Keystone Symposia

Fairmont The Queen Elizabeth Floorplan

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This meeting took place in 2019


Here are the related meetings in 2020:
Microbiome: Therapeutic Implications (T1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Microbiome: Chemical Mechanisms and Biological Consequences (C3)


Organizer(s) Dennis W. Wolan, Peter J. Turnbaugh and Emily P. Balskus
March 10—14, 2019
Fairmont The Queen Elizabeth • Montreal, QC Canada
Discounted Abstract Deadline: Nov 20, 2018
Abstract Deadline: Dec 6, 2018
Scholarship Deadline: Nov 20, 2018
Discounted Registration Deadline: Jan 16, 2019

Sponsored by Merck & Co., Inc.

Summary of Meeting:
Both the Unified Microbiome Initiative (Alivisatos et al., Science, 2015) and the National Microbiome Initiative have emphasized the need to move beyond sequencing to better understand the fundamental molecular and chemical mechanisms that shape microbial communities in host and environmental habitats. Understanding the chemistry of microbiomes has broad implications, including providing functional annotations for the vast “dark matter” of microbial genomes, insights into the chemical languages that link microbes to each other and to their habitat, and translational implications for precision medicine, environmental health, and sustainable living. This symposium brings together scientists in biology and chemistry who rarely interact to address common questions. The interdisciplinary collaborations that result will profoundly accelerate basic microbiome research as well as help understand the role of the microbiome in human health and disease. We will emphasize speakers that employ innovative new methods and/or hypothesis-driven research to understand microbial systems at the molecular level. There is an emphasis on speakers with innovative paradigm-shifting research programs in chemistry, synthetic biology, genome editing, precision medicine, etc. Finally, many of the program speakers may not normally be invited to give talks at traditional microbiome conferences; instead the program features key innovators w ho are making significant and exciting contributions to this emerging field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, March 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 14 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, March 15 in order to fully experience the meeting.

SUNDAY, MARCH 10

4:00—8:00 PM
Arrival and Registration

Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Av. Laurier

MONDAY, MARCH 11

7:30—8:30 AM
Breakfast

Square Dorchester/Parc Mont Royal
8:00—8:30 AM
Poster Setup

Square Dorchester/Parc Mont Royal
8:30 AM—5:00 PM
Poster Viewing

Square Dorchester/Parc Mont Royal
8:30—9:30 AM
Welcome and Keynote Address

Place du Canada
* Dennis W. Wolan, The Scripps Research Institute, USA

Jon Clardy, Harvard Medical School, USA
From Correlation to Causation: Phenotypic Screening of the Human Gut Microbiome

9:30—11:30 AM
Microbiome Biochemistry Insights and Innovations

Place du Canada
* Libusha Kelly, Albert Einstein College of Medicine, USA

Emily P. Balskus, Harvard University, USA
Deciphering the Human Microbiota using Chemistry

Coffee Break

Dennis W. Wolan, The Scripps Research Institute, USA
Functional Probes and Microbiome Metaproteomics

Ana S. Luis, University of Michigan, USA
Short Talk: Sulfatases and Fucosidases Play Critical Roles in Mucin Utilization by Bacteroides

Ashley Wolf, Washington University, USA
Short Talk: Catabolism of a Maillard Reaction Product Drives Expansion of a Human Gut Commensal

11:30 AM—1:00 PM
Lunch

Square Dorchester/Parc Mont Royal
12:30—3:00 PM
Poster Session 1

Square Dorchester/Parc Mont Royal
3:00—4:30 PM
Workshop 1: Chemical Biological Methods in Microbiome Studies

Place du Canada
* Aaron W. Puri, University of Utah, USA

Laura J. Keller, Stanford University, USA
Manipulating Microbial Communities: Using Chemical Tools to Identify and Inhibit Serine Hydrolases in Commensal Bacteria

Parth Jariwala, University of North Carolina at Chapel Hill, USA
Activity-Based Protein Profiling of Gut Microbial Beta-Glucuronidases

Bastien Castagner, McGill University, Canada
Illuminating Glycan Consumers in the Human Gut Microbiota

Solenne Marion, École Polytechnique Fédérale de Lausanne, Switzerland
Microbial Bile Acid Transformations in vitro and in vivo

Xiaoguang Lei, Peking University, China
Chemoproteomic Profiling of Bile Acid Interacting Proteins

Mengzhao Xue, Yale University, USA
Characterization of Natural Colibactin Nucleobase Adducts by Tandem MS and Isotopic Labeling

4:30—5:00 PM
Coffee Available

Square Dorchester/Parc Mont Royal
5:00—7:00 PM
Small Molecules in Host-Microbiome Crosstalk

