Herrenhausen Palace Floorplan
This meeting took place in 2022
Here are the related meetings in 2023:
B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers (Z5)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
B Cell-T Cell Collaboration: Regulation and Dysregulation (T4)
Organizer(s) Victor L.J. Tybulewicz, Kai-Michael Toellner, Julie Zikherman and Pamela L. Schwartzberg
April 3—6, 2022
Herrenhausen Palace • Hannover, Germany
Abstract Deadline: Jan 11, 2022
Scholarship Deadline: Dec 7, 2021
Discounted Registration Deadline: Feb 2, 2022
Sponsored by BioLegend, Inc. and Takeda Pharmaceutical Company Limited
In Collaboration with Volkswagen Foundation
Summary of Meeting:
B cell-T cell collaboration leads, via the germinal center reaction, to the generation of B cell memory and long-lived affinity-matured protective antibodies. This key immune response has been extensively studied, and, as a result, we have an increasingly refined understanding of the ligands, receptors, and intra-cellular pathways that are involved. However, many aspects of this remarkable process as it plays out in infections, vaccine responses, and chronic immunological diseases remain unknown. In particular, we still do not understand how B cells integrate complex antigenic and co-stimulatory inputs over time to make critical cell fate decisions, including the process of clonal selection in the germinal center as well as memory B cell and long-lived plasma cell differentiation. We do not fully appreciate the spectrum of ‘non-canonical’ B cell responses to various chronic and acute infections, especially those occurring in tissues rather than secondary lymphoid organs. And finally, many unanswered questions remain about normal and abnormal B cell responses to commensal flora, allergic antigens, and self-antigens that are essential to address if we hope to understand dysregulated B cell immune responses in inflammatory, allergic, and autoimmune disease. This meeting brings together scientists focused on both the B cell and the Tfh cell contributions to humoral immunity in order to share innovative research focused on addressing this broad set of questions. We aim to identify areas of future investigation, foster collaboration, and collectively generate the knowledge base required to design better vaccines and more precise strategies to treat diseases of immune dysregulation.
View Scholarships/Awards
B cell-T cell collaboration leads, via the germinal center reaction, to the generation of B cell memory and long-lived affinity-matured protective antibodies. This key immune response has been extensively studied, and, as a result, we have an increasingly refined understanding of the ligands, receptors, and intra-cellular pathways that are involved. However, many aspects of this remarkable process as it plays out in infections, vaccine responses, and chronic immunological diseases remain unknown. In particular, we still do not understand how B cells integrate complex antigenic and co-stimulatory inputs over time to make critical cell fate decisions, including the process of clonal selection in the germinal center as well as memory B cell and long-lived plasma cell differentiation. We do not fully appreciate the spectrum of ‘non-canonical’ B cell responses to various chronic and acute infections, especially those occurring in tissues rather than secondary lymphoid organs. And finally, many unanswered questions remain about normal and abnormal B cell responses to commensal flora, allergic antigens, and self-antigens that are essential to address if we hope to understand dysregulated B cell immune responses in inflammatory, allergic, and autoimmune disease. This meeting brings together scientists focused on both the B cell and the Tfh cell contributions to humoral immunity in order to share innovative research focused on addressing this broad set of questions. We aim to identify areas of future investigation, foster collaboration, and collectively generate the knowledge base required to design better vaccines and more precise strategies to treat diseases of immune dysregulation.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 6 with a closing plenary session from 15:30 to 18:30, followed by a social hour. We recommend return travel on Thursday, April 7 in order to fully experience the meeting.
SUNDAY, APRIL 3
MONDAY, APRIL 4
TUESDAY, APRIL 5
WEDNESDAY, APRIL 6
THURSDAY, APRIL 7
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 6 with a closing plenary session from 15:30 to 18:30, followed by a social hour. We recommend return travel on Thursday, April 7 in order to fully experience the meeting.
