Keystone Symposia

Granlibakken Tahoe Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2002



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

DNA Helicases, Cancer and Aging (C2)


Organizer(s) Ian D. Hickson and Judith Campisi
March 12—17, 2002
Granlibakken Tahoe • Tahoe City, CA USA
Abstract Deadline: Nov 12, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 11, 2002

Summary of Meeting:
Cancer and aging are frequently considered distinct disorders, although both are associated with genomic instability and are phenotypic consequences of the interplay between genes and the environment. The totally unexpected finding that defects in DNA helicases are responsible for several cancer-prone and/or premature aging syndromes in humans, indicates a need to integrate studies of the basic biology of helicases with studies of cancer and longevity. This conference will provide a unique opportunity to bring together world leaders in aging and cancer biology, with experts on the structure and function of DNA helicases. Sessions will cover structural and functional characterization of DNA helicases from humans and model organisms, and their roles in cancer predisposition or premature aging disorders. By bringing together scientists from the fields of structural biology, biochemistry, cell and molecular biology, cancer and aging research, the conference will facilitate the application of fundamental studies in biology to improvements in human health.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


TUESDAY, MARCH 12

4:00—7:00 PM
Registration

Lobby
5:00—6:00 PM
Cocktail Social

7:15—7:30 PM
Orientation

Granhall
7:30—8:30 PM
Keynote Address

Granhall
George M. Martin, University of Washington, USA
Classes of Gene Action that Escape the Force of Natural Selection and Thus Modulate Cancer and Senescence


WEDNESDAY, MARCH 13

7:00—8:00 AM
Breakfast

Granhall
8:00—11:00 AM
DNA Helicases: Structure and Function I

Mountain/Lake Room
Dale B. Wigley, Institute of Cancer Research, UK
Relating Structure to Mechanism in Helicases

Timothy M. Lohman, Washington University School of Medicine, USA
DNA Unwinding by the E. coli SF-1 Helicases, Rep and UvrD

* Steven W. Matson, University of North Carolina at Chapel Hill, USA
Biochemical and Genetic Studies of DNA Helicases I and II from E. coli

Edward H. Egelman, University of Virginia, USA
Structural Analysis of Oligomeric Helicases Using Electron Microscopy

9:20—9:40 AM
Coffee Break

Prefunction
11:00 AM—1:00 PM
Poster Setup

Lake
1:00—10:00 PM
Poster Viewing

Lake
2:30—4:30 PM
Workshop 1

Mountain/Lake Room
* Dale B. Wigley, Institute of Cancer Research, UK

Jennifer A. Cobb, University of Calgary, Canada
Evidence for Interaction Between Sgs1 and Rad53 in the S- Phase Checkpoint Response to HU

Matthew R. Redinbo, University of North Carolina at Chapel Hill, USA
WRN Exonuclease Forms a Hexamer on DNA and Possesses Both 3'-5' Exonuclease and 5'-Protruding Strand Endonuclease Activities

Moreshwar Bhanudas Vaze, Cequent Pharmaceuticals, USA
The SRS2 Helicase is Required for Cells to Recover from Checkpoint-Mediated Arrest that Precedes Repair of a Double-Strand Break

Lars Eide, National Hospital of Norway, Norway
Characterization of a Novel DNA Glycosylase / AP Lyase Activity that Removes Premutagenic Lesions from Mouse Mitochondrial DNA

Maria Spies, University of California, Davis, USA
Definition of the RecA Loading Domain of the RecBCD Helicase/Nuclease

Zeynep Ayse Ozsoy, University of North Carolina at Chapel Hill, USA
Biochemical Characterization of Small and Large Isoforms of Drosophila RecQ5

4:30—5:00 PM
Coffee & Snacks Available

Promenade
5:00—7:00 PM
DNA Helicases: Structure and Function II

Mountain/Lake Room
Stephen C. West, Francis Crick Institute, UK
Strand Transfer and DNA Helicase Activities in the Recombinational Repair of DNA Breaks

* Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
DNA Helicases and Replication Fork Restart

Fyodor D. Urnov, University of California, Berkeley, USA
Mechanisms of Chromatin Remodeling

7:00—8:00 PM
Dinner

Granhall
8:00—10:00 PM
Poster Session 1: DNA Helicases: Structure and Function

Lake
8:00—9:00 PM
Welcome Mixer

Lake

THURSDAY, MARCH 14

7:00—8:00 AM
Breakfast

Granhall
8:00—11:00 AM
Biochemistry and Genetics of DNA Helicases I

Mountain/Lake Room
Philip C. Hanawalt, Stanford University, USA
Discovery of Rec Q: Role of the Rec Q Helicase in E. coli

Clare H. McGowan, The Scripps Research Institute, USA
Human Mus81 Associated Endonuclease Cleaves Holliday Junctions in vitro

Jean-Marc Egly, Institut de Genetique et de Biologie Moleculaire Cellulaire, France
Transcription Defects Associated with Xeroderma pigmentosum and Cockayne Syndromes

* Rodney J. Rothstein, Columbia University Medical Center, USA
Genetic Analysis of the Sgs1/Top3 Complex of Saccharomyces cerevisiae

9:20—9:40 AM
Coffee Break

Prefunction
11:00 AM—1:00 PM
Poster Setup

Lake
1:00—10:00 PM
Poster Viewing

Lake
2:30—4:30 PM
Workshop 2

Mountain/Lake Room
* Nathan A. Ellis, University of Illinois, Chicago, USA

Hong Yan, Fox Chase Cancer Center, USA
Distinct Roles of Werner Syndrome Protein and Bloom Syndrome Protein in DNA Replication and Double-strand Break Repair

Giordano Liberi, F.I.R.C. Institute of Molecular Oncology Foundation, Italy
DNA Replication Fork Progression and Processing in sgs1 snd srs2 Mutant Cells Experiencing Intra-S DNA Damage

Steven M. Yannone, Lawrence Berkeley National Laboratory, USA
Werner Syndrome Protein is Regulated and Phosphorylated by DNA-Dependent Protein Kinase

Sharon B. Cantor, University of Massachusetts Medical School, USA
BACH1, a DNA Helicase that Binds Directly to BRCA1

Feyruz V. Rassool, Rayne Institute, UK
Increased Constitutive Replication-Associated DNA Damage in Bloom's Syndrome (BS) is Associated with Increased Infidelity of Non Homologous End-Joining (NHEJ): Implication for Chromosomal Instability in BS?

Hyeon-Sook Koo, Yonsei University, South Korea
The Functions of RecQ Family DNA Helicases in Caenorhabditis elegans

4:30—5:00 PM
Coffee & Snacks Available

Promenade
5:00—7:00 PM
Biochemistry and Genetics of DNA Helicases II

Mountain/Lake Room
* Stephen C. Kowalczykowski, University of California, Davis, USA
Mechanism of RecQ Helicase and Topoisomerase III Function

Virginia A. Zakian, Princeton University, USA
The Pif1-Subfamily of DNA Helicases: Functional Consequences of Sequence Similarity?

James E. Haber, Brandeis University, USA
Role of S. cerevisiae Sgs1 and Srs2 in Recombination and Checkpoint Control

John Bradsher, National Cancer Institute, National Institutes of Health, USA
Short Talk: Novel Roles for 3 Helicases in RNA pol I Transcription

7:00—8:00 PM
Dinner

Granhall
8:00—10:00 PM
Poster Session 2: Biochemistry and Genetics of DNA Helicases

Lake
8:00—9:00 PM
Welcome Mixer

Lake

FRIDAY, MARCH 15

7:00—8:00 AM
Breakfast

Granhall
8:00—11:00 AM
Helicases and Cancer I

Mountain/Lake Room
Ian D. Hickson, University of Copenhagen, Denmark
Molecular Pathways to Genome Instability and Cancer: Analysis of the Bloom's Syndrome Helicase

