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This meeting took place in 2006
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NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3)
Organizer(s) Alain Israël, David Baltimore and Yinon M. Ben-Neriah
March 23—28, 2006
Fairmont Banff Springs • Banff, AB Canada
Abstract Deadline: Nov 23, 2005
Late Abstract Deadline: Dec 16, 2005
Scholarship Deadline: Nov 23, 2005
Early Registration Deadline: Jan 23, 2006
Supported by The Director's Fund
Summary of Meeting:
The NF-kB signaling pathway is a critical determinant of the inflammatory response, and is involved in both innate and acquired immunity. It also controls apoptosis and is becoming an important target for anticancer therapy. While the components that lead to NF-kB activation are progressively identified, evidence for involvement of NF-kB in multiple human pathologies (cancer, immune deficiencies, diabetes and atherosclerosis) is accumulating. However, a number of questions remain unanswered: the structure of the IKK complex needs to be solved to understand its mode of activation; the respective roles of the multiple NF-kB species have to be precisely defined; the exact function of the multiple components and branches of this cascade need to be addressed by biochemical and genetic approaches. This meeting will bring together people with diverse backgrounds and should generate interactions required for better understanding of this pathway and its associated pathophysiology. Ultimately, these interactions could be translated into new therapeutic modalities.
View Scholarships/Awards
The NF-kB signaling pathway is a critical determinant of the inflammatory response, and is involved in both innate and acquired immunity. It also controls apoptosis and is becoming an important target for anticancer therapy. While the components that lead to NF-kB activation are progressively identified, evidence for involvement of NF-kB in multiple human pathologies (cancer, immune deficiencies, diabetes and atherosclerosis) is accumulating. However, a number of questions remain unanswered: the structure of the IKK complex needs to be solved to understand its mode of activation; the respective roles of the multiple NF-kB species have to be precisely defined; the exact function of the multiple components and branches of this cascade need to be addressed by biochemical and genetic approaches. This meeting will bring together people with diverse backgrounds and should generate interactions required for better understanding of this pathway and its associated pathophysiology. Ultimately, these interactions could be translated into new therapeutic modalities.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
THURSDAY, MARCH 23
FRIDAY, MARCH 24
SATURDAY, MARCH 25
SUNDAY, MARCH 26
MONDAY, MARCH 27
TUESDAY, MARCH 28
Conference Program Print | View meeting in 24 hr (international) time
THURSDAY, MARCH 23
7:30—8:30 PM
Keynote Address
David Baltimore,
California Institute of Technology, USA
NF-kappaB, 20 Years After
NF-kappaB, 20 Years After
8:00—11:15 AM
Signaling 1
*
Alain Israël,
Institut Pasteur, France
Sankar Ghosh,
Columbia University, USA
Regulation of NF-kappaB Transcriptional Activity
Regulation of NF-kappaB Transcriptional Activity
George Mosialos,
B.S.R.C. Alexander Fleming, Greece
Short Talk: Targeted Inactivation of the Cylindromatosis Tumor Suppressor Gene Causes Perinatal Lethality in Mice
Short Talk: Targeted Inactivation of the Cylindromatosis Tumor Suppressor Gene Causes Perinatal Lethality in Mice
Jun Zhang,
National Institutes of Health, USA
Short Talk: CYLD-deficient Mice Display Impaired Regulation of NF-kB and Increased Susceptibility to Colonic Inflammation and Tumorigenesis
Short Talk: CYLD-deficient Mice Display Impaired Regulation of NF-kB and Increased Susceptibility to Colonic Inflammation and Tumorigenesis
Shao-Cong Sun,
University of Texas MD Anderson Cancer Center, USA
