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This meeting took place in 2002
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Biological Response to the Extracellular Matrix (Z1)
Organizer(s) David A. Cheresh and Donald E. Ingber
February 8—13, 2002
Banff Centre • Banff, Alberta Canada
Abstract Deadline: Oct 8, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 7, 2001
Summary of Meeting:
The extracellular matrix (ECM) consists of structural and adhesive proteins that, together with growth factors, convey biochemical and mechanical information to cells. This meeting will bring together many of the leading cell biologists and biochemists to discuss the role of the ECM in regulating the fate and biological response of cells to their environment. This meeting will be held jointly with the Angiogenesis meeting chaired by Rakesh Jain, Peter Carmeliet and James Pluda. Therefore, the conference on ‘Biological Response to the Extracellular Matrix’ will focus on the response of vascular cells to the ECM. While the focus may involve vascular cells, it is clear that many of the ‘take home’ messages will apply to cells and tissues in a general way. The opening session includes three keynote speakers of world renown status who will discuss how intracellular pathways and extracellular events regulate complex mechanisms of cellular and tissue behavior. The general sessions will focus on the many roles the ECM plays in tissue remodeling associated with development, and cell invasion during tissue repair. There have been very exciting new developments in the area of cell signaling responsiveness to the ECM. This meeting will feature leaders in this emerging field and will represent one of four joint sessions. Other joint session topics include the role of the endothelial cell microenvironment in angiogenesis and the structural factors in cell and vessel regulation. Finally, the meeting will conclude with a session on therapeutic implications. This is important as several new drugs that target cell matrix interactions have been approved or are being clinically tested for specific disease indications. This program should attract a broad audience including basic and clinical scientists from academia to scientists within the commercial sector. It is clear that the fields of Angiogenesis and ECM biology have been naturally moving toward one another over the past several years. This joint meeting represents the first opportunity to enable vascular biologists and experts in the ECM to have a formal interchange of ideas. It is anticipated that both groups will greatly benefit from this interaction which may well lead to new insights in the mechanisms of angiogenesis and conceptual approaches to new therapeutic strategies for disease.
View Scholarships/Awards
The extracellular matrix (ECM) consists of structural and adhesive proteins that, together with growth factors, convey biochemical and mechanical information to cells. This meeting will bring together many of the leading cell biologists and biochemists to discuss the role of the ECM in regulating the fate and biological response of cells to their environment. This meeting will be held jointly with the Angiogenesis meeting chaired by Rakesh Jain, Peter Carmeliet and James Pluda. Therefore, the conference on ‘Biological Response to the Extracellular Matrix’ will focus on the response of vascular cells to the ECM. While the focus may involve vascular cells, it is clear that many of the ‘take home’ messages will apply to cells and tissues in a general way. The opening session includes three keynote speakers of world renown status who will discuss how intracellular pathways and extracellular events regulate complex mechanisms of cellular and tissue behavior. The general sessions will focus on the many roles the ECM plays in tissue remodeling associated with development, and cell invasion during tissue repair. There have been very exciting new developments in the area of cell signaling responsiveness to the ECM. This meeting will feature leaders in this emerging field and will represent one of four joint sessions. Other joint session topics include the role of the endothelial cell microenvironment in angiogenesis and the structural factors in cell and vessel regulation. Finally, the meeting will conclude with a session on therapeutic implications. This is important as several new drugs that target cell matrix interactions have been approved or are being clinically tested for specific disease indications. This program should attract a broad audience including basic and clinical scientists from academia to scientists within the commercial sector. It is clear that the fields of Angiogenesis and ECM biology have been naturally moving toward one another over the past several years. This joint meeting represents the first opportunity to enable vascular biologists and experts in the ECM to have a formal interchange of ideas. It is anticipated that both groups will greatly benefit from this interaction which may well lead to new insights in the mechanisms of angiogenesis and conceptual approaches to new therapeutic strategies for disease.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, FEBRUARY 8
SATURDAY, FEBRUARY 9
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
SUNDAY, FEBRUARY 10
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
MONDAY, FEBRUARY 11
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
TUESDAY, FEBRUARY 12
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
WEDNESDAY, FEBRUARY 13
Conference Program Print | View meeting in 24 hr (international) time
FRIDAY, FEBRUARY 8
7:30—10:00 PM
Keynote Session (Joint). Sponsored in part by OSI Pharmaceuticals, Inc.