SUNDAY, APRIL 3
4:00—8:00 PM
Arrival and Registration
Grand Mussmann Hotel, Tivoli Room
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
Central-Hotel Kaiserhof
8:00—9:00 AM
Breakfast (Individual Hotel)
Individual Hotel
9:00—10:30 AM
Welcome and Keynote Session
Auditorium
*
Pamela L. Schwartzberg,
NIAID, National Institutes of Health, USA
Session Chair
Session Chair
*
Julie Zikherman,
University of California, San Francisco, USA
Session Chair
Session Chair
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Immune Responses to Viruses and Vaccines
Immune Responses to Viruses and Vaccines
Garnett H. Kelsoe,
Duke University and Medical Center, USA
Germinal Centers and Broadly Neutralizing Antibodies
Germinal Centers and Broadly Neutralizing Antibodies
Coffee Break
11:00 AM—12:15 PM
Immunity to Infection
Auditorium
*
Victor L.J. Tybulewicz,
Francis Crick Institute, UK
Session Chair
Session Chair
Kathrin de la Rosa,
Max Delbruck Center, Germany
BIBAX: A Novel Structure-guided Approach to Improve Vaccine Safety and Efficacy
BIBAX: A Novel Structure-guided Approach to Improve Vaccine Safety and Efficacy
Nicole Baumgarth,
University of California, Davis, USA
Short Talk: Two Sides of One Coin: Extrafollicular B Cell Responses to Infections
Short Talk: Two Sides of One Coin: Extrafollicular B Cell Responses to Infections
Susan Moir,
NIAID, National Institutes of Health, USA
Signatures of B Cell Dysregulation in HIV Infection with Implications for SARS-CoV-2
Signatures of B Cell Dysregulation in HIV Infection with Implications for SARS-CoV-2
12:15—1:30 PM
Lunch
Ballroom
12:30—1:00 PM
Poster Setup
Foyer/Seminar Room
1:00—8:00 PM
Poster Viewing
Foyer/Seminar Room
1:30—3:00 PM
Workshop 1: Germinal Centers: Generation and Function
Auditorium
*
Kai-Michael Toellner,
University of Birmingham, UK
Session Chair
Session Chair
Spencer Chen,
Rockefeller University, USA
B Cell Receptor Signaling Prolongs Survival and Primes B cells for Germinal Center Selection
B Cell Receptor Signaling Prolongs Survival and Primes B cells for Germinal Center Selection
Clara Cousu,
Institut Necker Enfants Malades, France
B Cells, What HELLS
B Cells, What HELLS
J. Scott Hale,
University of Utah, USA
De Novo Methylation Enforces Long-term Lineage-specific T Follicular Helper and T Helper-1 Memory Cell Programing
De Novo Methylation Enforces Long-term Lineage-specific T Follicular Helper and T Helper-1 Memory Cell Programing
Ramin Herati,
New York University, USA
PD-1 Directed Immunotherapy Alters Tfh and Humoral Immune Responses to Seasonal Influenza Vaccine
PD-1 Directed Immunotherapy Alters Tfh and Humoral Immune Responses to Seasonal Influenza Vaccine
Kevin Ng,
Francis Crick Institute, UK
Checkpoint Blockade Boosts Protective Germinal Centre Responses in Cancer
Checkpoint Blockade Boosts Protective Germinal Centre Responses in Cancer
Michael Meyer-Hermann,
Helmholtz Centre for Infection Research, Germany
A Molecular Theory of B cell Selection by T Follicular Helper Cells
A Molecular Theory of B cell Selection by T Follicular Helper Cells
Coraline Mlynarczyk,
Weill Cornell Medicine, USA
A Faster Response to T Cell Help Selection Signals Yields “Super-competitor” B Cells Primed for Malignant Transformation
A Faster Response to T Cell Help Selection Signals Yields “Super-competitor” B Cells Primed for Malignant Transformation
Sandra Nakandakari Higa,
Rockefeller University, USA
Measuring T Cell Help to B Cells in Germinal Centers
Measuring T Cell Help to B Cells in Germinal Centers
Lingling Zhang,
Francis Crick Institute, UK
Ca2+ signalling in IgG1+ Germinal Centre (GC) B Cells is Actively Regulated to Favour Positive Selection