Place du Canada
* Jan Claesen, Cleveland Clinic, USA

Elaine Y. Hsiao, University of California, Los Angeles, USA
Host-Microbiome Interactions via the Gut Serotonergic System

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Interactions among the microbiota, the immune system, and the circadian clock

Kenya Honda, School of Medicine, Keio University, Japan
Identification of Gut Bacterial Strains Involved in the Regulation of Host Physiological Functions

Robert Quinn, University of California, San Diego, USA
Short Talk: Global Chemical Impacts of the Microbiome Include Novel Conjugated Bile Acids that Stimulate FXR

Sungwhan F. Oh, Brigham and Women's Hospital/Harvard Medical School, USA
Short Talk: Gut Symbiotic Alpha-Galactosylceramides: Molecular and Structural Characterization of Host Immunomodulatory Actions

7:00 PM
On Own for Dinner


TUESDAY, MARCH 12

7:30—8:30 AM
Breakfast

Square Dorchester/Parc Mont Royal
8:30—11:30 AM
Microbiome Toxicology and Pharmacology

Place du Canada
* Anna M. Seekatz, Clemson University, USA

Peter J. Turnbaugh, University of California, San Francisco, USA
Impact of the Human Gut Microbiome on Intestinal Drug Metabolism and Absorption

Shana Sturla, ETH Zürich, Switzerland
Impact of the Human Gut Microbiome on Chemical Metabolism and Toxicity

Coffee Break

Athanasios Typas, EMBL Heidelberg, Germany
Mapping and Understanding the Interactions of Drugs and Gut Microbes

Libusha Kelly, Albert Einstein College of Medicine, USA
The Microbial Ecology of Xenobiotic Metabolism

Yukuang Guo, University of Illinois at Chicago, USA
Short Talk: Commensal Gut Bacteria Convert Tacrolimus to Less Potent Metabolites

Orlando DeLeon, Medical College of Wisconsin, USA
Short Talk: Reutericyclin, a Specialized Metabolite of Lactobacillus Reuteri, Prevents Shifts in the Gut Microbiome and Abrogates Risperidone-Induced Weight Gain

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Square Dorchester/Parc Mont Royal
1:00—10:00 PM
Poster Viewing

Square Dorchester/Parc Mont Royal
4:30—5:00 PM
Coffee Available

Square Dorchester/Parc Mont Royal
5:00—7:00 PM
Antibiotics and the Microbiome

Place du Canada
* Harry Brumer, University of British Columbia, Canada

Kim Lewis, Northeastern University, USA
Growth Factors and Selective Antibiotics for the Microbiome

Gerry D. Wright, McMaster University, Canada
Antibiotic and Anticancer Drug Resistance in the Human Microbiome

Gautam Dantas, Washington University School of Medicine, USA
Predicting and Combatting Biotic and Abiotic Disruptions to Diverse Microbiomes

Jemila C. Kester, Massachusetts Institute of Technology, USA
Short Talk: Host-Dependent Effects of Antibiotics in C. Difficile Infection

Damien J. Cabral, Brown University, USA
Short Talk: Potential Role of Polysaccharide Utilization in the Response of the Gut Microbiome to Antibiotics

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Square Dorchester/Parc Mont Royal
7:30—10:00 PM
Poster Session 2

Square Dorchester/Parc Mont Royal

WEDNESDAY, MARCH 13

7:30—8:30 AM
Breakfast

Square Dorchester/Parc Mont Royal
8:30—11:30 AM
Microbiome Enzyme Discovery and Characterization

Place du Canada
* Pamela Chang, Cornell University, USA

Laura L. Kiessling, Massachusetts Institute of Technology, USA
Chemical Biology of Microbial Glycans

Aaron T. Wright, Pacific Northwest National Laboratory, USA
Probe-Enabled Selective Profiling of Functionally Active Subpopulations and Enzymes in the Gut Microbiome

Coffee Break

Andrew L. Goodman, Yale School of Medicine, USA
Disentangling Host and Microbiome Contributions to the Production of a Toxic Drug Metabolite

Michi E. Taga, University of California, Berkeley, USA
Decoding Nutritional Interactions in Microbiomes

Abigail Sloan Devlin, Harvard Medical School, USA
Short Talk: Bacterial Modification of Bile Acids Alters Host Metabolism

Catherine Robinson, University of Oregon, USA
Short Talk: SpdE, A Novel Amino Acid-Sensing Diguanylate Cyclase, Modulates Bacterial Motility to Facilitate Transmission within a Host-Microbe System

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Square Dorchester/Parc Mont Royal
1:00—10:00 PM
Poster Viewing

Square Dorchester/Parc Mont Royal
3:00—4:30 PM
Workshop 2: Roles of Pharmaceutical Industry in Microbiome Research

