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This meeting took place in 2009

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

B Cells in Context (C3)

Organizer(s) Ann Marshak-Rothstein, Michael P. Cancro and Mark S. Schlissel
February 24—March 1, 2009
Taos Convention Center (meeting only) • Taos, NM USA
Abstract Deadline: Oct 22, 2008
Late Abstract Deadline: Nov 25, 2008
Scholarship Deadline: Oct 22, 2008
Early Registration Deadline: Dec 29, 2008

Supported by the Directors' Fund

Summary of Meeting:
B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools. Failures in these processes can lead to autoimmune disease and lymphoid malignancy. These events involve highly choreographed cell-cell interactions and migratory behaviors. The goal of this meeting will be to ask how the various B cell microenvironments regulate the molecular events that determine B cell fate and function, and to explore how manipulation of the microenvironment can impact the immune response, autoimmunity, transformation and vaccine development.

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Conference Program    Print  |   View meeting in 24 hr (international) time


3:00—7:30 PM

Rio Grande D
6:30—7:30 PM

Rio Grande
7:30—8:30 PM
Keynote Address

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Signaling Life and Lifestyle through the BCR


7:00—8:00 AM

Rio Grande
8:00—11:15 AM
Lineage Commitment and BCR Generation

Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
A Recurring Gene Regulatory Network that Orchestrates Myeloid Versus B Cell Fate Choice

Christian Kosan, Institut de Recherches Cliniques de Montréal (IRCM), Canada
Short Talk: The POZ Domain Transcription Factor Miz-1 (Zbtb17) is Required for B Cell Lineage Commitment and Indispensable for the Formation of Mature Follicular B Cells

Hassan Jumaa, Institute for Immunology, Ulm University Hospital, Germany
Role of the Pre-BCR and BCR in Early B Cell Development

Marjorie A. Oettinger, Massachusetts General Hospital, USA
RAG2 Links Histone Methylation and VDJ Recombination

David G. Schatz, Yale University School of Medicine, USA
Short Talk: Focal Binding of RAG1 and RAG2 to Antigen Receptor loci Defines V(D)J "Recombination Centers"

* Mark S. Schlissel, University of California, Berkeley, USA
A Role for NF-kB in Receptor Editing

9:20—9:40 AM
Coffee Break

Rio Grande B/C
11:15 AM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Rio Grande
1:00—10:00 PM
Poster Viewing

Rio Grande
2:00—4:30 PM
Workshop 1: What Targets the lgH/lgL Loci for VDJ Recombination, CSR, and SHM?

Don Fernando Hall
* F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, Germany

* Michel C. Nussenzweig, HHMI/Rockefeller University, USA

Workshop 1A: AID Targeting (Cis and Trans-acting Elements)

Sebastian D. Fugmann, Chang Gung University, Taiwan
Identification of Cis-Regulatory Elements Targeting AID-Mediated Sequence Diversification to the Chicken Immunoglobulin Light Chain Gene

Barbara K. Birshtein, Albert Einstein College Of Medicine, USA
Active DNA Demethylation in the Immunoglobulin Heavy Chain 3’ Regulatory Region during Class Switch Recombination Involves GADD45A

Rebecca K. Delker, Rockefeller University, USA
Elucidating the Mechanism of Specificity Achieved by Activation Induced Cytidine Deaminase

Urszula Nowak, Weill Cornell Graduate School of Medical Sciences, USA
AID in Class Switch Recombination

Kevin M. McBride, University of Texas MD Anderson Cancer Center, USA
Identification of AID Interacting Proteins

Anne Durandy, Institut Imagine, France
Human PMS2 Deficiency is Associated with Impaired Immunoglobulin Class Switch Recombination

Jing H. Wang, University of Colorado Anschutz Medical Campus, USA
Mechanistic Factors That Promote Recurrent Translocations in Peripheral B Lymphocytes

Workshop 1B: RAg Interactions, VDJ Recombination and Allelic Exclusion

Moshe J. Sadofsky, Albert Einstein College Of Medicine, USA
A New Protein Interaction Motif in the Rag1 N-Terminal Domain

