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This meeting took place in 2007
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Host Cell Interaction and Response to the Cancer Cell (A8)
Organizer(s) David A. Cheresh and Nicholas P. Restifo
January 21—26, 2007
Keystone Resort • Keystone, CO USA
Abstract Deadline: Sep 21, 2006
Late Abstract Deadline: Oct 24, 2006
Scholarship Deadline: Sep 21, 2006
Early Registration Deadline: Nov 21, 2006
Supported by the Director's Fund
Summary of Meeting:
Tumor growth and invasion depends on the ability of tumor cells to respond to a wide range of host cells. However, it is clear that host cells also respond to the presence of the tumor. In fact it is the outcome of these cellular interactions that may well predict the clinical course of a wide variety of cancers. During growth at the primary site, tumor cells interact locally with fibroblasts and their extracellular matrix. Tumors often produce an inflammatory response causing immune cell recruitment to the tumor; the ability of a tumor cell to evade this immune recognition is a critical determinant of the tumor’s capacity to spread. Tumor cell invasion and metastasis also depend on the ability of tumor cells to recruit a blood supply to nourish the tumor. The resulting blood vessels often serve as a conduit for metastasis. While in the circulation, interactions between tumor cells and platelets can further facilitate tumor metastasis. Ultimately, tumors respond to a variety of cells and microenvironments in a wide range of organs including the lymph node, lung, liver, brain, and bone. Given the critical role of tumor cell-host cell interactions in tumor growth and metatasis as well as the therapeutic potential offered by intervening in these interactions, developing a better understanding of the molecular basis for these cellular interactions is imperative. In addition, it is critical to determine how these cell-cell interactions directly influence the cancer cell and its gene expression, proliferation rate, and capacity to evade recognition by host immune cells. The goal of this meeting is to bring together experts in areas such as tumor immunology, angiogenesis and tumor cell biology to begin to define the host cellular response to the tumor and to identify new molecular pathways leading to a better understanding of tumor invasion and metastasis.
View Scholarships/Awards
Tumor growth and invasion depends on the ability of tumor cells to respond to a wide range of host cells. However, it is clear that host cells also respond to the presence of the tumor. In fact it is the outcome of these cellular interactions that may well predict the clinical course of a wide variety of cancers. During growth at the primary site, tumor cells interact locally with fibroblasts and their extracellular matrix. Tumors often produce an inflammatory response causing immune cell recruitment to the tumor; the ability of a tumor cell to evade this immune recognition is a critical determinant of the tumor’s capacity to spread. Tumor cell invasion and metastasis also depend on the ability of tumor cells to recruit a blood supply to nourish the tumor. The resulting blood vessels often serve as a conduit for metastasis. While in the circulation, interactions between tumor cells and platelets can further facilitate tumor metastasis. Ultimately, tumors respond to a variety of cells and microenvironments in a wide range of organs including the lymph node, lung, liver, brain, and bone. Given the critical role of tumor cell-host cell interactions in tumor growth and metatasis as well as the therapeutic potential offered by intervening in these interactions, developing a better understanding of the molecular basis for these cellular interactions is imperative. In addition, it is critical to determine how these cell-cell interactions directly influence the cancer cell and its gene expression, proliferation rate, and capacity to evade recognition by host immune cells. The goal of this meeting is to bring together experts in areas such as tumor immunology, angiogenesis and tumor cell biology to begin to define the host cellular response to the tumor and to identify new molecular pathways leading to a better understanding of tumor invasion and metastasis.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 21
