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This meeting took place in 2008

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Chemokines and Chemokine Receptors (J3)

Organizer(s) Alberto Mantovani, Andrew D. Luster and Philip M. Murphy
January 13—18, 2008
Keystone Resort • Keystone, CO USA
Abstract Deadline: Sep 13, 2007
Late Abstract Deadline: Oct 16, 2007
Scholarship Deadline: Sep 13, 2007
Early Registration Deadline: Nov 13, 2007

Supported by the Director's Fund

Summary of Meeting:
Cell migration is a key element for the ontogenesis of lymphoid tissues under homeostatic and pathological conditions, for the patrolling of body compartments by leukocytes, and for the activation and orientation of innate and adaptive immunity. Chemokines are a major component of the trafficking, positioning and functional regulation of leukocytes and nonhematopoietic cells in normal conditions and in diverse pathologies. Structural analysis and imaging approaches have resulted in a better understanding of the action of this complex family of mediators. Chemokines are a prime target for the development of innovative therapeutic strategies, some of which are beginning to undergo clinical assessment. This meeting will bring together scientists and clinicians with different expertise to summarize the current understanding of the chemokine system and its involvement in human pathology, focusing on prospects and challenges for translation into new diagnostic and therapeutic tools.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


3:00—7:30 PM

Shavano Peak Foyer
6:30—7:30 PM

Shavano Peak Foyer
7:30—9:30 PM
Keynote Session (Joint)

Crestone/Red Cloud/Shavano
Timothy A. Springer, Immune Disease Institute, Harvard University, USA
Transendothelial Migration and Bidirectional Signal Transmission in Integrins

Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research Centre, Switzerland
Targeting the Chemokine System: From Technology to Evolution


7:00—8:00 AM

Grays Peak 1-3
8:00—11:15 AM
Cell Biology of Migration (Joint)

Crestone/Red Cloud/Shavano
* Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
PI3K gamma in Lymphocyte Trafficking

Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Cell Migration through Extracellular Matrix

Stephen J. Weiss, University of Michigan, USA
MMPs and Cell Migration: Just How Similar are Tumor Cells and Leukocytes?

Dimitris Kioussis, National Institute for Medical Research, UK
Imaging of the Lymphoid System and Associated Organs

Ashok Kumar, Mayo Clinic College of Medicine, USA
Short Talk: CXCR4 Signals in T lymphocytes by Trafficking into MTOC-Associated Signaling Endosome Complex (MSEC)

Lawrence R. Shiow, University of California, San Francisco, USA
Short Talk: Characterization of ptcd – a Spontaneous Thymic Egress Mutant

9:20—9:40 AM
Coffee Break

Shavano Peak Foyer
11:15 AM—1:00 PM
Poster Setup

Grays Peak 1-3
1:00—10:00 PM
Poster Viewing

Grays Peak 1-3

Following Session is for Leukocyte Trafficking (J4)

2:30—4:30 PM
Workshop 1: Trafficking of Innate Immune Cells

Crestone/Red Cloud
* Charles R. Mackay, Monash University, Australia
Innate Receptors for Inflammatory Responses: The Role of C5aR, C5L2, GPR43 and the Angiogenic Receptors CXCR2 and CXCR7

Eun Young Choi, National Cancer Institute, National Institutes of Health, USA
Del-1 (Developmentally regulated Endothelial Locus-1): a novel endogenous anti-adhesive protein that blocks inflammatory cell recruitment.

Jonathan S. Bromberg, University of Maryland School of Medicine, USA
S1P1 Stimulation Inhibits Afferent Lymphatic Migration

Elina Kivi, University of Turku, Finland
Identification of a counter-receptor for Vascular Adhesion Protein-1

Alexander Zarbock, University of Muenster, Germany
Gái2 is required for chemokine-induced neutrophil arrest.

