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This meeting took place in 2008

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NK and NKT Cell Biology (X5)

Organizer(s) Michael B. Brenner and Lewis L. Lanier
February 24—29, 2008
Keystone Resort • Keystone, CO USA
Abstract Deadline: Oct 29, 2007
Late Abstract Deadline: Nov 27, 2007
Scholarship Deadline: Oct 29, 2007
Early Registration Deadline: Dec 27, 2007

Sponsored by Novo Nordisk A/S

Summary of Meeting:
Innate immunity is immediate and involves invariant receptors that recognize conserved structures in microbes or host-encoded ligands induced by stress, inflammation or transformation. Although myeloid cells comprise the majority of leukocytes mediating innate immunity, two specialized lymphocyte populations, NK cells and NKT cells, play a central role in orchestrating and amplifying the innate response – and in shaping the nature of the adaptive response of T cells and B cells. The “NK and NKT Cell Biology” meeting will bring together, for the first time, researchers focusing on NK cells and NKT cells. This should initiate discussions, foster collaborations and lead to a better understanding how these cells use independent recognition mechanisms to achieve common effector functions and work coordinately to mediate immune responses against tumors and pathogens, as well as influence autoimmunity.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time



Shavano Peak Foyer

Shavano Peak Foyer
Keynote Address

Grays 2-3
Irving L. Weissman, Stanford University, USA
Self and Non-Self Recognition by the Innate Immune System

Keynote Address

Red Cloud/Shavano
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Michael Karin, University of California, San Diego, USA
IKK-NF-kappaB Signaling and the Control of Caspase Activation and Cell Survival



Grays 1/Torreys
Structure of NK and NKT Cell Recognition Molecules

Grays 2-3
Lewis L. Lanier, University of California, San Francisco, USA
Introduction & Welcome

Michael B. Brenner, Harvard Medical School, USA

Peter D. Sun, NIAID, National Institutes of Health, USA
Ligand Recognition by NK Receptors

Ian A. Wilson, The Scripps Research Institute, USA
Structural Analysis of Potent NKT Cell Agonists

* Yvonne Yvonne Jones, University of Oxford, UK
Structure of CD1 Molecules and the TCRs that Recognize them

Roland Strong, Fred Hutchinson Cancer Research Center, USA
The NKG2A/CD94/HLA-E Complex

Natalie A. Borg, Monash University, Australia
Short Talk: Glycolipid Recognition by an NKT Cell

TLR Signaling: Role of Adapters

Red Cloud/Shavano
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Cell Biology of TLR Signal Transduction

* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Novel Regulators of Toll-like Receptor Signaling

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Negative Regulation of Innate Immunity

Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Abigail M. Spear, Defence Science and Technology Laboratory, UK
Short Talk: Identification and Characterization of Toll/Interleukin-1 Receptor Family Proteins in a Range of Pathogenic Bacteria

Coffee Break

Shavano Peak Foyer
Poster Setup

Grays 1/Torreys
Poster Viewing

Grays 1/Torreys
Workshop 1 : Role of NK/NKT Cells in Infection

Grays 2-3
* Moriya Tsuji, Aaron Diamond AIDS Research Center (ADARC), USA

* Marcus Altfeld, Heinrich-Pette-Institute, Germany

Laurent Brossay, Brown University, USA
Valpha14i NK T Cells Participate to the Early Response to MCMV Infection

* Eric Vivier, Aix Marseille University, France
Natural Killer Cell Trafficking and Function

Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA
iNK T Cells Provide Cognate Help for Lipid Antigen Specific B Cells

Vasileios Bekiaris, , USA
Ly49H+ NK Cells Migrate to and Protect Splenic White Pulp Stroma from Murine Cytomegalovirus Infection: Cues for Reciprocal NK-Stroma interactions

Galit Alter, MIT and Harvard University, USA
Ligand Dependent Expansion of Clonal NK Cell Populations in Acute HIV-1 Infection

Agnès C. Lehuen, Institut Cochin, France
iNKT Cells Prevent Virus-Induced Diabetes by Promoting Plasmacytoid Dendritic Cell Function in the Pancreas