Ca2+ signalling in IgG1+ Germinal Centre (GC) B Cells is Actively Regulated to Favour Positive Selection
3:00—3:30 PM
Coffee Available
Foyer
3:30—6:00 PM
Selection in the Germinal Center
Auditorium
*
Roberta Pelanda,
University of Colorado Denver, USA
Session Chair
Session Chair
Hai Qi,
Tsinghua University, China
Remote Presentation: B Cell: T Cell Interactions in the Germinal Center
Remote Presentation: B Cell: T Cell Interactions in the Germinal Center
Victor L.J. Tybulewicz,
Francis Crick Institute, UK
Critical Roles for Water Flux in T-dependent B Cell Responses
Critical Roles for Water Flux in T-dependent B Cell Responses
Michael Reth,
Albert-Ludwigs University Freiburg, Germany
Short Talk: The Regulation of Different BCR Classes on Resting B Cells and their Function During Antigen Sensing
Short Talk: The Regulation of Different BCR Classes on Resting B Cells and their Function During Antigen Sensing
Gabriel D. Victora,
Rockefeller University, USA
Affinity Maturation in the Germinal Center
Affinity Maturation in the Germinal Center
Dessi Malinova,
Queen's University Belfast, UK
Short Talk: Novel Players in B Cell Antigen Uptake and Trafficking
Short Talk: Novel Players in B Cell Antigen Uptake and Trafficking
Anneli Peters,
Ludwig Maximilians University, Germany
T:B Cell Communication in Ectopic Lymphoid Follicles in CNS Autoimmunity
T:B Cell Communication in Ectopic Lymphoid Follicles in CNS Autoimmunity
6:00—7:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
7:00—8:30 PM
Poster Session 1
Foyer/Seminar Room
8:00—9:00 AM
Breakfast (Individual Hotel)
Individual Hotel
9:00 AM—12:00 PM
Tfh Cells
Auditorium
*
Nicole Baumgarth,
University of California, Davis, USA
Session Chair
Session Chair
Andrea Reboldi,
University of Massachusetts Medical School, USA
Short Talk: IgA B Cell Receptor Regulates Peyer's Patches Germinal Center Competition by Preventing Fas Counterselection
Short Talk: IgA B Cell Receptor Regulates Peyer's Patches Germinal Center Competition by Preventing Fas Counterselection
Pamela L. Schwartzberg,
NIAID, National Institutes of Health, USA
Genetic Approaches to Understanding Tfh Cells during Viral Infections
Genetic Approaches to Understanding Tfh Cells during Viral Infections
Coffee Break
Michelle A. Linterman,
Babraham Institute, UK
Rejuvenating the Germinal Centre Response
Rejuvenating the Germinal Centre Response
Michela Locci,
University of Pennsylvania, USA
Short Talk: Regulation of Tfh Cells and Germinal Center Responses by mRNA-LNP Vaccines
Short Talk: Regulation of Tfh Cells and Germinal Center Responses by mRNA-LNP Vaccines
Carola G. Vinuesa,
Francis Crick Institute, UK
Regulation of Antibody Responses by Tfr Cells
Regulation of Antibody Responses by Tfr Cells
12:00—1:30 PM
Lunch
Ballroom
12:30—1:00 PM
Poster Setup
Foyer/Seminar Room
1:00—8:00 PM
Poster Viewing
Foyer/Seminar Room
1:30—3:00 PM
Workshop 2: Immunological Memory
Auditorium
*
Lars Nitschke,
University of Erlangen, Germany
Session Chair
Session Chair
Pascal Chappert,
Institut Necker Enfants Malades, France
Dynamic Interactions within Splenic Niche and Long-lasting GC Imprinting Defines Anti-vaccinia Long-lived Memory B Cells
Dynamic Interactions within Splenic Niche and Long-lasting GC Imprinting Defines Anti-vaccinia Long-lived Memory B Cells
Liam Kealy,
Monash University, Australia
The Role of DOT1L in the Regulation of Humoral Immunity
The Role of DOT1L in the Regulation of Humoral Immunity
Jared Klarquist,
University of Colorado, Anschutz, USA
B Cells Regulate CD8 T Cell Naïve, Effector, and Memory Programming
B Cells Regulate CD8 T Cell Naïve, Effector, and Memory Programming
Casper Marsman,
Sanquin Research, Netherlands
