Cell Function through Metabolomic Signaling

Vamsi K. Mootha, Massachusetts General Hospital, USA
Hypoxia as a Therapy for Mitochondrial Disease

Agnes Görlach, German Heart Center Munich, TU Munich, Germany
Hypoxia and ROS Crosstalk in Programming of Cardiovascular Diseases

Margaret Ashcroft, University of Cambridge, UK
Short Talk: The Redox-Regulated Disulphide Relay System Controls Hypoxia Responses

Hanako Kobayashi, Vanderbilt University, USA
Short Talk: HIF Activation in TFAM-Deficient Tubular Epithelium Mitigates Renal Cyst Development

7:00—7:15 PM
Celebratory Toast to Nobel Prize

Grays Peak
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, JANUARY 22

7:00—8:00 AM
Breakfast

Longs/Quandary Peaks
8:00—11:00 AM
Hypoxia and Cancer

Grays Peak
* Agnes Görlach, German Heart Center Munich, TU Munich, Germany

Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Hypoxia-Inducible Factors Mediate Immune Evasion by Cancer Cells

Fatima Mechta-Grigoriou, Curie Research Institute, France
Role of Chronic Oxidative Stress in Cancer Development

Coffee Break

Jacques Pouysségur, University of Nice, France
Exploiting Acidic, Nutrient and Oxidative Stresses in Hypoxic Tumors

Silvia Pastorekova, Biomedical Research Center, Slovak Academy of Sciences, Slovakia
Hypoxia-Induced Carbonic Anhydrase IX: Contribution to Cancer Hallmarks and Clinical Prospects

Kelsey E. Sivick Gauthier, Arcus Biosciences, Inc., USA
Short Talk: Selective Inhibition of Hypoxia-Inducible Factor (HIF)-2α for the Treatment of Cancer

Tatsuya Suwa, Kyoto University, Japan
Short Talk: A Novel Hypoxia-Inducible Secretory Protein, HISP2, Causes Radioresistance of Hypoxic Cancer Cells in a Paracrine Manner

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Longs/Quandary Peaks
1:00—10:00 PM
Poster Viewing

Longs/Quandary Peaks
3:00—4:30 PM
Workshop 2

Grays Peak
Kathryn Jaques Schunke, University of Hawaii, USA
Regulation of HIF-1 by Chromatin Reader Protein Kinase C Binding Protein 1 (PRKCBP1)

Zachary Bacigalupa, Vanderbilt University Medical Center, USA
Targeting ACSS2 Inhibits HIF-2α Signaling and Oxidative Metabolism in ccRCC and Promotes Favorable Properties in CD4+ T Cells

* Carsten C. Scholz, University of Zürich, Switzerland
FIH-Mediated Oxygen-Dependent Regulation of the Deubiquitinase OTUB1

Violaine Sée, University of Liverpool, UK
Identification and Characterisation of Novel Post-Translational Modifications Regulating the Hypoxia Inducible Factors, HIF-1α and HIF-2α

Ben Wielockx, Technical University of Dresden, Germany
HIF2α Is a Direct Regulator of Neutrophil Motility

Andreas Bapst, Universität Zürich, Switzerland
Telopode Function in Cell Lines Derived from Erythropoietin-Tagged Mouse Kidney Telocytes

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—7:00 PM
New Trends and Techniques in Hypoxia Research

Grays Peak
* Erquan Zhang, National Institute of Biological Sciences, China

Joel A. Spencer, University of California, Merced, USA
Direct Oxygen Sensing in the Bone Marrow by Two-Photon Phosphorescence Lifetime Quenching

Sonia Rocha, University of Liverpool, UK
Chromatin Senses Oxygen Changes

Elaine Pinheiro, Merck Research Laboratories, USA
HIF 2alpha Inhibitors: Applications and Current Clinical Trials

F. Aisha Chow, FibroGen Inc., USA
Short Talk: Roxadustat Enhances Degradation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) in a HIF and INSIG Dependent Manner

Tom Keeley, University of Oxford, UK
Short Talk: Rapid Regulation of Protein Stability by 2-Aminoethanethiol Dioxygenase and the N-Degron Pathway

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
7:30—10:00 PM
Poster Session 3

Longs/Quandary Peaks

THURSDAY, JANUARY 23

7:00—8:00 AM
Breakfast

Longs/Quandary Peaks
8:00—11:00 AM
Hypoxia in Stem Cells, Cell Reprogramming, and Regeneration

Grays Peak
* Silvia Pastorekova, Biomedical Research Center, Slovak Academy of Sciences, Slovakia

Yoshinori Yoshida, Kyoto University, Japan
Hypoxia in Cell Reprogramming and Differentiation

Michaela Frye, Deutsches Krebsforschungszentrum, Germany
Post-Transcriptional Modifications in Development and Stem Cells

Coffee Break

Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Role of Hypoxia in Cardiac Regeneration

Silvia Martin-Puig, Fundación Centro Nacional de Investigaciones Cardiovasculares, Spain
Hypoxia, Cardiac Development and Disease

Yoshifumi Miyawaki, Kyoto University Graduate School of Medicine Medical Innovation Center, Japan
Short Talk: Novel Experimental Models for VHL Disease by Using Patient-Derived Induced Pluripotent Stem Cells

Tapio Röning, University of Oulu, Finland
Short Talk: Activation of Hypoxia Response Protects Against Age-Induced Cardiac Hypertrophy

11:00 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Longs Peak Foyer
5:00—6:45 PM
Hypoxia and Inflammation

Grays Peak
* Joseph A. Garcia, Columbia University Medical Center, USA

Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK
Hypoxic Reprogramming of Neutrophil Metabolism

Cormac Taylor, University College Dublin, Ireland
Hypoxia, Immunity and Inflammation

Alberto Pascual, Instituto de Biomedicina de Sevilla, Spain
Hypoxia, Microglia, and Endothelial Cells in Alzheimer’s Disease Pathogenesis

Laura Barbieri, Karolinska Institutet, Sweden
Short Talk: Lactate Is an Alternative Fuel for Cytotoxic CD8+ T Cells

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Grays Peak
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs/Quandary Peaks

FRIDAY, JANUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Akebia Therapeutics Merck & Co., Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

Baker Ruskinn Don Whitley Scientific Limited
HypOxygen
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL149442-01

Funding for this conference was made possible (in part) by 1R13HL149442-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Bio-Techne

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck Research Laboratories


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179