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This meeting took place in 2020



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Intra- and Intercellular Mechanisms of Aging (B2)


Organizer(s) Malene Hansen, Johan Auwerx and Heinrich Jasper
February 9—13, 2020
Fairmont Hotel Vancouver • Vancouver, BC Canada
Discounted Abstract Deadline: Oct 31, 2019
Abstract Deadline: Nov 7, 2019
Scholarship Deadline: Oct 31, 2019
Discounted Registration Deadline: Dec 11, 2019

Sponsored by Astellas Pharma Inc. and Cell Research

Summary of Meeting:
Over the past three decades, studies have highlighted numerous cell-autonomous mechanisms that contribute to organismal aging. Specifically, changes in many genes, pathways, biomolecules and organelles have been shown to affect aging in a number of model organisms in a conserved fashion. However, it has become increasingly clear that these intracellular mechanisms are complemented by cell non-autonomous signaling events to influence aging on a tissue and organismal level. Understanding how an initial deregulation of intracellular functions are likely communicated to other cells, tissues, or organs to thereby impact the lifespan and healthspan of the organism will be key to our understanding of aging and age-related diseases. This conference will focus on intra- and intercellular mechanisms of aging, by highlighting current research on key cell-autonomous mechanisms such as DNA, protein and mitochondrial homeostasis, as well as inter-tissue signaling events relevant to aging and age-related diseases, in particular neurodegenerative disorders.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, February 9 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 13 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 14 in order to fully experience the meeting.

SUNDAY, FEBRUARY 9

4:00—8:00 PM
Arrival and Registration

British/Columbia Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

British/Columbia Foyer

MONDAY, FEBRUARY 10

7:30—8:30 AM
Breakfast

Columbia Ballroom
8:00—8:30 AM
Poster Setup

Columbia Ballroom
8:30 AM—7:00 PM
Poster Viewing

Columbia Ballroom
8:30—9:30 AM
Welcome and Keynote Address

British Ballroom
* Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute, USA

* Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland

Andrew G. Dillin, University of California, Berkeley, USA
Cell Autonomous and Cell Non-Autonomous Regulation of Proteostasis

9:30 AM—12:00 PM
DNA / Chromatin Homeostasis

British Ballroom
* Jason G. Wood, Brown University, USA

* Julia von Maltzahn, Leibniz Institute on Aging, Germany

Peter D. Adams, Sanford Burnham Prebys Medical Discovery Institute, USA
The Dynamic Epigenome – A Challenge to Healthy Aging

Coffee Break

Joachim Lingner, École Polytechnique Fédérale de Lausanne, Switzerland
Critical Roles of Single Strand Telomere Binding Proteins to Prevent Telomeric DNA Damage, Checkpoint Signaling and Cellular Senescence

Judith Campisi, Buck Institute for Research on Aging, USA
Cellular Senescence and Aging: Cell Autonomous and Non-Autonomous Mechanisms

Abigail K. Brown, Brown University, USA
Short Talk: Long live FOXOs: Transcriptional and Epigenetic Effects of FOXO3 Pioneer-factor Activity in Humans

Siu Sylvia Sylvia Lee, Cornell University, USA
Short Talk: Chromatin Regulation and Longevity in C. elegans

12:00—12:45 PM
Lunch

Columbia Ballroom
12:00—2:30 PM
Poster Session 1

Columbia Ballroom
3:00—4:30 PM
Workshop 1: Emerging Concepts

British Ballroom
* Kristopher Burkewitz, Vanderbilt University, USA

* Shuhei Nakamura, Osaka University, Japan

Oliver Hahn, Stanford University, USA
Longitudinal Profiling of Murine Transcriptome in 17 Tissues Uncovers Global Aging Nodes with Organ-Specific Phase and Amplitude

Ann Zenobia Moore, NIA, National Institutes of Health, USA
Addressing the Biomarkers Challenge in Aging Research: The Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT) Study

Erik Ben van den Akker, Leiden University Medical Center, Netherlands
A Nine-Year Longitudinal Study in the Blood of A Supercentenarian Reveals an Extensive Subclonal Architecture with Ongoing Clonal Dynamics and a Functional Thymic Output

Francesco Della Valle, King Abdullah University of Science and Technology, Saudi Arabia
L1 RNA Knockdown Averts Heterochromatin Loss and Premature Ageing Phenotypes

Katrin Kalies, Martin-Luther-University Halle-Wittenberg, Germany
Reversing Endothelial Cell Aging by Partial Reprogramming

Michael A. Bonaguidi, University of Southern California, USA
New Single Cell Tools to Overcome Age-Related Stem Cell Dysfunction

