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This meeting took place in 2002
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Microbial - Epithelial - Lymphocyte Interactions in Mucosal Immunity (F1)
Organizer(s) Martin F. Kagnoff and Richard S. Blumberg
April 5—10, 2002
Beaver Run Resort • Breckenridge, CO USA
Abstract Deadline: Dec 13, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 5, 2002
Summary of Meeting:
Significant advances have occurred recently in understanding innate and acquired mucosal immune responses and their regulation. This meeting will focus on the mucosal immune system and the regulation of intestinal mucosal immune responses. Exciting new information will be presented that highlights new findings relevant to the development of the intestinal mucosal immune system, important luminal defense mechanisms, antigen entry and presentation at intestinal mucosal surfaces, mechanisms and functional consequences of signaling innate and adaptive mucosal immune responses, new concepts and data on the regulation of mucosal CD4 and CD8 T cell responses, and mechanisms by which abnormal regulation of intestinal mucosal immune responses results in mucosal immune and inflammatory disease. Insights derived from those sessions will be examined in the context of novel new strategies for treating mucosal immune and inflammatory responses.
View Scholarships/Awards
Significant advances have occurred recently in understanding innate and acquired mucosal immune responses and their regulation. This meeting will focus on the mucosal immune system and the regulation of intestinal mucosal immune responses. Exciting new information will be presented that highlights new findings relevant to the development of the intestinal mucosal immune system, important luminal defense mechanisms, antigen entry and presentation at intestinal mucosal surfaces, mechanisms and functional consequences of signaling innate and adaptive mucosal immune responses, new concepts and data on the regulation of mucosal CD4 and CD8 T cell responses, and mechanisms by which abnormal regulation of intestinal mucosal immune responses results in mucosal immune and inflammatory disease. Insights derived from those sessions will be examined in the context of novel new strategies for treating mucosal immune and inflammatory responses.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, APRIL 5
SATURDAY, APRIL 6
SUNDAY, APRIL 7
MONDAY, APRIL 8
TUESDAY, APRIL 9
WEDNESDAY, APRIL 10
Conference Program Print | View meeting in 24 hr (international) time
FRIDAY, APRIL 5
7:30—8:30 PM
Keynote Address
Laurie H. Glimcher,
Dana-Farber Cancer Institute, USA
T-Bet: A Transcription Factor with Key Functions in Both T and B Cells
T-Bet: A Transcription Factor with Key Functions in Both T and B Cells
8:00—11:00 AM
Development of the Enteric Mucosal Immune System
*
Jean-Pierre Kraehenbuhl,
Institut Suisse de Recherche Experimentale sur le Cancer, Switzerland
Ontogeny of Peyer’s Patches and Mucosa-Associated Lymphoid Tissue
Ontogeny of Peyer’s Patches and Mucosa-Associated Lymphoid Tissue
William W. Agace,
Lund University, Sweden
Selective Chemokine Targeting in the Development of the Intestinal Mucosal Immune System
Selective Chemokine Targeting in the Development of the Intestinal Mucosal Immune System
Lora V. Hooper,
University of Texas Southwestern Medical Center, USA
Life in a Microbial World: Exploring How Normal Gut Bacteria Influence Host Physiology and Development
Life in a Microbial World: Exploring How Normal Gut Bacteria Influence Host Physiology and Development
R. Balfour Sartor,
University of North Carolina at Chapel Hill, USA
Commensal Enteric Bacteria: An Essential Role in Immune Mediated Chronic Intestinal Inflammation
Commensal Enteric Bacteria: An Essential Role in Immune Mediated Chronic Intestinal Inflammation
2:30—4:30 PM
Workshop 1: Development and Expression of Mucosal Immunity
*
Sean P. Colgan,
University of Colorado Denver, USA
Charlotte Slayton Kaetzel,
University of Kentucky, USA