MONDAY, JANUARY 22
TUESDAY, JANUARY 23
WEDNESDAY, JANUARY 24
THURSDAY, JANUARY 25
FRIDAY, JANUARY 26
Conference Program Print | View meeting in 24 hr (international) time
SUNDAY, JANUARY 21
7:30—8:30 PM
Keynote Address: Cancer and the Inflammatory Response
Michael Karin,
University of California, San Diego, USA
Inflammation and Cancer
Inflammation and Cancer
8:00—11:00 AM
Tumor Response to Host Cells
*
Harold L. Moses,
Vanderbilt University, USA
TGF-beta Regulation of Stromal Cells in Cancer Initiation and Progression
TGF-beta Regulation of Stromal Cells in Cancer Initiation and Progression
Ronald A. DePinho,
University of Texas MD Anderson Cancer Center, USA
FoxOs in Cancer and Aging
FoxOs in Cancer and Aging
Filippo G. Giancotti,
Memorial Sloan-Kettering Cancer Center, USA
Genetic Analysis of Integrin Signaling during Breast Tumorigenesis
Genetic Analysis of Integrin Signaling during Breast Tumorigenesis
Yves A. DeClerck,
Children's Hospital Los Angeles, USA
Bone Marrow Microenvironment and Tumor Progression
Bone Marrow Microenvironment and Tumor Progression
Marina Bacac,
University of Lausanne, Switzerland
Short Talk: A Mouse Stromal Response to Tumor Invasion Predicts Prostate and Breast Cancer Patient Survival
Short Talk: A Mouse Stromal Response to Tumor Invasion Predicts Prostate and Breast Cancer Patient Survival
5:00—7:00 PM
Tumor Response to Host Cells II
*
Joan Massagué,
Memorial Sloan Kettering Cancer Center, USA
Site-Specific Metastasis Genes and Functions
Site-Specific Metastasis Genes and Functions
Brunhilde Felding-Habermann,
The Scripps Research Institute, USA
Platelet Adhesive Interactions with Tumor Cells
Platelet Adhesive Interactions with Tumor Cells
Ruth J. Muschel,
John Radcliffe Hospital, UK
Coagulation, Blood Vessels and Pulmonary Metastasis
Coagulation, Blood Vessels and Pulmonary Metastasis
Jennifer Kirstein,
University of Western Ontario, Canada
Short Talk: Effect of Coagulation on Melanoma Metastasis in Aprotinin Treated Animals
Short Talk: Effect of Coagulation on Melanoma Metastasis in Aprotinin Treated Animals
8:00—11:15 AM
Vascular Response to the Tumor
*
Gabriele A.I. Bergers,
University of Leuven, Belgium
Hypoxia-Dependent Mechanisms of Blood Vessel Formation in Tumors
Hypoxia-Dependent Mechanisms of Blood Vessel Formation in Tumors
Donald M. McDonald,
University of California, San Francisco, USA
Imaging the Vascular Compartment in Tumors: Effects of Angiogenesis Inhibitors
Imaging the Vascular Compartment in Tumors: Effects of Angiogenesis Inhibitors
Harold F. Dvorak,
Beth Israel Deaconess Medical Center, USA
Building Tumor Blood Vessels
Building Tumor Blood Vessels
Bruce R. Zetter,
Children's Hospital Boston, USA
Microenvironmental Control of Prostate Cancer Growth via Protein Degradation
Microenvironmental Control of Prostate Cancer Growth via Protein Degradation
Raghu Kalluri,
University of Texas MD Anderson Cancer Center, USA
Matrix and Tumor Microenvironment in Cancer Progression and Metastasis
Matrix and Tumor Microenvironment in Cancer Progression and Metastasis
5:00—7:00 PM
Vascular Response to the Tumor II
*
Judith A. Varner,
University of California, San Diego, USA
Integrin Roles in Tumor Angiogenesis and Lymphangiogenesis
Integrin Roles in Tumor Angiogenesis and Lymphangiogenesis
Elisabetta Dejana,
Uppsala University, Sweden
Cadherins in Cancer and Tumor Vasculature
Cadherins in Cancer and Tumor Vasculature
Alireza Alavi,
Autolus Inc, USA
Short Talk: Chemoresistance of Endothelial Cells Induced by bFGF Depends on Raf-1-Mediated Inhibition of the Pro-Apoptotic Kinase, ASK1
Short Talk: Chemoresistance of Endothelial Cells Induced by bFGF Depends on Raf-1-Mediated Inhibition of the Pro-Apoptotic Kinase, ASK1
Carmen Z. Cantemir-Stone,
Ohio State University, USA
Short Talk: Critical Role of Ets2 in Regulating Fibroblasts Survival and Activity in the Breast Cancer Microenvironment
Short Talk: Critical Role of Ets2 in Regulating Fibroblasts Survival and Activity in the Breast Cancer Microenvironment
8:00—11:00 AM
Vascular and Lymphatic Invasion
*
David A. Cheresh,
University of California, San Diego, USA
Angiogenesis Inhibition by Stabilizing the DFG/P-Loop Interaction in Raf
