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INEC Killarney Convention Centre Floorplan

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This meeting took place in 2019



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Microbiome: Therapeutic Implications (T1)


Organizer(s) Justin L. Sonnenburg, Fergus Shanahan and Suzanne Devkota
October 6—10, 2019
INEC Killarney Convention Centre • Killarney, Co. Kerry Ireland
Discounted Abstract Deadline: Jun 6, 2019
Abstract Deadline: Jul 9, 2019
Scholarship Deadline: Jun 6, 2019
Discounted Registration Deadline: Aug 7, 2019

Supported by the Directors' Fund

Summary of Meeting:
The microbial communities that inhabit the human body are connected to diverse aspects of our health. The plasticity and individuality of these communities promise great potential in the emerging vision of precision health, but formidable gaps to realizing this potential must be addressed. Critical challenges include the intrinsic complexity of dynamic microbial ecosystems, understanding how these microbes mechanistically connect to human biology, and identifying key therapeutic opportunities. This conference will bring together leaders across a range of disciplines from both academia and industry in microbiome sciences to present recent progress and innovative directions at addressing these gaps. This conference will provide a detailed view of the current status, future vision, and challenges of key modalities for predicting, diagnosing, and treating disease via the microbiome. In addition, there will be topics which augment the traditional biomedical paradigm of developing diagnostics and treatments with orthogonal approaches, such as pre-therapeutic prevention and health optimization strategies. Invited speakers will present key technologies and approaches for propelling the coming phases of basic and translational microbiome research. Finally, participants will receive key information about the current regulatory environment for microbial therapeutics. With the rapid expansion of translational microbiome efforts, this conference will enable synergies through the aggregation of knowledge and experiences from diverse body sites, disease states, and approaches. We combine facets of basic sciences including evolution, ecology, and technology development so an interdisciplinary collection of scientists can elucidate key steps for establishing a strong pipeline from fundamental understanding to therapeutic realization.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, October 6 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, October 10 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, October 11 in order to fully experience the meeting.

SUNDAY, OCTOBER 6

4:00—8:00 PM
Arrival and Registration

Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, OCTOBER 7

8:30—9:30 AM
Welcome and Keynote Address

Main Auditorium
* Fergus Shanahan, National University of Ireland, Ireland

David A. Relman, Stanford University, USA
Humans, History and the Study of Microbiomes: Where Have We Been, Where do We Need to Go?

9:30 AM—12:00 PM
Live Microbial Therapeutics

Main Auditorium
* Elena F. Verdu, McMaster University, Canada

Bernat Olle, Vedanta Biosciences, USA
Medicines Based on Defined Bacterial Consortia

Coffee Break

Ian A. Myles, NIAID, National Institutes of Health, USA
Short Talk: First-in-Human Topical Microbiome Transplantation with Roseomonas Mucosa for Atopic Dermatitis: Clinical Outcomes and Mechanistic Insights

Alice Cheng, Stanford University, USA
Short Talk: Design and Therapeutic Application of a Highly Complex Synthetic Microbial Community

Jessica Ravikoff Allegretti, Brigham and Women's Hospital, USA
FMT for C. difficile and Beyond

Paul E. Carlson, US Food and Drug Administration, USA
Regulatory Considerations for Microbiome Related Products

12:00—5:00 PM
On Own for Lunch

12:00—1:00 PM
Poster Setup

Foyer
1:00—10:00 PM
Poster Viewing

Foyer
2:30—4:30 PM
Workshop 1: Microbiome Science: Human-Centered Studies

Main Auditorium
* Tzu-Wen L. Cross, Purdue University, USA

Michael Woodworth, Emory University School of Medicine, USA
Clearance of Antibiotic-Resistant Enterobacteriaceae after Stool Enema Shown by Genome Sequencing of Stool-Derived and Clinical Isolates

Jessica McCann, Duke University, USA
Deciphering the Contribution of the Microbiome to Branched Chain Amino Acid (BCAA) Metabolism and Obesity in Adolescents and Mice

Anubhav Das, 4D Pharma Cork Ltd, Ireland
Impact of a Live Biotherapeutic on the Structure of the Gut Microbiota – Results from the Blautix Phase I Study in Irritable Bowel Syndrome

Julia Copeland, University of Toronto, Canada
The Impact of Immigration on the Gut Metagenome of South Asian Canadians

Carles Lerin, Hospital Sant Joan de Deu, Spain
Effects of Bifidobacterium animalis subsp. lactis BPL1 (CECT 8145) on Children with Prader-Willi Syndrome: A Randomized Crossover Trial

Philippa Margaret Wells, King's College London, UK
Genetic Risk of Rheumatoid Arthritis is Associated with the Oral and Gut Microbiota

