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This meeting took place in 2005

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Drugs Against Protozoan Parasites: Target Selection, Structural Biology and Medicinal Chemistry (X6)

Organizer(s) Margaret A. Phillips, Pradipsinh K. Rathod and William N. Hunter
April 9—13, 2005
Copper Mountain Resort • Copper Mountain, Colorado USA
Abstract Deadline: Dec 8, 2004
Late Abstract Deadline:
Scholarship Deadline: Dec 8, 2004
Early Registration Deadline: Feb 9, 2005

Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation and Sponsored by the International Center for Tropical Disease Research

Summary of Meeting:
Appreciate important issues in parasite drug development: Hundreds of millions of people worldwide suffer from diseases caused by protozoan parasites. Effective drugs are lacking for sleeping sickness and leishmaniasis, and current therapies for treating malaria are at risk due to drug resistance. Thus, the development of new lines of anti-protozoan agents is urgently needed. With the sequencing of genomes of organisms responsible for malaria, sleeping sickness, and leishmaniasis, this is an exciting time for the discovery and evaluation of new drug targets, especially when combined with structural biology, combinatorial chemistry, and parasite genetics. Groups of talks, given by chemists, structural biologists, and parasitologists, will exemplify the power of multi-disciplinary collaborations. Experts in drug development outside of parasitology will also be invited in an effort to stimulate their interests in tropical medicine and to learn from their experiences.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


3:00—7:30 PM

6:30—7:30 PM

7:30—8:30 PM
Keynote Address

Bighorn C
Michael H. Gelb, University of Washington, USA
Protein Farnesyltransferase Inhibitors as Agents Against Malaria: Drug Development at Universities with Help from Industry

7:30—8:30 PM
Keynote Address

Bighorn B
Vincent P. Laudet, Ecole Normale Superieure, France
Evolution of Nuclear Receptors


7:00—8:00 AM

8:00—11:15 AM
Comparative Biology. Session Sponsored by The Ellison Medical Foundation

Bighorn C
* Dyann F. Wirth, Harvard School of Public Health, USA

Alan H. Fairlamb, University of Dundee, UK
Enzymes of Trypanothione Metabolism

Daniel E. Goldberg, Washington University, USA
Plasmepsins as Antimalarial Targets

Kasturi Haldar, University of Notre Dame, USA
Host-Pathogen Interactions as Targets in Malarial Infection

William N. Hunter, University of Dundee, UK
Isoprenoid Biosynthetic Enzymes

Tomoyoshi Nozaki, Gunma University Graduate School of Medicine, Japan
Short Talk: Sulfur-Containing Amino Acid Degradation as a Drug Target for Amebiasis: Biochemical and Structural analyses of Methionine gamma-Lyase from Entamoeba histolytica

Achim Schnaufer, University of Edinburgh, UK
Short Talk: RNA Editing as a Drug Target in Trypanosomatids

8:00—11:15 AM
Status of Helminth Genome Projects

Bighorn B
* Najib M. El-Sayed, University of Maryland, USA
The Schistosoma mansoni Genome Project

Matthew Berriman, Wellcome Sanger Institute, UK
Short Talk: The Schistosoma mansoni Genome Project at the Sanger Institute and access via SchistoDB

Elodie Ghedin, New York University, USA
Whole-Genome Analysis of the Parasitic Nematode Brugia malayi

Barton E. Slatko, New England Biolabs, USA
The Genome of Wolbachia: A Parasite within the Human Filarial Parasite, Brugia malayi

Makedonka Mitreva, Washington University School of Medicine, USA
Investigating Hookworm Genomes by Comparative Analysis of Two Ancylostoma Species

Fiona J. Thompson, University of Oxford, UK
Short Talk: An EST Analysis of the Life-Cycle of the Parasitic Nematode Strongyloides ratti

9:20—9:40 AM
Coffee Break

11:15 AM—1:00 PM
Poster Setup

1:00—10:00 PM
Poster Viewing

2:30—4:30 PM
Workshop: Funding Opportunities

Bighorn C
* Akhil B. Vaidya, Drexel University College of Medicine, USA

Robert Ridley, World Health Organization, Switzerland

Solomon O. Nwaka, World Health Organization, Switzerland
Virtual Drug Discovery: lessons learned from public-private partnerships

Martin John Rogers, NIAID, National Institutes of Health, USA

Philip E. Coyne, Uniformed Services University of the Health Sciences, USA

Simon L. Croft, London School of Hygiene & Tropical Medicine, UK

4:30—5:00 PM
Coffee & Snacks Available

5:00—7:00 PM
Functional Genomics

Bighorn C
* Stephen M. Beverley, Washington University School of Medicine, USA

Brendan S. Crabb, Burnet Institute, Australia
The Plasmodium falciparum SERA Proteases are Novel Drug Targets

Gary E. Ward, University of Vermont, USA
Using Small Molecules to Study Host Cell Invasion by T. gondii

Elizabeth A. Winzeler, University of California, San Diego, USA
Short Talk: Systematic Determination of the Targets of Drug Resistance and Immunity