Angiogenesis Inhibition by Stabilizing the DFG/P-Loop Interaction in Raf
Carlos Bais,
Genentech, Inc., USA
Targeting VEGF to Attack Pathological Blood Supply
Targeting VEGF to Attack Pathological Blood Supply
Mary J.C. Hendrix,
Children's Memorial Research Center at Northwestern University, USA
Targeting the Plasticity of Metastatic Tumor Cells
Targeting the Plasticity of Metastatic Tumor Cells
Michael C. Schmid,
University of Liverpool, UK
Short Talk: SDF-1alpha and IL-1beta Activate Integrin alpha4beta1 to Promote Homing of Bone Marrow Derived Cells to Tumor Vasculature
Short Talk: SDF-1alpha and IL-1beta Activate Integrin alpha4beta1 to Promote Homing of Bone Marrow Derived Cells to Tumor Vasculature
Young Chul Kim,
University of Wisconsin, Madison, USA
Short Talk: Wnt1 Activates Stromal Cells and Mobilizes Endothelial Precursor Cells During Mouse Mammary Tumor Development
Short Talk: Wnt1 Activates Stromal Cells and Mobilizes Endothelial Precursor Cells During Mouse Mammary Tumor Development
5:00—7:00 PM
Recognition of the Cancer Cell
*
Ulf R. Rapp,
University of Wurzburg, Germany
Role of Angiogenic Switch Induction and Tumor Stem Cells in Progression of Raf-Induced Lung Tumors to Metastasis
Role of Angiogenic Switch Induction and Tumor Stem Cells in Progression of Raf-Induced Lung Tumors to Metastasis
Masataka Majima,
Kitasato University School of Medicine, Japan
Inflammatory Response to Cancer. Role of Prostaglandins in Tumor-associated Angiogenesis
Inflammatory Response to Cancer. Role of Prostaglandins in Tumor-associated Angiogenesis
Thomas Blankenstein,
Max Delbruck Center for Molecular Medicine, Germany
Transgenic Mice with Sporadic Immunogenic Tumors
Transgenic Mice with Sporadic Immunogenic Tumors
Mikala Egeblad,
Cold Spring Harbor Laboratory, USA
Short Talk: Dynamic Imaging in Living Mice Reveals Effects of the Tumor Microenvironment on Leukocyte Behavior
Short Talk: Dynamic Imaging in Living Mice Reveals Effects of the Tumor Microenvironment on Leukocyte Behavior
8:00—11:30 AM
How Tumor Cells Exploit Host Immune Defenses and Tissue / Stromal Barriers
*
Judith Campisi,
Buck Institute for Research on Aging, USA
Stromal-Epithelial Interactions in Aging and Cancer
Stromal-Epithelial Interactions in Aging and Cancer
Peter Friedl,
NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Protease Requirements in Cancer Invasion in vitro and in Vivo: From Individual to Collective Cell Migration
Protease Requirements in Cancer Invasion in vitro and in Vivo: From Individual to Collective Cell Migration
Jeffrey W. Pollard,
Queen's Medical Research Institute, UK
Tumor-Educated Macrophages as Promoters of Tumor Progression
Tumor-Educated Macrophages as Promoters of Tumor Progression
Alberto Mantovani,
Humanitas University, Italy
Smoldering Inflammation in the Initiation and Promotion of Malignant Disease
Smoldering Inflammation in the Initiation and Promotion of Malignant Disease
Michael Bouvet,
University of California, San Diego, USA
Short Talk: In vivo Color-Coded Imaging of the Interaction of Colon Cancer Cells and Splenocytes in the Formation of Liver Metastases
Short Talk: In vivo Color-Coded Imaging of the Interaction of Colon Cancer Cells and Splenocytes in the Formation of Liver Metastases
Shahin Rafii,
Weill Cornell Medical College, USA
Contribution of Bone Marrow's Vascular Microenvironment to Tumor Angiogenesis
Contribution of Bone Marrow's Vascular Microenvironment to Tumor Angiogenesis
5:00—7:00 PM
New Therapies Based on Host Interactions with the Cancer Cell
*
Hans Schreiber,
University of Chicago, USA
New Strategies of Cancer Therapy by Targeting Antigens Resulting from Tumor-Specific Mutations
New Strategies of Cancer Therapy by Targeting Antigens Resulting from Tumor-Specific Mutations
Drew M. Pardoll,
Johns Hopkins University School of Medicine, USA
How Suppression of Stat3 Activation Potentiates Innate and Adaptive Anti-Tumor Immunity
How Suppression of Stat3 Activation Potentiates Innate and Adaptive Anti-Tumor Immunity
Nicholas P. Restifo,
Lyell, USA
Adoptive Immunotherapy: Building on Success
Adoptive Immunotherapy: Building on Success
*Session Chair †Invited, not yet responded.
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