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This meeting took place in 2003

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Chemokines and Chemokine Receptors (A1)

Organizer(s) Ann Richmond, Sergio A. Lira, Steven L. Kunkel and Amanda E.I. Proudfoot Fichard
January 7—12, 2003
Beaver Run Resort • Breckenridge, CO USA
Abstract Deadline: Sep 16, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 7, 2002

Sponsored by Berlex Biosciences

Summary of Meeting:
Chemokines are members of a family of chemotactic cytokines that mediate their function through seven transmembrane G protein-coupled receptors. While these small proteins were initially characterized as modulators of leukocyte trafficking, they have since been associated with inflammatory disorders, allergic disease, infectious diseases, atherosclerosis, wound healing, angiogenesis and tumorigenesis. The mechanisms for activation, trafficking, signal transduction and modulation of gene expression mediated through chemokines are under intense study. One benefit of learning more about these processes will be the more rational design of small molecules to block responses to these factors. This is particularly critical, since in a number of disease processes, the failure to shut off biological response to chemokines is associated with tissue damage. This meeting will bring together scientists working on the molecular basis of chemokine responses with those working at the organismal level on problems of disease and the immune response. The resultant interaction should stimulate development of new approaches for more rational design of chemokine-directed therapeutics. Moreover, the basic scientists will benefit from learning about the small molecules that have been developed which may be useful for additional studies into mechanism of action of chemokines.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


3:00—7:00 PM

Third Floor Foyer
6:15—7:15 PM

Third Floor Foyer
7:15—7:30 PM

Peaks 4-5
7:30—9:30 PM
Keynote Addresses

Peaks 4-5
Peter N. Devreotes, Johns Hopkins University, USA
How Cells Sense Chemoattractant Gradients

Alberto Mantovani, Humanitas University, Italy
Chemokines on the Move


7:00—8:00 AM

Peaks 6-12
8:00—11:30 AM
Chemokine Receptors and Their Processing

Peaks 4-5
* Christine A. Power, Merck Serono, Switzerland

* Ann Richmond, Vanderbilt University School of Medicine, USA

Richard A. Firtel, University of California, San Diego, USA
Finding Their Way - How Cells Sense Direction

Mark Marsh, University College London, UK
Endocytic Trafficking of Cellular and Viral Chemokine Receptors

Jeffrey L. Benovic, Thomas Jefferson University, USA
Regulation of CXCR4 Ubiquitination and Sorting

Alissa M. Weaver, Vanderbilt University School of Medicine, USA
Regulation of Arp2/3 Complex-Induced Actin Assembly

Sundararajan Venkatesan, NIAID, National Institutes of Health, USA
Short Talk: Agonist-Driven Endocytosis of Chemokine Receptors Follows Clathrin-Dependent or Independent Pathways, Depending on the Receptor

Eric R. Prossnitz, University of New Mexico, USA
Short Talk: Mechanisms of G Protein-Coupled Receptor Arrestin Interactions

Mette M. Rosenkilde, Panum Institute, Denmark
Short Talk: Constitutively Active Virally Encoded Chemokine Receptors

Achim Frauenschuh, Merck Serono Pharmaceutical Research Institute, Switzerland
Short Talk: Identification of Novel Chemokine-Binding Proteins

9:20—9:40 AM
Coffee Break

11:30 AM—1:00 PM
Poster Setup

Peaks 1-3
1:00—9:00 PM
Poster Viewing

Peaks 1-3
4:00—4:30 PM
Coffee & Snacks Available

4:30—6:30 PM
Chemokine Ligands: Structure; Interaction of Ligands with GAGS; Processing, Novel Chemokines

Peaks 4-5
* Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research Centre, Switzerland
The Chemokine/GAG Interaction: A Novel Anti-Inflammatory Strategy

Tracy M. Handel, University of California, San Diego, USA
Structural Views of Chemokine:GAG Interfaces

Jo Van Damme, University of Leuven, Belgium
Processing of Chemokines Alters their Biological Activity

Richard M. Ransohoff, Third Rock Ventures, USA
Chemokines and their Receptors in Neurological Disorders

