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This meeting took place in 2008
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Molecular Evolution as a Driving Force in Infectious Diseases (D4)
Organizer(s) Jeffery K. Taubenberger, Edward C. Holmes and Thomas S. Whittam
April 8—13, 2008
Beaver Run Resort • Breckenridge, CO USA
Abstract Deadline: Dec 10, 2007
Late Abstract Deadline: Jan 14, 2008
Scholarship Deadline: Dec 10, 2007
Early Registration Deadline: Feb 11, 2008
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Infectious diseases have been a key driving force in evolution, both of the hosts and the pathogens. The era of genomics has made it possible to evaluate both infectious agents and their hosts at the genomic level. The evolutionary dynamics of viruses, bacteria and parasites, in their adaptive evolution to changes in host response or adaptation to new hosts is enormously complex. The burden of infectious diseases on people and domestic animals is staggering. We are only now beginning to achieve an understanding of how infectious organisms cause disease and how the complex patterns of immune response generated by their infections mitigate it. By bringing together experts in the evolution of viruses, bacteria and parasites, plus those studying host adaptation and evolution of the immune response, we hope that this meeting will stimulate further interaction between widely disparate lines of investigation.
View Scholarships/Awards
Infectious diseases have been a key driving force in evolution, both of the hosts and the pathogens. The era of genomics has made it possible to evaluate both infectious agents and their hosts at the genomic level. The evolutionary dynamics of viruses, bacteria and parasites, in their adaptive evolution to changes in host response or adaptation to new hosts is enormously complex. The burden of infectious diseases on people and domestic animals is staggering. We are only now beginning to achieve an understanding of how infectious organisms cause disease and how the complex patterns of immune response generated by their infections mitigate it. By bringing together experts in the evolution of viruses, bacteria and parasites, plus those studying host adaptation and evolution of the immune response, we hope that this meeting will stimulate further interaction between widely disparate lines of investigation.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, APRIL 8
WEDNESDAY, APRIL 9
THURSDAY, APRIL 10
FRIDAY, APRIL 11
SATURDAY, APRIL 12
SUNDAY, APRIL 13
Conference Program Print | View meeting in 24 hr (international) time
TUESDAY, APRIL 8
7:30—8:30 PM
Keynote Address
David J. Weatherall,
University of Oxford, John Radcliffe Hospital, UK
The Role of Genetic Variation in Susceptibility to Malaria in Human Evolution: Was Haldane Right?
The Role of Genetic Variation in Susceptibility to Malaria in Human Evolution: Was Haldane Right?
8:00—11:15 AM
RNA Viruses I
Jeffery K. Taubenberger,
NIAID, National Institutes of Health, USA
The Evolutionary Dynamics of Influenza A Viruses
The Evolutionary Dynamics of Influenza A Viruses
*
Edward C. Holmes,
University of Sydney, Australia
The Molecular Evolution and Phylodynamics of Dengue Virus
The Molecular Evolution and Phylodynamics of Dengue Virus
Oliver G. Pybus,
University of Oxford, UK
Integrating Evolutionary and Epidemiological Dynamics: HIV and the Hepatitis C Virus
Integrating Evolutionary and Epidemiological Dynamics: HIV and the Hepatitis C Virus
Paul A. Rota,
Centers for Disease Control, USA
Molecular Epidemiology of Measles and Mumps Viruses
Molecular Epidemiology of Measles and Mumps Viruses
Philippe Lemey,
Katholieke Universiteit Leuven, Belgium
Short Talk: Tracing Virus Migration Using Bayesian Phylogeographic Inference
Short Talk: Tracing Virus Migration Using Bayesian Phylogeographic Inference
Naomi Lynne Forrester,
University of Texas Medical Branch, USA
Short Talk: Use of Phylogenetic Analysis to Reveal the Evolution, Epidemiology and Origin of Rabbit Haemorrhagic Disease Virus
Short Talk: Use of Phylogenetic Analysis to Reveal the Evolution, Epidemiology and Origin of Rabbit Haemorrhagic Disease Virus
5:00—7:00 PM
RNA Viruses II
Kathryn V. Holmes,
University of Colorado School of Medicine, USA
Coronaviruses and Host Adaptation
Coronaviruses and Host Adaptation
Alan D.T. Barrett,
University of Texas Medical Branch, USA
Introduction of West Nile Virus into North America: Of Humans, Birds, Mosquitoes and Mice
Introduction of West Nile Virus into North America: Of Humans, Birds, Mosquitoes and Mice
Michael G. Katze,
University of Washington, USA
Functional Genomics will Save the World from Killer Viruses (but it Better Happen Soon!)