Short Talk: CYLD: A Novel Target of IKK Regulating Lck Ubiquitination and T Cell Development
Short Talk: CYLD: A Novel Target of IKK Regulating Lck Ubiquitination and T Cell Development
5:00—7:00 PM
Signaling 2
*
Vishva M. Dixit,
Genentech, Inc., USA
Deciphering the Pathway from the TCR/BCR to NF-kappaB: New Functions for Old Molecules
Deciphering the Pathway from the TCR/BCR to NF-kappaB: New Functions for Old Molecules
Zhijian "James" Chen,
University of Texas Southwestern Medical Center, USA
Mavericks Defense: A Tale of Host Defense Against Viral Offense
Mavericks Defense: A Tale of Host Defense Against Viral Offense
Ezra Burstein,
University of Texas Southwestern Medical Center, USA
Short Talk: COMMD Proteins Inhibit kappaB-Mediated Transcription by Promoting the Ubiquitination of NF-kappaB Subunits through a Cullin E3 Ligase
Short Talk: COMMD Proteins Inhibit kappaB-Mediated Transcription by Promoting the Ubiquitination of NF-kappaB Subunits through a Cullin E3 Ligase
8:00—11:15 AM
Immunity 1
Jules A. Hoffmann,
Institute of Cellular and Molecular Biology, France
NF-kappaB Signaling during Bacterial and Fungal Infection
NF-kappaB Signaling during Bacterial and Fungal Infection
Anjana Rao,
La Jolla Institute for Immunology, USA
NFAT and NF-kappaB: Structural and Functional Similarities and Dissimiliarities
NFAT and NF-kappaB: Structural and Functional Similarities and Dissimiliarities
Tak W. Mak,
Campbell Family Institute for Breast Cancer, Canada
Genetic Dissection of the NFkB Pathways
Genetic Dissection of the NFkB Pathways
*
Klaus Rajewsky,
Max Delbrück Center for Molecular Medicine, Germany
In vivo Analysis of NFkappaB Function in Normal and Malignant B Cell Development
In vivo Analysis of NFkappaB Function in Normal and Malignant B Cell Development
Steven C. Ley,
Francis Crick Institute, UK
Short Talk: Regulation of the TPL-2 / ERK MAP kinase pathway
Short Talk: Regulation of the TPL-2 / ERK MAP kinase pathway
Sophie Janssens,
VIB-UGent Center for Inflammation Research, Belgium
Short Talk
Short Talk
2:30—4:30 PM
Workshop 1: Systems Biology
*
Andre Levchenko,
Yale University, USA
Kevin A. Janes,
University of Virginia, USA
Data Models Linking Cytokines to NF-kappaB to Apoptosis
Data Models Linking Cytokines to NF-kappaB to Apoptosis
Erin H. Breese,
Indiana University School of Medicine, USA
Elucidating SIMPL’s Co-Activator Function through Characterization of Protein-Protein Interactions and NF-kappaB Dependent Promoter Occupancy
Elucidating SIMPL’s Co-Activator Function through Characterization of Protein-Protein Interactions and NF-kappaB Dependent Promoter Occupancy
Raymond Cheong,
Johns Hopkins University, USA
Towards Systems-Level Understanding of NF-kappaB Signaling through Integrated Modeling and Experimentation
Towards Systems-Level Understanding of NF-kappaB Signaling through Integrated Modeling and Experimentation
Barbara Kaltschmidt,
Bielefeld University, Germany
NF-kappaB Regulates Memory Formation and Synaptic Plasticity through PKA/CREB Signaling
NF-kappaB Regulates Memory Formation and Synaptic Plasticity through PKA/CREB Signaling
Stephnie M. Kennedy,
University of Liverpool, UK
Development of Higher throughput Dynamic Imaging of the Function of NF-kappaB Proteins
Development of Higher throughput Dynamic Imaging of the Function of NF-kappaB Proteins
Alison M. O'Mahony,
Bioseek Inc, USA
NF-kappaB/Rel is a Key Regulator of Inhibitory Neuron Function and Synaptic Plasticity
NF-kappaB/Rel is a Key Regulator of Inhibitory Neuron Function and Synaptic Plasticity
Irina A. Udalova,
University of Oxford, UK
Static and Dynamic Conservation of NF-kappaB Binding Sites in Drosophilid Genomes
Static and Dynamic Conservation of NF-kappaB Binding Sites in Drosophilid Genomes
Zhong Chen,
NIDCD, National Institutes of Health, USA
Molecular Profiling Distinguishes Head and Neck Squamous Cell Carcinomas Expressing Novel Gene Signatures Related to NF-kappaB and p53 Status
