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This meeting took place in 2008
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Translational Regulatory Mechanisms (A7)
Organizer(s) Nahum Sonenberg, Alan G. Hinnebusch and Joel D. Richter
January 28—February 2, 2008
Coeur d'Alene Resort • Coeur d'Alene, Idaho USA
Abstract Deadline: Sep 26, 2007
Late Abstract Deadline: Oct 31, 2007
Scholarship Deadline: Sep 26, 2007
Early Registration Deadline: Nov 28, 2007
Supported by the Director's Fund
Summary of Meeting:
There are many exciting new findings in the field of translational control. The discovery that microRNAs control 30-40% of the genomes of many organisms underscores the paramount importance of translational control. Other exciting research involves identification of subcellular components (P-bodies and stress granules), which link translational control to mRNA stability, and associate with the microRNA machinery. The 3-D structures of initiation factors and bacterial ribosomes have been obtained, and recent findings implicate translational control in diseases (diabetes, obesity, virus infection) and in learning and memory. A critical shortcoming in microRNA research is the lack of understanding of the molecular mechanism. Another problem is the lack of structures of mammalian ribosomes with and without translation factors. The meeting’s goals are to discuss experimental approaches to understand the mechanisms of microRNA action, the structural basis of translation and its control, the link between translation and mRNA stability and, finally, defects in translation that cause disease.
View Scholarships/Awards
There are many exciting new findings in the field of translational control. The discovery that microRNAs control 30-40% of the genomes of many organisms underscores the paramount importance of translational control. Other exciting research involves identification of subcellular components (P-bodies and stress granules), which link translational control to mRNA stability, and associate with the microRNA machinery. The 3-D structures of initiation factors and bacterial ribosomes have been obtained, and recent findings implicate translational control in diseases (diabetes, obesity, virus infection) and in learning and memory. A critical shortcoming in microRNA research is the lack of understanding of the molecular mechanism. Another problem is the lack of structures of mammalian ribosomes with and without translation factors. The meeting’s goals are to discuss experimental approaches to understand the mechanisms of microRNA action, the structural basis of translation and its control, the link between translation and mRNA stability and, finally, defects in translation that cause disease.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
MONDAY, JANUARY 28
TUESDAY, JANUARY 29
WEDNESDAY, JANUARY 30
THURSDAY, JANUARY 31
FRIDAY, FEBRUARY 1
SATURDAY, FEBRUARY 2
Conference Program Print | View meeting in 24 hr (international) time
MONDAY, JANUARY 28
7:30—9:30 PM
Keynote Session
Matthias W. Hentze,
European Molecular Biology Laboratory, Germany
Translational Control by miRNAs and RNA-Binding Proteins
Translational Control by miRNAs and RNA-Binding Proteins
Robert H. Singer,
Albert Einstein College of Medicine, USA
Conserved Translational Mechanisms of Localized mRNA
Conserved Translational Mechanisms of Localized mRNA
8:00—11:15 AM
The Translational Apparatus: Prokaryotes versus Eukaryotes
Venki Ramakrishnan,
MRC Laboratory of Molecular Biology, UK
Structural Studies on Functional Complexes of the Ribosome
Structural Studies on Functional Complexes of the Ribosome
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
Getting the Message: Ribosome Recruitment by Viruses and Cells
Getting the Message: Ribosome Recruitment by Viruses and Cells
*
Rachel Green,
Johns Hopkins University School of Medicine, USA
Mechanistic Studies of Ribosome Function and Potential Implications for Translational Control
Mechanistic Studies of Ribosome Function and Potential Implications for Translational Control
Alan G. Hinnebusch,
National Institutes of Health, USA
Functions of eIF1, eIF1A, and 18S rRNA in Preinitation Complex Assembly and AUG Selection
Functions of eIF1, eIF1A, and 18S rRNA in Preinitation Complex Assembly and AUG Selection
5:00—7:30 PM
New Insight into Translation Initiation