Jane A. Skok, New York University School of Medicine, USA
Recombinase-Dependent Homologous Pairing of Ig Alleles: A Novel Regulatory Aspect of Allelic Exclusion

Laurel A. Eckhardt, Hunter College of CUNY, USA
A Role for the IgH Intronic Enhancer, Eu, in Enforcing Allelic Exclusion

2:30—4:30 PM
Workshop 2: Dysregulated B Cells in Autoimmunity

Council Chambers
* Peter E. Lipsky, AMPEL Biosolutions, USA

* John F. Kearney, University of Alabama, Birmingham, USA

Michelle L. Harris, Yale University School of Medicine, USA
APRIL Promotes AM14 Rheumatoid Factor B-Cell Activation and Maturation

Andrea Bottaro, University of Rochester School of Medicine and Dentistry, USA
Accumulation and Relocation of B Cells in the Popliteal Lymph Nodes of TNF-Transgenic Mice Accompanies Development of Knee Arthritis

Sarah R. Fintushel, University of Pennsylvania, USA
B Cell Recirculation through Skin

Tineke Cantaert, Institut Pasteur Cambodia, Cambodia
Ectopic Lymphoid Neogenesis is not Functionally Competent to Drive Humoral Autoimmunity in Rheumatoid Synovitis

Julie Kujawa, Biogen Idec, USA
Abnormalities in Lymphoid Subsets and Architecture Associated with the Onset of Autoimmunity in an Interferon-Accelerated Murine Lupus Model

Magdalena A. Berkowska, Leiden University Medical Center, Netherlands
Molecular Analysis of Human Memory B-cell Subsets Suggests Different Origins and Maturation Pathways

2:30—4:30 PM
Workshop 3: Computation and Mathematical Modeling in the Study of B Cell Biology

* Ramit Mehr, Bar-Ilan University, Israel
B Cell Immunomics - From Analyzing Single Mutations to Modeling Cell Populations

Andrew M. Collins, University of New South Wales, Australia
Immunoglobulin Sequences of Different Isotypes and from Patients with Different Diseases Show Distinct Patterns of Somatic Point Mutation

Ying Li, University of Chicago, USA
Gene Regulatory Model for B Cell Fate Specification

Yoram Louzoun, Bar Ilan University, Israel
Autoantibody Repertoire Shift as Early Clinical Marker of Cancer

Kamila Karolina Matulewicz, University Hospital of Georg August University, Germany
Dissecting the Molecular Events in Burkitt’s Lymphoma

Michael Meyer-Hermann, Helmholtz Centre for Infection Research, Germany
Coherent Data, Divergent Interpretations: Mathematical Modeling Clarifies the Interpretation of Two-Photon Imaging Data of Germinal Centers

Jamie L. Duke, Yale University, USA
Computational Modeling of Genome-Wide Targeting of Somatic Hypermutation

Thomas B. Kepler, Boston University, USA
Adjuvants and the Reorganization of Leukocytes in Humoral Immunity: A Computational Systems Approach

4:30—5:00 PM
Coffee Available

Rio Grande B/C
5:00—7:00 PM
Selection and Survival of Primary B Cells

John F. Kearney, University of Alabama, Birmingham, USA
Primary B Cell Repertoire Determination

Sarah F. Andrews, National Institutes of Health, USA
Short Talk: Transitional B Cells Exhibit a BCR-Specific Nuclear Defect in Gene Transcription

Shiv Pillai, Massachusetts General Hospital, USA
The role of a 9-O sialylacetylesterase in peripheral B cell development and autoimmunity

* Michael P. Cancro, University of Pennsylvania, USA
Molecular and Cellular Cross-Talk in the Actions of BLyS Ligands and Receptors

