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This meeting took place in 2005
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Ubiquitin and Signaling (B7)
Organizer(s) Tony Hunter, Claudio Joazeiro and Mark Hochstrasser
February 22—27, 2005
Taos Convention Center (meeting only) • Taos, NM USA
Abstract Deadline: Oct 21, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 22, 2004
Supported by The Director's Fund
Summary of Meeting:
Our understanding of how ubiquitin regulates cellular function has greatly expanded recently, spurred by discoveries of protein families involved in ubiquitin conjugation and de-conjugation and of non-proteasomal signaling functions for ubiquitin. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in various diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins; the challenge is to determine their functions and mechanistic links to the ubiquitin system. The goal of the meeting is to bring together experts from different areas of ubiquitin research, as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.
View Scholarships/Awards
Our understanding of how ubiquitin regulates cellular function has greatly expanded recently, spurred by discoveries of protein families involved in ubiquitin conjugation and de-conjugation and of non-proteasomal signaling functions for ubiquitin. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in various diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins; the challenge is to determine their functions and mechanistic links to the ubiquitin system. The goal of the meeting is to bring together experts from different areas of ubiquitin research, as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, FEBRUARY 22
WEDNESDAY, FEBRUARY 23
THURSDAY, FEBRUARY 24
FRIDAY, FEBRUARY 25
SATURDAY, FEBRUARY 26
SUNDAY, FEBRUARY 27
Conference Program Print | View meeting in 24 hr (international) time
TUESDAY, FEBRUARY 22
7:30—8:30 PM
Keynote Address
Cecile M. Pickart,
Johns Hopkins University, USA
Assembly and Recognition of Polyubiquitin Signals
Assembly and Recognition of Polyubiquitin Signals
8:00—11:15 AM
E3 Ubiquitin Ligases: Function and Substrate Recognition I
*
Daniel J. Finley,
Harvard University, USA
Alexander Varshavsky,
California Institute of Technology, USA
The Functions of the N-End Rule Pathway
The Functions of the N-End Rule Pathway
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
Two SCF-Like Ubiquitin Ligases Linked to Cancer
Two SCF-Like Ubiquitin Ligases Linked to Cancer
Gina D. Visser,
University of Iowa, Carver College of Medicine, USA
Short Talk: c-Cbl RING Finger Tail Sequences are Critical Determinants of EGF Receptor and Sprouty2 Fate
Short Talk: c-Cbl RING Finger Tail Sequences are Critical Determinants of EGF Receptor and Sprouty2 Fate
Cam Patterson,
University of North Carolina at Chapel Hill, USA
CHIP and Degradation of Unfolded Proteins
CHIP and Degradation of Unfolded Proteins
Kathleen L. Gould,
Vanderbilt University, USA
Structure of APC and U box E3s
Structure of APC and U box E3s
Peter S. Brzovic,
University of Washington, USA
Short Talk: NMR Investigations of BRCA1-Directed Ubiquitination: Assembly and Structure of a Multi-Protein Ubiquitin Ligase Complex
Short Talk: NMR Investigations of BRCA1-Directed Ubiquitination: Assembly and Structure of a Multi-Protein Ubiquitin Ligase Complex
4:45—7:00 PM
E3 Ubiquitin Ligases: Function and Substrate Recognition II
Kim D. Finley,
San Diego State University, USA
Short Talk: Defects in Autophagy and Clearance of Ubiquitinated-Proteins are Associated with Progressive Neural Degeneration in Drosophila
Short Talk: Defects in Autophagy and Clearance of Ubiquitinated-Proteins are Associated with Progressive Neural Degeneration in Drosophila
Keiji Tanaka,