Jon R. Lorsch,
Johns Hopkins School of Medicine, USA
The Molecular Mechanics of Start Site Recognition by the Eukaryotic Translational Machinery
The Molecular Mechanics of Start Site Recognition by the Eukaryotic Translational Machinery
Tatyana V. Pestova,
SUNY Downstate Medical Center, USA
Assembly of 48S Initiation Complexes on mRNAs with Highly Structured 5’-UTRs
Assembly of 48S Initiation Complexes on mRNAs with Highly Structured 5’-UTRs
Gerhard Wagner,
Harvard Medical School, USA
Protein Interactions in Eukaryotic Translation Initiation and their Inhibition
Protein Interactions in Eukaryotic Translation Initiation and their Inhibition
Richard J. Jackson,
University of Cambridge, UK
Reinitiation Mechanisms in Mammalian mRNA Translation
Reinitiation Mechanisms in Mammalian mRNA Translation
Assen Marintchev,
Harvard Medical School, USA
Short Talk: Organization of the eIF4A/4G/4H Complex: from Model to Experiment
Short Talk: Organization of the eIF4A/4G/4H Complex: from Model to Experiment
8:00—11:00 AM
mRNA Transport and Localization
Anne Ephrussi,
European Molecular Biology Laboratory, Germany
oskar RNP Assembly for Coordinated Transport and Translation Control
oskar RNP Assembly for Coordinated Transport and Translation Control
Elisa Izaurralde,
Max Planck Institute for Developmental Biology, Germany
The P-Body Component GW182 is Essential for miRNA-Mediated Gene Silencing
The P-Body Component GW182 is Essential for miRNA-Mediated Gene Silencing
Jennifer Darnell,
Rockefeller University, USA
Crosslinking-IP (CLIP) Identification of Novel Pre- and Post-Synaptic RNA Targets of the Fragile X Mental Retardation Protein, FMRP
Crosslinking-IP (CLIP) Identification of Novel Pre- and Post-Synaptic RNA Targets of the Fragile X Mental Retardation Protein, FMRP
Jason M. Casolari,
Stanford University, USA
Short Talk: mRNA Localization and Organization in S. cerevisiae
Short Talk: mRNA Localization and Organization in S. cerevisiae
John H. Carson,
University of Connecticut Health Center, USA
Short Talk: Multiplexed Dendritic Targeting of LTP RNAs by the A2 Pathway
Short Talk: Multiplexed Dendritic Targeting of LTP RNAs by the A2 Pathway
Alexander F. Palazzo,
Harvard Medical School, USA
Short Talk: The Signal Sequence Coding Region Promotes Nuclear Export of mRNA
Short Talk: The Signal Sequence Coding Region Promotes Nuclear Export of mRNA
5:00—7:15 PM
Translational Control of Development
*
Matthias W. Hentze,
European Molecular Biology Laboratory, Germany
Robert J. Schneider,
New York University School of Medicine, USA
eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy
eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy
Joel D. Richter,
University of Massachusetts Medical School, USA
Translational Control of Cellular Senescence by CPEB
Translational Control of Cellular Senescence by CPEB
Howard Lipshitz,
University of Toronto, Canada
Control of mRNA Translation, Stability and Localization during Early Drosophila Development
Control of mRNA Translation, Stability and Localization during Early Drosophila Development
Scott L. Noble,
University of Colorado Denver Health Sciences Center, USA
Short Talk: P-body/Stress Granule-Like Particles are Regulated and Linked to Maternal mRNA Control during C. Elegans Development
Short Talk: P-body/Stress Granule-Like Particles are Regulated and Linked to Maternal mRNA Control during C. Elegans Development
Robin P. Wharton,
Duke University Medical Center, USA
Short Talk: RNA Tethering to Explore Mechanisms of Regulation in the Early Drosophila Embryo
Short Talk: RNA Tethering to Explore Mechanisms of Regulation in the Early Drosophila Embryo
8:00—11:00 AM
Translational Control in Learning and Memory
*
Joel D. Richter,
University of Massachusetts Medical School, USA
Eric Klann,
New York University, USA
Synaptic Plasticity and Memory Phenotypes in Mice with Mutations for Translational Control Proteins
Synaptic Plasticity and Memory Phenotypes in Mice with Mutations for Translational Control Proteins
Nahum Sonenberg,
McGill University, Canada
Control of Memory by eIF2
Control of Memory by eIF2
Melissa J. Moore,
Moderna Therapeutics, USA
Interactions between eIF4A and its Accessory Factors eIF4B and eIF4H
Interactions between eIF4A and its Accessory Factors eIF4B and eIF4H
Jean-Claude Lacaille,
Université de Montréal, Canada
