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This meeting took place in 2019



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Autophagy: From Model Systems to Therapeutic Opportunities (B2)


Organizer(s) Vojo Deretic, Li Yu and Leon O. Murphy
February 17—21, 2019
Eldorado Hotel & Spa • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 23, 2018
Abstract Deadline: Nov 15, 2018
Scholarship Deadline: Oct 23, 2018
Discounted Registration Deadline: Dec 13, 2018

This activity is supported by an educational grant from Celgene Corporation

Summary of Meeting:
Autophagy is a homeostatic process strategically positioned at the intersection of metabolism and intracellular quality control, with broad physiological and medical manifestations ranging from metabolic imbalance to neurodegeneration, infections, immune disorders, cancer and aging. In yeast, the formation and organization of the autophagosomal apparatus follows a highly prescribed sequence, starting with the pre-autophagosomal structure and ending in autophagosomal fusion with the yeast vacuole. However, in other model organisms, as well as in mammals, the autophagy machinery and its regulators show both similarities and notable differences relative to yeast. The goals/aims of the conference are: 1) Compare and contrast autophagy in yeast and higher organisms with a focus on both the shared regulators and on those factors that have no counterparts in yeast. 2) Cover the intersection of autophagy with energy metabolism, innate immune signaling and endomembrane damage. 3) Cover how signaling cascades regulate the process of selective autophagy whereby substrates are recruited to forming autophagosomes by receptors and molecular tags such as ubiquitin, galectins, or through other modalities. The conference will cover fundamental principles as outlined above and how they apply to basic and translational aspects of human disease. Intersections with several other stress response processes will be addressed.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 21 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 22 in order to fully experience the meeting.

SUNDAY, FEBRUARY 17

4:00—8:00 PM
Arrival and Registration

Cava Santa Fe
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Cava Santa Fe

MONDAY, FEBRUARY 18

7:00—8:00 AM
Breakfast

Cava Santa Fe
7:30—8:00 AM
Poster Setup

Cava Santa Fe
8:00 AM—7:00 PM
Poster Viewing

Cava Santa Fe
8:00—9:00 AM
Welcome and Keynote Address

Eldorado Grand Ballroom
* Vojo Deretic, University of New Mexico Health Sciences Center, USA

Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy – A View from Mammalian and Metazoan Studies

9:00—11:15 AM
Autophagy Fundamentals

Eldorado Grand Ballroom
* Anne Simonsen, University of Oslo, Norway

* Patrice Codogno, INSERM, France

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Different Forms of Selective Autophagy

Coffee Break

Terje Johansen, Institute of Medical Biology, Norway
Selective Autophagy Mediated by Both Sequestosome 1/p62-Like Receptors and Mitophagy Receptors

Chiara De Leonibus, Telethon Institute of Genetics and Medicine, Italy
Short Talk: A Selective ER-Phagy Exerts Procollagen Quality Control via a CALNEXIN-FAM134B Complex

J. Wade Harper, Harvard Medical School, USA
Exploring Proteome Homeostasis Mechanisms using Quantitative Proteomics

11:15 AM—12:15 PM
Lunch

Cava Santa Fe
12:00—2:30 PM
Poster Session 1

Cava Santa Fe
2:30—4:30 PM
Workshop 1: Structural Biology and Proteomics and Autophagy

Eldorado Grand Ballroom
* Christian Behrends, Ludwig Maximilians University München, Germany
Proteomics Studies of Autophagy Systems

Sharan Swarup, Harvard Medical School, USA
Profiling the Lysophagy Pathway through Quantitative Proteomics

* James H. Hurley, University of California, Berkeley, USA
Structural Studies of Autophagy Systems

Takanori Otomo, The Scripps Research Institute, USA
Insights into Phagophore Expansion from Structural and Biochemical Analyses of the ATG2A-WIPI4 Complex

Carsten Sachse, Forschungszentrum Jülich, Germany
Structural Basis and in situ Visualization of p62/SQSTM1 Polymers by Electron Microscopy

4:30—5:00 PM
Coffee Available

Concourse
5:00—7:00 PM
mTOR, AMPK, TFEB – Relationship to Autophagy and Other Pathways

Eldorado Grand Ballroom
* Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain

Roberto Zoncu, University of California, Berkeley, USA
Molecular Mechanisms of Lysosomal mTORC1 Regulation by Cellular Lipids

Wei Liu, Zhejiang University, China
Signal Regulation of Autophagy Initiation

Nuno Raimundo, University Medical Center Goettingen, Germany
Short Talk: Mitochondrial Malfunction Impairs Lysosomal Hydrolysis via AMPK-PtdIns(3,5)P2

