Keystone Symposia

Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2009


Here are the related meetings in 2020:
Pain: Aligning the Target (J7)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Neurobiology of Pain and Analgesia (C2)


Organizer(s) Clifford J. Woolf, Ardem Patapoutian and Simon Tate
February 22—27, 2009
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, NM USA
Abstract Deadline: Oct 21, 2008
Late Abstract Deadline: Nov 21, 2008
Scholarship Deadline: Oct 21, 2008
Early Registration Deadline: Dec 22, 2008

Sponsored by Abbott Laboratories and AstraZeneca Pharmaceuticals, L.P.

Summary of Meeting:
This symposium will highlight the substantial advances made in our understanding of the neurobiology and pathophysiology of pain and the enormous opportunities these present for identifying and exploiting new targets for therapy. Current therapy is largely empirical and is based on suppressing symptoms. The future offers treatment targeted at the specific neural mechanisms responsible. This requires understanding the mechanisms, being able to identify which mechanism operates in which patient, and having pharmacological tools to act on the molecular targets that drive these mechanisms. Furthermore, we need to identify which patient is at risk of developing pain and develop preventative disease-modifying treatments to abort the establishment of pain. This symposium will address how these goals can be achieved by the combined effort of academics and industry.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


SUNDAY, FEBRUARY 22

3:00—7:30 PM
Registration

Promenade
6:30—7:30 PM
Refreshments

Promenade
7:30—9:30 PM
Keynote Session

Mesa A-B
* Clifford J. Woolf, Children's Hospital, USA

Michael J. Detke, MedAvante Research Institute, USA
New Treatments for Pain: Starting with the End in Mind – Market, Regulatory, and Development Challenges, and How These Relate to Neurobiology

Xinzhong Dong, Johns Hopkins University, USA
Short Talk: Regulation of TRP Channels by Pirt

Samer Eid, Merck & Co., Inc., USA
Short Talk: To Feel or not to Feel - Targeting the Heat Sensor TRPV1 for Pain Treatment


MONDAY, FEBRUARY 23

7:00—8:00 AM
Breakfast

Chamisa
8:00—11:00 AM
Nociceptor Transduction and Plasticity

Mesa A-B
* Ardem Patapoutian, The Scripps Research Institute, USA

Jon Levine, University of California, San Francisco, USA
Kinases - Nociceptors Pain Switches

Peter McNaughton, Kings College London, UK
Sensitization in Nociceptors

David Shelton, , USA
NGF and Anti-NGF: The Ying and Yang of Pain

Stephen B. McMahon, King's College London, UK
Nociceptor Mechano-Sensitisation Induced by UVB Irradiation in Human and Rodent Skin

9:20—9:40 AM
Coffee Break

Promenade
11:00 AM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Mesa C
1:00—10:00 PM
Poster Viewing

Mesa C
4:30—5:00 PM
Coffee Available

Promenade
5:00—7:00 PM
TRP Channels

Mesa A-B
* Stephen B. McMahon, King's College London, UK

Ardem Patapoutian, The Scripps Research Institute, USA
Molecular Mechanisms of Thermosensation

David Julius, University of California, San Francisco, USA
From Peppers to Peppermints: Natural Products as Probes of the Pain Pathway

Magdalene Moran, Hydra Biosciences, USA
TRPs as Analgesic Drug Targets

Cheryl L. Stucky, Medical College of Wisconsin, USA
Short Talk: TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons via Neuronal and Keratinocyte Expression

7:00—8:00 PM
Social Hour with Lite Bites

Chamisa
7:30—10:00 PM
Poster Session 1

Mesa C

TUESDAY, FEBRUARY 24

7:00—8:00 AM
Breakfast

Chamisa
8:00—11:00 AM
Synaptic Plasticity

Mesa A-B
* David Julius, University of California, San Francisco, USA

Robert W. Gereau, Washington University Pain Center, USA
Postsynaptic Mechanisms of Plasticity in Dorsal Horn Neurons

Sandra Garraway, Texas A & M, USA
Activation of Neuronal ERK2 is Required for Inflammation-Induced Pain

Frank Porreca, University of Arizona, USA
Modulating Descending Modulation

Hans Ulrich Zeilhofer, University of Zurich, Switzerland
GABA-A Receptor Subunit-Specific Analgesia

9:20—9:40 AM
Coffee Break

Promenade
11:00 AM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Mesa C
1:00—10:00 PM
Poster Viewing

Mesa C
4:30—5:00 PM
Coffee Available

Promenade
5:00—7:00 PM
Sodium and Calcium Channels

Mesa A-B
* Prisca Honore, Abbott Bioresearch Center, USA

Peter W. Reeh, University of Erlangen - Nurnberg, Germany
Nociceptor Sodium Channels – Few but Decisive

Alex Binshtok, Harvard Medical School, USA
Interleukin 1beta and Sodium Channels - From Slow Inactivation to Fast Nociception

Diane Lipscombe, Brown University, USA
Nociceptors Modulate Calcium Channel Activity by Alternative Splicing.