Joseph C. Sun, Memorial Sloan Kettering Cancer Center, USA
Tolerance of NK Cells Encountering their Viral Ligand during Development

Sandeep K. Tripathy, Washington University School of Medicine, USA
Self-MHC-Specific Inhibitory Receptor effects on Natural Killer Cell Tolerance Induced by Self-Specific Activation Receptor Engagement

Coffee Available

Shavano Peak Foyer
Pathways of Ligand Presentation and Immune Evasion

Grays 2-3
* Michael B. Brenner, Harvard Medical School, USA
Antigen Presentation by CD1 Results in both Innate and Adaptive Immunity

Randy R. Brutkiewicz, Indiana University School of Medicine, USA
Viral Immune Evasion of NKT Cells

Stipan Jonjic, University of Rijeka, Faculty of Medicine, Croatia
NK Cell Immune Evasion by Murine Cytomegalovirus

Seung-Hwan Lee, University of Ottawa, Canada
Short Talk: A Role for Ly49H Receptor in Controlling NK Cell Proliferation during MCMV Infection

TLR Signaling: Role of Protein Kinases

Red Cloud/Shavano
Alexander Tarakhovsky, Rockefeller University, USA
Essential Role of Histone Lysine Methyltransferase G9a in Innate Antiviral Response

* Sankar Ghosh, Columbia University, USA
TLR-Mediated Signaling to NF-kappaB

Carla V. Rothlin, Yale University, USA
Short Talk: TAM Receptors are Pleiotropic Inhibitors of the Innate Immune Response

Sinead Keating, Trinity College Dublin, Ireland
Short Talk: IRAK-2 Participates in Multiple Toll-Like Receptor Signalling Pathways to NF-kappaB via Activation of TRAF6 Ubiquitination

Social Hour with Lite Bites

Grays 1/Torreys
Poster Session 1

Grays 1/Torreys



Grays 1/Torreys
NKT/NK Cell Development

Grays 2-3
* James P. Di Santo, Institut Pasteur, France
NK Cell Developmental Pathways

Markus Boos, University of Chicago, USA
Short Talk: Differential Requirements for Id2 in Natural Killer Cell Development in Distinct Microenvironments

Michael Caligiuri, Ohio State University, USA
Development of NK Cells in Humans

Chyung-Ru Wang, Northwestern University Feinberg School of Medicine, USA
Analysis of the Development and Activation of CD1d-restricted NKT Cells

Albert S. Bendelac, University of Chicago, USA
NKT Cell Self-Antigens and Thymic Selection

Victoria J. Lawson, Institute of Cancer Research, UK
Short Talk: The AP-1 Transcription Factor Fra-2 is Required for Normal NKT Cell Ontogeny and Function

NLR Signaling

Red Cloud/Shavano
* Jürg Tschopp, University of Lausanne, Switzerland
The Inflammasomes

Gabriel Nuñez, University of Michigan, USA
Role of NLRs in Innate Immunity and Disease

Dana Philpott, University of Toronto, Canada
Title to be Determined

Mihai G. Netea, Radboud University, Netherlands
Short Talk: Monocytes are not Macrophages: One-Hit Versus Two-Hit Stimulation for LPS-Driven Activation of the Human Inflammasome for IL-1beta

Marie-Cécile Michallet, INSERM, France
Short Talk: Tradd is an Essential Component of the RIG-like Helicases (RLH) Antiviral Pathway

Chris B. Moore, Arbutus Biopharma, USA
Short Talk: NLRX1: a Novel Member of the NLR Family which Regulates RLH-Mediated Mitochondrial Antiviral Signaling

Coffee Break

Shavano Peak Foyer
Poster Setup

Grays 1/Torreys
Poster Viewing

Grays 1/Torreys
Workshop 2 : NKT/NK Recognition of Ligands and Antigens

Grays 2-3
* Sebastian Joyce, Vanderbilt University School of Medicine, USA

* Marco Colonna, Washington University School of Medicine, USA

Joanna Brzostek, Imperial College London, UK
The Role of Ligand Dimensions in NK Cell Triggering