*
David A. Cheresh,
University of California, San Diego, USA
*
Rakesh K. Jain,
Massachusetts General Hospital and Harvard Medical School, USA
Bjorn Reino Olsen,
Harvard Medical School, USA
Molecular Mechanisms of Endostatin: Lessons from Collagen XVIII Knock-Out Mice
Molecular Mechanisms of Endostatin: Lessons from Collagen XVIII Knock-Out Mice
M. Amin Arnaout,
Massachusetts General Hospital, USA
Crystal Structure of Heterodimeric Integrin aVb3.
Crystal Structure of Heterodimeric Integrin aVb3.
M. Judah Folkman,
Children's Hospital Boston, USA
Anti-Angiogenic Therapy of Cancer: Lessons from the Clinical Trials
Anti-Angiogenic Therapy of Cancer: Lessons from the Clinical Trials
8:00—11:00 AM
The Matrix in Development
*
Elaine V. Fuchs,
Rockefeller University, USA
Beauty is Skin Deep: Differentiation and Development in the Skin
Beauty is Skin Deep: Differentiation and Development in the Skin
Robert Benezra,
Memorial Sloan-Kettering Cancer Center, USA
The Id Proteins are Required for Tumor Angiogenesis
The Id Proteins are Required for Tumor Angiogenesis
Mina J. Bissell,
Lawrence Berkeley National Laboratory, USA
The Structural Basis of Tissue-Specific Signaling in Normal and Malignant Breast
The Structural Basis of Tissue-Specific Signaling in Normal and Malignant Breast
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
8:00—11:00 AM
Endothelial Stem Cells and Vascular Development
*
Shahin Rafii,
Weill Cornell Medical College, USA
Co-Recruitment of Marrow-Derived VEGFR1 (+)Hematopoietic and VEGFR2+ Vasculogenic Progenitors Cells by Angiogenic Factors is Essential for Angiogenesis.
Co-Recruitment of Marrow-Derived VEGFR1 (+)Hematopoietic and VEGFR2+ Vasculogenic Progenitors Cells by Angiogenic Factors is Essential for Angiogenesis.
Jun Yamashita,
Kyoto University Graduate School of Medicine, Japan
Vascular Progenitor Cells Common to Endothelial and Mural Cells
Vascular Progenitor Cells Common to Endothelial and Mural Cells
Patrick H. Maxwell,
Rayne Institute, UK
Cellular Oxygen Sensing - A Key Regulator of Angiogenesis
Cellular Oxygen Sensing - A Key Regulator of Angiogenesis
Sarah J. Childs,
University of Calgary, Canada
Short Talk: Patterning Angiogenesis in the Zebrafish Embryo
Short Talk: Patterning Angiogenesis in the Zebrafish Embryo
5:00—7:00 PM
Matrix Structure and Assembly
*
Peter D. Yurchenco,
UMDNJ RW Johnson Medical School, USA
Matrix Assembly, Regulatory and Survival Functions of Laminin and its Receptors in Embryonic Stem Cell Differentiation
Matrix Assembly, Regulatory and Survival Functions of Laminin and its Receptors in Embryonic Stem Cell Differentiation
Harold P. Erickson,
Duke University Medical Center, USA
Stretching Fibronectin Matrix Fibrils and Single Molecules
Stretching Fibronectin Matrix Fibrils and Single Molecules
Bianca Tomasini-Johansson,
University of Wisconsin-Madison, USA
Cellular Control of Fibronectin Assembly
Cellular Control of Fibronectin Assembly
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
5:00—7:00 PM
Endothelial Specification: Arteries, Veins, Lymphatics
Jan K. Kitajewski,
Columbia University, USA
Notch Function in Vascular Specification
Notch Function in Vascular Specification
*
Harold F. Dvorak,
Beth Israel Deaconess Medical Center, USA
Structure and Function of Cytokine Induced Vessels: Tumor Vessel Surrogates?
