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This meeting took place in 2020



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Stromal Cells in Immunity and Disease (Q5)


Organizer(s) Scott N. Mueller, Jason G. Cyster, Reina E. Mebius and Theresa T. Lu
February 19—23, 2020
Fairmont Empress Victoria / Victoria Conference Centre • Victoria, BC Canada
Discounted Abstract Deadline: Oct 17, 2019
Abstract Deadline: Nov 20, 2019
Scholarship Deadline: Oct 17, 2019
Discounted Registration Deadline: Dec 18, 2019

Sponsored by Merck & Co., Inc. and Roche


Summary of Meeting:
Non-hematopoietic stromal cells play important roles in many tissues, constructing tissue microenvironments, contributing to tissue repair, defense and immune responses. Within lymphoid organs, stromal cells organize and interact with leukocytes in an immunologically important manner. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, stromal cells support the migration and interactions between antigen presenting cells and naïve T and B cells during the initiation of immune responses and influence the outcome between tolerance and immunity. Stromal cells also play instrumental roles in coordinating immune responses in non-lymphoid tissues, in inflammatory and autoimmune diseases, and in chronic infection. For instance, stromal cell dysregulation has been seen in HIV infection and in cancer patients. Furthermore, stromal cells are being harnessed for therapeutic applications in several diseases, an area that holds great promise for improving human health. Our understanding of stromal cell populations and their contributions to innate and adaptive immunity as well as immunological diseases, cancer and vaccination has grown exponentially over the past few years. This emerging field has gained enormous momentum due to increasingly sophisticated tools to dissect the fundamental biology and clinical importance of this cellular compartment. This conference is being held jointly with Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches. This joint pairing will bring together basic and clinical scientists with interdisciplinary interests in stromal cell biology and disease treatment to discuss critical fundamental and translational advances. The goals of this conference are to showcase cutting-edge results and new directions in the field, stimulate interactions and provide a forum for trainees and new investigators to present their work and interact with leaders in the field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Wednesday, February 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Sunday, February 23 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Monday, February 24 in order to fully experience the meeting.

WEDNESDAY, FEBRUARY 19

4:00—8:00 PM
Arrival and Registration

Palm Court
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Palm Court

THURSDAY, FEBRUARY 20

7:00—8:00 AM
Breakfast

Crystal Gardens
7:30—8:00 AM
Poster Setup

Crystal Gardens
8:00 AM—7:00 PM
Poster Viewing

Crystal Gardens
8:00—9:30 AM
Welcome and Keynote Session (Joint)

Salon A/B
* Scott N. Mueller, University of Melbourne, Australia

* Shannon J. Turley, Genentech, Inc., USA

David A. Brenner, University of California, San Diego, USA
Linking Inflammation and Myofibroblast Activation

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Macrophage-Fibroblast Circuits

9:30—10:00 AM
Coffee Break

Prefunction
10:00 AM—12:00 PM
Stromal Cells in Lymphoid Tissue Development

Salon C
* Jason G. Cyster, HHMI/University of California, San Francisco, USA

Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
Fibroblastic Stromal Cells Direct Lymphoid Organ Development and Immune Activation

Reina E. Mebius, Amsterdam UMC-VUmc, Netherlands
Control of the Adaptive Immunity by Lymph Node Stromal Cells

Sanjiv A. Luther, University of Lausanne, Switzerland
Fibroblasts of the Intestinal Lamina Propria are Important Niche Cells Regulating IgA+ Plasma Cell Homeostasis and Function

Mark C. Coles, University of Oxford, UK
Short Talk: B-Cell Zone Reticular Cell Microenvironments Shape Chemotactic Gradient Formation

Anne Chauveau, Oxford University, UK
Short Talk: Perivascular Pathways Direct One-Way Migration of T Cells into Splenic T Zones

10:00 AM—12:00 PM
Tissue Fibroblasts and Pericytes in Fibrosis

Salon A/B
* Shannon J. Turley, Genentech, Inc., USA

* Dean Sheppard, University of California, San Francisco, USA

Jonathan M. Kurie, University of Texas MD Anderson Cancer Center, USA
The Fibrotic Tumor Stroma