7:00—8:00 PM
Social Hour with Lite Bites

Rio Grande
7:30—10:00 PM
Poster Session 1

Rio Grande


7:00—8:00 AM

Rio Grande
8:00—11:15 AM
Differentiation Decisions

Robert C. Rickert, Pfizer Inc., USA
Short Talk: Distinct Roles for Foxo1 at Multiple Stages of B Cell Differentiation

Eric Meffre, Yale University School of Medicine, USA
Autoreactive B Cell Counterselection in Humans

* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Activating autoreactive B Cells: Roles of T cells, Tolls and Time

Stephen C. Jameson, University of Minnesota Medical School, USA
Short Talk: KLF2 Deficiency dysregulates multiple B Cell Subsets

Jean-Claude Weill, INSERM U1151 Institut Necker-Enfants Malades, France
Multiple Layers of B cell memory with different effector functions

David M. Tarlinton, Monash University, Australia
Molecular Regulation of Memory

9:20—9:40 AM
Coffee Break

Rio Grande B/C
11:15 AM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Rio Grande
1:00—10:00 PM
Poster Viewing

Rio Grande
2:00—4:30 PM
Workshop 4: What is B Cell Memory? How are Cells Committed to Memory or Plasma Cell Differentiation?

Don Fernando Hall
* Ian C.M. MacLennan, University of Birmingham, UK

Workshop 4A: Commitment to Germinal Center of Plasmablast Differentiation

Daniel James Hodson, NCI, National Institutes of Health, USA
The RNA Binding Protein TIS11b is Expressed in the Germinal Centre and Suppresses Immune Regulatory Genes

Shinu A. John, University at Buffalo, State University of New York, USA
ETS-1 Plays a Unique and Non-Redundant Role in Inhibiting Blimp-1 Activity and Preventing Plasma Cell Differentiation

B. Hilda Ye, Albert Einstein College Of Medicine, USA
STAT3 and NF-kappaB Synergistically Promote Plasma Cell Differentiation Through Upregulation of IRF4 and Blimp-1

Tyani D. Chan, Garvan Institute of Medical Research, Australia
In vivo Dynamics and Affinty Regulation of Early T-dependent B Cell Responses

Workshop 4B: B Cell Memory

Jeremy Foote, University of Alabama at Birmingham, USA
Generation of B cell memory to the TI-2 antigen a 1.3-dextran

Eliver Eid Bou Ghosn, Emory University, USA
Novel Properties of B-1 Memory

Ismail Dogan, Hôpital Necker, France
B Cell Memory Subsets

Kim Good-Jacobson, Monash University, Australia
Role of PD-1 in Memory B Cell Formation and Responses

Workshop 4C: The Regulation of Plasmblast Maturation and Survival

Sefat Khuda, University of Virginia, USA
Deregulated c-Myc Negatively Controls B Cell Immunity

Bimba Franziska Hoyer, Charité University Medicine, Germany

Bimba Franziska Hoyer, Charité University Medicine, Germany

Dong-Mi Shin, NIAID, National Institutes of Health, USA
Interferon Regulatory Factor 6 (IRF6) Influences Late B Cell Differentiation

Selina Chen-Kiang, Weill Medical College of Cornell University, USA
The Cdk4/6 Inhibitor p18INK4c Targets Rapidly Cycling and Apoptotic Plasma Cell Precursors for Homeostatic Control of Terminal Plasma Cell Differentiation

2:30—4:30 PM
Workshop 5: Interactions between B Cells and the Innate Immune System

* Silvia Bolland, NIAID, National Institutes of Health, USA

* Gregg J. Silverman, New York University Langone Medical Center, USA
VH Inheritance Determines Apoptotic Cell Neo-Antigen Recognition by Antibodies that Regulate Phagocytosis and Inflammatory Responses by Immature Dendritic Cells

Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA
Characterizing iNK T and B Cell Memory Responses to Lipid Antigen

Marcus R. Clark, University of Chicago, USA
Endocytic Sequestration of the B Cell Antigen Receptor and Toll-like Receptor 9 in Anergic Cells