4:30—5:00 PM
Coffee Available

Shavano Peak Foyer
5:00—7:00 PM
Chemokines in Lymphoid Tissue Homeostasis

* Reinhold Förster, Hannover Medical School, Germany

Tsvee Lapidot, Weizmann Institute of Science, Israel
Regulation of Stem Cell Trafficking, Retention and Development

Sergio A. Lira, Mount Sinai School of Medicine, USA
Construction of Extranodal Lymphoid Tissue in Pathology

Yousuke Takahama, University of Tokushima, Japan
The Chemokine System in the Construction and Function of the Thymus

Scott N. Mueller, University of Melbourne, Australia
Short Talk: Regulation of Homeostatic Chemokine Expression and Cell Trafficking during Immune Responses

Following Session is for Leukocyte Trafficking (J4)

5:00—7:15 PM
In Vivo Insights into Effector and Memory Lymphocyte Trafficking

Crestone/Red Cloud
* Alf Hamann, Charité University Medicine Berlin, Germany
Imprinting of Homing Behavior in Regulatory and Conventional T Cells

Jorge Rodrigo Mora, Takeda Pharmaceuticals, USA
Conditioning Dendritic Cells to Imprint Gut-Homing Lymphocytes

Leo Lefrançois, University of Connecticut Health Center, USA
Imaging the Endogenous CD8 T Cell Response to Infection in situ

Linda F. Thompson, Oklahoma Medical Research Foundation, USA
Short Talk: CD73-generated Adenosine Regulates Lymphocyte Migration into Draining Lymph Nodes

Irina Mazo, Harvard Medical School, USA
Short Talk: Kinetics of primary and secondary CD8 T cell-mediated immune response in bone marrow

7:00—8:00 PM
Social Hour with Lite Bites

Grays Peak 1-3
7:30—10:00 PM
Poster Session 1

Grays Peak 1-3


7:00—8:00 AM

Grays Peak 1-3
8:00—11:15 AM
In Situ Visualization of Lymphocyte Migration and Activation (Joint)

Crestone/Red Cloud/Shavano
Michael Sixt, Institute of Science and Technology Austria, Austria
The Role of Integrins in Leukocyte Migration and Motility

* Ronald N. Germain, NIAID, National Institutes of Health, USA
Dynamic Intravital Visualization of Immune Cell Activity Using 2-Photon Microscopy

Michael L. Dustin, University of Oxford, UK
Natural Killer Patrolling of Liver Sinusoids

Charles P. Lin, Harvard Medical School, Massachusetts General Hospital, USA
In vivo Flow Cytometry

Steffen Jung, Weizmann Institute of Science, Israel
Short Talk: Perivascular Bone Marrow Dendritic cell clusters provide critical B cell survival signals

Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
Short Talk: In vivo imaging of natalizumab reduced T cell interaction with the blood-brain barrier

9:20—9:40 AM
Coffee Break

Shavano Peak Foyer
11:15 AM—1:00 PM
Poster Setup

Grays Peak 1-3
1:00—10:00 PM
Poster Viewing

Grays Peak 1-3
2:30—4:30 PM
Workshop 1: Chemokine Immunobiology and Signaling

* Ann Richmond, Vanderbilt University School of Medicine, USA

* Jo Van Damme, University of Leuven, Belgium

Konstanitina Alexandropoulos, Immunology Institute, Mt. Sinai School of Medicine, USA
A Signaling Complex Comprised of the Adapter Proteins Chat-H and CasL Regulates Activated but not Homeostatic T Cell Migration

Songhai Chen, University of Iowa, USA
RACK1 Regulates Directional Cell Migration by Acting on G Protein beta gamma Subunits at the Interface with its Effectors PLCbeta and PI3Kgamma

Richard A. Colvin, Massachusetts General Hospital, USA
CXCR3 Requires a Terminal PDZ-Binding Domain and Functionally Interacts with a PDZ-Domain containing Protein

Giljun Park, University of Tennessee at Knoxville, USA
An N-terminal Single Point Mutation in CXCR2 Induces Constitutive Activity and Results in Cellular Transformation of NIH 3T3 Cells

Daniel Campbell, Benaroya Research Institute, USA
Transcriptional Control of Regulatory T Cell Migration in vivo

Ji-Liang Gao, National Institutes of Health, USA
Defective Cognitive Function In Mice Lacking of CX3CR1

Aiko Shirakawa, Kinki University School of Medicine, Japan
Induction of CCR10 by 1,25-Dihydroxyvitamin D3 in Terminally Differentiating Human B Cells

Antje Margret Wengner, Imperial College London, UK
The Co-Ordinated Action of G-CSF and ELR+CXC Chemokines in Neutrophil Mobilisation during Acute Inflammation