Yuval Rinkevich, Helmholtz Zentrum München, GmbH, Germany
Two Succeeding Fibroblastic Lineages Drive Dermal Development and the Transition from Regeneration to Scarring

Scott M. Turner, Pliant Therapeutics, USA
Identification and Evaluation of Small Molecule Integrin Inhibitors: From Cell Systems to Human Trials

Tatsuya Tsukui, University of California, San Francisco, USA
Short Talk: Collagen-Producing Lung Cell Atlas Identifies Multiple Subsets with Distinct Localization and Relevance to Fibrosis

Dianhua Jiang, Cedars-Sinai Medical Center, USA
Short Talk: Longitudinal Transcriptomics Identifies Fibroblast Subtypes during Lung Development and Fibrosis

12:00—1:00 PM
Lunch

Crystal Gardens
12:00—2:30 PM
Poster Session 1

Crystal Gardens
2:30—4:30 PM
Workshop 1: Stromal Orchestration and Immune Responses

Salon C
* Mandy J. McGeachy, University of Pittsburgh, USA

* Ruth Ganss, Harry Perkins Institute of Medical Research, Australia

Catarina Gago da Graca, Amsterdam UMC - VUMC, Netherlands
Characterization of MHC-II Expressing FRCs in Steady State and Inflammatory Conditions

Ana Martínez-Riaño, Francis Crick Institute, UK
Cellular Dynamics of Follicular Dendritic Cells Control Antigen Presentation during the Humoral Response

Yannick Alexandre, University of Melbourne, Australia
Mesenchymal Stromal Cells Coordinate Protective Adaptive Immune Responses during Viral Infections in the Spleen

Joshua D. Brandstadter, University of Pennsylvania, USA
Distinct Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes Express Individual Notch Ligands and Prime Graft-versus-Host Disease after Bone Marrow Transplantation

Junko Sawada, Johns Hopkins All Children's Hospital, USA
TNFα Upregulates R-Ras Expression in High Endothelial Venule and Capillary Endothelium in Lymph Node, Facilitating T Cell Recruitment upon Inflammation

Jennifer Eom, University of Auckland, New Zealand
Phenotypically Distinct Fibroblastic Populations in Melanoma-Infiltrated Human Lymph Nodes Provide Unique Microenvironment for T Lymphocytes

Ian Boothby, University of California, San Francisco, USA
Neonatal Tregs Suppress the Development of a Stromal Niche for Th2 Cells in Skin

Ari B. Molofsky, University of California, San Francisco, USA
Stromal Crosstalk with Type 2 Immunity at Tissue Adventitial Niches

2:30—4:30 PM
Workshop 1: Core Mechanisms versus Organ Specific Mediators of Fibrosis

Salon A/B
* Thirumalai R. Ramalingam, Genentech, Inc., USA

* Karen Piper Hanley, University of Manchester, UK

Daniel Abebayehu, University of Virginia, USA
Inflammatory Cytokines Induce Unique Immuno-Fibroblast Subpopulations Prone to Myofibroblastic Differentiation

Daryle J. DePianto, Genentech, Inc., USA
Molecular Mapping of Epithelial Cell Senescence in IPF

Tien Peng, University of California, San Francisco, USA
Gli1+ Mesenchymal Cells Modulate Epithelial Progenitor Metaplasia in Lung Fibrosis

Lynn M. Williams, Kennedy Institute of Rheumatology, UK
CREBBP/EP300 Regulation of Collagen VI is a Key Determinant of the Myofibroblast Phenotype in Human Fibrosis

Sonia Chothani, Duke-NUS Medical School, Singapore
RNA-Binding Proteins: Drivers of Translational Regulation in Cardiac Fibrosis

Preethi Vijayaraj, University of California, Los Angeles, USA
Fibrotic Lung Disease is Associated with Proliferation and Desquamation of Ciliated Bronchiolar Epithelium

Ahmad N. Nabhan, Genentech, Inc., USA
A Molecular Cell Atlas of the Human Lung from Single Cell RNA Sequencing

