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This meeting took place in 2008



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Molecular Evolution as a Driving Force in Infectious Diseases (D4)


Organizer(s) Jeffery K. Taubenberger, Edward C. Holmes and Thomas S. Whittam
April 8—13, 2008
Beaver Run Resort • Breckenridge, CO USA
Abstract Deadline: Dec 10, 2007
Late Abstract Deadline: Jan 14, 2008
Scholarship Deadline: Dec 10, 2007
Early Registration Deadline: Feb 11, 2008

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Infectious diseases have been a key driving force in evolution, both of the hosts and the pathogens. The era of genomics has made it possible to evaluate both infectious agents and their hosts at the genomic level. The evolutionary dynamics of viruses, bacteria and parasites, in their adaptive evolution to changes in host response or adaptation to new hosts is enormously complex. The burden of infectious diseases on people and domestic animals is staggering. We are only now beginning to achieve an understanding of how infectious organisms cause disease and how the complex patterns of immune response generated by their infections mitigate it. By bringing together experts in the evolution of viruses, bacteria and parasites, plus those studying host adaptation and evolution of the immune response, we hope that this meeting will stimulate further interaction between widely disparate lines of investigation.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


TUESDAY, APRIL 8

3:00—7:30 PM
Registration

Foyer
6:30—7:30 PM
Refreshments

Foyer
7:30—8:30 PM
Keynote Address

Peaks 4-5
* Jeffery K. Taubenberger, NIAID, National Institutes of Health, USA

David J. Weatherall, University of Oxford, John Radcliffe Hospital, UK
The Role of Genetic Variation in Susceptibility to Malaria in Human Evolution: Was Haldane Right?


WEDNESDAY, APRIL 9

7:00—8:00 AM
Breakfast

Peaks 1-4
8:00—11:15 AM
RNA Viruses I

Peak 5
Jeffery K. Taubenberger, NIAID, National Institutes of Health, USA
The Evolutionary Dynamics of Influenza A Viruses

* Edward C. Holmes, University of Sydney, Australia
The Molecular Evolution and Phylodynamics of Dengue Virus

Oliver G. Pybus, University of Oxford, UK
Integrating Evolutionary and Epidemiological Dynamics: HIV and the Hepatitis C Virus

Paul A. Rota, Centers for Disease Control, USA
Molecular Epidemiology of Measles and Mumps Viruses

Philippe Lemey, Katholieke Universiteit Leuven, Belgium
Short Talk: Tracing Virus Migration Using Bayesian Phylogeographic Inference

Naomi Lynne Forrester, University of Texas Medical Branch, USA
Short Talk: Use of Phylogenetic Analysis to Reveal the Evolution, Epidemiology and Origin of Rabbit Haemorrhagic Disease Virus

9:20—9:40 AM
Coffee Break

Foyer
11:15 AM—1:00 PM
Poster Setup

Peaks 1-4
11:15 AM
On Own for Lunch

1:00—10:00 PM
Poster Viewing

Peaks 1-4
4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
RNA Viruses II

Peak 5
* Jeffery K. Taubenberger, NIAID, National Institutes of Health, USA

Kathryn V. Holmes, University of Colorado School of Medicine, USA
Coronaviruses and Host Adaptation

Alan D.T. Barrett, University of Texas Medical Branch, USA
Introduction of West Nile Virus into North America: Of Humans, Birds, Mosquitoes and Mice

Michael G. Katze, University of Washington, USA
Functional Genomics will Save the World from Killer Viruses (but it Better Happen Soon!)

Chung-Chau Hon, University of Hong Kong, Hong Kong
Short Talk: Evidence of the Recombinant Origin of a Bat SARS-like Coronavirus and its Implications on the Direct Ancestor of SARS Coronavirus

7:00—8:00 PM
Social Hour with Lite Bites

Peaks 1-4
7:30—10:00 PM
Poster Session 1

Peaks 1-4

THURSDAY, APRIL 10

7:00—8:00 AM
Breakfast

Peaks 1-4
7:00—8:00 AM
Poster Setup

Peaks 1-4
8:00—11:15 AM
DNA Viruses

Peak 5
Elliot J. Lefkowitz, University of Alabama at Birmingham, USA
Gene Acquisition and Gene Loss as Controlling Events in Poxvirus Speciation and Pathogenesis

* Colin R. Parrish, Cornell University, USA
Variation and Evolution of Parvoviruses and the Controls of Host Ranges

Thomas F. Schulz, Medizinische Hochschule Hannover, Germany
Functional Diversification of a Terminal Membrane Protein during Rhadinoviral Evolution

Mary R. Odom, University of Alabama, Birmingham, USA
Short Talk: Poxvirus Gene Evolution: The Contribution of Gene Capture from the Host

Edgar E. Sevilla-Reyes, Instituto Nacional de Enfermedades Respiratorias, Mexico
Short Talk: The Dynamic Gene Content of Human Cytomegalovirus

9:20—9:40 AM
Coffee Break

Foyer
11:15 AM—12:00 PM
Lunch

Peaks 1-4
12:00—2:30 PM
Poster Session 2

Peaks 1-4
2:30—4:30 PM
Workshop

Peaks 4-5
* Edward C. Holmes, University of Sydney, Australia

Nels C. Elde, University of Utah, USA
Adaptive Evolution of Protein Kinase R Defeats a Substrate Mimic Encoded by Poxviruses

Willem M. van Ballegooijen, National Institute of Public Health and the Environment, Netherlands
DNA of Hepatitis B Virus Reveals Impact of Vaccination

Elodie Ghedin, New York University, USA
Intra-Host Diversity and Evolutionary Dynamics of Influenza Virus

Ma Luo, University of Manitoba, Canada
Rapid Selection for HLA alleles that Protect against HIV-1 Infection Correlates Significantly to the Declining Incidence of HIV-1 in an East African Sex Worker Population

Molly Ohainle, Fred Hutchinson Cancer Research Center, USA
The Conserved Anti-Retroelemement Activity of APOBEC3H was Independently Lost Twice in Recent Human Evolution

Bouke C. de Jong, Institute of Tropical Medicine, Antwerp, Belgium
Mycobacterium Africanum: First to Arrive in West Africa?

