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This meeting took place in 2008



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Inflammation, Microenvironment and Cancer (D2)


Organizer(s) Michael Karin and Mina J. Bissell
March 30—April 4, 2008
Snowbird Resort • Snowbird, UT USA
Abstract Deadline: Dec 4, 2007
Late Abstract Deadline: Jan 2, 2008
Scholarship Deadline: Dec 4, 2007
Early Registration Deadline: Jan 30, 2008

Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development

Summary of Meeting:
In recent years it has become increasingly clear that the inflammatory and innate immune system plays a critical role in cancer development and progression. Initial hints for a potential link between infection, inflammation and cancer came from epidemiological studies. However the subsequent proof of a mechanistic link between inflammation and cancer came from studies in mouse models of cancer. Such studies have highlighted the important function of cells of the innate immune system, especially macrophages, in cancer development and progression. In addition such studies provided evidence for the important pro-carcinogenic function of certain inflammatory signal transduction pathways, especially those leading to NF-kappaB activation. However, it is also becoming evident that the adaptive immune system has a considerable impact on tumor development that can be both negative and positive. Undoubtedly, future development of immunotherapeutic approaches to cancer treatment will have to consider all of these factors and manipulate them in a way that will allow more effective tumor elimination. This meeting will consider the different mechanisms and pathways through which inflammation and immunity affect cancer development. In addition, the contribution of other cells in the tumor microenvironments, such as myofibroblasts and cancer stem cells, will be discussed. Presentations will include state-of-the-art animal studies indicating that even potent oncogenes do not lead to cancer without assistance from activated inflammatory cells. In addition to being a fertile area for research and an important source for new ideas in cancer biology, the inflammation and cancer field is likely to provide us with novel therapeutic opportunities. This meeting will therefore be a source of inspiration of basic and translational researchers alike.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


SUNDAY, MARCH 30

3:00—7:30 PM
Registration

Ballroom Lobby
6:30—7:30 PM
Refreshments

Ballroom Lobby
7:30—8:30 PM
Keynote Address

Ballroom 2-3
Alberto Mantovani, Humanitas University, Italy
Inflammation and Cancer: An Intrinsic and an Extrinsic Pathway


MONDAY, MARCH 31

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles
8:00—11:00 AM
Innate Immunity and Cancer

Ballroom 2-3
* Jürg Tschopp, University of Lausanne, Switzerland
RNA Helicases and HCV

Laurence Zitvogel, Institut Gustave Roussy, France
The Molecular Bases of the Immunogenicity of Cell Death

Vishva M. Dixit, Genentech, Inc., USA
Role of cIAP1/2 in the Non-Canonical NF-kappaB Survival Pathway

Robert D. Schreiber, Washington University School of Medicine, USA
Cancer Immunoediting: Distinct Roles for Innate and Adaptive Immunity in Cancer Control and Promotion

9:20—9:40 AM
Coffee Break

Ballroom Lobby & Mezzanine
11:00 AM—1:00 PM
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
1:00—10:00 PM
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
4:30—5:00 PM
Coffee Available

Ballroom Lobby & Mezzanine
5:00—7:00 PM
Adaptive Immunity

Ballroom 2-3
Martin Oft, ARMO BioSciences, USA
IL-23 Induces Immune Deviation in Tumors

* Hans Schreiber, University of Chicago, USA
Stromal Cross-Presentation and the Destruction of the Tumor Microenvironment by T Cells

George C. Prendergast, Lankenau Institute for Medical Research, USA
Genetics and Therapeutic Correction of Immune Escape in Cancer

Matthias Ernst, Olivia Newton-John Cancer Research Institute, Australia
Short Talk: Stat3 and Stat1 Functionally Cooperate in IL-11-Dependent, Inflammation-Associated Gastric Cancer in gp130 Mutant Mice

7:00—8:00 PM
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
7:30—10:00 PM
Poster Session 1

Superior/Superior Lobby/Wasatch/Maybird

TUESDAY, APRIL 1

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles
8:00—11:00 AM
Microenvironment

Ballroom 2-3
Claire E. Lewis, University of Sheffield Medical School, UK
Activation of the Potent, Pro-Tumour Functions of Macrophages by the Tumour Microenvironment

Randall S. Johnson, University of Cambridge, UK
Hypoxia

Shahin Rafii, Weill Cornell Medical College, USA
Contribution of Pro-Angiogenic Hematopoietic Cells to Tumor Growth

* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Control of Cell Deaths in Tumour Microenviroment

9:20—9:40 AM
Coffee Break

Ballroom Lobby & Mezzanine
11:00 AM—1:00 PM
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
1:00—10:00 PM
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
4:30—5:00 PM
Coffee Available

Ballroom Lobby & Mezzanine
5:00—7:00 PM
Cytokines and Chemokines

Ballroom 2-3
Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Targeting Inflammatory Cytokines in the Tumor Microenvironment

Markus F. Neurath, University Hospital Erlangen, Germany
IL-6 in Chronic Intestinal Inflammation and Colon Cancer

* Ann Richmond, Vanderbilt University School of Medicine, USA
Chemokines and Cancer Biology

7:00—8:00 PM
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
7:30—10:00 PM
Poster Session 2

Superior/Superior Lobby/Wasatch/Maybird

WEDNESDAY, APRIL 2

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles
8:00—11:00 AM
Animal Models

Ballroom 2-3
Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas, Spain
Ras Oncogenes, Inflammation and Pancreatic Cancer

* Dafna Bar-Sagi, New York University School of Medicine, USA
Chronic Inflammation and the Pathogenesis of Pancreatic Cancer

Lisa M. Coussens, Oregon Health & Science University, USA
Polarized Immune Responses Differentially Regulate Cancer Development

Eli Pikarsky, Hadassah, Hebrew University Medical Center, Israel
Short Talk: Molecular Mechanisms for Liver Tumor Inhibition by non Steroidal Anti- Inflammatory Drugs

Michael Karin, University of California, San Diego, USA
Inflammatory Processes in Metastatic Progression

9:20—9:40 AM
Coffee Break

Ballroom Lobby & Mezzanine
11:00 AM—1:00 PM
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
1:00—10:00 PM
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
4:30—5:00 PM
Coffee Available

Ballroom Lobby & Mezzanine
5:00—7:00 PM
Bacteria Viruses Tissue Injury

Ballroom 2-3
James G. Fox, Massachusetts Institute of Technology, USA
Helicobacters, Chronic Inflammation and Cancer

Timothy C. Wang, Columbia University, USA
Gastric Cancer

* Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
AP-1(Fos/Jun) in Inflammation and Cancer Development

Xin-Yuan Fu, National University of Singapore, Singapore
Short Talk: Stats and Inflammation

7:00—8:00 PM
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
7:30—10:00 PM
Poster Session 3

Superior/Superior Lobby/Wasatch/Maybird

THURSDAY, APRIL 3

7:00—8:00 AM
Breakfast

Golden Cliff/Eagles
8:00—11:00 AM
Fibroblasts and Stem Cells

Ballroom 2-3
Nancy J. Boudreau, NCI, National Institutes of Health, USA
The Role of Microenvironment in Breast Cancer and Mammary Cell Fate

Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Regulation of in Situ to Invasive Carcinoma Transition

Judith Campisi, Buck Institute for Research on Aging, USA
The Pro-Inflammatory and Pro-Carcinogenic Senescent Microenvironment

Harold L. Moses, Vanderbilt University, USA
TGF-beta and Metastasis

9:20—9:40 AM
Coffee Break

Ballroom Lobby & Mezzanine
4:30—5:00 PM
Coffee Available

Ballroom Lobby & Mezzanine
5:00—7:15 PM
Therapeutics

Ballroom 2-3
Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Targeting Host Stromal Microenvironment in Developing New Cancer Therapies

Roya Khosravi-Far, Harvard Medical School, Beth Israel Deaconess Medical Center, USA
A Novel Connection between the Bcr-Abl and the Forkhead Family of Tumor Suppressors

* David A. Cheresh, University of California, San Diego, USA
Raf Kinase as Target for Tumor Growth and Angiogenesis

Douglas Hanahan, ISREC, Switzerland
Short Talk: Distinctive Pro-Angiogenic Roles by Cancer-Associated Fibroblasts and Inflammatory Macrophages in the Neoplasctic Cell Enveronment.

George C. Prendergast, Lankenau Institute for Medical Research, USA
Genetics and Therapeutic Correction of Immune Escape in Cancer

8:00—9:00 PM
Social Hour with Lite Bites

Ballroom 2-3
8:00—11:00 PM
Entertainment

Ballroom 2-3

FRIDAY, APRIL 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA132250-01




We gratefully acknowledge additional support for this conference from:

EntreMed, Inc. Pfizer Global Research & Development

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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