Veronica Larcher, Goethe University, Germany
Parallel Lineage Tracing Studies Establish Fibroblasts as the Prevailing in vivo Adipocyte Progenitor

4:30—5:00 PM
Coffee Available

Prefunction
5:00—7:00 PM
Stromal Cells and Immunity in Non-Lymphoid Tissues

Salon C
* Ari B. Molofsky, University of California, San Francisco, USA

Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA
Langerhans Cells and Skin Protection in Lupus Photosensitivity

Shruti Naik, New York University, USA
Inflammatory Tuning of Epithelial Stem Cells

Jeremiah Bernier-Latmani, University of Lausanne, Switzerland
Blood Vessel / Telocyte Crosstalk at the Small Intestinal Villus Tip

Matthew B. Buechler, Genentech, Inc., USA
Short Talk: Tissue-Specific Programming Determines Tenor of Fibroblast and Mesothelial Cell Plasticity and Activation

Bing Su, Shanghai JiaoTong University School of Medicine, China
Short Talk: Map3k2-Regulated Intestinal Stromal Cells Define a Stem Cell Niche via Wnt Agonist R-spondin1

5:00—7:00 PM
Myeloid Cells in Fibrosis

Salon A/B
* Neil C. Henderson, University of Edinburgh, Queen's Medical Research Institute, UK

* Tatiana Kisseleva, University of California, San Diego, USA

Akira Shizuo, Osaka University, Japan
Molecular Mechanism of Bleomycin-Induced Lung Fibrosis

Harris Perlman, Northwestern University, USA
Monocyte Derived Macrophages in Inflammation and Fibrosis

Frank Tacke, Charité Universitätsmedizin Berlin, Germany
Macrophage Heterogeneity in Liver Homeostasis, Inflammation, and Fibrosis

Prakash Ramachandran, University of Edinburgh, UK
Short Talk: Defining a Novel Macrophage Subpopulation Which Promotes Human Liver Fibrosis

Resat Cinar, NIAAA, National Institutes of Health, USA
Short Talk: Cannabinoid 1 Receptors (CB1R) in Myeloid Cells Promote Fibrosis in Lung: Paracrine Control Drives Fibroproliferative Microenvironment via Multiple Mechanisms

7:00 PM
On Own for Dinner


FRIDAY, FEBRUARY 21

7:00—8:00 AM
Breakfast

Crystal Gardens
8:00—11:00 AM
Stromal Cell Functions in Primary and Secondary Lymphoid Tissues

Salon C
* Reina E. Mebius, Amsterdam UMC-VUmc, Netherlands

João Pereira, Yale University School of Medicine, USA
Cell Circuits, B cells, and Systemic Responses to Microbial Infections

Madelon M. E. de Jong, Erasmus MC, Netherlands
Short Talk: A Unique Inflammatory Stromal Cell Population Associated with NFkappaB Signaling in the Multiple Myeloma Bone Marrow

Tomoya Katakai, Niigata University, Japan
Stromal Cell Diversity in Lymph Nodes

Coffee Break

Beth A. Tamburini, University of Colorado Denver Anchutz Medical Campus, USA
Control of Immune Responses in Lymph Nodes by Lymphatic Endothelial Cells

Dragos Cristian Dasoveanu, Hospital for Special Surgery, USA
Short Talk: Lymph Node Stromal CCL2 Limits Antibody Responses

Natalia Pikor, Kantonsspital St. Gallen, Switzerland
Short Talk: CXCL12-Dependent Remodeling of Light and Dark Zone Follicular Dendritic Cells Governs the Germinal Center Response

Lorenz Jahn, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Transcriptional Responses of Thymic Epithelium, Endothelium, and Mesenchyme to Acute Injury on a Single Cell Level

8:00—11:00 AM
Advances in Organ Fibrosis

Salon A/B
* Cory M. Hogaboam, Cedars-Sinai Medical Center, USA

* Katalin Susztak, University of Pennsylvania, USA

Ivan O. Rosas, Baylor College of Medicine, USA
Insights into the Complexity and Diversity of Cell Populations in IPF and COPD using Single Cell RNA-seq