Tokyo Metropolitan Institute of Medical Science, Japan
Recognition of Glycosylated Substrates by SCF(Fbs) Ubiquitin Ligases
Recognition of Glycosylated Substrates by SCF(Fbs) Ubiquitin Ligases
Raymond J. Deshaies,
Amgen, Inc., USA
Quantitative Mass Spectrometry for Identification of Targets in the Proteasome Ubiquitin System
Quantitative Mass Spectrometry for Identification of Targets in the Proteasome Ubiquitin System
Jian Hu,
University of North Carolina at Chapel Hill, USA
Short Talk: Targeted Ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 Ligase in Response to DNA Damage
Short Talk: Targeted Ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 Ligase in Response to DNA Damage
8:00—11:00 AM
Deubiquitinating Enzymes
Keith D. Wilkinson,
Emory University, USA
Tools for Analyses of Deubiquitinating Enzymes
Tools for Analyses of Deubiquitinating Enzymes
Kim Orth,
University of Texas Southwestern Medical Center, USA
Short Talk: Biochemical and Structural Characterization of the Effector Protein XopD
Short Talk: Biochemical and Structural Characterization of the Effector Protein XopD
Robert E. Cohen,
University of Iowa, USA
Proteasome-Associated Deubiquitination
Proteasome-Associated Deubiquitination
Sebastian M. B. Nijman,
CeMM, Austrian Academy of Sciences, Austria
Functional Annotation of Deubiquitinating Enzymes Using RNA Interference
Functional Annotation of Deubiquitinating Enzymes Using RNA Interference
Greg Odorizzi,
University of Colorado, USA
Short Talk: The Ubiquitin Thiolesterase Doa4 Controls Vesicle Size in Multivesicular Bodies in Yeast
Short Talk: The Ubiquitin Thiolesterase Doa4 Controls Vesicle Size in Multivesicular Bodies in Yeast
Christopher P. Hill,
University of Utah, USA
Proteasome Activation
Proteasome Activation
4:45—7:00 PM
Ubiquitin-Like Proteins
*
Keith D. Wilkinson,
Emory University, USA
Dong-Er Zhang,
Regents of the University of California, San Diego, USA
ISG15-Specific Isopeptidase UBP43 and Protein ISGylation
ISG15-Specific Isopeptidase UBP43 and Protein ISGylation
Chen Zhao,
University of Texas at Austin, USA
Short Talk: The Human ISD15 Conjugation System Targets both Interferon Induced and Constitutive Espressed Proteins in Diverse Cellular Pathways
Short Talk: The Human ISD15 Conjugation System Targets both Interferon Induced and Constitutive Espressed Proteins in Diverse Cellular Pathways
Frauke Melchior,
Universität Heidelberg, Germany
Postranslational Modification with Ubiquitin Related Proteins of the SUMO Family
Postranslational Modification with Ubiquitin Related Proteins of the SUMO Family
David Reverter,
Sloan-Kettering Institute, USA
Short Talk: Structure and Analysis of an Ubl-Substrate-E2-E3 Complex between SUMO, RanGAP1, Ubc9, and Nup358/RanBP2
Short Talk: Structure and Analysis of an Ubl-Substrate-E2-E3 Complex between SUMO, RanGAP1, Ubc9, and Nup358/RanBP2
Brenda A. Schulman,
Max Planck Institute of Biochemistry, Germany
Structural and Mechanistic Insights into the Nedd8 Conjugation Cascade
Structural and Mechanistic Insights into the Nedd8 Conjugation Cascade
8:00—11:15 AM
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficking
Linda Hicke,
Northwestern University, USA
Regulation of Receptor Endocytosis by Monoubiquitin Signals
Regulation of Receptor Endocytosis by Monoubiquitin Signals
Simona Polo,
FIRC Institute of Molecular Oncology, Italy
Ubiquitination Directs Clathrin-Independent Internalization
Ubiquitination Directs Clathrin-Independent Internalization
James H. Hurley,
University of California, Berkeley, USA
Structural Mechanisms for Intracellular Sorting of Monoubiquitinated Membrane Proteins
Structural Mechanisms for Intracellular Sorting of Monoubiquitinated Membrane Proteins
Ivan Dikic,
Goethe University Medical School, Germany