* Errol C. Friedberg, University of Texas Southwestern Medical Center, USA
Error-Prone DNA Polymerases, Mutagenesis and Cancer

Wim Vermeulen, Erasmus University, Netherlands
DNA Repair and Transcription Defects in the Human Population

Nathan A. Ellis, University of Illinois, Chicago, USA
Bloom's Syndrome: Genomic Instability, Nuclear Bodies, and the BLM Helicase

9:20—9:40 AM
Coffee Break

Prefunction
11:00 AM—1:00 PM
Poster Setup

Lake
1:00—10:00 PM
Poster Viewing

Lake
2:30—4:30 PM
Workshop 3

Mountain/Lake Room
* Edward J. Louis, University of Nottingham, UK

Narendra Tuteja, International Center Genetic Engineering & Biotechnology, India
A Pea Homologue of Human DNA Helicase I is Upregulated by Phosphorylation and is Localised Within the Nucleolus

Lucio Comai, University of Southern California, USA
The Werner Syndrome Protein and DNA Damage

Brad Brad Johnson, University of Pennsylvania, USA
Testing the Function of the Werner and Bloom Syndrome Genes in Mice Lacking Telomerase

Lisa L. Wang, Baylor College of Medicine, USA
Deleterious Mutations in RecQL4 are Associated with Osteosarcoma Risk in Rothmund-Thomson Syndrome

Robert Michael Brosh Jr., NIA, National Institutes of Health, USA
Dual Functions of Werner Syndrome Protein as a DNA Helicase and Activator of Flap Endonuclease 1

4:30—5:00 PM
Coffee & Snacks Available

Promenade
5:00—7:00 PM
Helicases and Cancer II

Mountain/Lake Room
* Curtis C. Harris, NCI, National Institutes of Health, USA
p53-Mediated Apoptosis and Genomic Instability Syndromes

Joanna L. Groden, Ohio State University, USA
Mouse Models for Studying Cancer Predisposition

Hans Spelbrink, University of Tampere, Finland
Human Mitochondrial DNA Instability Caused By Mutations in Twinkle, a Helicase with Similarity to Phage T7 gp4

7:00—8:00 PM
Dinner

Granhall
8:00—10:00 PM
Poster Session 3: Helicases and Cancer/Helicases and Aging

Lake
8:00—9:00 PM
Welcome Mixer

Lake

SATURDAY, MARCH 16

7:00—8:00 AM
Breakfast

Granhall
8:00—11:00 AM
Helicases and Aging I

Mountain/Lake Room
Judith Campisi, Buck Institute for Research on Aging, USA
Mammalian RECQ-Like Helicases and Cellular Senescence

Edward J. Louis, University of Nottingham, UK
Helicases, Telomere Maintenance and Genome Stability

* Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Werner Protein Function, Interactions and Pathways

Junko Oshima, University of Washington, USA
Role of the WRN Gene in Maintenance of Genome Stability and Aging

9:20—9:40 AM
Coffee Break

Prefunction
4:30—5:00 PM
Coffee & Snacks Available

Prefunction
5:00—7:00 PM
Helicases and Aging II

Mountain/Lake Room
* Raymond J. Monnat Jr., University of Washington, USA
Genome Instability and Cancer Pathogenesis in the Human RecQ Helicase Deficiencies

Yasuhiro Furuichi, GeneCare Research Institute Co., Ltd., Japan
Upregulation of Human RecQ Helicases in Transformed and Cancer Cells

Jan Vijg, Albert Einstein College of Medicine, USA
Genomic Instability in Mouse Models of Aging and Cancer

7:00—8:00 PM
Welcome Mixer

Granhall
8:00—9:00 PM
Dinner

Granhall
9:00 PM—12:00 AM
Entertainment

Granhall

SUNDAY, MARCH 17

7:00—8:00 AM
Breakfast

Granhall
 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA94351-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179