Neil C. Henderson, University of Edinburgh, Queen's Medical Research Institute, UK
Using Single Cell Genomics to Decode the Hepatic Fibrotic Niche

Coffee Break

Katalin Susztak, University of Pennsylvania, USA
Fatty Acid Oxidation in Tubular Epithelial Cells Regulates Kidney Fibrosis

Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, Blade Therapeutics, USA
New Mechanisms and Vulnerabilities of Fibrosis

Ying Wei, University of California, San Francisco, USA
Short Talk: Reversal of TGFbeta1-Driven Pro-Fibrotic State in Pulmonary Fibrosis Patients

Satish K. Madala, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Transcriptional Regulation of Fibroblast Activation in Severe Fibrotic Lung Disease

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Crystal Gardens
1:00—10:00 PM
Poster Viewing

Crystal Gardens
2:30—4:30 PM
Workshop 2: Novel Technologies and Models in Stromal Cell Biology and Fibrosis (Joint)

Salon A/B
* Lucie Peduto, Institut Pasteur, France

* Michael Underhill, University of British Columbia, Canada

Lee A. Borthwick, Newcastle University, UK
A Bioreactor Technology for Modelling Fibrosis in Human and Rodent Precision-Cut Liver Slices

Michael Jeffrey Podolsky, University of California, San Francisco, USA
Genome-Wide Screens Identify Novel Regulators of Cell-Mediated Collagen Degradation

Maha AlSharqi, McGill University, Canada
Development of CD109-Based Molecules as TGF-Beta Antagonists and Antifibrotic Agents in Scleroderma Fibroblasts

Laura Elisabeth Kähäri, University of Turku, Finland
Targeted Delivery of Antibodies to the Draining Lymph Node through the Subcapsular Sinus Floor

Kristine Lai, Cornell University, USA
ImmuneChip with Stromal-Specific Chemokine Gradient to Capture Germinal Center B Cell Dynamics

Heather J. Faust, Brigham and Womens Hospital, USA
Utilization of 3D Organoids to Study Synovial Fibroblast-Immune Cell Interactions

Anastasia Kousa, Memorial Sloan Kettering Sloan Cancer Center, USA
Construction of a Cellular Interactome Across Epithelium, Endothelium, and Mesenchyme During Thymic Regeneration

4:30—5:00 PM
Coffee Available

Prefunction
5:00—7:00 PM
Endothelial Cells in Immunity and Disease

Salon C
* Amanda Lund, New York University, USA

Scott N. Mueller, University of Melbourne, Australia
Disentangling the Splenic Stromal Cell Network in Health in Disease

Cornelia Halin, ETH Zürich, Switzerland
Leukocyte Migration through Afferent Lymphatic Vessels

Ulrich H. Von Andrian, Harvard Medical School, USA
Lymphocyte Patrol of Blood Vessel Endothelium

Akira Takeda, University of Turku, Finland
Short Talk: Human Lymphatic Endothelial Heterogeneity in Health and Disease

Madeline Churchill, Oregon Health and Science University, USA
Short Talk: Dermal Lymphatic Capillary ‘Zippering’ Enhances CD8+ T Cell Priming Following Cutaneous Viral Infection

5:00—7:00 PM
Unique Drivers of Inflammation and Fibrosis

Salon A/B
* Boris Hinz, University of Toronto, Canada

* Maria Trojanowska, Boston University School of Medicine, USA

Anissa A. Widjaja, DUKE-NUS Medical School, Singapore
Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity and Stromal Inflammation

Pilar Alcaide, Tufts University School of Medicine, USA
T Cell Regulation of Cardiac Fibrosis

Jelena Mann, Newcastle University, UK
Epigenetics and Fibrosis

Ning Ding, Genentech, Inc., USA
Short Talk: WISP1 Activates MRTF to Promote the Progression of Established Liver Fibrosis

Akiyoshi Uemura, Nagoya City University, Japan
Short Talk: Activated Microglia Promote Fibrosis in Pericyte-Deficient Retina