Rebecca Anne Sweet, John Curtin School of Medical Research, Australia
Extrafollicular Activation of Autoreactive RF B Cells Leads to Memory B Cell Development

John H. Kehrl, NIAID, National Institutes of Health, USA
Toll-Like Receptor 4 Signaling Augments B lymphocyte Migratory and Proliferative Programs, and Overcomes the Restriction that Limits Access to the Dark Zones of Germinal Centers

Almut Meyer-Bahlburg, University Medicine Greifswald, Germany
Reduced c-myc Expression Levels Limit Follicular Mature B Cell Cycling in Response to TLR Signals

Lenka L. Allan, University of British Columbia, Canada
Apolipoprotein-mediated Lipid Antigen Presentation in B cells

2:30—4:30 PM
Workshop 6: Regulating B Lineage Specification and Commitment

Council Chambers
* Ranjan Sen, National Institute of Aging, National Institutes of Health, USA

* Shiv Pillai, Massachusetts General Hospital, USA

John David Colgan, University of Iowa, USA
The Justy Mutation Identifies the Gon4L Gene as an Essential regulator of B Cell Development

Qi Yang, University Of Pittsburgh, USA
E47 Controls the Developmental Integrity and Cell Cycle Quiescence of Multipotential Hematopoietic Progenitors during Progression to B Lineage

James R. Hagman, National Jewish Health, USA
Combined Haploinsufficiency of Ebf1 and Runx1 Genes Impedes B Cell Lineage Progression and Identity

Stephen L. Nutt, Walter and Eliza Hall Institute, Australia
Myb Is Critical For Early B Cell Development

Hans-Willem E. Snoeck, Columbia University Medical Center, USA
Differential Specification of Lymphoid Progenitor Populations to Distinct B Cell Development Programs

Jane Seagal, Immune Disease Institute, USA
Developmental Plasticity of Mature B Cell Populations

David M. Allman, University of Pennsylvania, USA
Unique Requirement for AKT1 and AKT2 in Marginal Zone B Cell Development

4:30—5:00 PM
Coffee Available

Rio Grande B/C
5:00—7:00 PM
B Cell Activation and Regulation

Susan K. Pierce, NIAID, National Institutes of Health, USA
A “conformation-induced oligomerization” Model for the Initiation of B cell receptor signaling

Michael Reth, Albert-Ludwigs University Freiburg, Germany
BCR Signaling Pathways: From Autoinhibition to Activation

Thomas L. Rothstein, Western Michigan University, USA
Short Talk: Reprogramming BCR Signaling through Receptor Crosstalk

* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Modulation of autoreactive B cell responses by IFNbeta and BCR engagement

7:00—8:00 PM
Social Hour with Lite Bites

Rio Grande
7:30—10:00 PM
Poster Session 2

Rio Grande


7:00—8:00 AM

Rio Grande
8:00—11:00 AM
B Cell Niches, Contacts, and Effector Function

Rita Carsetti, Bambino Gesù Children Hospital, Italy
Mucosal B Cell Ontogeny in Mouse and Man

Nicole Baumgarth, University of California, Davis, USA
Short Talk: B cells in the context of Influenca

Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Directed Trafficking of Chemokines and Small Antigens into LNs via Follicular Conduits

Shiv Pillai, Massachusetts General Hospital, USA

* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany
Plasma Cell Niches and Dynamics

Frances E. Lund, University of Alabama at Birmingham, USA
Effector B Cell Subsets: Multiple antibody independent roles for B cells in immunity

Louis B. Justement, University of Alabama, Birmingham, USA
Short Talk: Cross-Talk between Marginal Zone B Cells and Marginal Zone Macrophages

9:20—9:40 AM
Coffee Break

Rio Grande B/C
11:00 AM
On Own for Lunch

11:00 AM—1:00 PM
Poster Setup

Rio Grande
1:00—10:00 PM
Poster Viewing

Rio Grande
2:30—4:30 PM
Workshop 7: Unique Aspects of Mucosal Immunity

Don Fernando Hall
* Katherine L. Knight, Loyola University, USA

SangKon Oh, Baylor Research Institute, USA
A T Cell-Dependent Mechanism for the Induction of Human Mucosal Homing IgA-Secreting Plasmablasts