Sarah E. Canetta, Columbia University, USA
Short Talk: Type III Nrg1-erbB Signaling Affects Peripheral Nociception

7:00—8:00 PM
Social Hour with Lite Bites

Chamisa
7:30—10:00 PM
Poster Session 2

Mesa C

WEDNESDAY, FEBRUARY 25

7:00—8:00 AM
Breakfast

Chamisa
8:00—11:00 AM
Discovering Pain Targets

Mesa A-B
* Simon Tate, GlaxoSmithKline, UK

Clifford J. Woolf, Children's Hospital, USA
Finding Novel Analgesic Targets

Qiufu Ma, Dana Farber Cancer Institute, USA
Regulation of Nociceptor Phenotype and Pain Behavior

Benjamin F. Cravatt III, The Scripps Research Institute, USA
Modulating Pain by Blockade of Endocannabinoid Metabolism

Gary R. Lewin, Max Delbrück Center for Molecular Medicine, Germany
Mechanostransducers as Targets for Pain Therapy

9:20—9:40 AM
Coffee Break

Promenade
11:00 AM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Promenade
5:00—7:00 PM
Pain Circuits

Mesa A-B
* Gary R. Lewin, Max Delbrück Center for Molecular Medicine, Germany

Mark Zylka, University of North Carolina, USA
Biochemical Modulation of Nociceptive Circuits

Allan I. Basbaum, University of California, San Francisco, USA
Behaviorally Relevant Specificity of Nociceptors and Their Differential Regulation via mu and delta Opioid Receptors

Joyce A. DeLeo, Dartmouth Medical School, USA
Glial-Neuronal Circuits

Sarah Ross, University of Pittsburgh, USA
Short Talk: Bhlhb5 Is Critical for the Formation of Nociceptive Circuits in the Developing Spinal Cord

7:00—8:00 PM
Social Hour with Lite Bites

Chamisa

THURSDAY, FEBRUARY 26

7:00—8:00 AM
Breakfast

Chamisa
8:00—11:00 AM
Validating Pain Targets and Developing Analgesics

Mesa A-B
* Allan I. Basbaum, University of California, San Francisco, USA

Simon Tate, GlaxoSmithKline, UK
Progressing Pain Targets: A Focus on in vitro Screening

Rohini Kuner, University of Heidelberg, Germany
Target Validation using Genetically Modified Mice

Prisca Honore, Abbott Bioresearch Center, USA
Pharmacological Validation for Analgesia Targets

Kenneth M. Verburg, Pfizer Inc., USA
Pain Therapeutics: Focus on Development

9:20—9:40 AM
Coffee Break

Promenade
11:00 AM
On Own for Lunch

4:30—5:00 PM
Coffee Available

Promenade
5:00—7:00 PM
Pain Genetics

Mesa A-B
* Peter W. Reeh, University of Erlangen - Nurnberg, Germany

Annemieke Kavelaars, University of Texas MD Anderson Cancer Center, USA
Short Talk: GRK2 Deficiency Prolongs PGE2-Induced Hyperalgesia via a Switch in Signaling from PKA to ERK

Michele Hummel, Wyeth Research, USA
Short Talk: Corticotropin Releasing Factor1 Receptors Mediate Inflammatory- and Neuropathic-Like Pain

Achim Schmidtko, Goethe University, Germany
Short Talk: Reduced Inflammatory and Neuropathic Pain in Mice Lacking Nitric Oxide-Sensitive Guanylyl Cyclase

Jeff S. Mogil, McGill University, Canada
Genetics of Pain in the Laboratory Mouse

Luda Diatchenko, University of North Carolina School of Dentistry, USA
Expansion of the Human mu-Opioid Receptor Gene Locus: Novel Functional Variants

7:00—7:15 PM
Concluding Remarks

Mesa A-B
Clifford J. Woolf, Children's Hospital, USA

Simon Tate, GlaxoSmithKline, UK

Ardem Patapoutian, The Scripps Research Institute, USA

7:15—8:15 PM
Social Hour with Lite Bites

Mesa A-B
8:00—11:00 PM
Entertainment

Mesa A-B

FRIDAY, FEBRUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS064604-01




We gratefully acknowledge additional support for this conference from:

Abbott Laboratories AstraZeneca Pharmaceuticals, L.P.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Educational grant from Lilly USA, LLC


GlaxoSmithKline


Pfizer Global Research & Development


Pfizer Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-1179