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Crystal Gardens
7:30—10:00 PM
Poster Session 2

Crystal Gardens

SATURDAY, FEBRUARY 22

7:00—8:00 AM
Breakfast

Crystal Gardens
8:00—11:00 AM
Stromal Cells in Cancer and Anti-Tumor Immunity

Salon C
* Hélène Salmon, Institut Curie and Mount Sinai School of Medicine, France

Amanda Lund, New York University, USA
Lymphatic Vessels and the Cancer Immunity Life Cycle

Anne Fletcher, Monash University, Australia
Human T Cell Suppression Triggered through Cross-Talk with Cancer-Associated Fibroblasts

Coffee Break

Ruth Ganss, Harry Perkins Institute of Medical Research, Australia
Stromal Remodeling and Targeting in Cancer

Jacqui Shields, University of Cambridge, UK
Beyond the Cancer Cell: Exploring the Tumour Stroma as Immune Modulators

John Andrew Grout, Mount Sinai School of Medicine, USA
Short Talk: Single Cell Transcriptomic Dissection of the Stromal Cell Compartment in Early-Stage Non-Small Cell Lung Carcinoma (NSCLC)

Anthony B. Rodriguez, University of Virginia School of Medicine, USA
Short Talk: Tumor-Associated Fibroblasts Act As Surrogate Lymphoid Tissue Organizer Cells That Orchestrate Tumor-Associated Tertiary Lymphoid Structure Development

8:00—11:00 AM
Novel Pathways and Strategies to Ameliorate Fibrosis

Salon A/B
* Derek A. Mann, Newcastle University, UK

Thomas A. Wynn, Pfizer, USA
Targeting Type 1 and Type 2 Fibrosis

Tatiana Kisseleva, University of California, San Diego, USA
The Role of Mesothelin in the Pathogenesis of Parenchymal Organs

Coffee Break

Scott L. Friedman, Icahn School of Medicine at Mount Sinai, USA
Target Selection and Validation for Antifibrotic Therapies in Liver

Christine Kim Garcia, Columbia University Medical Center, USA
Pulmonary Fibrosis: Inherited Susceptibilities and Personalized Prognostics

Jennifer Y. Chen, University of California, San Francisco, USA
Short Talk: Targeting Acid Ceramidase Inhibits YAP/TAZ Mechanosignaling to Ameliorate Fibrosis

Andreas Schlitzer, University of Bonn, Germany
Short Talk: Inflammation Experienced Trem2+ Monocyte-Derived Alveolar Macrophages Control Pulmonal Inflammatory Reactivity and Protect from Lung Fibrosis

11:00 AM—5:00 PM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Crystal Gardens
1:00—10:00 PM
Poster Viewing

Crystal Gardens
4:30—5:00 PM
Coffee Available

Prefunction
5:00—7:00 PM
Stroma Cell Contributions During Infection and Inflammation

Salon C
* Sanjiv A. Luther, University of Lausanne, Switzerland

Melody A. Swartz, University of Chicago, USA
Role of Lymphatic Endothelial Cells in the Regulation of T Cell Memory

Susan R. Schwab, New York University School of Medicine, USA
Exit Strategies: S1P Gradients in Inflammation

Marc Bajénoff, Centre d'Immunologie Marseille-Luminy, France
Lymphoid Stromal Cells are Essential Components of Macrophage Niches

Mandy J. McGeachy, University of Pittsburgh, USA
Short Talk: IL-17 Signals to Lymphoid Stroma to Support Function during Th17 Autoimmune and Th1/CTL Anti-Viral Responses

David F. Boyd, St. Jude Children's Research Hospital, USA
Short Talk: Inflammatory Fibroblasts Determine the Outcome of Severe Respiratory Infection in an ADAMTS4-Dependent Manner

5:00—7:00 PM
Distinct and Common Mechanisms of Fibrosis Revealed by Different Tissues

Salon A/B
* Robert V. Martinez, Pfizer Inc., USA

* Anna Burkart Sadusky, NIDDK, National Institutes of Health, USA

Florian Rieder, Cleveland Clinic, USA
Mechanisms and Future Clinical Trial Endpoints of Intestinal Fibrosis