Douglas A. Kuperman, Northwestern University, USA
Secretory IgA is Increased in the Airways of 12/15-lipoxygenase Deficient Mice

Bertrand Huard, Centre Medical Universitaire, Switzerland
Neutrophils Create Survival Niches Rich in APRIL for Plasma Cells

Henrik E. Mei, German Rheumatism Research Center, Germany
Blood-borne Human Plasma Cells are Derived from Mucosal Immune Responses and are Refractory to Therapeutic B Cell Depletion

HyeMee Joo, Baylor Institute Research, USA
The State of B Cell Memory in the Lung is Profoundly Influenced by the Nature of Immunization

Kristina Rothaeusler, California National Primate Research Center, USA
Evidence for Extrafollicular Foci-derived Self-renewing Lung Tissue Plasma Cells following Influenza Virus Infection

* Troy D. Randall, University of Alabama at Birmingham, USA
Milky Spots in the Omentum Independently Support T-dependent B Cell Responses to Peritoneal Antigens

Wojciech Wojciechowski, University of Rochester, USA
TNF-alpha Producing B Cells are Involved in the Generation of Protective Immunity against Intestinal Nematode Parasite Heligmosmoides Polygyrus

Venkata A. Yeramilli, Loyola University Chicago, USA
B Lymphocyte Development in GALT

2:30—4:30 PM
Workshop 8: Integrating Signaling Cascades

Council Chambers
* Thomas L. Rothstein, Western Michigan University, USA

* Robert T. Woodland, University of Massachusetts Medical School, USA

Kevin L. Otipoby, Biogen Idec, USA
BCR Expression Regulates Gsk3 activation, c-Myc Protein Levels and B Cell Proliferation

Josquin Nys, National Institute for Medical Research, UK
to provide comment for above presentation

Shannon O'Neill, University of Colorado Denver, USA
Monophosphorylation of the Igá ITAM Initiates an Inhibitory Cascade Required for B Cell Anergy

Lenka Sinik, Array BioPharma, USA
to provide comment for above presentation

H. Christine Patterson, Immune Disease Institute, USA
Negative Regulation of B Cell Antigen Receptor Signaling Strength by Ig Alpha Serine/Threonine Phosphorylation Inhibits Poly- and Autoreactive Plasma Cell Formation

Corinne Lara DePersis, University of Colorado Health Science Center, USA
to provide comment for above presentation

Sarah Rowland, Washington University in St. Louis, USA
Suboptimal BCR Levels and Tonic BCR Signals Prevent Differentiation of Immature B Cells

Nichol E. Holodick, WMU Medical School, USA
to provide comment for above presentation

Bazarragchaa Damdinsuren, National Institute on Aging, National Institutes of Health, USA
Functional Consequences of Single Round Antigen Receptor Signaling in Naïve B Cells

2:30—4:30 PM
Workshop 9: Epigenetic Regulation and microRNA Control

* Ann J. Feeney, The Scripps Research Institute, USA

* Rafael Casellas, NIAMS-NCI, National Institutes of Health, USA

Sergei B. Koralov, New York University, USA
Role of miRNAs in B Cell Development

Stefan Kuchen, National Institutes of Health, USA
A Systems Approach Using Genome-Wide Small RNA Profiling for Studying B Cell Development, Activation, and Differentiation

Giuseppe Testa, European Institute of Oncology, Italy
Functional Dissection of Histone Lysine Methylation in B Cell specification

Marieta Caganova, Fondazione Istituto Italiano di Tecnologia (IIT), Italy
The Role of the Polycomb Group Protein Ezh2 in Adaptive B Cell Immunity and Terminal Differentiation

Ramesh Subrahmanyam, National Institute on Aging, National Institutes of Health, USA
Rearrangement Associated Epigenetic Changes Distinguish DJH Junctions for VH Recombination

