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This meeting took place in 2001



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The PPARs - A Transcription Odyssey (F1)


Organizer(s) Bruce M. Spiegelman and Ronald M. Evans
February 4—9, 2001
Keystone Resort • Keystone, CO USA
Abstract Deadline: Oct 4, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 4, 2000

Summary of Meeting:
Research studies of the PPAR group of nuclear receptors are increasing very rapidly. Since the discovery of PPARALPHA in 1990, they have been implicated in many aspects of development and metabolic disease. The PPARALPHA and GAMMA are the functional receptors for both hypolipidemic and anti-diabetic drugs, respectively. Of greatest current interest are: (1) Defining the role of the PPARs in various physiological and pathophysiological settings such as obesity, diabetes, cardiovascular disease and immune cell function. (2) Identifying new ligands, both biological and synthetic, that will help open up new avenues of investigation and therapeutic intervention. (3) Defining long-term benefits and risks of PPAR active drugs. (4) Identifying new coactivator/corepressor proteins and, in particular, determining which of these components are associated with specific biological programs. This meeting will bring together experts from academia, pharmaceutical and biotechnology industries. Although the PPARs are discussed at meetings focused on nuclear receptors, diabetes, obesity or gene transcription, this conference promotes a unique confluence of experts who approach this field with differing backgrounds and interests. It is believed that this synergy will push this exciting field forward at an accelerated pace.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


SUNDAY, FEBRUARY 4

2:00—7:00 PM
Registration

Quandry Foyer
6:15—7:15 PM
Welcome

Quandry Foyer
7:15—7:30 PM
Orientation

Quandry I

MONDAY, FEBRUARY 5

7:00—8:00 AM
Breakfast

Longs
8:00—11:00 AM
Adipogenesis and Metabolism I. Session Sponsored in part by Novo Nordisk A/S.

Quandry I-II
* Daniel P. Kelly, University of Pennsylvania, USA
The Role of PPAR in the Control of Cardiac Energy Metabolism

Bruce M. Spiegelman, Harvard Medical School, USA
Regulation of Adipogenesis and Energy Expenditure Through PPARgamma and PGC-1

Takashi Kadowaki, University of Tokyo, Japan
Crucial Role of PPARgamma in the Regulation of Insulin Sensitivity

Sheila Collins, Vanderbilt University Medical Center, USA
Adipocyte Adrenergic Receptor Signaling Mechanisms and Cross-Talk

9:20—9:40 AM
Coffee Break

Quandry Foyer
11:00 AM—1:00 PM
Poster Setup

Quandry III
4:00—6:00 PM
POSTER SESSION 1: Adipogenesis and Metabolism

Quandry III
5:00—6:00 PM
Social Hour

Quandry III
8:00—9:00 PM
Coffee Available

Quandry Foyer
8:00—10:00 PM
Adipogenesis and Metabolism II. Session Sponsored in part by Novo Nordisk A/S.

Quandry I-II
* Andrea Dunaif, Icahn School of Medicine at Mount Sinai, USA
Metabolism and Reproduction: Insights from Studies with PPAR Ligands

Jacqueline M. Stephens, Louisiana State University, USA
Cross-Talk Between STATs and PPARgamma in Adipocytes

Stephen R. Farmer, Boston University School of Medicine, USA
Regulation of PPARgamma Expression and Activity During Adipogenesis


TUESDAY, FEBRUARY 6

7:00—8:00 AM
Breakfast

Longs
8:00—11:00 AM
Monocyte/Macrophage Biology

Quandry I-II
* Christopher K. Glass, University of California, San Diego, USA
Regulation of Macrophage Development and Function by PPARs

Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors in Obesity, Diabetes and Cardiovascular Disease

Bart Staels, Institut Pasteur de Lille, Université Lille, France
Control of Reverse Cholesterol Transport by PPARs

9:20—9:40 AM
Coffee Break

Quandry Foyer
11:00 AM—1:00 PM
Poster Setup

Quandry III
4:00—6:00 PM
POSTER SESSION 2: Monocyte/Macrophage Biology/Coactivators/Corepressors