Daniel Tschumperlin, Mayo Clinic, USA
Targeting YAP/TAZ in Lung and Liver Fibrosis

Valerie M. Weaver, University of California, San Francisco, USA
Tissue Tension Induces Matricellular Fibrosis and Tumor Progression in Pancreas

Tapas Mukherjee, University of Toronto, Canada
Short Talk: Deciphering the Influence of Crohn's Disease-Associated Genetic Risk Factor, NOD2 in Intestinal Fibrosis

Ji Zhang, Merck & Co., Inc., USA
Short Talk: Molecular Profiling Reveals A Common Metabolic Signature of Tissue Fibrosis

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Crystal Gardens
7:30—10:00 PM
Poster Session 3

Crystal Gardens

SUNDAY, FEBRUARY 23

7:00—8:00 AM
Breakfast

Crystal Gardens
8:00—11:15 AM
Interrogating Stromal Functions in Disease

Salon C
* Theresa T. Lu, Hospital for Special Surgery/Weill Cornell Medicine, USA

Michael B. Brenner, Harvard Medical School, USA
Fibroblast Positional Identity Controlled by Inductive Notch Signaling Underlies Pathologic Damage in Inflammatory Arthritis

Lucie Peduto, Institut Pasteur, France
Mesenchymal Cells in Pathology and Tissue Repair

Coffee Break

George A. Kollias, Alexander Fleming Biomedical Sciences Research Center, Greece
Mesenchymal Causalities in Inflammation, Immunity and Cancer

Ankur Singh, Cornell University, USA
Immune Organoids to Study Immunity and Epigenetics in Health and Diseases

Manolis Roulis, Yale University, USA
Short Talk: Paracrine Orchestration of Intestinal Tumorigenesis by a Confined Mesenchymal Niche

Viviana Cremasco, Novartis Institutes for BioMedical Research, USA
Short Talk: TGFβ-Blockade Uncovers Stromal Plasticity in Tumors by Revealing the Existence of a Novel Subset of Interferon-Licensed Fibroblasts

Guillaume Harlé, University of Geneva, Switzerland
Short Talk: Autophagy in Lymphatic Endothelial Cells Dampens Collagen-Induced Arthritis Severity by Regulating Sphingosine-1-Phosphate Production

8:00—11:00 AM
Progenitor Cells in Tissue Repair and Organ Regeneration

Salon A/B
* Andrew Leask, University of Saskatoon, Canada

Dean Sheppard, University of California, San Francisco, USA
Enhancement of Anti-Tumor Immunity by Inhibition of TGFbeta Activation by the Integrin alphavbeta8

Harold A. Chapman, University of California, San Francisco, USA
Lung Progenitors in Epithelial Renewal Following Injury

Coffee Break

Joseph R. Arron, Genentech, Inc., USA
Reprogramming Pathogenic Cells to Promote Tissue Repair

Chris Cox, Genentech, Inc., USA
Short Talk: Interleukin 1 Maintains the Intestinal Stem Cell Compartment during C. rodentium Infection through Grem1+ Stromal Derived R-spondin 3

Miriam Hohmann, Cedars-Sinai Medical Center, USA
Short Talk: Role of the C-C Chemokine Receptor (CCR10) in Mesenchymal Progenitor Cells in IPF

Wilder Scott, University of British Columbia, Canada
Short Talk: ScRNA-seq and scATAC-seq Uncover the Fate and Function of Adult Mesenchymal Progenitors at Homeostasis and during Regeneration

Farshad Babaeijandaghi, University of British Columbia, Canada
Short Talk: CSF1R-Dependent Tissue-Resident and Infiltrating Macrophages Play Distinct Roles in Muscle Regeneration and are Promising Targets to Treat Muscular Dystrophies

11:15 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 3: Role of Stromal Cells in Inflammation and Anti-Tumor Immunity