Bo Wu, University of Pennsylvania, USA
Short Talk: Heme Metabolism in Apicomplexan Parasites

Paul Hunt, University of Edinburgh, UK
Short Talk: Linkage Group Selection – A Rapid Molecular Genetics Strategy for Identifying loci Underlying Drug Resistance

5:00—7:00 PM
Transcriptome and Proteome of Helminths

Bighorn B
* Karl F. Hoffmann, University of Cambridge, UK
Identifying Drug Targets From Transcriptome Analysis Of Schistosome Conjugal Biology

Peter Ashton, University of York, UK
Studies on the Schistosome Proteome

Cornelis H. Hokke, Leiden University Medical Center, Netherlands
Schistosome Glycoproteomics: Global Approaches - Detailed Findings

Ben-Wen Li, Washington University School of Medicine, USA
Short Talk: Profiling of Gender-Regulated Gene Transcripts in the Filarial Nematode Brugia malayi by cDNA Oligonucleotide Array Analysis

Steven A. Williams, Smith College, USA
Short Talk: An Update on the New Bruzui Malayi Microarray and other Resources Available through FR3

7:00—8:00 PM
Social Hour

7:30—10:00 PM
Poster Session 1

Bighorn C


7:00—8:00 AM

8:00—11:15 AM
Established Drugs and Targets

Bighorn C
* James H. McKerrow, University of California, San Diego, USA

Sanjeev Krishna, St. George's Hospital Medical School, UK
Artemisinin Targets

Francisco Gamarro, Consejo Superior de Investigaciones Científicas, Spain
Mechanism of Miltefosine Resistance in Leishmania

Stephen A. Ward, Liverpool School of Tropical Medicine, UK
Quinoline QSAR and Heme Access

Paul D. Roepe, Georgetown University, USA
Analysis of Pfcrt Function: Toward a Molecular Understanding of Chloroquine Resistance

Barry P. Rosen, Florida International University, USA
Short Talk: Pentostam Activation and Uptake in Leishmania major: Role of the Sb(V) Reductase LmAcr2 and the Aquaglyceroporin LmAqp1

Maria Paola Costi, University of Modena and Reggio Emilia, Italy
Short Talk: Inhibition of the Folate Pathway in Parasites: Do Antifolates Still Work?

8:00—11:15 AM
Tools to Manipulate Helminth Gene Expression

Bighorn B
* Richard E. Davis, University of Colorado School of Medicine, USA
In vivo and in vitro Analysis of Gene Expression in Helminths

Timothy P. Yoshino, University of Wisconsin-Madison, USA
Gene “muffling” by RNAi in larval schistosomes: an effective functional genomics tool?

Christoph G. Grevelding, Institute for Parasitology, Germany
Short Talk: Transgenic Schistosomes: Progress and Challenges

Mark L. Blaxter, University of Edinburgh, UK
Comparative Nematode Genomics: Exploiting Expressed Sequence Tag and Genome Surveys of Nuclear and Symbiont Genomes

James B. Lok, University of Pennsylvania, USA
Transfection in Strongyloides

Sara Lustigman, New York Blood Center, USA
Short Talk: Cysteine Proteases of Filarial Nematodes: From Genome to Biology

9:20—9:40 AM
Coffee Break

11:15 AM—1:00 PM
Poster Setup

1:00—10:00 PM
Poster Viewing

2:30—4:30 PM
Workshop: RNAi/Transfections in Helminths

* Christoph G. Grevelding, Institute for Parasitology, Germany

* Sara Lustigman, New York Blood Center, USA

Karen L. Bennett, University of Missouri, USA
Cross-Species RNAi: Ascaris Genes Sterilize C. elegans

Jason M. Correnti, Thomas Jefferson University, USA
Longterm Suppression of Cathepsin B Levels by RNAi Retards Schistosome Growth

Julie-Anne Fritz, Australian National University, Australia
Functional Analysis of Nematode-Specific Genes using the Free-Living Nematode, Caenorhabditis elegans

Nicholas Patocka, McGill University, Canada
Cloning and Gene Silencing of a SERT – like Serotonin Transporter of Schistosoma Mansoni

Ahmed Abd El-Aziz Sayed, Illinois State University, USA
Validation by RNAi of Schistosoma mansoni Peroxiredoxins as Essential Parasite Proteins

Warwick N. Grant, , New Zealand
Efficient RNA Inhibition in Trichostrongylus colubriformis

Bernd H. Kalinna, , Germany
Structural Analysis of the Transcribed Sequence of Boudicca, a Schistosoma mansoni Retrotransposon

4:30—5:00 PM
Coffee & Snacks Available

5:00—7:15 PM
Libraries and Screens

Bighorn C
* Simon L. Croft, London School of Hygiene & Tropical Medicine, UK

Meg Phillips, University of Texas Southwestern Medical Center, USA
Targeting Plasmodium Dihydroorotate Dehydrogenase

Mary Ann Powles, Merck Research Laboratories, USA
Discovery of Anti-Infective Agents