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Vesicle/Membrane Homeostasis

British Ballroom
* Ashley E. Webb, Brown University, USA

* Brian J. North, Creighton University, USA

Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute, USA
Regulation of Autophagy in Aging and Disease

Hua Bai, Iowa State University, USA
Peroxisome Aging and Inter-Organ Communication

Dorota Skowronska-Krawczyk, University of California, San Diego, USA
Aging Membranes – Connecting “Methylation Clock” to the Lipid Metabolism in the Aging Eye

Shi Quan Wong, Brown University, USA
Short Talk: Neuronal HLH-30/TFEB in Stress and Longevity

Antonio Gomez-Muñoz, University of the Basque Country, Spain
Short Talk: Regulation of Autophagy and Cell Survival by Ceramide 1-Phosphate

7:00 PM
On Own for Dinner


TUESDAY, FEBRUARY 11

7:30—8:30 AM
Breakfast

Columbia Ballroom
8:30—11:30 AM
Protein Homeostasis

British Ballroom
* Claudia Chini, Mayo Clinic, USA

* Hua Bai, Iowa State University, USA

Judith Frydman, Stanford University, USA
Proteostasis Disfunction and Aggregate Management: Implications for Aging and Neurodegenerative Disease

Richard I. Morimoto, Northwestern University, USA
Cell Non-Autonomous Regulation of Organismal Proteostasis

Coffee Break

Benoit Lehallier, Stanford University, USA
Short Talk: Undulating Changes in Human Plasma Proteome Profiles Across the Lifespan are Linked to Disease

Ashley E. Frakes, University of California, Berkeley, USA
Short Talk: Four Glial Cells Regulate ER Stress Resistance and Longevity via Neuropeptide Signaling

Ao-Lin Allen Hsu, University of Michigan, USA
Short Talk: HSB-1/HSF-1 Pathway Modulates Histone H4 in Mitochondria to Control mtDNA Transcription and Longevity

Alessandro Ori, Leibniz Institute on Aging, Germany
Short Talk: Reduced Proteasome Activity in the Aging Brain Results in Ribosome Stoichiometry Loss and Aggregation

11:30 AM—5:00 PM
On Own for Lunch

11:30 AM—1:00 PM
Poster Setup

Columbia Ballroom
1:00—10:00 PM
Poster Viewing

Columbia Ballroom
2:30—4:30 PM
Workshop 2: Mentoring - Career Roundtable

British/Columbia Ballroom
* Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute, USA

Anna Kriebs, Nature Communications, Germany

Julie Sollier, Developmental Cell, USA

Felipe Sierra, NIA, National Institutes of Health, USA

Tracy Rankin, NIDDK, National Institutes of Health, USA

Ashley E. Webb, Brown University, USA

Dario Riccardo Valenzano, Max-Planck Institute for Biology of Ageing, Germany

Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland

Heinrich Jasper, Genentech, Inc., USA

Chee-Yeun Chung, Yumanity Therapeutics, USA

Laurent Taupenot, CSR, National Institutes of Health, USA

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Mitochondrial Homeostasis

British Ballroom
* Maria Ermolaeva, Leibniz Institute on Aging, Germany

* Mark McCormick, University of New Mexico, USA

Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
A Conserved Role of CBP/p300 in Mitochondrial Stress Response and Longevity

David Walker, University of California, Los Angeles, USA
Role of Mitophagy in Drosophila Aging

Cole M. Haynes, University of Massachusetts Medical School, USA
Scaling Mitochondrial Network Expansion with Cell Growth or Recovery

Amanda J. Audesse, Brown University, USA
Short Talk: Elucidating the Function of Mitophagy in the Maintenance of Metabolic Stability Throughout Neural Stem Cell Aging

Kristopher Burkewitz, Vanderbilt University, USA
Short Talk: Exploring the Roles of ER-Mitochondrial Calcium Coordination in Aging

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Columbia Ballroom
7:30—10:00 PM
Poster Session 2

Columbia Ballroom

WEDNESDAY, FEBRUARY 12

7:30—8:30 AM
Breakfast

Columbia Ballroom
8:30—11:45 AM
Inter-Tissue Signaling

British Ballroom
* Dorota Skowronska-Krawczyk, University of California, San Diego, USA

* Louis R. Lapierre, Brown University, USA

William B. Mair, Harvard School of Public Health, USA
Metabolic Communication and Longevity

Coleen T. Murphy, Princeton University, USA
CREB and TGF-beta Non-Autonomously Regulate Reproductive Aging through Hedgehog/Patched Signaling

Coffee Break

Fabio Demontis, St. Jude Children's Research Hospital, USA
Systemic Nutrient Signaling via Myokines