Quandry III
5:00—6:00 PM
Social Hour

Quandry III
8:00—9:00 PM
Coffee Available

Quandry Foyer
8:00—10:15 PM
Coactivators/Corepressors

Quandry I-II
Eckardt Treuter, Karolinska Institutet, Sweden
Negative Coregulation by the Atypical Orphan Receptors SHP and DAX-1

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Linking PPARgamma to Insulin Resistance

* Janardan K. Reddy, Northwestern University Medical School, USA
Upstream and Downstream Modulation of PPARalpha Mediated Responses

Leonard P. Freedman, Global Biological Standards Institute, USA
Discrete Roles for PPARgamma and RXR in Recruiting Nuclear Receptor Coactivators


WEDNESDAY, FEBRUARY 7

7:00—8:00 AM
Breakfast

Longs
8:00—10:20 AM
Animal/Genetic Studies

Quandry I-II
* Walter Wahli, Nanyang Technological University, Singapore
Roles of PPARs in Energy Metabolism and Epidermis Differentiation

Frank J. Gonzalez, National Institutes of Health, USA
PPARgamma Conditional Knock-Out Mice

Todd Leff, Wayne State University, USA
Regulation of PPAR/Coactivator Interactions by Phosphorylation

10:20—11:00 AM
Lightning Session

James R. Paterniti, Ligand Pharmaceuticals, USA
A Selective PPARgamma Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes

Short Talk(s) to be Announced

9:20—9:40 AM
Coffee Break

Quandry Foyer
11:00 AM—1:00 PM
Poster Setup

Quandry III
4:00—6:00 PM
POSTER SESSION 3: Animal/Genetic Studies/Structure/Ligands/Cancer/Gastro-Intestinal Biology/New Developments

Quandry III
5:00—6:00 PM
Social Hour

Quandry III
8:00—9:00 PM
Coffee Available

Quandry Foyer
8:00—10:00 PM
Structure/Ligands

Quandry I-II
Millard H. Lambert, GlaxoSmithKline, USA
PPAR Structure and Function

Jin-Long Chen, NGM Biopharmaceuticals, Inc., USA
Elucidating PPARgamma Biology Using Novel Ligands

* Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
New Insights into PPAR Biology

10:00—10:30 PM
Lightning Session

Barry Marc Forman, City of Hope, USA
Identification of a PPARgamma Ligand Whose Affinity is Enhanced by the Nuclear Receptor Coactivator PBP

Short Talk(s) to be Announced


THURSDAY, FEBRUARY 8

7:00—8:00 AM
Breakfast

Longs
8:00—11:00 AM
Cancer

Quandry I-II
* George D. Demetri, Dana Farber Cancer Institute, USA
Development of PPARgamma Ligands as Anticancer Agents - Expanding and Testing Hypotheses in Patients

H. Phillip Koeffler, Cedars-Sinai Medical Center, USA
Anticancer Activity of Ligands of Nuclear Hormone Receptors

Todd G. Kroll, University of Chicago School of Medicine, USA
Chromosomal Translocations Involving PPARgamma in Human Thyroid Cancer

Michael B. Sporn, Dartmouth Medical School, USA
Inhibition of Carcinogenesis by PPAR-gamma Ligands

9:20—9:40 AM
Coffee Break

Quandry Foyer
2:00—3:20 PM
Gastro-Intestinal Biology

Quandry I-II
* Gary D. Wu, University of Pennsylvania, USA
PPARgamma Ligands and Intestinal Inflammation

Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
PPARgamma: An X-ceptor for Xs

3:20—4:00 PM
Lightning Session

Short Talk(s) to be Announced

4:00—5:00 PM
Coffee Available

Quandry Foyer
4:00—6:00 PM
Lightning Session for New Developments

Quandry I-II
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Regulation of Adipocyte Differentiation by the GATA Family of Transcription Factors

* Peter Tontonoz, University of California, Los Angeles, USA
Crosstalk Between PPARgamma and LXR in the Control of Macrophage Lipid Metabolism

Short Talk(s) to be Announced

7:00—8:00 PM
Social Hour

Longs Foyer
8:00—10:00 PM
Banquet

Longs
9:00 PM—12:00 AM
Entertainment

Longs

FRIDAY, FEBRUARY 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK59277-01




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