Regulation of the Polymeric Ig Receptor by Herpesviruses
Regulation of the Polymeric Ig Receptor by Herpesviruses
Erika B. Stromberg,
Göteborg University, Sweden
Increased Frequencies of CTLA-4 Positive Cells in the Duodenum of Helicobacter Pylori-Infected Duodenal Ulcer Patients
Increased Frequencies of CTLA-4 Positive Cells in the Duodenum of Helicobacter Pylori-Infected Duodenal Ulcer Patients
Harnisha N. Dalwadi,
University of California, Los Angeles, USA
T2 and MZ B Cells: Role in Mucosal Immunologic Homeostasis, and Developmental Requirement for the Galphai2 Gene
T2 and MZ B Cells: Role in Mucosal Immunologic Homeostasis, and Developmental Requirement for the Galphai2 Gene
Donald Smith,
Massachusetts General Hospital, USA
Presentation of Model Immunogenic and Tolerogenic Antigens by the Gut Associated Lymphoid Tissue
Presentation of Model Immunogenic and Tolerogenic Antigens by the Gut Associated Lymphoid Tissue
Ifor Williams,
Science Immunology, USA
CD8alphaalpha-Expressing Intraepithelial Lymphocytes (IEL) with an alphabeta TCR are Selectively Expanded in the Intestine of CCR6 Deficient Mice
CD8alphaalpha-Expressing Intraepithelial Lymphocytes (IEL) with an alphabeta TCR are Selectively Expanded in the Intestine of CCR6 Deficient Mice
Masafumi Yamamoto,
Nihon University, Japan
Role of TNF/LT and LTalpha/beta for the Intestinal Mucosal Immunity
Role of TNF/LT and LTalpha/beta for the Intestinal Mucosal Immunity
Ana Maria Terres,
Trinity College Dublin, Ireland
Synergistic Effect of Lipopolysaccharide and Soluble Proteins from Helicobacter pylori Induce Endocytosis Dependent-Blistering of Polarized Epithelia. An Ulcerogenic Mechanism?
Synergistic Effect of Lipopolysaccharide and Soluble Proteins from Helicobacter pylori Induce Endocytosis Dependent-Blistering of Polarized Epithelia. An Ulcerogenic Mechanism?
Donald P. Satchell,
University of California, Irvine, USA
Processing and Activation of alpha-Defensins in Mouse Small Intestinal Paneth Cells
Processing and Activation of alpha-Defensins in Mouse Small Intestinal Paneth Cells
Vijay K. Shreedhar,
Wyeth Inc., USA
Orally-Administered Cholera Toxin Induces Migration of Dendritic Cells from the Sub-Epithelial Dome Region to T and B Cell Areas of Peyer’s Patches
Orally-Administered Cholera Toxin Induces Migration of Dendritic Cells from the Sub-Epithelial Dome Region to T and B Cell Areas of Peyer’s Patches
Edward Nieuwenhuis,
Vrije Universiteit Medical Center, USA
5:00—7:00 PM
Luminal Host Defense Mechanisms
*
Andre J. Ouellette,
University of California, Irvine, USA
Paneth Cells, alpha-Defensins, and Mucosal Immunity in the Small Intestine
Paneth Cells, alpha-Defensins, and Mucosal Immunity in the Small Intestine
Judith Appleton,
Cornell University, USA
Glycan Specific Antibodies Perturb the Epithelial Habitat of Trichinella Spirals
Glycan Specific Antibodies Perturb the Epithelial Habitat of Trichinella Spirals
Pascale Cossart,
Institut Pasteur, France
Transgenic Mouse Models for Studying Intestinal Microbial Infection: The Listeria Paradigm
Transgenic Mouse Models for Studying Intestinal Microbial Infection: The Listeria Paradigm
8:00—11:00 AM
Antigen Entry and Presentation at Enteric Mucosal Surfaces
*
Daniel Louvard,
Institut Curie, France
Role of Intestinal Epithelial Cell Cytoskeletal Proteins in Regulating Motility of Intracellular Pathogens
Role of Intestinal Epithelial Cell Cytoskeletal Proteins in Regulating Motility of Intracellular Pathogens
G. Gordon MacPherson,
University of Oxford, UK
Dendritic Cells and Antigen Transport from the Intestine
Dendritic Cells and Antigen Transport from the Intestine
Paola Ricciardi-Castagnoli,
Toscana Life Science Foundation, Italy
Mechanisms of Tight Junction Penetration and Antigen Uptake by Mucosal Dendritic Cells
Mechanisms of Tight Junction Penetration and Antigen Uptake by Mucosal Dendritic Cells
Wayne Lencer,
Children's Hospital Boston, USA
IgG Transport Across Mucosal Barriers: Functional Expression of FcRn in the Mouse Lung and Bronchial Epithelium of the Human and Non-Human Primate.