Termination of CD40L Co-stimulation Promotes Human B Cell Differentiation Into Antibody-Secreting Cells
Termination of CD40L Co-stimulation Promotes Human B Cell Differentiation Into Antibody-Secreting Cells
Adam J. Fike,
Pennsylvania State University College of Medicine, USA
B Cell Intrinsic STAT3 Controls Germinal Center Zone Organization, and Recycling and Plasma Cell Selection but not B cell Memory
B Cell Intrinsic STAT3 Controls Germinal Center Zone Organization, and Recycling and Plasma Cell Selection but not B cell Memory
Lauren B. Rodda,
University of Washington, USA
SARS-CoV-2-specific Infection-imprinted Features of Hybrid Immunity are not Recapitulated by Repeated Vaccination
SARS-CoV-2-specific Infection-imprinted Features of Hybrid Immunity are not Recapitulated by Repeated Vaccination
Annemiek B. van Spriel,
Radboud University Medical Center, Netherlands
Humoral Immunity is Controlled by Tetraspanins through Protein organization in the Plasma Membrane
Humoral Immunity is Controlled by Tetraspanins through Protein organization in the Plasma Membrane
3:00—3:30 PM
Coffee Available
Foyer
3:30—6:00 PM
Memory
Auditorium
*
Julie Zikherman†,
University of California, San Francisco, USA
Session Chair
Session Chair
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Generation of Memory B Cells
Generation of Memory B Cells
Taras Kreslavsky,
Karolinska Institutet, Sweden
Short Talk: Regulation of Cell Fate Decisions in Early B Cell Activation
Short Talk: Regulation of Cell Fate Decisions in Early B Cell Activation
Thomas H. Winkler,
FAU, Germany
Short Talk: Dynamic Selection Processes By-pass the Affinity Dead-end of Low Affinity Anti-NP Specific B Cells and Generate Low-affinity Memory B Cells
Short Talk: Dynamic Selection Processes By-pass the Affinity Dead-end of Low Affinity Anti-NP Specific B Cells and Generate Low-affinity Memory B Cells
Kai-Michael Toellner,
University of Birmingham, UK
Migration of Memory B Cells
Migration of Memory B Cells
Tri Giang Phan,
Garvan Institute of Medical Research, Australia
Reactivation of Memory B Cells
Reactivation of Memory B Cells
Mark J. Shlomchik,
University of Pittsburgh School of Medicine, USA
Functions and Heterogeneity of Memory B Cells
Functions and Heterogeneity of Memory B Cells
6:00—7:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
7:00—8:30 PM
Poster Session 2
Foyer/Seminar Room
8:00—9:00 AM
Breakfast (Individual Hotel)
Individual Hotel
9:00 AM—12:00 PM
Autoimmunity
Auditorium
*
Carola G. Vinuesa,
Francis Crick Institute, UK
Session Chair
Session Chair
Christopher C. Goodnow,
Garvan Institute of Medical Research, Australia
Remote Presentation: Progression from Benign to Pathogenic Autoantibody by Somatic Mutation in a Rogue Clone
Remote Presentation: Progression from Benign to Pathogenic Autoantibody by Somatic Mutation in a Rogue Clone
Andrew Getahun,
University of Colorado School of Medicine, USA
Short Talk: Dysregulated PI3K Signaling can Make Autoreactive B Cells Receptive to Bystander T Cell Help
Short Talk: Dysregulated PI3K Signaling can Make Autoreactive B Cells Receptive to Bystander T Cell Help
Julie Zikherman,
University of California, San Francisco, USA
Balancing Tolerance and Humoral Immunity
Balancing Tolerance and Humoral Immunity
Coffee Break
Roberta Pelanda,
University of Colorado Denver, USA
Active PI3-Kinase Signaling and Downmodulation of CXCR4 Abrogate Central Tolerance in Autoreactive B Cells
Active PI3-Kinase Signaling and Downmodulation of CXCR4 Abrogate Central Tolerance in Autoreactive B Cells
Marvin van Luijn,
Erasmus MC, University Medical Center, Netherlands