Reuben J. Shaw, The Salk Institute for Biological Studies, USA
AMPK and ULK1: Two Critical Kinases in Autophagy Initiation

7:00 PM
On Own for Dinner


TUESDAY, FEBRUARY 19

7:00—8:00 AM
Breakfast

Cava Santa Fe
8:00—11:00 AM
Membrane Trafficking and its Role in Autophagy

Eldorado Grand Ballroom
* Fulvio Reggiori, University Medical Centre Groningen, Netherlands

Ivan Dikic, Goethe University Medical School, Germany
Multiplex CRISPR/Cas Library Screens Targeting Autophagy Networks

Jin-Mi Heo, Harvard Medical School, USA
Short Talk: RAB7A Phosphorylation by TBK1 Promotes Mitophagy via the PINK-Parkin Pathway

Noboru Mizushima, University of Tokyo, Japan
Evolution of the ATG12 Conjugation System

Coffee Break

Cheng-Wei Hsieh, Institute of Biological Chemistry, Taiwan
Short Talk: Omegasome-Proximal PtdIns(4,5)P2 Couples F-Actin Mediated Mitoaggregate Disassembly with Autophagosome Formation during Mitophagy

Felix Randow, Medical Research Council, UK
Autophagy in Cell-Autonomous Immunity

Li Yu, Tsinghua University, China
p62 Phase Separation in Autophagy

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Cava Santa Fe
1:00—10:00 PM
Poster Viewing

Cava Santa Fe
4:30—5:00 PM
Coffee Available

Concourse
5:00—7:00 PM
Autophagy Regulation and Processes

Eldorado Grand Ballroom
* Maria Ines Vaccaro, University of Buenos Aires, Argentina

* Qing Zhong, Shanghai Jiao Tong University School of Medicine, China

Sharon A. Tooze, Francis Crick Institute, UK
Initiation of Autophagosome Formation

Elizabeth A. Allen, University of Massachusetts Medical School, USA
Short Talk: A Myotubularin-Related Phosphatase that Regulates Autophagic Flux

David C. Rubinsztein, Cambridge Institute for Medical Research, UK
Depletion of Acetyl-Coenzyme A by Starvation Inhibits mTORC1 Pathway via EP300

Qiming Sun, Zhejiang University, China
Short Talk: FAM134B Oligomerization Drives ER Membrane Scission for ER-Phagy

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy Regulation by Galectins during Membrane Damage Homeostasis

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cava Santa Fe
7:30—10:00 PM
Poster Session 2

Cava Santa Fe

WEDNESDAY, FEBRUARY 20

7:00—8:00 AM
Breakfast

Cava Santa Fe
8:00—11:00 AM
Autophagy, Proteostasis and Organellar Homeostasis

Eldorado Grand Ballroom
* Eeva-Liisa Eskelinen, University of Turku, Finland

Kevin M. Ryan, Beatson Institute for Cancer Research, UK
Autophagy in Tissue Growth and Tumor Development

Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Cross-Talk between Lipid Droplets, Autophagy and Mitochondria Drives Cell Survival Under Starvation

Martin Graef, Max Planck Institute for Biology of Aging, Germany
Short Talk: System-Wide Profiling of Mitotic Aging Reveals Pro-Aging Functions of the Autophagy Machinery

Coffee Break

Tamotsu Yoshimori, Osaka University, Japan
Suppression of Autophagic Activity by Rubicon is a Signature of Aging

Meagan J. McGrath, Monash University, Australia
Short Talk: Defective Lysosome Homeostasis during Autophagy Causes Skeletal Muscle Disease

Anastasia Henry, Denali Therapeutics, USA
The Role of Leucine-Rich Repeat Kinase 2 (LRRK2) in Regulating Endo-Lysosomal Function

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Cava Santa Fe
1:00—10:00 PM
Poster Viewing

Cava Santa Fe
2:30—4:30 PM
Panel: Women in Science at All Career Stages

Eldorado Grand Ballroom
* Anne Simonsen, University of Oslo, Norway

* Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute, USA

Magdalene Moran, Rheostat Therapeutics, USA

Helin Vakifahmetoglu-Norberg, Karolinska Institutet, Sweden

Aurore L. Claude-Taupin, University of New Mexico, USA

Eun-Kyeong Jo, Chungnam National University, South Korea

Marie Bao, Cell Press, USA

4:30—5:00 PM
Coffee Available

Concourse
5:00—7:00 PM
Autophagy in Aging, Degenerative, and Inflammatory Disease