Regulation of Ub-Binding Proteins by Monoubiquitination
Regulation of Ub-Binding Proteins by Monoubiquitination
Hsiangling Teo,
Nanyang Technological University, Singapore
Short Talk: ESCRT-I and ESCRT-II: Crystal Structures and Interactions
Short Talk: ESCRT-I and ESCRT-II: Crystal Structures and Interactions
Hemmo Meyer,
University Duisburg-Essen, Germany
Short Talk: p97/Cdc48 and its Adapters: a Multifunctional Ubiquitin-Dependent Chaperone System
Short Talk: p97/Cdc48 and its Adapters: a Multifunctional Ubiquitin-Dependent Chaperone System
4:45—7:00 PM
Non-Proteasomal Functions of Ubiquitin II: The Nucleus
Mary Ann Osley,
University of New Mexico School of Medicine, USA
Histone Ubiquitylation: Roles in Transcription Initiation and Elongation
Histone Ubiquitylation: Roles in Transcription Initiation and Elongation
Peter Kaiser,
University of California, Irvine, USA
Short Talk: Ubiquitination Regulates Several Components of the Met4 Transcription Complex
Short Talk: Ubiquitination Regulates Several Components of the Met4 Transcription Complex
Lijun Sun,
University of Texas Southwestern Medical Center, USA
Short Talk: Ubiquitin Signaling in the NF-kappaB Pathway
Short Talk: Ubiquitin Signaling in the NF-kappaB Pathway
Jonathon Pines,
University of Cambridge, UK
Mitosis - What's Ubiquitin Got To Do With It?
Mitosis - What's Ubiquitin Got To Do With It?
8:00—11:00 AM
New Trends
Daniel J. Finley,
Harvard University, USA
Elongation and Disassembly of Multiubiquitin Chains Bound to the Proteasome: Opposing Roles of Ubiquitin-Ligase Hul5 and Deubiquitinating Enzyme Ubp6
Elongation and Disassembly of Multiubiquitin Chains Bound to the Proteasome: Opposing Roles of Ubiquitin-Ligase Hul5 and Deubiquitinating Enzyme Ubp6
Wei Gu,
Columbia University, USA
Dissecting the Complexity in the p53-Ubiquitination Pathway
Dissecting the Complexity in the p53-Ubiquitination Pathway
Sudha K. Shenoy,
Duke University Medical Center, USA
Regulation of ERK Scaffolding and Signaling by Beta-Arrestin Ubiquitination
Regulation of ERK Scaffolding and Signaling by Beta-Arrestin Ubiquitination
Leonard Girnita,
Karolinska Institute, Sweden
Short Talk: Insulin-like Growth Factor-1 (IGF-1R) Ubiquitination: Functional Impact on IGF-1R Signaling Pathways
Short Talk: Insulin-like Growth Factor-1 (IGF-1R) Ubiquitination: Functional Impact on IGF-1R Signaling Pathways
Chris Stefan,
University of California, San Diego, USA
Short Talk: Genome-Wide Screening for Membrane Protein Quality
Short Talk: Genome-Wide Screening for Membrane Protein Quality
Tom K. Kerppola,
University of Michigan, USA
Short Talk: Visualization of Ubiquitination in Living Cells by Ubiquitin-Mediated Fluoresence Complementation
Short Talk: Visualization of Ubiquitination in Living Cells by Ubiquitin-Mediated Fluoresence Complementation
4:45—7:00 PM
The Ubiquitin System: Disease and Drug Targets
*
Christopher P. Hill,
University of Utah, USA
David J. Glass,
Regeneron Pharmaceuticals, Inc., USA
Signaling Pathways Mediating Skeletal Muscle Hypertrophy and Atrophy
Signaling Pathways Mediating Skeletal Muscle Hypertrophy and Atrophy
James Gavin,
Takeda Boston, USA
Short Talk: Drug Discovery in the Pathways for Ubiquitin and Ubiquitin-like Protein Conjugation
Short Talk: Drug Discovery in the Pathways for Ubiquitin and Ubiquitin-like Protein Conjugation
Steven P. Gygi,
Harvard Medical School, USA
Quantitative Proteomics Strategies for the Study of Protein Ubiquitination
Quantitative Proteomics Strategies for the Study of Protein Ubiquitination
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge additional support for this conference from:
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Global Peptide Services |
Proteome Resources LLC |
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