Molecular Profiling Distinguishes Head and Neck Squamous Cell Carcinomas Expressing Novel Gene Signatures Related to NF-kappaB and p53 Status
5:00—7:00 PM
Immunity 2
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
Toll pathway of innate immunity
Toll pathway of innate immunity
Akira Shizuo,
Osaka University, Japan
TLR-dependent and-independent signaling pathways in pathogen recognition
TLR-dependent and-independent signaling pathways in pathogen recognition
*
Ulrich K. Siebenlist,
NIAID, National Institutes of Health, USA
Roles of NF-kappaB in Control of Autoimmunity
Roles of NF-kappaB in Control of Autoimmunity
Kenya Honda,
Keio University School of Medicine, Japan
Short Talk: Regulation of MyD88-Dependent Signaling Pathways by IRF-1
Short Talk: Regulation of MyD88-Dependent Signaling Pathways by IRF-1
8:00—11:00 AM
Transcription
*
Albert S. Baldwin Jr.,
University of North Carolina School of Medicine, USA
NF-kappaB/IKK Pathways in Control of Gene Expression and Oncogenesis
NF-kappaB/IKK Pathways in Control of Gene Expression and Oncogenesis
Alexander Hoffmann,
University of California, Los Angeles, USA
Achieving Stimulus-Specific Gene Expression via NF-kappaB
Achieving Stimulus-Specific Gene Expression via NF-kappaB
Yinon M. Ben-Neriah,
Hebrew University, Hadassah Medical School, Israel
Tissue Specific Control of NF-kappaB Activation
Tissue Specific Control of NF-kappaB Activation
Genhong Cheng,
University of California, Los Angeles, USA
Short Talk: Rescue of TRAF3 Null Mice by p100 NF-kB Deficiency
Short Talk: Rescue of TRAF3 Null Mice by p100 NF-kB Deficiency
Denis C. Guttridge,
Ohio State University, USA
Short Talk
Short Talk
2:30—4:30 PM
Workshop 2: Diseases and Therapeutics
*
Frank Mercurio,
BioTheryX, Inc., USA
Roberta Brambilla,
University of Miami, USA
Transgenic Inactivation of Astroglial NF-kappaB Improves Functional Recovery Following Spinal Cord Injury and Experimental Autoimmune Encephalomyelitis
Transgenic Inactivation of Astroglial NF-kappaB Improves Functional Recovery Following Spinal Cord Injury and Experimental Autoimmune Encephalomyelitis
Jessica E. Hutti,
AbbVie, Inc., USA
The Role of IKK Substrate Specificity in Coordinating Innate Immune Signaling Responses
The Role of IKK Substrate Specificity in Coordinating Innate Immune Signaling Responses
Scott J. Russo,
Icahn School of Medicine at Mount Sinai, USA
NF-kappaB Signaling Controls Behavioral and Cellular Plasticity Associated with Cocaine Addiction
NF-kappaB Signaling Controls Behavioral and Cellular Plasticity Associated with Cocaine Addiction
Carter Van Waes,
NIDCD, National Institutes of Health, USA
The Proteasome, IKK, and p53 in Activation of NF-kappaB and Therapy of Head and Neck Squamous Cell Carcinoma
The Proteasome, IKK, and p53 in Activation of NF-kappaB and Therapy of Head and Neck Squamous Cell Carcinoma
Catherine E. Wharry,
University of Pennsylvania, USA
Non-Canonical NF-kappaB Regulation in Pancreatic Ductal Carcinoma
Non-Canonical NF-kappaB Regulation in Pancreatic Ductal Carcinoma
Florian R. Greten,
Institute for Tumor Biology and Experimental Therapy, Germany
Increased IL-1beta Processing Leads to Impaired Survival of Myeloid Specific IKKbeta Deficient Mice during LPS-Induced Septic Shock
Increased IL-1beta Processing Leads to Impaired Survival of Myeloid Specific IKKbeta Deficient Mice during LPS-Induced Septic Shock
Derek A. Mann,
Newcastle University, UK
Real-Time in vivo Analysis of NF-kappaB Activation Reveals a Role for the Liver as a Regulator of Acute Brain Inflammation
Real-Time in vivo Analysis of NF-kappaB Activation Reveals a Role for the Liver as a Regulator of Acute Brain Inflammation
Thomas Wirth,
Ulm University, Germany
Constitutive Activation of IKK2 is Sufficient to Induce Pancreatitis
Constitutive Activation of IKK2 is Sufficient to Induce Pancreatitis
5:00—7:00 PM
Cancer
Shigeki Miyamoto,
University of Wisconsin, Madison, USA
Mechanisms of NF-kappaB Activation in Response to Genotoxic Stimuli.