4:30—5:00 PM
Coffee Available

Shavano Peak Foyer
5:00—7:00 PM
The Chemokine System in Adaptive Immunity

* Bernhard Moser, Cardiff University School of Medicine, UK

Joshua M. Farber, NIAID, National Institutes of Health, USA
Chemokine Receptors on Th17 Cells and Other CD4+ Effector/Memory T Cell Subsets in Humans

Gwendalyn J. Randolph, Washington University, USA
The Unexpected Passage Of DC To Lymph Node Through Perinodal Adipose Tissue

Karen E. Hedin, Mayo Clinic, USA
New Paradigms for Understanding How Chemokines Regulate Immunity: CXCR4 Signaling via the TCR

James J. Campbell, Brigham and Women's Hospital, USA
Short Talk: Specificity And Dissemination Of Thropic Memory T Cells

Following Session is for Leukocyte Trafficking (J4)

5:00—7:15 PM
Regulation of Leukocyte Traffic by Endothelial Cells

Crestone/Red Cloud
Steffen Massberg, Ludwig-Maximilians-Universität München, Germany
Trafficking Routes of Hematopoietic Stem and Progenitor Cells

* Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Germany
Control of Leukocyte Diapedesis by Endothelial Cell Contact Proteins

Sussan Nourshargh, Barts and The London Medical School, UK
Leukocyte Transmigration in Vivo: Role of Endothelial Cell Junctional Molecules and Basement Membrane Remodelling

Gabriele Bixel, Max Planck Institute of Molecular Biomedicine, Germany
Short Talk: CD99 and CD99L2 Mediate Neutrophil Extravasation to Inflamed Sites

Lynn M. Schnapp, University of Wisconsin-Madison, USA
Short Talk: Ligand-Induced Adhesion Depends on Cdk4 and Mediates Lymphocyte Binding

7:00—8:00 PM
Social Hour with Lite Bites

Grays Peak 1-3
7:30—10:00 PM
Poster Session 2

Grays Peak 1-3


7:00—8:00 AM

Grays Peak 1-3
8:00—11:15 AM
Tuning Chemokines in Inflammation

* Robert J. Nibbs, University of Glasgow, UK

Massimo Locatti, Istituto Clinico Humanitas IRCCS, Italy
Role of the Chemokine Decoy Receptor D6 in Balancing Inflammation, Immune Activation and Antimicrobial Resistance

Antonio Alcami, Centro de Biologia Molecular Severo Ochoa, Spain
Immune Modulation by Chemokine Binding Proteins from Herpesviruses

John H. Kehrl, NIAID, National Institutes of Health, USA
Heterodimeric G Proteins In Chemokine Receptor Signalling and Lymphocyte Trafficking

Marc E. Rothenberg, Cincinnati Children's Hospital Medical Center, USA
Chemokines in Eosinophils and Type II Inflammation

Paul Proost, Rega Institute, K.U.Leuven, Belgium
Short Talk: CD13/Aminopeptidase N-Processed I-TAC/CXCL11 has Reduced CXCR3 and CXCR7 Binding and Signaling Properties that Result in Impaired Lymphocyte Chemotaxis and Reduced Inhibition of Endothelial Cell Migration

Yi Le, Naval Medical Research Center, USA
Short Talk: Developmental Regulation of CXCR4-FAK Signaling by SOCS3 during B Lymphopoiesis

Following Session is for Leukocyte Trafficking (J4)

8:00—11:00 AM
Adhesion Molecules and Signaling in Leukocyte Arrest and Migration

Crestone/Red Cloud
Ronen Alon, Weizmann Institute of Science, Israel
Force Regulated Chemokine Cues for Lymphocyte Adhesion and Motility on Vascular Endothelium and in Interstitial Spaces

Carlo Laudanna, , Italy
Modularity of Signaling Networks Controlling Integrin Activation: The Rho-Module of LFA-1 Affinity Triggering

Sirpa T. Jalkanen, University of Turku, Finland
Ectoenzyme-Mediated Leukocyte Recruitment

* Denisa D. Wagner, Harvard Medical School, USA
CalDAG-GEFI and von Willebrand Factor in Leukocyte Adhesion

Jens V. Stein, University of Bern, Switzerland
Short Talk: In vivo imaging of the roles of endothelial ICAM-1 and ICAM-2 during lymphocyte adhesion in lymph node venules