Structure and Function of Cytokine Induced Vessels: Tumor Vessel Surrogates?
Rüdiger Klein,
Max Planck Institute of Neurobiology, Germany
Requirements for Bi-Directional Eph/Ephrin Signaling in vivo
Requirements for Bi-Directional Eph/Ephrin Signaling in vivo
8:00—10:00 PM
Poster Session 1: The Matrix in Development, Tissue Remodeling and Disease
8:00—11:00 AM
Biological Consequences of Matrix Turnover
Vito Quaranta,
Vanderbilt University School of Medicine, USA
Laminin Processing by MMPs in Tumor Invasion Across Basement Membranes
Laminin Processing by MMPs in Tumor Invasion Across Basement Membranes
Marsha A. Moses,
Children's Hospital, USA
Matrix Metalloproteinases: Positive and Negative Regulators of Angiogenesis and Tumor Progression
Matrix Metalloproteinases: Positive and Negative Regulators of Angiogenesis and Tumor Progression
Nathalie Ortega,
University of California, San Francisco, USA
Biological Response to ECM Degradation: Insights from Endochondral Ossification and MMPs
Biological Response to ECM Degradation: Insights from Endochondral Ossification and MMPs
*
Raghu Kalluri,
University of Texas MD Anderson Cancer Center, USA
Regulation of Angiogenesis by Vascular Basement Membrane
Regulation of Angiogenesis by Vascular Basement Membrane
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
8:00—11:00 AM
Angiogenesis and Neurogenesis
Elizabeth Lindsay Illingsworth Baldini,
Texas A&M Health Science Center, USA
Genetic Dissection of the Vascular Defects in DiGeorge Syndrome
Genetic Dissection of the Vascular Defects in DiGeorge Syndrome
*
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
The VEGF Family: Angiogenesis and Beyond
The VEGF Family: Angiogenesis and Beyond
Didier Stainier,
Max Planck Institute for Heart and Lung Research, Germany
Function of VEGF-C in Angiogenesis, Organogenesis and Neurogenesis
Function of VEGF-C in Angiogenesis, Organogenesis and Neurogenesis
5:00—7:00 PM
Angiogenesis and Endothelial Microenvironment (Joint). Session Sponsored by Cell Genesys, Inc.
*
David A. Cheresh,
University of California, San Diego, USA
Differential Raf-ERK Activation by Distinct Integrin/Growth Factor Receptor Pairs During Two Pathways of Angiogenesis: Therapeutic Implications
Differential Raf-ERK Activation by Distinct Integrin/Growth Factor Receptor Pairs During Two Pathways of Angiogenesis: Therapeutic Implications
Rakesh K. Jain,
Massachusetts General Hospital and Harvard Medical School, USA
Functional Heterogeneity in Blood and Lymphatic Vessels in Tumors: Insight from Intravital Microscopy
Functional Heterogeneity in Blood and Lymphatic Vessels in Tumors: Insight from Intravital Microscopy
Erkki Ruoslahti,
Sanford-Burnham Medical Research Institute, USA
Targeting the Endothelium
Targeting the Endothelium
8:00—11:00 AM
Matrix/Growth Factor Dependent Signaling (Joint)
*
Martin Schwartz,
Yale School of Medicine, USA
Integrins and Rho Family GTPases in Mechanotransduction
Integrins and Rho Family GTPases in Mechanotransduction
Anne J. Ridley,
King's College London, UK
Rho GTPase Signaling in Endothelial Cells
Rho GTPase Signaling in Endothelial Cells
Richard K. Assoian,
University of Pennsylvania School of Medicine, USA
Defining the Requirement for Stress Fibers During G1 Phase Cell Cycle Progression
Defining the Requirement for Stress Fibers During G1 Phase Cell Cycle Progression
Tony Hunter,
The Salk Institute for Biological Sciences, USA
Signaling by Tyrosine Phosphorylation
Signaling by Tyrosine Phosphorylation
5:00—7:00 PM
Mechanical and Cytoskeletal Responses
*
Keith W.T. Burridge,
University of North Carolina at Chapel Hill, USA
Signaling from Adhesion to Rho Family GTPases
Signaling from Adhesion to Rho Family GTPases
Paul A. Janmey,
University of Pennsylvania, USA
The Cytoskeleton and Signal Transduction
The Cytoskeleton and Signal Transduction
Christopher S. Chen,
Boston University, USA
Short Talk: New Microengineered Microenvironments to Study Cell Adhesion and Mechanics
Short Talk: New Microengineered Microenvironments to Study Cell Adhesion and Mechanics
Peter F. Davies,
University of Pennsylvania, USA
Title to be Determined
Title to be Determined
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
5:00—7:00 PM
Tumor and Pathological Angiogenesis. Session Sponsored by Enzon, Inc.