Pooja Arora, Albert Einstein College of Medicine, USA
Selective Trafficking of CD1d-Glycolipid Complexes Formed with N-acyl Variants of alpha-Galactosylceramide Ligands

Deborah L. Hodge, Center for Scientific Review, NIH, USA
Phenotypic Changes in IFN-gamma 3’UTR ARE Knock out Mice

Laurent Gapin, University of Colorado and National Jewish Medical and Research Center, USA
An Avidity Model to Explain the Vbeta use by Natural Killer TCRs

Kimberly L. Jordan, Purdue University, USA
Differing Roles of AP-1 Inhibitors in the Development of NK and NKT Cells in vivo

Susanna Cardell, Göteborg University, Sweden
Dependence of the Fatty Acid Chain of Sulfatide for Activation of CD1d-Restricted NK T Cells

Shouxiong Huang, University of Cincinnati, USA
MR1 uses an Endocytic Pathway to Activate Mucosal-Associated Invariant T Cells

* Jenny E. Gumperz, University of Wisconsin-Madison School of Medicine and Public Health, USA
Distinct Processes of Autoreactive and Foreign Antigenic Activation of NKT Cells

Workshop: At the Interface between Innate Immunity and Inflammation

Red Cloud/Shavano
* Alan Sher, NIAID, National Institutes of Health, USA

Anna-Marie Fairhurst, Singapore Immunology Network, Singapore
Yaa-Autoimmune Phenotypes are Conferred by an Overexpression of TLR7

Hsin-Jung Joyce Wu, University of Arizona, USA
Inflammatory Arthritis can be Reined in by CpG-Induced DC-NK Cell Cross Talk

Sandra M. Sacre, University of Sussex, UK
Toll-Like Receptor 8 is a Novel Therapeutic Target for Rheumatoid Arthritis

Liliana Schaefer, Goethe University, Germany
The Matrix Component Biglycan as an Endogenous Ligand to Toll-like Receptor-4 and -2 Aggravates Inflammation and Sepsis

R. William DePaolo, University of Washington, USA
Infectious Tolerance Induced by Yersinia Involves JNK2-Dependent IL-10 Production

Monica Andrea Delgado Vargas, Lovelace Respiratory Research Institute, USA
Toll Like Receptors Control Autophagy

Rowan Higgs, Royal College of Surgeons in Ireland, Ireland
The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-beta Gene Transcription by Initiating Proteasomal Degradation of IRF3

Ashish Banerjee, Monash University, Australia
Non-Transcriptional Role of NF-kappaB in Regulating B Cell Survival

Neal Silverman, University of Massachusetts Medical School, USA
Recognition and Signaling in the Drosophila IMD Pathway

Coffee Available

Shavano Peak Foyer
Activation, Inactivation and Homeostasis of NK/NKT Cells

Grays 2-3
* Dale I. Godfrey, University of Melbourne, Australia
Identification of a Novel, Developmentally Distinct, IL-17-Producing CD4-NK1.1- NKT Cell Subpopulation.

Wayne M. Yokoyama, Washington University School of Medicine, USA
Regulation of NK Cell Responses

Werner Held, Ludwig Institute, Switzerland
Short Talk: Functional Adaptation of NK Cells to Self-MHC Class I

Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
NKT Cells Sense Bacterial Infection and Recognize Bacterial Glycolipids

RIG-I-Like Receptors and Viral Sensing

Red Cloud/Shavano
Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Non-Self RNA Sensing Mechanism of RIG-I-Like Helicases and Activation of Antiviral Immune Responses

Paula M. Pitha-Rowe, Johns Hopkins University, USA
The Role of IRF-5 in the Innate Antiviral and Inflammatory Response

* Akira Shizuo, Osaka University, Japan
TLR- and RLR-Dependent Anti-Viral Responses

Hiroyuki Oshiumi, Hokkaido University, Japan
Short Talk: Riplet: A Novel RING Finger Protein that Activates RIG-I

Shohei Koyama, Research Institute for Microbial Diseases, Japan
Short Talk: Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination

Social Hour with Lite Bites

Grays 1/Torreys
Poster Session 2

Grays 1/Torreys



Grays 1/Torreys
Role of NK/NKT Cells in Infection

Grays 2-3
D. Branch Moody, Brigham and Women's Hospital, USA
Pathogens Provide Lipid Ligands for CD1 and Regulate CD1 Gene expression

Ling-Pei Ho, Weatherall Institute of Molecular Medicine, UK
Short Talk: Activation of Liver-Resident Invariant NKT Cells Improves Outcome from Influenza Virus Infection

Luis J. Sigal, Fox Chase Cancer Center, USA
Short Talk: Mechanisms of NK Cell-Mediated Resistance to Mousepox

Silvia Vidal, McGill University, Canada
NK Cell Recognition of Cytomegalovirus

Eleanor M. Riley, Roslin Institute, UK
NK Cell Responses to Infection: Roles of Accessory Cells and MHC Receptors

* Jody L. Baron, University of California, San Francisco, USA
Blockade of NKG2D on NKT Cells Prevents the Acute Immune Response to Hepatitis B Virus

Genetic Variation in Signaling Molecules in Innate Immunity

Red Cloud/Shavano
* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs at the Intersection of Death and Immunity

Jean-Laurent Casanova, Rockefeller University, USA
A Genetic Dissection of Immunity to Infection in natura

Warren Strober, National Institutes of Health, USA
The Molecular Basis of NOD2 Susceptibility Mutations in Crohn’s Disease

Jennifer Greene, Case Western Reserve University, USA
Short Talk: A 22bp Deletion Polymorphism in the 5’ Untranslated Region of the TLR2 Gene is Associated with Protection from Cerebral Malaria

Richard I. Tapping, University of Illinois, USA
Short Talk: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects Against Leprosy

Gordon D. Brown, University of Aberdeen, UK

Coffee Break

Shavano Peak Foyer
Poster Setup

Grays 1/Torreys
Poster Viewing

Grays 1/Torreys
Workshop 3 : NKT and NK Cells in Autoimmunity and Immunoregulation

Grays 2-3
* Luc Van Kaer, Vanderbilt University School of Medicine, USA

* Franck Housseau, Johns Hopkins School of Medicine, USA
IKDCs: the other NK cells

Jochen Mattner, Cincinnati Children's Hospital Medical Center, USA
The Role of NKT Cells in Liver Disease

Kori Wallace, University of Virginia, USA
The Role of NK and NK-T Cells in Pulmonary Dysfunction in a Transgenic Model of Sickle Cell Disease

Toshinori Nakayama, Chiba University, Japan
Combination Therapy of In vitro Expanded Natural Killer T Cells and alpha-Galactosylceramide-pulsed Antigen Presenting Cells in Patients with Recurrent Head and Neck Carcinoma

* Laurence Zitvogel, Institut Gustave Roussy, France
Do Regulatory NK Cells Exist?

Jin Seon S. Im, MD Anderson Cancer Center, USA
Mechanisms of Modulation of CD1d-Restricted NKT Cell Functions by Th2-Biasing á-Galactosylceramide Analogues

Joshua Beilke, Celgene, USA
Differing NK Cell Phenotypes in Diabetic Mice

Peggy Jacques, University Ghent, Belgium
iNKT Cells: Regulators of TNFá Driven Murine Spondyloarthropathy

Coffee Available

Shavano Peak Foyer
Role of NK/NKT Cells in Tumor Immunity

Grays 2-3
David H. Raulet, University of California, Berkeley, USA
Natural Killer Cell Receptors and Tumor Immunity

Adelheid Cerwenka, University of Heidelberg, Germany
Short Talk: Myeloid Derived “Suppressor” Cells Mediate NK Cell Activation

* Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia
Role of NK and NKT Cells in Tumor Immune Surveillance and Immunotherapy

Andrea Velardi, University of Perugia, Italy
Impact of NK Cell Alloreactivity on Human Hematopoietic Stem Cell Transplantation

Signaling: Biophysical and Structural Aspects

Red Cloud/Shavano
* Nick Gay, University of Cambridge, UK
Molecular Mechanism of Signal Transduction by the Toll and Toll-Like Receptors