Joel O. Wertheim, University of Arizona, USA
Dating the Origin of SIV from Sooty Mangabey using a Relaxed Molecular Clock

Tsan Yuk (Tommy) Lam, University of Hong Kong, China
Transmission Dynamics of Natural Reassortant H5N1 Influenza Viruses in Indonesia

4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Retroviruses

Peak 5
Beatrice H. Hahn, University of Pennsylvania, USA
Origins of HIV-1 and Adaptation to its Human Host

John V. Moran, University of Michigan Medical School, USA
Studies of a Human Transposable Element

* Nathan D. Wolfe, University of California, Los Angeles, USA
Cross-Species Transmission and Establishment of Novel Human Retroviruses

Christine L. Clouser, University of Minnesota, USA
Short Talk: Exploiting the Mutation Rate of HIV

7:00 PM
On Own for Dinner


FRIDAY, APRIL 11

7:00—8:00 AM
Breakfast

Peaks 1-4
8:00—11:00 AM
Bacteria I

Peak 5
Eun Chung Park, NIAID, USA
Short Talk

David Alland, Rutgers University – NJMS, USA
Evaluating the Evolution of Drug Resistance in Mycobacterium Tuberculosis

M. Cristina Gutiérrez Perez, Institut Pasteur, France
Mycobacterium tuberculosis and other Mycobacteria: Rethinking Tuberculosis in the Light of Evolution

* Bruce R. Levin, Emory University, USA
The Evolution, Rate and Population Genetics of Recombination in Bacteria with a Particular Focus on Transformation: An Opinionated Rant

Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Short Talk: A Multilocus Sequence Analysis of Mycobacterium tuberculosis

Anne M. Buboltz, Pennsylvania State University, USA
Short Talk: Replacement of Adenylate Cyclase Toxin in a Prominent Lineage of Bordetella bronchiseptica

9:20—9:40 AM
Coffee Break

Foyer
11:15 AM—1:00 PM
Poster Setup

Peaks 1-4
11:15 AM
On Own for Lunch

1:00—10:00 PM
Poster Viewing

Peaks 1-4
4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Bacteria II

Peak 5
* James M. Musser, Methodist Hospital Research Institute, USA
Evolution of Virulence in Group A Streptococcus, the Flesh-Eater

Nancy A. Moran, University of Texas at Austin, USA
The Evolutionary Genomics of Bacterial Symbionts in Insects

Mark Achtman, University College Cork, Ireland
Helicobacter pylori

Martin Antonio, Medical Research Council Laboratories, Gambia
Short Talk: Enhanced Invasiveness of ST618 Streptococcus pneumoniae Serotype 1 Clone from The Gambia, West Africa

7:00—8:00 PM
Social Hour with Lite Bites

Peaks 1-4
7:30—10:00 PM
Poster Session 3

Peaks 1-4

SATURDAY, APRIL 12

7:00—8:00 AM
Breakfast

Peaks 1-4
8:00—11:00 AM
Parasites and Host Evolution I

Peak 5
Mark Achtman, University College Cork, Ireland
Salmonela Thypi and Versinia Pestis

Wendy Gibson, University of Bristol, UK
Evolution of the Pathogenic Trypanosomes

* Peter Parham, Stanford University, USA
Host Evolution: Interactions between Polymorphic Human Receptors and Ligands that Influence Immune Defense and Reproduction

Peter Sarnow, Stanford University School of Medicine, USA
Host Evolution: Evolution of microRNA miR-122 to Aid in Hepatitis C Virus Replication

Jenny Tan, Genome Institute of Singapore, Singapore
Short Talk: Elevated Levels of Common Nonsynonymous Variants in the Human Macrophage Receptor Gene, EMR1, Result from Balancing Selection

9:20—9:40 AM
Coffee Break

Foyer
11:00 AM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Foyer
5:00—7:00 PM
Parasites and Host Evolution II

Peak 5
* Martin F. Flajnik, University of Maryland, USA
Evolution of Adaptive Immunity

Richard Carter, University of Edinburgh, UK
Plasmodium vivax: Where in the World has it Been?

Sunetra Gupta, University of Oxford, UK
Transmission Dynamics and Evolution of the Influenza Virus

Sara L. Sawyer, University of Texas at Austin, USA
Short Talk: Evolution of the Anti-Retroviral TRIM5 and Related Genes

7:00—8:00 PM
Social Hour with Lite Bites

Peaks 1-4
8:00—11:00 PM
Entertainment

Peaks 1-4

SUNDAY, APRIL 13

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI078558-01




National Institutes of Health

Grant No. 5U13AI60000-05



We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Burroughs Wellcome Fund

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