Napoleone Ferrara,
University of California, San Diego, USA
New Insights into the Regulation of Angiogenesis by VEGF
New Insights into the Regulation of Angiogenesis by VEGF
Richard O. Hynes,
Massachusetts Institute of Technology, USA
Alpha-v Integrins as Negative Regulators of Angiogenesis
Alpha-v Integrins as Negative Regulators of Angiogenesis
*
Robert S. Kerbel,
Sunnybrook Research Institute, Canada
Metronomic Antiangiogenic Chemotherapy: Genetic and Epigenetic Mechanisms Governing Longterm Response and Resistance
Metronomic Antiangiogenic Chemotherapy: Genetic and Epigenetic Mechanisms Governing Longterm Response and Resistance
Dwayne G. Stupack,
The Scripps Research Institute, USA
Short Talk: Intergrin-Mediated Death: Establishing a New Role for alphanu Intergrins in Angiogenesis
Short Talk: Intergrin-Mediated Death: Establishing a New Role for alphanu Intergrins in Angiogenesis
8:00—10:00 PM
Poster Session 3: Matrix-Dependent Cell Signaling and Cell Function/Matrix-Dependent Cell Structure and Cell Function
8:00—11:00 AM
Structural Factors in Cell and Vessel Regulation (Joint)
*
Donald E. Ingber,
Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Mechanochemical Signaling and Control of Angiogenesis
Mechanochemical Signaling and Control of Angiogenesis
Donald M. McDonald,
University of California, San Francisco, USA
Structural Heterogeneity of Angiogenic Blood Vessels
Structural Heterogeneity of Angiogenic Blood Vessels
Michael P. Sheetz,
Mechanobiology Institute, National University of Singapore, Singapore
Force-Dependent Signals in Cell Motility
Force-Dependent Signals in Cell Motility
Elisabetta Dejana,
Uppsala University, Sweden
Role of Adherence Junctions in Endothelial Cell Proliferation and Angiogenesis
Role of Adherence Junctions in Endothelial Cell Proliferation and Angiogenesis
5:00—7:00 PM
Disruption of ECM Interactions: Therapeutic Implications
*
Judith A. Varner,
University of California, San Diego, USA
Role of Fibronectin and its Receptors in Angiogenesis
Role of Fibronectin and its Receptors in Angiogenesis
Peter C. Brooks,
New York University School of Medicine, USA
Cryptic ECM Elements and the Regulation of Angiogenesis and Tumor Invasion
Cryptic ECM Elements and the Regulation of Angiogenesis and Tumor Invasion
Mark D. Bednarski,
Targesome, Inc., USA
Integrin Targeted Nanoparticles for Imaging and Therapeutics
Integrin Targeted Nanoparticles for Imaging and Therapeutics
Following Session is for Angiogenesis in Cancer and Other Diseases: From Genes to Function to Therapy (Z2)
5:00—7:00 PM
Therapeutic Angiogenesis/Inhibition. Session Sponsored by the Juvenile Diabetes Research Foundation.
Katherine W. Ferrara,
University of California, Davis, USA
Imaging of Angiogenesis
Imaging of Angiogenesis
*
James M. Pluda,
MedImmune, Inc., USA
Lessons from Anti-Angiogenesis Clinical Trials
Lessons from Anti-Angiogenesis Clinical Trials
*Session Chair †Invited, not yet responded.
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