Douglas Golenbock, University of Massachusetts Medical School, USA
How TLRs Achieve an Active State: Implications for Disease

Joshua N. Leonard, National Institutes of Health, National Cancer Institute, USA
The Signaling Complex of TLR3

James Michael Elliott, Genentech, USA
Short Talk: Crystal Structure of Procaspase-1 and its Implications for Activation

Clare E. Bryant, University of Cambridge, UK
Short Talk: Elucidation of the MD-2/TLR4 Interface Required for Signalling by Lipid IVa

Social Hour with Lite Bites

Grays 1/Torreys
Poster Session 3

Grays 1/Torreys



Grays 1/Torreys
Role of NK/NKT Cells in Autoimmunity and Immunopathology

Grays 2-3
* Lewis L. Lanier, University of California, San Francisco, USA
NK Cell Receptors in Immunity and Autoimmunity

Gennaro De Libero, University Hospital Basel, Switzerland
CD1 Restricted Self-Reactive T Cells

Rene de Waal Malefyt, Merck Research Labs, USA
Short Talk: IL-25 is a Growth and Activation Factor for NKT Cells

Philip W. Askenase, Yale University School of Medicine, USA
Role of NK and NKT Cells in Immunopathology

Drug Targets in Innate Signaling

Red Cloud/Shavano
* Anthony J. Coyle, Pfizer, USA
Danger Signals and Interferons in Autoimmune Disease

Mary Collins, Wyeth Research, USA
IL-22: A Th17 cytokine contributes to chronic inflammation

Anthony M. Manning, Momenta Pharmaceuticals, USA
Drug Discovery Targeting MAP Kinases: From Innate Immunity to Clinical Benefit

Jie-Oh Lee, Korea Advanced Institute of Science and Technology, South Korea
Ligand Recognition by the TLR Complexes

Lani R. San Mateo, Janssen R&D, USA
Short Talk: Down Modulation of Human TLR3 Function by a Monoclonal Antibody

Karen Colbjørn Larsen, University of Oxford, UK
Short Talk: Combining TLR Signaling Molecules as Vaccine Adjuvants

Coffee Break

Shavano Peak Foyer
Coffee Available

Shavano Peak Foyer
Interaction of NKT and NK Cells with APC and Modulation of Adaptive Immunity

Grays 2-3
Vincenzo Cerundolo, University of Oxford, UK
Role of NKT Cells in Modulation of Adaptive Immunity

Steven A. Porcelli, Albert Einstein College of Medicine, USA
Modulation of Immunoregulatory Activities of CD1d-Restricted NKT Cells by Modified Glycosylceramide Analogues

Silke Paust, Baylor College of Medicine, USA
Short Talk: T and B cell Independent Adaptive Immune Responses Mediated by Natural Killer Cells

* Mariapia A. Degli-Esposti, LEI, University of Western Australia, Australia
Interplay between Mouse NK Cells and Dendritic Cells

Pathogen Manipulation of Signaling and Immunomodulation

Red Cloud/Shavano
* Andrew G. Bowie, Trinity College Dublin, Ireland
Insights into Innate Immune Signaling Afforded by Viral Evasion and Subversion

Anne O'Garra, Francis Crick Institute, UK
Regulation of IL-10 Expression in Dendritic Cells and Macrophages and Implications for Regulation of the Immune Response to Pathogens

David E. Levy, New York University School of Medicine, USA
Transcriptional and Post-Transcriptional Regulation of Gene Expression in the IFN Innate Immune Response

Tsukasa Seya, Graduate School of Medicine, Hokkaido University, Japan
Functional Evolution of the TRIF/TLCAM-1 Pathway

Amanda Mercedes Jamieson, Max F. Perutz Laboratories, University of Vienna, Austria
Short Talk: Modulation of the Innate Immune Response to Bacteria by Viral Infection

Concluding Remarks

* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Social Hour with Lite Bites

Grays 1/Torreys

Grays 1/Torreys



*Session Chair †Invited, not yet responded.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AI077250-01

We gratefully acknowledge additional support for this conference from:

Novo Nordisk A/S

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