IgG Transport Across Mucosal Barriers: Functional Expression of FcRn in the Mouse Lung and Bronchial Epithelium of the Human and Non-Human Primate.
5:00—7:00 PM
Innate Mucosal Immunity and Luminal Host Defense Mechanisms
Daniel K. Podolsky,
Massachusetts General Hospital, USA
Toll-Like Receptors and the Mucosal Frontier
Toll-Like Receptors and the Mucosal Frontier
Gabriel Nuñez,
University of Michigan, USA
Nods: Apaf-1-Like Molecules Regulating the Host Response to Pathogens
Nods: Apaf-1-Like Molecules Regulating the Host Response to Pathogens
*
Martin F. Kagnoff,
University of California, San Diego, USA
Epithelial Cells as a Signal Integrator in the Host Response to Microbial Infection
Epithelial Cells as a Signal Integrator in the Host Response to Microbial Infection
8:00—11:00 AM
Signaling the Onset of Adaptive Mucosal Immune Responses
Ferric C. Fang,
University of Washington School of Medicine, USA
Critical Role of Reactive Nitrogen and Oxygen Species in Innate Immunity to Salmonella typhimurium
Critical Role of Reactive Nitrogen and Oxygen Species in Innate Immunity to Salmonella typhimurium
Ludger Johannes,
Institut Curie, France
Microbial Toxins as Probes for Antigen Uptake and Trafficking and as Vehicles for Initiating Host Adaptive Immunity: Lessons from Shiga Toxin
Microbial Toxins as Probes for Antigen Uptake and Trafficking and as Vehicles for Initiating Host Adaptive Immunity: Lessons from Shiga Toxin
*
Terrence A. Barrett,
Northwestern University Medical School, USA
T Cell Activation Regulates Epithelial Cell Differentiation and Induces Innate Immune Responses in the Intestine
T Cell Activation Regulates Epithelial Cell Differentiation and Induces Innate Immune Responses in the Intestine
Lloyd F. Mayer,
Mount Sinai Medical Center, USA
Unique Antigens and Cell Surface Interactions Define the Activation of Regulatory T Cells by Intestinal Epithelium
Unique Antigens and Cell Surface Interactions Define the Activation of Regulatory T Cells by Intestinal Epithelium
2:30—4:50 PM
Workshop 2: Epithelial Cell Interactions and Microbial Infections
*
Lars Eckmann,
University of California, San Diego, USA
M. Cecilia Berin,
Mount Sinai School of Medicine, USA
Activation of Epithelial Cell NF-kappaB and MAP Kinase Signaling Pathways by Enterohemorrhagic E. coli: Role of Bacterial Virulence Factors
Activation of Epithelial Cell NF-kappaB and MAP Kinase Signaling Pathways by Enterohemorrhagic E. coli: Role of Bacterial Virulence Factors
Dirk Haller,
Technical University of Munich, Germany
Immune-Mediated Inhibition of Bacteroides vulgatus Induced NF-kappaB Activation and Gene Expression in Intestinal Epithelial Cells by Blocking IkappaBalpha Degradation
Immune-Mediated Inhibition of Bacteroides vulgatus Induced NF-kappaB Activation and Gene Expression in Intestinal Epithelial Cells by Blocking IkappaBalpha Degradation
*
Maria T. Abreu,
University of Miami, Miller School of Medicine, USA
TLR4 and MD-2 Expression are Regulated by Th1 Cytokines in Human Intestinal Epithelial Cells (IEC)
TLR4 and MD-2 Expression are Regulated by Th1 Cytokines in Human Intestinal Epithelial Cells (IEC)
Maria T. Abreu,
University of Miami, Miller School of Medicine, USA
Intestinal Epithelial Cells (IEC) are Broadly Unresponsive to TLR2-Dependent Bacterial Ligands
Intestinal Epithelial Cells (IEC) are Broadly Unresponsive to TLR2-Dependent Bacterial Ligands
Karen L. Madsen,
University of Alberta, Canada
DNA from Probiotic Bacteria Exerts Anti-Inflammatory Actions on Intestinal Epithelial Cells by Inhibition of NF-kappaB
DNA from Probiotic Bacteria Exerts Anti-Inflammatory Actions on Intestinal Epithelial Cells by Inhibition of NF-kappaB