Sean T. Prigge, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: Inhibition of Malaria Fatty Acid Biosynthesis: Targeting the beta-ketoacyl-ACP Synthase Enzymes

David A. Fidock, Columbia University Medical Center, USA
Short Talk: Inhibition of Plasmodium falciparum Enoyl ACP Reductase as a Target for Antimalarial Drug Development

Karl A. Werbovetz, Ohio State University, USA
Short Talk: Activity, Metabolism, and Pharmacokinetics of Antikinetoplastid Antimitotic N1,N4-substituted 3,5-Dinitro Sulfanilamides

5:00—7:00 PM
Signaling Pathways in Helminths

Bighorn B
* Philip T. LoVerde, University of Texas Health Science Center, USA
Nuclear Receptors in Schistosomes

Ahmed Osman Egiza, University at Buffalo, State University of New York, USA
Transforming Growth Factor-beta (TGF-beta) Signaling in Schistosoma mansoni

Colette Dissous, INSERM, Institut Pasteur, France
Short Talk: Conservation and Divergence of Receptor Tyrosine Kinase Signaling in the Platyhelminth Schistosoma mansoni

Klaus Ruediger Brehm, Universität Würzburg, Germany
Signaling in Tapeworms

7:00—8:00 PM
Social Hour

7:30—10:00 PM
Poster Session 2

Bighorn C


7:00—8:00 AM

8:00—11:30 AM
Inhibitor Design

Bighorn C
* Wim G.J. Hol, University of Washington, USA

Ian H. Gilbert, University of Dundee, UK
Steroid Biosynthesis as a Drug Target in Parasitic Protozoa

Vern L. Schramm, Albert Einstein College of Medicine, USA
Exploiting the Unique Pathways for Purine and Polyamine Metabolism in Malaria

Lizbeth Hedstrom, Brandeis University, USA
IMP Dehydrogenase and the Dynamics of Drug Selectivity

Pradipsinh K. Rathod, University of Washington, USA
Drug-Induced Mutagenesis in Malaria

Amy C. Anderson, University of Connecticut, USA
Short Talk: A New Architecture for Bifunctional Dihydrofolate Reductase-Thymidylate Synthase: The Structure of the Enzyme from Cryptosporidium hominis

R. Kip Guy, St. Jude Children's Research Hospital, USA
Privileged Scaffold Discovery Libraries for Anti-Protozoan Drug Discovery

Frederick S. Buckner, University of Washington, USA
Short Talk: Protein Farnesyltransferase as a Target for Trypanosoma brucei Drug Development

8:00—11:15 AM
Parasite Molecules that Modulate Host Immune Response

Bighorn B
* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Immunoregulatory Network in Helminth Infections and the Lipid/Immune System Cross Talk

Kalyanasundaram Ramaswamy, University of Illinois, USA
Schistosome-derived molecule in Host Immunoregulation

William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK
Immunomodulatory Properties of the Filarial Nematode Secreted Product, ES-62

Susanne Hartmann, Humboldt University at Berlin, Germany
Short Talk: Filarial tropomyosin: A Potential Allergen and Inducer of IL-10 via TLR-2 Signalling

Malcolm W. Kennedy, University of Glasgow, UK
Short Talk: Atomic Structure and Function of the Polyprotein Allergens of Nematodes

Alison M. Elliott, MRC/UVRI & LSHTM Uganda Research Unit, Uganda
Short Talk

9:20—9:40 AM
Coffee Break

4:30—5:00 PM
Coffee & Snacks Available

5:00—7:00 PM
Clinical Advances

Bighorn C
* Terry Shapiro, Johns Hopkins University, USA

Federico Gómez de las Heras, GlaxoSmithKline, Spain
Discovery of New Antimalarial Drugs

Jonathan L. Vennerstrom, University of Nebraska Medical Center, USA
Synthetic Peroxides as Antimalarials

Christian Burri, Swiss Tropical Institute, Switzerland
Difficulties in the Conduct of Clinical Trials for Registration of New Drugs against Neglected Diseases in Africa

5:00—7:00 PM
Contributions of Immune System to Helminth Development

Bighorn B
* James H. McKerrow, University of California, San Diego, USA
Factors Determining Schistosome Development in the Host Vasculature

Isabelle Christiane Wolowczuk, Institut Pasteur / Institut de Biologie, France
Role of Interleukin-7 in Schistosome development

Sheila M. Donnelly, University of Technology, Sydney, Australia
Short Talk: The Effect of Cathepsin L and Thioredoxin Peroxidase on Macrophages Promotes the Development of Th2 Responses during Infection with Fasciola hepatica

Linda S. Mansfield, Michigan State University, USA
Short Talk

7:00—8:00 PM
Social Hour

Ptarmigan Foyer
8:00—11:00 PM




*Session Chair †Invited, not yet responded.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1 U13 AI60000-01

National Institutes of Health

Grant No. 1R13-AI063800-01

We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Burroughs Wellcome Fund
Institute for OneWorld Health
International Center for Tropical Disease Research

The Ellison Medical Foundation

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:


Merck Research Laboratories

Merck Research Laboratories

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