Minho M. Shong, Chungnam National University School of Medicine, South Korea
Role of Mammalian Mitokine GDF15 in Mammalian Metabolism

Alana M. Horowitz, University of California, San Francisco, USA
Short Talk: Circulating Blood Factors Confer the Rejuvenating Benefits of Exercise on the Aged Brain

Mikolaj Ogrodnik, Mayo Clinic, USA
Short Talk: Relationship Between Lipid Metabolism and Inflammation of Senescent Cells and Its Impact on Obesity- and Aging-Related Brain Dysfunctions

Chris Morrow, University of Wisconsin - Madison, USA
Short Talk: Aggresome-Mediated Quiescent Neural Stem Cell Activation

11:45 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:15 PM
Stem Cells

British Ballroom
* Saul A. Villeda, University of California, San Francisco, USA

* Fabio Demontis, St. Jude Children's Research Hospital, USA

Heinrich Jasper, Genentech, Inc., USA
Intestinal Stem Cells and Aging in Flies and Beyond

Pekka Katajisto, University of Helsinki, Finland
Role of Stem Cell Niche in Intestinal Aging

Pura Munoz Munoz Canoves, Universitat Pompeu Fabra, Spain
Identification of an Age-Resistant Quiescent Muscle Stem-Cell State

Indranil Sinha, Brigham and Women's Hospital, USA
Short Talk: Aging-Associated Loss of ARNT Limits Skeletal Muscle Regeneration

Daniel E. Colquhoun, Monash University, Australia
Short Talk: Hmga1a Suppresses mTOR Signaling Following Activation to Allow for Lifelong Maintenance of Neural Stem/Progenitor Cells

Helen Tauc, Genentech, Inc., USA
Short Talk: Identity Crisis? A Story about Aging Drosophila Intestinal Stem Cells

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Columbia Ballroom

THURSDAY, FEBRUARY 13

7:30—8:30 AM
Breakfast

Columbia Ballroom
8:30 AM—12:00 PM
Metabolism

British Ballroom
* Erik Ben van den Akker, Leiden University Medical Center, Netherlands

Meng C. Wang, Baylor College of Medicine/HHMI, USA
Metabolite Signals in Longevity Regulation

Dario Riccardo Valenzano, Max-Planck Institute for Biology of Ageing, Germany
Systemic Regulation of Aging via the Gut Microbiota

Coffee Break

Anne Brunet, Stanford University, USA
Identifying Mechanisms of Brain Aging

P. Eline Slagboom, Leiden University, Netherlands
Hall Marks of Human Aging in the Molecular Profiles of Intervention and Cohort Studies

Hillary Miller, University of Michigan, USA
Short Talk: Serotonin Signaling in Food Perception and Dietary Restriction

Eduardo Nunes Chini, Mayo Clinic, USA
Short Talk: The Ecto-Enzyme CD38 Links Cellular Senescence and NAD Metabolism During Aging

Maria Ermolaeva, Leibniz Institute on Aging, Germany
Short Talk: The Longevity Benefits of Metformin Are Age and Gender Dependent

Priyanka Narayan, Massachusetts Institute of Technology, USA
Short Talk: Identifying and Reversing APOE4-Induced Cellular Pathologies

12:00—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

British/Columbia Foyer
5:00—7:00 PM
Neurodegenerative Diseases

British Ballroom
* Michael A. Bonaguidi, University of Southern California, USA

* Chia-Chen Lu, Fu Jen Catholic University, Taiwan

Saul A. Villeda, University of California, San Francisco, USA
Mechanisms of Brain Aging and Rejuvenation

Chee-Yeun Chung, Yumanity Therapeutics, USA
From Yeast to Neurons to Patients: A Novel Drug Discovery Platform for Neurodegenerative Diseases

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Role of Chaperone-Mediated Autophagy in Neurodegeneration and Aging

Kathryn A. Jewett, University of Washington, USA
Short Talk: Non-Cell Autonomous Mechanisms Regulating Protein Aggregation in a Drosophila Model of Parkinson’s Disease

Kaspar Russ, Lundbeck and Lund University, Denmark
Short Talk: TNFα and α-Synuclein Assemblies Differently Regulate Human Astrocyte Reactivity: Implications for Parkinson’s Disease

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions

British Ballroom
Heinrich Jasper, Genentech, Inc., USA

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Columbia Ballroom
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Columbia Ballroom

FRIDAY, FEBRUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Astellas Pharma Inc. Cell Research

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AG064967-01

Funding for this conference was made possible (in part) by 1R13AG064967-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

eLife

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Calico


Calico Life Sciences LLC


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