Geraldine O. Canny,
Central University Hospital of Vaud, Switzerland
Lipid Mediator-Induction of Bactericidal / Permeability-Increasing Protein (BPI) in Human Epithelia
Lipid Mediator-Induction of Bactericidal / Permeability-Increasing Protein (BPI) in Human Epithelia
David L. Boone,
Indiana University School of Medicine, USA
Expression of A20 in Hematopoietic Cells is Critical for the Regulation of Intestinal Inflammation
Expression of A20 in Hematopoietic Cells is Critical for the Regulation of Intestinal Inflammation
Dominique Buzoni-Gatel,
Institut Pasteur, France
Importance of Chemokine Receptors for the Leukocyte Trafficking and Protection Against Intestinal Inflammation during T.gondii Infection
Importance of Chemokine Receptors for the Leukocyte Trafficking and Protection Against Intestinal Inflammation during T.gondii Infection
Nicolas K. Rachinel,
Dartmouth College, USA
Cellular Events in Pathogen Induced Acute Ileitis Driven by a Single Parasite Membrane Antigen (SAG1)
Cellular Events in Pathogen Induced Acute Ileitis Driven by a Single Parasite Membrane Antigen (SAG1)
Sonia Lacroix-Lamande,
Institut National de La Recherche Agronomique, France
Intestinal Chemokine Response during Cryptosporidium parvum Infection
Intestinal Chemokine Response during Cryptosporidium parvum Infection
Christian Maaser,
University of Muenster, Germany
Clearance of Citrobacter rodentium Requires B Cells but not Secretory IgA or IgM Antibodies
Clearance of Citrobacter rodentium Requires B Cells but not Secretory IgA or IgM Antibodies
Bana Jabri,
University of Chicago, USA
Isotypes of the NKG2 Family of NK Receptors Tightly Regulate the Function of Normal and Celiac Intestinal alpha/beta T Lymphocytes
Isotypes of the NKG2 Family of NK Receptors Tightly Regulate the Function of Normal and Celiac Intestinal alpha/beta T Lymphocytes
5:15—7:00 PM
Regulation of Mucosal CD4 and CD8 T Cell Responses
Hiroshi Kiyono,
University of Tokyo, Japan
Cross Communication of Mucosal and Systemic T Cells for Allergic Responses in Gastrointestinal Tract
Cross Communication of Mucosal and Systemic T Cells for Allergic Responses in Gastrointestinal Tract
*
Richard S. Blumberg,
Brigham and Women's Hospital, USA
Epstein-Barr Virus-Induced Gene 3 (EBI3) Deficiency Disrupts T Helper 2-Mediated Immune Responses
Epstein-Barr Virus-Induced Gene 3 (EBI3) Deficiency Disrupts T Helper 2-Mediated Immune Responses
Hilde Cheroutre,
La Jolla Institute for Allergy and Immunology, USA
Adapt and Survive! A Well Kept Sercret of CD8aa Expressing T Cells
Adapt and Survive! A Well Kept Sercret of CD8aa Expressing T Cells
8:00—11:00 AM
Abnormal Mucosal Regulation and Mucosal Disease
Dale T. Umetsu,
Genentech, Inc., USA
Asthma as a Mucosal Disease: Mucosal Antigen Induces T Cell Tolerance and Protects Against Asthma
Asthma as a Mucosal Disease: Mucosal Antigen Induces T Cell Tolerance and Protects Against Asthma
*
Warren Strober,
National Institutes of Health, USA
Spontaneous and Induced Immunoregulation of Experimental Mucosal Inflammation
Spontaneous and Induced Immunoregulation of Experimental Mucosal Inflammation
Sean P. Colgan,
University of Colorado Denver, USA
Hypoxia-Inducible Factor (HIF) is Protective for Experimental Murine Colitis
Hypoxia-Inducible Factor (HIF) is Protective for Experimental Murine Colitis
Markus F. Neurath,
University Hospital Erlangen, Germany
The Life and Death of Mucosal Lymphocytes
The Life and Death of Mucosal Lymphocytes
2:30—4:30 PM
Worskshop 3: Inflammatory and Immune Processes in IBD
*
Lloyd H. Kasper,
Geisel School of Medicine at Dartmouth, USA
*
Eyal Raz,