Eleanor N. Fish, University Health Network, Toronto General Research Institute, Canada
Short Talk: CCL5 Induces Apoptosis in T Cells: A Requirement for Glycosaminoglycan Binding and and CCL5 Aggregation

6:30—7:30 PM
Social Hour

Peaks 1-3
7:30—9:00 PM
Poster Session 1: Processes Affecting Chemokine/Chemokine Receptor Activity

Peaks 1-3


7:00—8:00 AM

Peaks 6-12
8:00—11:30 AM
Signals from Chemokines/Chemokine Receptors

Peaks 4-5
* Steven L. Kunkel, University of Michigan Medical School, USA

Stephen G. Ward, University of Bath, UK
Dissecting Out Role of PI3K Isoforms and Lipid Phosphatases in Chemokine Signaling

Gary M. Bokoch, The Scripps Research Institute, USA
Rho GTPase Activation Dynamics Live Neutrophil Chemotaxis

Michael D. Gunn, Duke University Medical Center, USA

Paola Casarosa, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany
Short Talk: Human Cytomegalovirus-Encoded Receptor US28 Potentiates CC-Chemokine Receptor CCR1 Signaling

Yi Le, Naval Medical Research Center, USA
Short Talk: CXCL12-Mediated Responses and their Modulation by RGS1 are Compartmentalized in Membrane Lipid Rafts

Dzung H. Nguyen, National Institutes of Health, USA
Short Talk: Inhibition of Chemokine Receptor Function by Microbial Cholesterol Oxidase and Sphingomyelinase

Anuska V. Andjelkovic, University of Michigan, USA
Short Talk: Monocyte Chemoattractant Protein-1 Alters Blood-Brain-Barrier Permeability: Role of Rho:PKCs Cross Talk

9:20—9:40 AM
Coffee Break

11:30 AM—1:00 PM
Poster Setup

Peaks 1-3
1:00—8:00 PM
Poster Viewing

Peaks 1-3
4:00—4:30 PM
Coffee & Snacks Available

4:30—6:30 PM
Chemokines in Innate and Adaptive Immunity

Peaks 4-5
* Joshua M. Farber, NIAID, National Institutes of Health, USA

Barrett J. Rollins, Dana Farber Cancer Institute, USA
Chemokine Modulation of Inflammation and T Helper Cell Polarization

Stephen W. Chensue, VA Medical Center, University of Michigan, USA
Chemokine and Chemokine Receptor Dynamics during Type-1 and Type-2 Hypersensitivity-Type Pulmonary Inflammation

Christine A. Biron, Brown University, USA
Sorting Out Cytokine and Chemokine Networks in Antiviral Defense

6:30—7:30 PM
Social Hour

Peaks 1-3
6:30—8:00 PM
Poster Session 2: Chemokine Signal Transduction

Peaks 1-3
8:00—10:00 PM
Workshop 1

Peaks 4-5
* Craig Gerard, Children's Hospital Harvard University, USA

* Israel F. Charo, ChemoCentryx, Inc., USA

Erez Raz, Max Planck Institute for Biophysical Chemistry, Germany
Direction of Primordial Germ Cell Migration in Zebrafish by Chemokine Signaling

Alexandra R. Lucas, Arizona State University, USA
Viral Chemokine Binding Proteins Modulate Early Inflammatory Responses in Rat Aortic Allograft Vasculopathy Development

Javier Navarro, University of Texas Medical Branch, USA
Identification of a Signal Transduction Switch in the Chemokine Receptor CXCR1

Kunio Hieshima, Kinki University School of Medicine, Japan
CCL28 Has a Dual Role in Mucosal Immunity as a Chemokine with a Broad-Spectrum Antimicrobial Activity

Mark C. Poznansky, Massachusetts General Hospital, USA
Bidirectional T-Cell Migration: Differential Expression of Genes Encoding Signal Transduction Molecules by T-Cells Following Exposure to Specific Gradients of SDF-1