Chaggai E. Rosenbluh, Icahn School of Medicine at Mount Sinai, USA
Epigenetic Regulation - A Key Mediator of Allelic Exclusion

Zhixin Zhang, University of Nebraska Medical Center, USA
Association with the Nuclear Matrix is Essential for Pax5 to Fully Activate its Target Genes in Murine Pro B

Julita A. Ramirez, University of Washington, USA
Opposing Effects of Swi/Snf and Mi-2 NuRD Chromatin Remodeling Complexes on Epigenetic Reprogramming by EBF and Pax5

4:30—5:00 PM
Coffee Available

Rio Grande B/C
5:00—7:15 PM
B Cells on the Move

Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Early events in B cell response to antigen

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Dynamics of B Cell Antigen Encounter

* Ronald N. Germain, NIAID, National Institutes of Health, USA
Visualizing the Cell-Cell Interactions Underlying Humoral Immune Responses

Marc K. Jenkins, University of Minnesota Medical School, USA
Analysis of Antigen-Specific Memory B Cell Formation in Normal Mice

7:00—8:00 PM
Social Hour with Lite Bites

Rio Grande
7:30—10:00 PM
Poster Session 3

Rio Grande


7:00—8:00 AM

Rio Grande
8:00—11:30 AM
Therapeutic Manipulation of B Cell Subsets

Jennifer H. Anolik, University of Rochester, USA
B Cell Subsets Targeted by Rituximab: Understanding Clinical and Immunological Outcomes After B Cell Depletion in Autoimmune Disease

* Hergen Spits, University of Amsterdam, Netherlands
Immortalization of BCR+ Antibody Producing Human B Cells by Genetic Programming

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Development of B Cell Targeted Vaccines

Barton F. Haynes, Duke University Medical Center, USA
Induction of B Cell Polyclonal Differentiation and Apoptosis With Massive Gastrointestinal Tract Germinal Center Loss In the Earliest Stages of HIV-1 Infection

Kenneth K. Yu, California Institute of Technology, USA
Short Talk: Engineering Immunity Against HIV: A Stem Cell Vaccine

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Pax5 in Normal and Neoplastic B Cell Development

Geetha P. Bansal, National Institutes of Health, USA
Short Talk: Update on NIAID Funding Opportunities

9:20—9:40 AM
Coffee Break

Rio Grande B/C
11:00 AM
On Own for Lunch

2:30—4:30 PM
Workshop 10: Targeted Vaccine Strategies for Chronic Infection

Don Fernando Hall
* Nancy L. Haigwood, Oregon Health & Science University, USA

Workshop 10A: B Cells and Non-HIV Infections

Filiz Demircik, Uniklinik, Germany
The Role of B Cells in Murine Cytomegalovirus (MCMV) Infection

Denise A. Kaminski, University of Rochester, USA
Nucleoprotein-Immune Antibody Protects Against Influenza Virus by a T Cell-Mediated Mechanism

Shane Crotty, La Jolla Institute for Immunology, USA
Characterization of Protective B Cell Responses to Vaccinia virus, the Smallpox Vaccine, and Generation of Protective Human Monoclonal Antibodies

Workshop 10B: B Cells and HIV Infections

Julien van Grevenynghe†, Lady Davis Institute, Canada
Depletion of Peripheral CD19+CD27+ Memory B-cells from HIV-Infected Individuals is Associated with FOXO3a Activation

Oluwadamilola Unuigbe, Malawi-Liverpool Wellcome Trust, Malawi
The Loss of B Cell Memory to Pneumococcal Protein Antigens in Malawian Children during HIV Infection

Rogier W. Sanders, University of Amsterdam and Weill Cornell Medical College, Netherlands
Enhancing the Immunogenicity of HIV-1 Envelope Glycoprotein Trimers by Fusion to CD40 Ligand

Mattias Forsell, Umeå University, Sweden
Direct Interaction of a Viral Surface Protein with its Primary Receptor is Required for B Cell Receptor Recognition of a Conserved Co-Receptor Binding Surface.