Salon C
* Viviana Cremasco, Novartis Institutes for BioMedical Research, USA

* Anne Fletcher, Monash University, Australia

Hung N. Nguyen, Brigham and Women's Hospital, USA
Transcriptional Regulation of Fibroblasts in Inflammation

Fumitaka Mizoguchi, Tokyo Medical and Dental University, Japan
Gene Expression Profiling of Synovial Fibroblast Subsets Revealed Novel Transcription Factors Driving Their Pathogenic Functions in Rheumatoid Arthritis

Maria Steele, Oregon Health & Science University, USA
Lymphatic-Mediated Egress of Tumor-Specific CD8+ T Cells Limits Anti-Tumor Immunity in Melanoma

Hafsa Munir, University of Cambridge, UK
Cancer-Associated Fibroblast-Derived Amyloid β Drives Neutrophil Extracellular Trap Formation to Promote Tumor Progression

Sandra Ring, Kantonsspital St. Gallen, Switzerland
IL-33 Provision by Reprogrammed Tumor Fibroblastic Stromal Cells Promotes Local T Cell Activity and Grants Melanoma Eradication

Laura Donlin, Hospital for Special Surgery & Weill Cornell Medicine, USA
Fibroblast Activation by ‘Pro-Invasive’ Macrophages in Human Autoimmunity

Elisabetta Dondi, INSERM, France
Chronic Lymphocytic Leukemia Nurse-Like Cells are an Alternative Source of CCL21 Homeostatic Chemokine in Disorganized Lymph Nodes

2:30—4:30 PM
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to the Clinic

Salon A/B
* Edda Fiebiger, Abbvie, USA

* Paul J. Yaworsky, Mediar Therapeutics, USA

Claude Jourdan Le Saux, University of California, San Francisco, USA
Serum Biomarker Responses of Pulmonary Fibrosis Patients after Treatment with the LOXL2/TGFβ1 Inhibitor EGCG

Guiquan Jia, Genentech, Inc., USA
Modulation of a Plasma Cell Signature by Interleukin 6 in Systemic Sclerosis Skin Tissue

Juan Juan Marugan, NCATS, National Institutes of Health, USA
ML290 Ameliorates Fibrosis in Multiple in vivo Models

Alex Peidl, Western University, Canada
Therapeutic Peptides Based on CCN3 Treat Systemic Sclerosis in a Mouse Model of the Disease

Martin Hausmann, University Hospital Zurich, Switzerland
New Therapeutic Approach to Intestinal Fibrosis by Inhibition of pH-Sensing Receptor GPR4-Induced Rho Activation

Martin Leduc, Liminal R&D BioSciences Inc., Canada
Fezagepras (PBI-4050) Reduces Pulmonary Fibroblast Activation, Proliferation, and AKT/mTORC/4E-BP1 Signaling

Piotr L. Sklepkiewicz, OncoArendi Therapeutics SA, Poland
Chitotriosidase (CHIT1) as a Novel Therapeutic Target in Idiopathic Pulmonary Fibrosis (IPF)

4:30—5:00 PM
Coffee Available

Prefunction
5:00—7:00 PM
New Directions in Dissecting Stromal Cell Functions (Joint)

Salon A/B
* Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland

* Thomas A. Wynn, Pfizer, USA

Stuart J. Forbes, University of Edinburgh, UK
Liver Stem Cells and Tissue Regeneration

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Stromal Cells as Orchestrators of Humoral Immunity

Shannon J. Turley, Genentech, Inc., USA
Stromal Cells in Cancer Immunology and Immunotherapy

Lesley A. Hill, University of British Columbia, Canada
Short Talk: Fate and Function of “Mesenchymal” Progenitors in Liver Regeneration and Fibrosis

Ruth A. Franklin, Yale School of Medicine, USA
Short Talk: Environmental Sensing by Fibroblasts Controls Growth Factor Production

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Joint)

Salon A/B
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Crystal Gardens
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Crystal Gardens

MONDAY, FEBRUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Merck & Co., Inc. Roche

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI149882-01

Funding for this conference was made possible (in part) by 1R13AI149882-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

American Society of Gene & Cell Therapy (ASGCT)

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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