Gabriele S.V. Campanella, Massachusetts General Hospital, USA
CXCR3 and Glycosaminoglycan Binding Site of the Chemokine IP-10 (CXCL10)

Thilo Mokros, Max-Delbrück-Center for Molecular Medicine, Germany
Surface Expression and Endocytosis of the Human Cytomegalovirus-Encoded Chemokine Receptor US28 is Regulated by Agonist-Independent Phosphorylation

Fleur François, Mount Sinai School of Medicine, USA
HIV-1 Engagement of Chemokine Receptors Activates PI3-Kinase and Regulates Replication Following Viral Entry

Clare M. Wain, University of Bath, UK
Regulation of SDF-1(CXCL12)/CXCR4-Stimulated PI3K-Dependent Signaling Events by the Lipid Phosphatase SHIP

Alexandre Garin, Merck Serono, Switzerland
Two Novel Fully Functional CX3CR1 Isoforms Are Potent HIV Coreceptors


7:00—8:00 AM

Peaks 6-12
8:00—11:30 AM
Immune Function/Homing and Trafficking

Peaks 4-5
* Michael D. Gunn, Duke University Medical Center, USA

Martin Lipp, Max-Delbrueck-Center, MDC, Germany
Systemic Organization of the Immune Response by Homeostatic Chemokines

James J. Campbell, Brigham and Women's Hospital, USA
Developmental Switch in Chemokine Responses during T Cell Maturation

Kouji Matsushima, University of Tokyo School of Medicine, Japan
Regulation of Immune Responses by Chemokines and Dendritic Cells

Uta Elisabeth Höpken, Max Delbruck Center for Molecular Medicine, Germany
Short Talk: The Chemokine Receptor CCR7 Controls Allogeneic Cytotoxic T Cell Priming

Sanjiv A. Luther, University of Lausanne, Switzerland
Short Talk: Overlapping Roles of CXCR5, IL-7 Receptor alpha and CCR7 in Lymph Node Development

Carla Eponina Carvalho-Pinto, Centro Nacional de Biotecnologia, Spain
Short Talk: Characterization of Chemokines and their Receptor Expression Pattern during Insulitis in IDDM

Jana Barlic, National Institutes of Health, USA
Short Talk: IL-15 Negatively Regulates CX3CR1 Surface Expression and Message Accumulation

9:20—9:40 AM
Coffee Break

11:30 AM—1:00 PM
Poster Setup

Peaks 1-3
1:00—9:00 PM
Poster Viewing

Peaks 1-3
4:00—4:30 PM
Coffee & Snacks Available

4:30—6:30 PM
Chemokines and Disease I

Peaks 4-5
* Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK

Sergio A. Lira, Mount Sinai School of Medicine, USA
The Role of HHV8-ORF74 in Angiogenesis

Philip M. Murphy, NIAID, National Institutes of Health, USA
Role of CX3CR1 in Atherosclerotic Cardiovascular Disease in Man

Adit Ben-Baruch, Tel Aviv University, Israel
CCL5 and CCL2 in Breast Cancer Progression: Potential Mechanisms of Pro-Malignant Activity

Robert M. Strieter, University of Virginia School of Medicine, USA
CXC Chemokines in Angiogenesis and Organ-Specific Metastases of Lung Cancer

6:30—7:30 PM
Social Hour

Peaks 1-3
7:30—9:00 PM
Poster Session 3: Chemokines in Homing, Cell Trafficking and Disease; Chemokines in Innate and Adaptive Immunity

Peaks 1-3


7:00—8:00 AM

Peaks 6-12
8:00—11:30 AM
Chemokines and Disease II

Peaks 4-5
* Joan W. Berman, Albert Einstein College of Medicine, USA

Timothy J. Williams, Imperial College Faculty of Medicine, UK
The Role of Chemokines in Asthma and Allergy

William J. Karpus, Northwestern University, USA
Chemokine Regulation of Immune-Mediated Demyelinating Disease

Andrew D. Luster, Massachusetts General Hospital, USA
Chemokine Regulation of Fibroblast and Microglial Trafficking in Disease