University of California, San Diego, USA
Nicolaas A. Bos,
University of Groningen, Netherlands
iNOS and FAS Expression in Colonic Enterocytes in SCID Mice after Induction of Inflammatory Bowel Disease by CD45RBhigh , CD4+ T Cells
iNOS and FAS Expression in Colonic Enterocytes in SCID Mice after Induction of Inflammatory Bowel Disease by CD45RBhigh , CD4+ T Cells
Franck J.D. Mennechet,
Universite Montpellier 2, France
Lamina propria CD4+ T Lymphocytes Synergize with Murine Intestinal Epithelial Cells to Enhance Pro-Inflammatory Response Against an Intracellular Pathogen
Lamina propria CD4+ T Lymphocytes Synergize with Murine Intestinal Epithelial Cells to Enhance Pro-Inflammatory Response Against an Intracellular Pathogen
Britta Siegmund,
University of Colorado Health Sciences Center, USA
Leptin: A Critical Proinflammatory Mediator in Different Models of Experimental Colitis
Leptin: A Critical Proinflammatory Mediator in Different Models of Experimental Colitis
Kiyoshi Takeda,
Osaka University, Japan
IL-12 is Essential for Development of Chronic Enterocolitis in Macrophage-Specific Stat3-Deficient Mice
IL-12 is Essential for Development of Chronic Enterocolitis in Macrophage-Specific Stat3-Deficient Mice
John S. Whoriskey,
Amgen Inc., USA
Transgenic Mice Over-Expressing B7.2 Develop an Intestinal Pathology Similar to Human Inflammatory Bowel Disease
Transgenic Mice Over-Expressing B7.2 Develop an Intestinal Pathology Similar to Human Inflammatory Bowel Disease
Marika C. Kullberg,
Centre for Immunology and Infection, University of York, UK
Bacterial-Induced IL-10-Producing CD4+ CD45RBlow CD25+ and CD25- Regulatory T Cells Suppress Helicobacter hepaticus-Triggered Colitis
Bacterial-Induced IL-10-Producing CD4+ CD45RBlow CD25+ and CD25- Regulatory T Cells Suppress Helicobacter hepaticus-Triggered Colitis
Han-Qing Jiang,
University of Pennsylvania, USA
Monoassociation of Germ Free SCID Mice with Helicobacter muridarum Provokes Inflammatory Bowel Disease upon Transfer of CD4+ CD45RBhigh T cells
Monoassociation of Germ Free SCID Mice with Helicobacter muridarum Provokes Inflammatory Bowel Disease upon Transfer of CD4+ CD45RBhigh T cells
Nadia Corazza,
Brigham and Women's Hospital, USA
Impaired Function of NK-T Cells in EB13-Deficient Animals
Impaired Function of NK-T Cells in EB13-Deficient Animals
Susetta Finotto,
University of Mainz, Germany
Development of Spontaneous Airway Hyperresponsiveness and Remodeling Consistent with Human Asthma in Mice Lacking T-bet
Development of Spontaneous Airway Hyperresponsiveness and Remodeling Consistent with Human Asthma in Mice Lacking T-bet
Lothar Steidler,
Alimentary Pharmabiotic Centre, Ireland
Ingestion of MouseTFF1, 2 or 3 Producing Recombinant Lactococcus lactis Prevents Acute Colitis in Mice
Ingestion of MouseTFF1, 2 or 3 Producing Recombinant Lactococcus lactis Prevents Acute Colitis in Mice
Theresa Torres Pizarro,
University of Virginia, USA
5:00—7:00 PM
Novel Therapeutic Approaches for Treating Mucosal Inflammation
*
Eyal Raz,
University of California, San Diego, USA
DNA-Based Immunotherapeutics for the Treatment of Enteric Inflammatory Diseases
DNA-Based Immunotherapeutics for the Treatment of Enteric Inflammatory Diseases
Averil I. Ma,
University of California, San Francisco, USA
A20—Pleiotropic Regulator of Intestinal Immune Homeostasis
A20—Pleiotropic Regulator of Intestinal Immune Homeostasis
Cathryn R. Nagler,
University of Chicago, USA
Regulation of Tolerance and Immunity in the Intestinal Mucosa
Regulation of Tolerance and Immunity in the Intestinal Mucosa
*Session Chair †Invited, not yet responded.
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