Functional Genomics will Save the World from Killer Viruses (but it Better Happen Soon!)
Chung-Chau Hon,
University of Hong Kong, Hong Kong
Short Talk: Evidence of the Recombinant Origin of a Bat SARS-like Coronavirus and its Implications on the Direct Ancestor of SARS Coronavirus
Short Talk: Evidence of the Recombinant Origin of a Bat SARS-like Coronavirus and its Implications on the Direct Ancestor of SARS Coronavirus
8:00—11:15 AM
DNA Viruses
Elliot J. Lefkowitz,
University of Alabama at Birmingham, USA
Gene Acquisition and Gene Loss as Controlling Events in Poxvirus Speciation and Pathogenesis
Gene Acquisition and Gene Loss as Controlling Events in Poxvirus Speciation and Pathogenesis
*
Colin R. Parrish,
Cornell University, USA
Variation and Evolution of Parvoviruses and the Controls of Host Ranges
Variation and Evolution of Parvoviruses and the Controls of Host Ranges
Thomas F. Schulz,
Medizinische Hochschule Hannover, Germany
Functional Diversification of a Terminal Membrane Protein during Rhadinoviral Evolution
Functional Diversification of a Terminal Membrane Protein during Rhadinoviral Evolution
Mary R. Odom,
University of Alabama, Birmingham, USA
Short Talk: Poxvirus Gene Evolution: The Contribution of Gene Capture from the Host
Short Talk: Poxvirus Gene Evolution: The Contribution of Gene Capture from the Host
Edgar E. Sevilla-Reyes,
Instituto Nacional de Enfermedades Respiratorias, Mexico
Short Talk: The Dynamic Gene Content of Human Cytomegalovirus
Short Talk: The Dynamic Gene Content of Human Cytomegalovirus
2:30—4:30 PM
Workshop
Nels C. Elde,
University of Utah, USA
Adaptive Evolution of Protein Kinase R Defeats a Substrate Mimic Encoded by Poxviruses
Adaptive Evolution of Protein Kinase R Defeats a Substrate Mimic Encoded by Poxviruses
Willem M. van Ballegooijen,
National Institute of Public Health and the Environment, Netherlands
DNA of Hepatitis B Virus Reveals Impact of Vaccination
DNA of Hepatitis B Virus Reveals Impact of Vaccination
Elodie Ghedin,
New York University, USA
Intra-Host Diversity and Evolutionary Dynamics of Influenza Virus
Intra-Host Diversity and Evolutionary Dynamics of Influenza Virus
Ma Luo,
University of Manitoba, Canada
Rapid Selection for HLA alleles that Protect against HIV-1 Infection Correlates Significantly to the Declining Incidence of HIV-1 in an East African Sex Worker Population
Rapid Selection for HLA alleles that Protect against HIV-1 Infection Correlates Significantly to the Declining Incidence of HIV-1 in an East African Sex Worker Population
Molly Ohainle,
Fred Hutchinson Cancer Research Center, USA
The Conserved Anti-Retroelemement Activity of APOBEC3H was Independently Lost Twice in Recent Human Evolution
The Conserved Anti-Retroelemement Activity of APOBEC3H was Independently Lost Twice in Recent Human Evolution
Bouke C. de Jong,
Institute of Tropical Medicine, Antwerp, Belgium
Mycobacterium Africanum: First to Arrive in West Africa?
Mycobacterium Africanum: First to Arrive in West Africa?