Nicholas W. Lukacs, University of Michigan, USA
The Role of Chemokines and their Receptors in Airway Disease

O.M. Zack Howard, National Cancer Institute, National Institutes of Health, USA
Short Talk: Several Autoimmune Antigens are Chemoattractants for Immature Dendritic Cells

Stephen C. Robinson, University of California, San Francisco, USA
Short Talk: The Effects of Modifying the Leukocyte Infiltrate in a Mouse Model of Breast Cancer

Michael Briskin, Trammel Therapeutics, USA
Short Talk: CCR9 Plays a Major Role in the Establishment of Intestinal Inflammation in a Murine Model of Inflammatory Bowel Disease

Padraic Fallon, Trinity College Dublin, Ireland
Short Talk: Identification of a Schistosoma mansoni Chemokine-Binding Protein

9:20—9:40 AM
Coffee Break

2:00—4:00 PM
Workshop 2: In Memory of Ian Clark-Lewis, University of British Columbia

Peaks 4-5
* Ji Ming Wang, National Cancer Institute, National Institutes of Health, USA

Ann-Charlotte Lundstedt, Lund University, Sweden
Low CXCR1 Expression, SNPs and Susceptibility to Pyelonephritis

Rachel E. Kohler, University of Adelaide, Australia
Regulation of Chemokine Receptor Expression during Central Nervous System (CNS) Inflammation

Erik H.W.G.M. Boddeke, University of Groningen, Netherlands
Neuronal Damage and Induction of CCL21 Expression

Michael T. Liu, University of California, Irvine, USA
CXCL10 Selectively Regulates T Cell Accumulation within the Central Nervous System in a Viral Model of Multiple Sclerosis

Kim L. Nelson, AnorMED, Inc., Canada
AMD3100 is a Specific Antagonist of CXCR4

Bodduluri Haribabu†, University of Louisville Health Sciences, USA
Leukotriene B4 Receptors Promote Atherosclerosis by Multiple Mechanisms

Merav Darash-Yahana, NIAID, National Institutes of Health, USA
High Expression Levels of CXCS4 Stimulates Human Prostate Cancer Growth and Vascularization

Christina Anne Bursill, Heart Reserach Institute, Australia
Adenoviral-Mediated Delivery of a Vaccinia Viral Protein ('35K') Blocks CC-Chemokine Activity in vitro and in vivo

Manuela M. Martins-Green, University of California, Riverside, USA
N- and C-Terminal Peptides of IL-8 and Homologous Chemokines are Independent Ligands for CXCR1-Type Receptors

4:00—4:30 PM
Coffee & Snacks Available

4:30—7:00 PM
Emerging Therapeutics

Peaks 4-5
* Thomas J. Schall, ChemoCentryx, Inc., USA

* Andrew D. Luster, Massachusetts General Hospital, USA

Christopher A. Haskell, Bayer HealthCare, USA
The CCR1 Antagonist BX 471: An Update

Julie M. Strizki, Merck and Co., USA
Development of Small Molecule Antagonists of CCR5 for HIV Therapy

Thomas J. Schall, ChemoCentryx, Inc., USA

Patricia C. Fulkerson, University of Cincinnati College of Medicine, USA
Short Talk: The Chemokine Monokine Induced by IFN-gamma (Mig, CXCL9) is a Potent Inhibitor of Eosinophils in vitro and in vivo

Ada H.C. Kung, Bridge Pharmaceuticals, Inc., USA
Short Talk: Preclinical Anti-HIV Evaluations of Chemically Synthesized RANTES-Based Molecules

Kathy I. Amiri, Vanderbilt-Ingram Cancer Center, USA
Short Talk: The Novel Proteosome Inhibitor VELCADE TM, Formerly Known as PS-341, Blocks Chemokine Mediated Tumor Growth and Induces Apoptosis

7:00—8:00 PM
Social Hour

Peaks 1-3
8:00—11:00 PM

Peaks 1-3



*Session Chair †Invited, not yet responded.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1 R13 AI054464-01

We gratefully acknowledge additional support for this conference from:

Berlex Biosciences

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