9:20—9:40 AM
Coffee Break

Shavano Peak Foyer
11:15 AM—1:00 PM
Poster Setup

Grays Peak 1-3
1:00—10:00 PM
Poster Viewing

Grays Peak 1-3

Following Session is for Leukocyte Trafficking (J4)

2:30—4:30 PM
Workshop 2: Lymphocyte Migration in Inflammation and Infection

Crestone/Red Cloud
* Craig Gerard, Children's Hospital Harvard University, USA
C5L2 Does Not Signal through ERK Kinase Pathways

Norbert Wagner, RWTH Aachen University Hospital, Germany
Generation and analysis of a mouse mutant deficient for the adhesion molecule MAdCAM-1

João Pereira, Yale University School of Medicine, USA
Transient alpha4beta1 integrin-mediated retention of immature B cells in bone marrow sinusoids during egress

Stefano Angiari, Trinity College Dublin, Ireland
Role of Fucosyltransferase-VII and P-selectin glycoprotein ligand-1 in the migration of CD4+CD25+ regulatory T cells in inflamed brain

Charles Colin Brinkman, University of Virginia, USA
Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory cell characteristics

Linda S. Cauley, University of Connecticut Health Center, USA
Naïve and memory influenza-specific CD8 T cells respond to different APCs in reactive lymph nodes during late antigen presentation

4:30—5:00 PM
Coffee Available

Shavano Peak Foyer
5:00—7:15 PM
Lipids and Novel Modulators of Leukocyte Traffic (Joint)

Crestone/Red Cloud/Shavano
* Joost J. Oppenheim, National Institutes of Health, USA

Christian Weber, University Hospital Aachen, Germany
Chemokine-Like Functions of MIF in Leukocyte Recruitment

Annalisa Del Prete, University of Bari, Italy
The Role of Chemerin in the Recruitment of Plasmacytoid Dendritic Cells in Normal and Pathological Conditions

Andrew M. Tager, Massachusetts General Hospital, USA
Grease On Fire: Lipid-Chemokine Cooperation On Leukocyte Trafficking

Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Short Talk: CRTAM regulates retention of T cells within lymph node and delivery to effecter tissues

Masayuki Miyasaka, Osaka University, Japan
Short Talk: The role of a cell-motility inducing protein, autotaxin, in high endothelial venules of lymph nodes and Peyer’s patches

7:15—8:15 PM
Social Hour with Lite Bites

Grays Peak 1-3
7:30—10:00 PM
Poster Session 3

Grays Peak 1-3


7:00—8:00 AM

Grays Peak 1-3
8:00—11:15 AM
The Chemokine System in Pathology and Clinics

* Robert M. Strieter, University of Virginia School of Medicine, USA

Richard M. Ransohoff, Third Rock Ventures, USA
CXCR2 Deficiency Promotes CNS Myelin Repair: Anti-Inflammatory Neurobiological Effects

Nicholas W. Lukacs, University of Michigan, USA
Chemokine Receptors and Leukocyte Accumulation Influence Pulmonary Disease Pathology

Luigi D. Notarangelo, Children's Hospital, Boston, USA
Chemokine-Guided Leukocyte Traffic: Lessons from Human Congenital Immunodeficiencies

Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Chemokines and their Receptors in Gynaecological Malignancies

Martine J. Smit†, VU University Amsterdam, Netherlands
Short Talk: Viral Chemokine Receptor US28 Acts as Potential Oncogene: A Key Role for COX-2 in US28-Induced Tumorigenesis

Nikolaos G. Frangogiannis, Baylor College of Medicine, USA
Short Talk: CXCL10/IP-10 Induction Orchestrates Infarct Healing

Following Session is for Leukocyte Trafficking (J4)

8:00—11:15 AM
Immune Cell Trafficking in Inflammation and Atherosclerosis

Crestone/Red Cloud
Tanya N. Mayadas, Brigham and Women's Hospital, USA
Immune Complex-Mediated Leukocyte Trafficking and Injury In vivo

Andrew H. Lichtman, Brigham and Women's Hospital, USA
Regulation of T Cell Responses in Atherosclerosis

* Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Migratory and Functional Properties of Monocyte Subsets

Francois Mach, University Hospital, Geneva Foundation for Medical Research, Switzerland
Cannabinoid Receptors in Atherosclerosis

Elena Galkina, Eastern Virginia Medical School, USA
Short Talk: CXCR6 promotes atherosclerosis by supporting T cell homing, interferon gamma production and macrophage accumulation in the aortic wall