Mechanisms of NF-kappaB Activation in Response to Genotoxic Stimuli.
*
Claus Scheidereit,
Max Delbrück Center for Molecular Medicine, Germany
NF-kappaB Function in Tumor Cells and Morphogenesis
NF-kappaB Function in Tumor Cells and Morphogenesis
Manolis Pasparakis,
University of Cologne, Germany
Function of IKK Subunits in Physiology and Disease
Function of IKK Subunits in Physiology and Disease
Laura M. DeBusk,
Vanderbilt University, USA
Short Talk: IKK-alpha Activation Induces Tumor Angiogenesis
Short Talk: IKK-alpha Activation Induces Tumor Angiogenesis
8:00—11:15 AM
Human Pathologies/Global System Analysis 1
*
Michael Karin,
University of California, San Diego, USA
The IKK Complex and its Role in Normal and Diseased Tissues
The IKK Complex and its Role in Normal and Diseased Tissues
*
Steve D. Gerondakis,
Monash University, Australia
NF-kappaB Regulation of Myeloid Differentiation
NF-kappaB Regulation of Myeloid Differentiation
Giulio Superti-Furga,
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Mapping Complex Regulatory Networks
Mapping Complex Regulatory Networks
Mollie K. Meffert,
Johns Hopkins University School of Medicine, USA
NF-kappaB in Synaptic Function:
NF-kappaB in Synaptic Function:
Deborah Veis Novack,
Washington University, USA
Short Talk: RelB is Critical for Stimulated Osteoclastogenesis
Short Talk: RelB is Critical for Stimulated Osteoclastogenesis
Brendan J. O'Sullivan,
Centre for Immunology and Cancer Research, Australia
Short Talk: RelB Serves a Dual Role in Hemopoietic and Stromal Cell Compartments to Maintain Tolerance and Contain Inflammation through Dendritic Cells and Regulatory T Cells
Short Talk: RelB Serves a Dual Role in Hemopoietic and Stromal Cell Compartments to Maintain Tolerance and Contain Inflammation through Dendritic Cells and Regulatory T Cells
5:00—7:00 PM
Human Pathologies/Global System Analysis 2
*
Alain Israël,
Institut Pasteur, France
Genetic and Biochemical Analysis of the NF-ƒÛB Signaling Cascade
Genetic and Biochemical Analysis of the NF-ƒÛB Signaling Cascade
Louis M. Staudt,
NCI, National Institutes of Health, USA
Genetic Screens with an RNA Interference Library to Identify New Molecular Targets in Cancer
Genetic Screens with an RNA Interference Library to Identify New Molecular Targets in Cancer
Howard Y. Chang,
Stanford University, USA
Short Talk: Reversal of Epidermal Aging by NF-kappaB Blockade
Short Talk: Reversal of Epidermal Aging by NF-kappaB Blockade
*Session Chair †Invited, not yet responded.
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