2:30—4:30 PM
Workshop 11: Drug Targets for Immune Modulation

Council Chambers
* John G. Monroe, Genentech, Inc., USA

Inbal Binsky-Ehrenreich, Weizmann Institute, Israel
CD74 Induces the Expression of TAp63, which Regulates B-CLL Survival and Migration to the Bone Marrow

* Lisa Borghesi, University of Pittsburgh, USA
Targeted Knockdown of the B Lineage Transcriptional Activator E2A in B Cell Chronic Lymphocytic Leukemia (CLL) Enhances Lenalidomide Sensitivity and Regulates Cellular Proliferation

Bridget S. Wilson, University of New Mexico Health Science Center, USA
Select gamma-Secretase Inhibitors Induce Apoptosis in Pre-B ALL Cells and Disrupt the Balance between Constitutive Notch Signaling and Repression

Laura R. Wasil, University of Pittsburgh Graduate School of Public Health, USA
Immortalization of B Cells by Epstein-Barr Virus Requires both the Products of the Latent Membrane Protein 2 Gene

Geetha Chalasani, University of Pittsburgh, USA
B Cells Promote Development of Alloreactive Memory T Cells

Peggy L. Kendall, Vanderbilt University Medical Center, USA
Bruton’s Tyrosine Kinase Deficiency Ameliorates Type 1 Diabetes

Yue Wang, MedImmune, Inc, USA
An Afucosylated Anti-human-CD19 Antibody Exhibits Potent Depletion of Bone Marrow and Peripheral B Cells in Mice

Chung Park, NIAID, National Institutes of Health, USA
B Lymphocytes Exit Lymph Nodes through Cortical Lymphatic Sinusoids Near to Lymph Node Follicles by a Mechanism Independent of S1P-Mediated Chemotaxis

2:30—4:30 PM
Workshop 12: Human B Cell Subsets in Health and Disease

* Ignacio Sanz, Emory University, School of Medicine, USA

Santi Suryani, Garvan Institute of Medical Research, Australia
Characterisation of Human Transitional B cell Subsets

Panida Sriaroon, University of South Florida, USA
Memory CD27+ B220- B Cell Subpopulation is Decreased in Human Immunodeficiency Virus Disease (HIV) on Therapy, Common Variable Immune Deficiency (CVID) and Systemic Lupus Erythematosus (SLE)

Isabelle Isnardi, Novartis Pharma, Switzerland
Defective Receptor Editing Results in the Appearance of Anergic B cells in Humans

Jonathan Michael Irish, Vanderbilt University, USA
Abnormal B cell Receptor Signaling in a Subset of Lymphoma B cells Distinguishes Follicular Lymphoma Patients with Poor Clinical Outcomes

Isabelle Bekeredjian-Ding, University of Heidelberg, Germany
Immunostimulatory DNA ODN and BAFF/BlyS Selectively Target Human IgM+ B cell Subsets

Patrick C. Wilson, University of Chicago, USA
A Memory Compartment Origin for Early Antibody-Secreting B cells during the Anti-Influenza Vaccine Response

4:30—5:00 PM
Coffee Available

Rio Grande B/C
5:00—7:15 PM

Jeffrey L. Browning, Boston University School of Medicine, USA
Blockade of the Lymphotoxin-LIGHT Pathway and the Treatment of Autoimmune Disease

Jing H. Wang, University of Colorado Anschutz Medical Campus, USA
Short Talk: DNA double strand breaks, translocations, and B cell lymphoma

* Rafael Casellas, NIAMS-NCI, National Institutes of Health, USA
AID tumorigenic activity

Lin He, University of California, Berkeley, USA
Mir17-92 as a putative oncogene for B cell lymphomas

7:15—8:15 PM
Social Hour with Lite Bites

Rio Grande
8:15—11:00 PM

Rio Grande



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AI081355-01

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Press

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email:,
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