Short Talk: B Cells Infiltrating the Human Brain: From Peripheral Induction to Local Effector Function
Short Talk: B Cells Infiltrating the Human Brain: From Peripheral Induction to Local Effector Function
Jennifer L. Gommerman,
University of Toronto, Canada
Remote Presentation: B Cells and CNS inflammation
Remote Presentation: B Cells and CNS inflammation
12:00—1:30 PM
Lunch
Ballroom
12:30—1:00 PM
Poster Setup
Foyer/Seminar Room
1:00—8:00 PM
Poster Viewing
Foyer/Seminar Room
1:30—3:00 PM
Workshop 3: Autoimmunity and Immune Dysregulation
Auditorium
*
Thomas H. Winkler†,
FAU, Germany
Session Chair
Session Chair
Kristen Bricker,
Penn State University COM, USA
miR-21 Promotes B Cell Autoreactivity, Inflammatory Signaling, and Metabolism in TLR7-Driven Systemic Autoimmunity
miR-21 Promotes B Cell Autoreactivity, Inflammatory Signaling, and Metabolism in TLR7-Driven Systemic Autoimmunity
Rasmus Iversen,
University of Oslo, Norway
Circulating Autoreactive B Cells in Celiac Disease are Gut-homing Pre-plasma Cells Derived from Naïve B Cells
Circulating Autoreactive B Cells in Celiac Disease are Gut-homing Pre-plasma Cells Derived from Naïve B Cells
Niklas Krausse,
Lund University, Sweden
Linking Early Life B Lymphopoiesis to B Cell Neoplasms Later in Life
Linking Early Life B Lymphopoiesis to B Cell Neoplasms Later in Life
Shannon McGettigan,
Thomas Jefferson University, USA
Secreted IgM Modulates the Pool of IL-10 Producing B Cells
Secreted IgM Modulates the Pool of IL-10 Producing B Cells
Mia J. Smith,
University of Colorado Denver - Anschutz Medical Campus, USA
Activation of Extrafollicular Insulin-binding B Cells in Type 1 Diabetes Subjects
Activation of Extrafollicular Insulin-binding B Cells in Type 1 Diabetes Subjects
Eva Maria Stork,
Leiden University Medical Center, Netherlands
T Helper Cell Subsets Differentially Modulate Human IgG Fc Glycosylation
T Helper Cell Subsets Differentially Modulate Human IgG Fc Glycosylation
Carla R. Nowosad,
New York University, USA
Tunable Dynamics of B Cell Selection in Gut-draining Germinal Centers
Tunable Dynamics of B Cell Selection in Gut-draining Germinal Centers
3:00—3:30 PM
Coffee Available
Foyer
3:30—6:15 PM
Immune Dysregulation
Auditorium
*
Pamela L. Schwartzberg,
NIAID, National Institutes of Health, USA
Session Chair
Session Chair
Lars Nitschke,
University of Erlangen, Germany
Short Talk: Siglec-G Controls the Severity of Chronic Lymphocytic Leukemia
Short Talk: Siglec-G Controls the Severity of Chronic Lymphocytic Leukemia
Christopher D. C. Allen,
University of California, San Francisco, USA
Generation and Function of IgE in Allergy
Generation and Function of IgE in Allergy
Andre Limnander,
Regeneron, USA
Short Talk: A Therapeutic Strategy to Eliminate all Sources of IgE and Reset the Allergic Immune Response
Short Talk: A Therapeutic Strategy to Eliminate all Sources of IgE and Reset the Allergic Immune Response
Jagan R. Muppidi,
NCI, National Institutes of Health, USA
Short Talk: The Tumor Suppressor Ga13 Inhibits Germinal Center B Cell Proliferation by Limiting Cyclin D3 and Myc Protein Abundance
Short Talk: The Tumor Suppressor Ga13 Inhibits Germinal Center B Cell Proliferation by Limiting Cyclin D3 and Myc Protein Abundance
Ziv Shulman,
Weizmann Institute, Israel
How Do Bacterial Infections Disrupt Germinal Center Reactions?
How Do Bacterial Infections Disrupt Germinal Center Reactions?
6:15—6:30 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Auditorium
6:30—7:30 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
7:30—9:00 PM
Poster Session 3
Foyer/Seminar Room
8:00—8:00 AM
Departure
*Session Chair †Invited, not yet responded.
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