Madelief Wijdeveld, Amsterdam University Medical Center, Netherlands
Relation Between Intestinal Acetate Production and Plasma Glucose Levels in Healthy Subjects

Christopher B. Ford, Seres Therapeutics, USA
Engraftment of Investigational Microbiome Drug, SER-262, in Subjects Receiving Vancomycin is Associated with Reduced Rates of Recurrence after Primary Clostridium difficile Infection (CDI)

4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Using the Microbiome to Alter Immune Status: Beyond Colonic Bacteria

Main Auditorium
* Justin L. Sonnenburg, Stanford University, USA

David M. Underhill, Cedars-Sinai Medical Center, USA
A Role for the Fungal Microbiota in Crohn’s Disease?

Susan V. Lynch, University of California, San Francisco, USA
Infant Probiotics to Combat Allergies and Asthma

Elena F. Verdu, McMaster University, Canada
Small Intestinal Microbiome and Gluten Metabolism: A Missing Ingredient in Celiac Disease?

David Chaim Jacob Zilber, Noma Restaurant, Denmark
Democratizing Deliciousness

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer
7:30—10:00 PM
Poster Session 1

Foyer

TUESDAY, OCTOBER 8

8:30—11:45 AM
Diet as a Lever for Altering the Microbiome

Main Auditorium
* Suzanne Devkota, Cedars-Sinai Medical Center, USA

Christopher J. Damman, Bill & Melinda Gates Foundation, USA
Food, Microbes, and the Gut for Good Growth in Global Health

Arjun Raman, Washington University in St. Louis, USA
Short Talk: A Sparse Co-Varying Unit that Describes Healthy and Impaired Community Development

Paul W. O'Toole, University College Cork, Ireland
The Impact of Diet on Microbiome in Aging

Coffee Break

Brianna Petrone, Duke University, USA
Short Talk: DNA Metabarcoding, a Molecular Diet Survey for Studies of Human Gut Microbiota

Liping Zhao, Shanghai Jiao Tong University, China and Rutgers University, USA
Diets, Microbes and Diabetes

Wenjie Ma, Massachusetts General Hospital, USA
Short Talk: Dietary Fiber Intake, the Gut Microbiome, and Chronic Systemic Inflammation

Ivan Vujkovic-Cvijin, NIAID, National Institutes of Health, USA
Short Talk: Mining Immune Memory to Identify Pro-Inflammatory Gut Microbiota Members in Mice and Humans

Mark Sampson, Azitra Inc., USA
Short Talk: Engineering the Skin Microbiome to Treat Skin Disease: A Phase I First-in-Human Safety Study with Topical Application of Engineered S. Epidermidis

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Foyer
1:00—10:00 PM
Poster Viewing

Foyer
4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Controlling Microbial Metabolism

Main Auditorium
* David A. Relman, Stanford University, USA

Eric C. Martens, University of Michigan Medical School, USA
Diet-Induced, Microbial Mucus Erosion as a Catalyst for Intestinal Diseases

Patricia Wolf, University of Illinois at Urbana-Champaign, USA
Short Talk: Network Modeling of Bile Acid Metabolomics and Cecal Bacterial Metatranscriptomic Responses to Berberine in a Gnotobiotic Mouse Model Constituted with the B4PC2 Human Microbial Consortium

Weston Whitaker, Novome Biotechnologies, USA
Synthetic Biology for Engineering Gut Microbes

Gary D. Wu, University of Pennsylvania, USA
Engineering the Environment of the Gut to Modify the Gut Microbiota and its Metabolome

Will Van Treuren, Stanford University, USA
Short Talk: Strain-Resolved Metabolomics of >150 Human Gut-Resident Bacterial Species Reveals Large-Scale Ecological Patterns, Novel Metabolic Strategies, and Widespread Production of Physiologically Relevant Molecules

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer
7:30—10:00 PM
Poster Session 2

Foyer

WEDNESDAY, OCTOBER 9

8:00—8:30 AM
Poster Setup

Foyer
8:30 AM—5:00 PM
Poster Viewing

Foyer
8:30—11:45 AM
Looking to the Past, Predicting the Future

Main Auditorium
* Kelly Swanson, University of Illinois at Urbana-Champaign, USA

Justin L. Sonnenburg, Stanford University, USA
Ancestral Microbes and Precision Human Interventions

Marsha C. Wibowo, Harvard Medical School, USA
Short Talk: Reconstruction of Ancient Microbial Genomes from the Human Gut

Nicolai Karcher, University of Trento, Italy
Short Talk: Analysis of 1,321 Eubacterium Rectale Genomes from Metagenomes Unravels Complex Phylogeographic Population Structure and Subspecies Functional Adaptations