Joel O. Wertheim,
University of Arizona, USA
Dating the Origin of SIV from Sooty Mangabey using a Relaxed Molecular Clock
Dating the Origin of SIV from Sooty Mangabey using a Relaxed Molecular Clock
Tsan Yuk (Tommy) Lam,
University of Hong Kong, China
Transmission Dynamics of Natural Reassortant H5N1 Influenza Viruses in Indonesia
Transmission Dynamics of Natural Reassortant H5N1 Influenza Viruses in Indonesia
5:00—7:00 PM
Retroviruses
Beatrice H. Hahn,
University of Pennsylvania, USA
Origins of HIV-1 and Adaptation to its Human Host
Origins of HIV-1 and Adaptation to its Human Host
*
Nathan D. Wolfe,
University of California, Los Angeles, USA
Cross-Species Transmission and Establishment of Novel Human Retroviruses
Cross-Species Transmission and Establishment of Novel Human Retroviruses
Christine L. Clouser,
University of Minnesota, USA
Short Talk: Exploiting the Mutation Rate of HIV
Short Talk: Exploiting the Mutation Rate of HIV
8:00—11:00 AM
Bacteria I
Eun Chung Park,
NIAID, USA
Short Talk
Short Talk
David Alland,
Rutgers University – NJMS, USA
Evaluating the Evolution of Drug Resistance in Mycobacterium Tuberculosis
Evaluating the Evolution of Drug Resistance in Mycobacterium Tuberculosis
M. Cristina Gutiérrez Perez,
Institut Pasteur, France
Mycobacterium tuberculosis and other Mycobacteria: Rethinking Tuberculosis in the Light of Evolution
Mycobacterium tuberculosis and other Mycobacteria: Rethinking Tuberculosis in the Light of Evolution
*
Bruce R. Levin,
Emory University, USA
The Evolution, Rate and Population Genetics of Recombination in Bacteria with a Particular Focus on Transformation: An Opinionated Rant
The Evolution, Rate and Population Genetics of Recombination in Bacteria with a Particular Focus on Transformation: An Opinionated Rant
Sébastien Gagneux,
Swiss Tropical and Public Health Institute, Switzerland
Short Talk: A Multilocus Sequence Analysis of Mycobacterium tuberculosis
Short Talk: A Multilocus Sequence Analysis of Mycobacterium tuberculosis
Anne M. Buboltz,
Pennsylvania State University, USA
Short Talk: Replacement of Adenylate Cyclase Toxin in a Prominent Lineage of Bordetella bronchiseptica
Short Talk: Replacement of Adenylate Cyclase Toxin in a Prominent Lineage of Bordetella bronchiseptica
5:00—7:00 PM
Bacteria II
*
James M. Musser,
Methodist Hospital Research Institute, USA
Evolution of Virulence in Group A Streptococcus, the Flesh-Eater
Evolution of Virulence in Group A Streptococcus, the Flesh-Eater
Nancy A. Moran,
University of Texas at Austin, USA
The Evolutionary Genomics of Bacterial Symbionts in Insects
The Evolutionary Genomics of Bacterial Symbionts in Insects
Martin Antonio,
Medical Research Council Laboratories, Gambia
Short Talk: Enhanced Invasiveness of ST618 Streptococcus pneumoniae Serotype 1 Clone from The Gambia, West Africa
Short Talk: Enhanced Invasiveness of ST618 Streptococcus pneumoniae Serotype 1 Clone from The Gambia, West Africa
8:00—11:00 AM
Parasites and Host Evolution I
Wendy Gibson,
University of Bristol, UK
Evolution of the Pathogenic Trypanosomes
Evolution of the Pathogenic Trypanosomes
*
Peter Parham,
Stanford University, USA
Host Evolution: Interactions between Polymorphic Human Receptors and Ligands that Influence Immune Defense and Reproduction
Host Evolution: Interactions between Polymorphic Human Receptors and Ligands that Influence Immune Defense and Reproduction
Peter Sarnow,
Stanford University School of Medicine, USA
Host Evolution: Evolution of microRNA miR-122 to Aid in Hepatitis C Virus Replication
Host Evolution: Evolution of microRNA miR-122 to Aid in Hepatitis C Virus Replication
Jenny Tan,
Genome Institute of Singapore, Singapore
Short Talk: Elevated Levels of Common Nonsynonymous Variants in the Human Macrophage Receptor Gene, EMR1, Result from Balancing Selection
Short Talk: Elevated Levels of Common Nonsynonymous Variants in the Human Macrophage Receptor Gene, EMR1, Result from Balancing Selection
5:00—7:00 PM
Parasites and Host Evolution II
*
Martin F. Flajnik,
University of Maryland, USA
Evolution of Adaptive Immunity
Evolution of Adaptive Immunity
Richard Carter,
University of Edinburgh, UK
Plasmodium vivax: Where in the World has it Been?
Plasmodium vivax: Where in the World has it Been?
Sara L. Sawyer,
University of Texas at Austin, USA
Short Talk: Evolution of the Anti-Retroviral TRIM5 and Related Genes
Short Talk: Evolution of the Anti-Retroviral TRIM5 and Related Genes
*Session Chair †Invited, not yet responded.
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