Place du Canada
* Peter J. Turnbaugh, University of California, San Francisco, USA

Nathaniel D. Chu, Massachusetts Institute of Technology, USA
Ecological and Evolutionary Dynamics of Fecal Transplant in Inflammatory Bowel Disease Patients, from Microbes to Molecules

John Eid, Whole Biome Inc., USA
Development of a Synbiotic Formulation for Metabolic Syndrome

Vincent Thomas, BIOASTER, Microbiology Technology Institute, France
Targeted Culturomics: High-Throughput Sorting and Cultivation of Commensal Bacterial Species from Fecal Microbiota

Christopher Liu, Kaleido Biosciences, Inc., USA
Developing a Drug Discovery Platform to Target Gut Microbiota-Associated Ammonia Production

Frank Schuren, TNO, Netherlands
I-Screen: In vitro Platform to Study Human Gut Microbiota Induced Metabolism of Parent Drugs and their Metabolites

Jonathan W. Kotula, Caribou Biosciences, USA
CRISPR-Based Genome Editing for Microbiome Engineering

4:30—5:00 PM
Coffee Available

Square Dorchester/Parc Mont Royal
5:00—7:00 PM
Emerging Technologies and Applications

Place du Canada
* Meredith Hullar, Fred Hutchinson Cancer Research Center, USA

Joel Kralj, University of Colorado, Boulder, USA
The Role of Bacterial Electrophysiology

Ashleigh B. Theberge, University of Washington, USA
Studying Cell Signaling in Complex Environments using Open Microfluidic Models

Rustem F. Ismagilov, California Institute of Technology, USA
Biophysics, Dynamics, Quantitative Analysis and Visualization of Gut Mucosal Microbial Communities

Per Malkus, Duke University, USA
Short Talk: Genetic Analysis of Mucin Metabolism and Host Colonization in Akkermansia Muciniphila

Fangchao Song, Lawrence Berkeley National Laboratory, USA
Short Talk: A Droplet-Based High-Throughput Method to Reveal Microbial Interactions in Complex Microbial Community

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Square Dorchester/Parc Mont Royal
7:30—10:00 PM
Poster Session 3

Square Dorchester/Parc Mont Royal

THURSDAY, MARCH 14

7:30—8:30 AM
Breakfast

Square Dorchester/Parc Mont Royal
8:30—11:30 AM
Microbiome-Based Natural Products

Place du Canada
* Marie-Claire Arrieta, University of Calgary, Canada

Mohammad R. Seyedsayamdost, Princeton University, USA
Inducing Silent Biosynthetic Gene Clusters in Diverse Bacteria Using Low Doses of Antibiotics

Katherine P. Lemon, Forsyth Institute, USA
Picking Sides: Bacterial Interactions in the Nose

Coffee Break

Mohamed S. Donia, Princeton University, USA
Small Molecule-Mediated Interactions in the Human Microbiome

Anne E. Osbourn, John Innes Centre, UK
Plant Metabolic Clusters – From Genetics to Genomics

Caleb Fischer, Vanderbilt University, USA
Short Talk: A Predator-Prey System for Natural Product Discovery

Fang-Yuan Chang, Massachusetts Institute of Technology, USA
Short Talk: In vitro Substrate Combinatorics for Genome-Mining-Based Characterization of Human Gut Clostridia Chemical Modulators

11:30 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Square Dorchester/Parc Mont Royal
5:00—7:00 PM
Synthetic and Systems Microbial Ecology

Place du Canada
* Abigail Sloan Devlin, Harvard Medical School, USA

Pamela A. Silver, Harvard Medical School, USA
Designing Diagnostics and Therapeutics for the Gut Microbiome

Adam P. Arkin, University of California, Berkeley, USA
Physiological and Genetic Dissection of Microbial Interactions in Subcommunities of Human and Environmental Microbiomes

Danielle Tullman-Ercek, Northwestern University, USA
Exploring the Role of Compartmentalization and Secretion on Salmonella Survival in the Gut

Max Villa, Duke University, USA
Short Talk: Massively Parallel Culture of the Human Gut Microbiome Reveals Differences in the Prevalence of Fiber-Degrading Microbes across Individuals

Darryl Wesener, Washington University, USA
Short Talk: Synthetic Food Particles to Identify Bioactive Glycans in Foods that Modulate Gut Microbiota Structure/Function

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Place du Canada
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Square Dorchester/Parc Mont Royal
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Square Dorchester/Parc Mont Royal

FRIDAY, MARCH 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Merck & Co., Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

Anaerobe Systems Diversigen
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

ACS Chemical Biology Research Diets, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179