Scott I. Simon, University of California, Davis, USA
Short Talk: Triglyceride-Rich Lipoproteins Prime Aortic Endothelium For Enhanced Inflammation

9:20—9:40 AM
Coffee Break

Shavano Peak Foyer
2:30—4:30 PM
Workshop 2: Chemokines in Pathology and Therapy

* Nicholas W. Lukacs, University of Michigan, USA

Ting Jia, Memorial Sloan Kettering Cancer Center, USA
Role of MCP-3 in Monocyte Recruitment and Innate Immune Defense during Intracellular Bacterial Infection

Shiro Kanegasaki, Effector Cell Institute, Inc., Japan
ECI301, an Active Variant of MIP-1alpha, Consistently Induced the Abscopal Effect of Radiation

Pawel Kalinski, University of Pittsburgh, USA
Dendritic Cells Regulate the Lymphoid/Memory versus Peripheral/ Effector Pathway of Differentiation of CD8+ T Cells

Marion Leick, University Hospital Freiburg, Germany
The Orphan Chemokine Receptor CRAM-A/B is an Atypical Receptor Expressed on B Cells in a Maturation Stage Dependent and CCL5 Modulated Manner

Jean K. Lim, Icahn School of Medicine at Mount Sinai, USA
Chemokine Receptor CCR2 Directs Macrophage Recruitment to the CNS and Promotes Survival from West Nile Virus Infection in Mice

Federica Marchesi, IRCCS Istituto Clinico Humanitas, Italy
The Neurotactin/Fractalkine Chemokine Receptor CX3CR1 Mediates Perineural Invasion and Malignant Behavior of Human Ductal Pancreatic Adenocarcinoma

Benjamin D. Medoff, Massachusetts General Hospital, USA
CD11b+ Dendritic Cells are the Critical Cellular Mediator of Th2 Cell Homing into the Lung in Allergic Airway Inflammation

Marco Prinz, University of Freiburg, Germany
Spatial and Temporal Expression of CCR2 Determines the Outcome of Autoimmunity in the Central Nervous System

4:30—5:00 PM
Coffee Available

Shavano Peak Foyer
5:00—7:15 PM
Chemokines as Targets for Pharmacological Intervention

* Kouji Matsushima, University of Tokyo School of Medicine, Japan

Thomas J. Schall, ChemoCentryx, Inc., USA
Targeting CCR9: Rationale and Clinical Development

Elna Van Der Ryst, Pfizer Global Research and Development, UK
Challenges in the Design and Development of Maraviroc, a Novel CCR5 Antagonist for the Treatment of CCR5-Tropic HIV-1 Infection

John F. Dipersio, Washington University, USA
CXCR4 and Hemopoietic Precursor Mobilization in the Clinic

R. William Hipkin, Schering-Plough Research Institute, USA
Short Talk: SCH 527123: a Potent, Orally-Active CXCR2 Antagonist

Following Session is for Leukocyte Trafficking (J4)

5:00—7:00 PM
Preclinical and Clinical Anti-Adhesion and Anti-Chemokine Therapy

Crestone/Red Cloud
* Gabriela Constantin, University of Verona, INSTITUTI BIOLOGICI, Italy
Anti-Leukocyte Recruitment Treatment for the Prevention and Therapy of Epilepsy

Stefan Hemmerich, Y's Therapeutics Inc., USA
Clinical Development of a Recombinant Selectin Antagonist for Prevention of Ischemia Repurfusion Injury in Solid Organ Transplantation

Daniel Bock, Revotar Biopharmaceuticals, Germany
Short Talk: Targeting Selectins: Thinking Outside the Paradigm

Martin K. Wild, Max Planck Institute of Molecular Biomedicine, Germany
Leukocyte Adhesion Deficiency II: In vivo leukocyte migration and therapy

7:15—8:15 PM
Social Hour with Lite Bites

Grays Peak 1-3
8:00—11:00 PM

Grays Peak 1-3



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AI075642-01

We gratefully acknowledge additional support for this conference from:

ChemoCentryx, Inc. Merck & Co., Inc.

GlaxoSmithKline Research & Development, Ltd.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

ChemoCentryx, Inc.

Pfizer Global Research & Development

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Phone:+1 970-262-2690

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