Short Talk: Staufen1 Regulation of Protein Synthesis-Dependent Long-Term Potentiation and Synaptic Function in Hippocampal Pyramidal Cells
Short Talk: Staufen1 Regulation of Protein Synthesis-Dependent Long-Term Potentiation and Synaptic Function in Hippocampal Pyramidal Cells
Joseph Rayman,
Columbia University, USA
Short Talk: Functional Studies of a Neuronal Aplysia TIA Ortholog
Short Talk: Functional Studies of a Neuronal Aplysia TIA Ortholog
Douglas R. Cavener,
Pennsylvania State University, USA
Short Talk: PERK is Required to Regulate Different Cellular Functions in the Endocrine and Exocrine Pancreas and Bone
Short Talk: PERK is Required to Regulate Different Cellular Functions in the Endocrine and Exocrine Pancreas and Bone
5:00—7:15 PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bodies) I
Allan Jacobson,
University of Massachusetts Medical School, USA
NMD: mRNA Decay Solves a Translational Problem
NMD: mRNA Decay Solves a Translational Problem
Lynne E. Maquat,
University of Rochester Medical Center, USA
Efficiency of the Pioneer Round of Translation Affects the Cellular Site of Nonsense-Mediated mRNA Decay
Efficiency of the Pioneer Round of Translation Affects the Cellular Site of Nonsense-Mediated mRNA Decay
Paul J. Anderson,
Harvard Medical School, USA
A Genomic siRNA Screen Identifies Signaling Pathways Required for the Assembly of Stress Granules and P-Bodies
A Genomic siRNA Screen Identifies Signaling Pathways Required for the Assembly of Stress Granules and P-Bodies
Oliver Mühlemann,
University of Bern, Switzerland
Short Talk: Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3’ Untranslated Region
Short Talk: Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3’ Untranslated Region
Yuichi Otsuka,
Ohio State University, USA
Short Talk: 5’ Capping of Endonuclease-Generated mRNA Decay Intermediates by a Cytoplasmic Capping Enzyme Complex
Short Talk: 5’ Capping of Endonuclease-Generated mRNA Decay Intermediates by a Cytoplasmic Capping Enzyme Complex
8:00—11:15 AM
Translational Control and Disease Models
*
Nahum Sonenberg,
McGill University, Canada
David Ron,
University of Cambridge, UK
Regulation of Intermediary Metabolism by Endoplasmic Reticulum Stress-Induced Phosphorylation of Translation Initiation Factor 2-alpha
Regulation of Intermediary Metabolism by Endoplasmic Reticulum Stress-Induced Phosphorylation of Translation Initiation Factor 2-alpha
Peter Sarnow,
Stanford University School of Medicine, USA
Subversion of a Liver-Specific microRNA by Hepatitus C Virus
Subversion of a Liver-Specific microRNA by Hepatitus C Virus
Ian J. Mohr,
New York University School of Medicine, USA
Assembly of Translation Initiation Factor Complexes in Virus-Infected Cells
Assembly of Translation Initiation Factor Complexes in Virus-Infected Cells
Thomas E. Dever,
National Institutes of Health, USA
Regulation of the eIF2 Kinase PKR
Regulation of the eIF2 Kinase PKR
Suzanne Komili,
Harvard Medical School, USA
Short Talk: Functional Specificity among Duplicated Ribosomal Protein Genes Regulates Gene Expression in Yeast
Short Talk: Functional Specificity among Duplicated Ribosomal Protein Genes Regulates Gene Expression in Yeast
Mauro Costa-Mattioli,
Baylor College of Medicine, USA
Short Talk: Translational Control of the Innate Immune Response
Short Talk: Translational Control of the Innate Immune Response
5:00—7:30 PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bodies) II
Joel G. Belasco,
New York University School of Medicine, USA
Translational Repression, mRNA Decay, and RNA Interference
Translational Repression, mRNA Decay, and RNA Interference
Zissimos Mourelatos,
University of Pennsylvania School of Medicine, USA
Mammalian microRNAs and piRNAs
Mammalian microRNAs and piRNAs
Matthias Selbach,
Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Large Scale Identification of Translational and Transcriptional miRNA Targets
Short Talk: Large Scale Identification of Translational and Transcriptional miRNA Targets
Herve Le Hir,
CNRS-Centre de Genetique Moleculaire, France
Short Talk: The NMD Factors Upf2 and Upf3 Recruit Upf1 to the Exon-Junction Complex and Stimulate its RNA Helicase Activity
Short Talk: The NMD Factors Upf2 and Upf3 Recruit Upf1 to the Exon-Junction Complex and Stimulate its RNA Helicase Activity
*Session Chair †Invited, not yet responded.
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