Eldorado Grand Ballroom
* Jennifer Martinez, NIEHS, National Institutes of Health, USA

* Phyllis I. Hanson, University of Michigan, USA

Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute, USA
Regulation of Autophagy in Aging and Disease

Franck Oury, Institut Necker Enfants-Malades, France
Short Talk: Autophagy Induction is Required to Enhance Cognition and Integrate the Effects of Youthful Systemic Factors in the Aged Brain

Mondira Kundu, St. Jude Children's Hospital, USA
ULK/Atg1 Function: From Development to Disease

Rupert Beale, University of Cambridge, UK
Short Talk: Influenza A Virus Triggers a Pathway that Resembles Autophagy but Has a Distinct Molecular Basis

Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Role of Autophagy and Autophagy Genes in Infection, Inflammation and Immunity

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cava Santa Fe
7:30—10:00 PM
Poster Session 3

Cava Santa Fe

THURSDAY, FEBRUARY 21

7:00—8:00 AM
Breakfast

Cava Santa Fe
8:00—11:00 AM
Autophagy in Metabolism, Growth Control and Cancer

Eldorado Grand Ballroom
* Devrim Gozuacik, Sabanci University, Turkey

* Leon O. Murphy, Casma Therapeutics, USA

Eileen P. White, Rutgers University, USA
Autophagy Maintains Host and Tumor Metabolism and an Anti-Cancer Immune Response

Rushika M. Perera, University of California, San Francisco, USA
Short Talk: Lysosome Mediated Remodeling of the Cancer Proteome

Tor Erik Rusten, Institute for Cancer Research, Norway
Autophagy and Cancer: What Flies Tell Us

Coffee Break

Beat Nyfeler, Novartis Institutes for BioMedical Research, Switzerland
VPS34 and Autolysosomal Regulation

Nunzia Pastore, Baylor College of Medicine, USA
Short Talk: MiT-TFE Transcription Factors Couple Autophagy and Metabolism to the Peripheral Clock

Jayanta Debnath, University of California, San Francisco, USA
Autophagy and Metastatic Colonization

11:00 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 2: Current Controversies

Eldorado Grand Ballroom
* Michael Lazarou, Monash University, Australia
Function of Mammalian Atg8s (LC3s and GABARAPs) in Autophagy: New Insights and Controversies

Shigeomi Shimizu, Tokyo Medical and Dental University, Japan
New Insights into the Mechanism and Biological Roles of Atg5-Independent Macroautophagy

Shenliang Yu, Yale University, USA
ATG2 Is a Lipid Transporter at ER-Autophagosome Contacts during Autophagosome Biogenesis

Richard I. Odle, Babraham Institute, UK
Repression of Autophagy and Phosphorylation of Autophagy Regulators during Mitosis Is Independent of mTORC1

Helin Vakifahmetoglu-Norberg, Karolinska Institutet, Sweden
Targetome Analysis of Chaperone-Mediated Autophagy in Cancer Cells

4:30—5:00 PM
Coffee Available

Concourse
5:00—7:00 PM
Autophagy from Model Systems to Humans – Closing the Circle

Eldorado Grand Ballroom
* Quan Chen, Nankai University, China

* Zvulun Elazar, Weizmann Institute of Science, Israel

Angela Ianniciello, University of Glasgow, UK
Short Talk: ULK1 Regulates Central Carbon Metabolism and Drug-Sensitivity in Leukemic Stem Cells in Autophagy-Independent and Autophagy-Dependent Manner

Hong Zhang, Chinese Academy of Sciences, China
Ciliated Sensory Neurons Detect Cuticle Damage in C. elegans and Activate Autophagy in Multiple Tissues via a TGFbeta-AMPK Axis

Eric H. Baehrecke, University of Massachusetts Medical School, USA
Discovery of Novel Regulators of Autophagy in Animals

Ai Yamamoto, Columbia University, USA
Short Talk: The Physiologic Cargoes of Macroautophagy in Aging and Disease

Andrew M. Thorburn, University of Colorado AMC, USA
Targeting Autophagy in Cancer Treatment

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions

Eldorado Grand Ballroom
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cava Santa Fe
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Cava Santa Fe

FRIDAY, FEBRUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

This activity was supported by an educational grant from Celgene Corporation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA232432-01

Funding for this conference was made possible (in part) by 1 R13 CA232432-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

GeneTex, Inc. Bio-Techne

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Denali Therapeutics Inc.


Novartis Institutes for BioMedical Research


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