Coffee Break

Susan Bullman, Fred Hutchinson Cancer Research Center, USA
The Tumor Microbiota: A Role in Cancer Progression and Treatment

David Zeevi, Rockefeller University, USA
Structural Variation in the Gut Microbiome Associates with Host Health

Matthew R. Olm, University of California, Berkeley, USA
Short Talk: Metagenomic Identification of Fecal Microbial Signatures Preceding Acute Intestinal Inflammation in Premature Infants

Fergus Shanahan, National University of Ireland, Ireland
Translating Microbiome Science – Lessons from the Past and Future Directions

11:45 AM—12:30 PM
Lunch

Foyer
12:00—2:30 PM
Poster Session 3

Foyer
2:30—4:30 PM
Workshop 2: Considerations for Conducting Human Trials and Testing Investigational New Drugs

Main Auditorium
* Suzanne Devkota, Cedars-Sinai Medical Center, USA

Paul E. Carlson, US Food and Drug Administration, USA

Susan V. Lynch, University of California, San Francisco, USA

Bernat Olle, Vedanta Biosciences, USA

Jessica Ravikoff Allegretti, Brigham and Women's Hospital, USA

Purna C. Kashyap, Mayo Clinic, USA

4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Therapeutics - A Whole Body Approach

Main Auditorium
* Premysl Bercik, McMaster University, Canada

Purna C. Kashyap, Mayo Clinic, USA
An Integrated Top Down and Bottom Up Strategy for Delineating the Role of Gut Microbiome in Functional Bowel Disorders

Hagit Shapiro, Weizmann Institute of Science, Israel
Short Talk: Potential Roles of the Gut Microbiome in Modulation of Murine ALS

John Cryan, University College Cork, Ireland
Microbes and the Mind: Moving Toward Mechanisms

Hannah Yan, Baylor College of Medicine, USA
Short Talk: The Bacterial Microbiome Regulates Steady-State Hematopoiesis via Immune Signaling Pathways

Eileen Murphy, Alimentary Health, Ireland
The Pipeline from Concept to Market - Harnessing the Microbiome for Health

7:00 PM
On Own for Dinner


THURSDAY, OCTOBER 10

8:30—11:45 AM
Antibiotic Resistance, Microbe Killing, and Survival

Main Auditorium
* Robert A. Britton, Baylor College of Medicine, USA

Kevin Foster, University of Oxford, UK
Cooperation and Competition in Bacteria: From Model Systems to the Microbiome

Daniel C. Propheter, University of Texas Southwestern Medical Center, USA
Short Talk: Adiponectin is a Novel Intestinal Antibacterial Defense Protein

Suzanne Devkota, Cedars-Sinai Medical Center, USA
Creeping Fat: Microbial Translocation Drives Cellular Restructuring of Adipose Tissue in Humans

Coffee Break

Eric G. Pamer, University of Chicago, USA
Exploiting the Microbiota to Reduce Antibiotic-Resistant Infections

Sujatha Srinivasan, Fred Hutchinson Cancer Research Center, USA
Short Talk: Periodic Presumptive Treatment (PPT) with Metronidazole Reduces Abundance of Vaginal Bacteria Associated with HIV Risk

Ami S. Bhatt, Stanford University, USA
Mechanisms of Microbial Diversification and Resistance

Takuji Yamada, Tokyo Institute of Technology, Japan
Short Talk: Metagenomic and Metabolomic Analyses Reveal Distinct Stage-Specific Phenotypes of the Gut Microbiota in Colorectal Cancer

11:45 AM—5:00 PM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Foyer
5:00—6:45 PM
Next-Gen Therapeutics and New Frontiers

Main Auditorium
* Ami S. Bhatt, Stanford University, USA

Jeff F. Miller, University of California, Los Angeles, USA
Diversity-Generating Retroelements in Phage, Microbes, and Microbiomes

Ines Thiele, National University of Ireland, Galway, Ireland
Modeling Gut Microbiome Metabolism

Ravi U. Sheth, Columbia University, USA
Short Talk: Spatial Metagenomic Characterization of Microbial Biogeography in the Gut

Trevor Lawley, Wellcome Sanger Institute, UK
Integrating Mass Culturing and Metagenomic Analysis for Human Microbiome Translational Science

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Main Auditorium
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Foyer

FRIDAY, OCTOBER 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support from these exhibitors at this conference:

CosmosID Don Whitley Scientific Limited
Microbiology International
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Center for Advancing Translational Sciences (NCATS)

Grant No. 1R13AI147695-01

Funding for this conference was made possible (in part) by 1R13AI147695-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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