Keystone Symposia

Royal Orchid Sheraton Hotel Floorplan

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This meeting took place in 2008

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Pathogenesis and Control of Emerging Infections and Drug-Resistant Organisms (S4)

Organizer(s) B. Brett Finlay, Alan Cowman, Stephen Hughes, Sumalee Kamchonwongpaisan, Valerie Mizrahi and Philippe J. Sansonetti
October 22—27, 2008
Royal Orchid Sheraton Hotel • Bangkok, Thailand
Abstract Deadline: Jun 23, 2008
Late Abstract Deadline: Jul 28, 2008
Scholarship Deadline: Jun 23, 2008
Early Registration Deadline: Aug 25, 2008

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
This meeting will review the most recent developments in the molecular and cellular analysis of infectious disease processes, and how discoveries in this field can be translated into innovative tools (i.e. diagnostic assays, new drugs, vaccines and other therapeutics) for better surveillance and control. Emphasis will be on the neglected infectious and parasitic diseases that plague the developing world (with lessons taken from better studied organisms), and on issues such as drug resistance that are common themes, regardless of geographic and economic situations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


2:00—5:00 PM

Group Lobby
5:00—5:30 PM
Transportation by Boat to Dinner Event

Royal Orchid Sheraton Pier
5:30—6:00 PM
Social Hour

Royal Navy Hall
6:00—10:00 PM
Joint Dinner with Grand Challenges in Global Health Conference
The GCGH and Keystone Joint Dinner: A semi-formal dinner at the Royal Thai Navy Convention Hall, with an address by HRH Princess Maha Chakri Sirindhorn. HRH Princess Maha Chakri Sirindhorn is also President of the Prince Mahidol Award Foundation. This is a joint dinner for Grand Challenges in Global Health and Keystone Symposia participants and is an event not to be missed! Protocol dictates that guests may not arrive to the hotel after 4pm, nor depart the event before the end of the formalities. (Note: Attire recommendations below) Attire for all meeting sessions is business casual. The same applies to evening events, with the exception of the dinner on Wednesday, October 22nd at the Royal Thai Navy Convention Hall. For this event, in honor of HRH Princess Machachakri Sirindhom, who will be attending this event, smart business casual is recommended. Thai ladies will often wear a silk costume for any function attended by royalty, but for non-Thai ladies, a smart dress (not evening gown) is preferred. For men a pair of business pants and open neck shirt is recommended.

Royal Navy Hall
10:00—10:30 PM
Transportation by Boat to Hotel

Royal Navy Hall


7:00—8:00 AM

etc Restaurant
7:00—8:00 AM
Poster Setup

Riverside Ballrooms
8:00—8:30 AM
Orientation and Opening Remarks

Ballroom 2-3
8:30—11:30 AM
Infection Biology

Ballroom 2-3
Craig R. Roy, Yale University School of Medicine, USA
Modulation of Host Cell Functions by Type IV Effector Proteins

Dana Philpott, University of Toronto, Canada
Role of Nod-like Receptors in Innate and Adaptive Immunity

William R. Jacobs, Jr., HHMI/Albert Einstein College of Medicine, USA
IKEPLUS, A Recombinant M. smegmatis that Elicits Bacteriocidal Immunity Against Virulent M. tuberculosis

Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
Neutrophil Extracellular Traps

9:40—10:00 AM
Coffee Break

Riverside Foyer/Ballrooms
11:30 AM—12:30 PM

Ballroom 1/Riverside
12:00—2:00 PM
Poster Session 1

Riverside Ballrooms
2:00—4:00 PM
HIV Drug Resistance

Ballroom 2-3
Edward V. Arnold, Rutgers University, USA
RT Structure and Structure-Guided Design of Novel Inhibitors Targeting Multiple Sites

* Stephen Hughes, NCI-Frederick, NIH, USA
HIV-1 RT: Drug Resistance and Drug Development

Alexandre Alcaïs, University of Paris René Descartes-INSERM U550, France
Human Genetics of Infectious Diseases: From Proof-of-Principle Towards New Paradigm

4:00—4:30 PM
Coffee Break

Riverside Foyer/Ballrooms
4:30—6:30 PM
Workshop 1: TB

Ballroom 2-3
* Tanya Parish, Infectious Disease Research Institute, USA

Jean-Philippe Carralot, Institut Pasteur Korea, South Korea
HTS/HCS Genome-wide siRNA Screening of Host Genes Involved in the Blockage of Phagolysosome Maturation and in the Survival of M. Tuberculosis in Raw 264.7 Macrophages

Thuong T. T. Nguyen, Oxford University Clinical Research Unit, Vietnam
Epiregulin (EREG) Variation is Associated with Tuberculosis

Liana Tsenova, Public Health Research Institute, USA
Immunomodulation with CC-3052 Accelerates Antibiotics Efficacy in Experimental M. Tuberculosis Infection

Catherine Vilchèze, Howard Hughes Medical Institute - AECOM, USA
Novel Inhibitors of InhA Efficiently Kill Multidrug-resistant Tuberculosis

Saradee Warit, National Center for Genetic Engineering and Biotechnology, Thailand
Mechanism of Clarithromycin Sensitivity in Clinical Isolates of Mycobacterium Tuberculosis

Martin Handfield, University of Florida, USA
Probing for Mycobacterial in vivo Induced Antigens in Tuberculosis

Rajpal Singh Kashyap, Central India Institute of Medical Sciences, India
Evaluation of ELISA-based Antigen Detection Kit for Diagnosis of Pulmonary and Extrapulmonory Tuberculosis

Amnuay Khumsung, Mahidol University, Thailand
XDR-TB Testing using MTT Assay


7:00—8:00 AM

etc Restaurant
7:00—8:00 AM
Poster Setup

Riverside Ballrooms
8:00—11:30 AM

Ballroom 2-3
Robert Ménard, Institut Pasteur, France
In vivo Imaging of Plasmodium Pre-erythrocytic Stages in a Rodent Model

Louis Schofield, James Cook University, Australia
Malaria and Vaccines

Daniel E. Goldberg, Washington University, USA
Characterization of a Potential Drug Target: Plasmodium Calpain

* Alan F. Cowman, Walter and Eliza Hall Institute of Medical Research, Australia
Invasion and Remodeling of the Human Erythrocyte by the Malaria Parasite

Sumalee Kamchonwongpaisan, National Center for Genetic Engineering and Biotechnology, Thailand
Basic Understanding of Artemisinin Action against Plasmodium falciparum In Vitro

Yongyuth Yuthavong, BIOTEC, Thailand National Science and Technology Development Agency, Thailand
Development of Target-Based Antimalarials

10:00—10:20 AM
Coffee Break

Riverside Foyer/Ballrooms
11:30 AM—12:30 PM

Ballroom 1/Riverside
12:00—2:00 PM
Poster Session 2

Riverside Ballrooms
2:00—5:00 PM
Diarrhea and Vaccines

Ballroom 2-3
E. Peter Greenberg, University of Washington, USA
What's New in ACYL-Homoserine Lactone Quorum Sensing: Strange Signals and Strange Receptors

Julian Guttman, Simon Fraser University, Canada
Epithelial Cell Alterations that Influence Diarrhea Generation during Attaching and Effacing Bacterial Infections

* John J. Mekalanos, Harvard Medical School, USA
Secretion Systems in the Pathobiology of Vibrio and Pseudomonas Disease

3:20—3:40 PM
Coffee Break

Riverside Foyer/Ballrooms


7:00—8:00 AM

etc Restaurant
7:00—8:00 AM
Poster Setup

Riverside Ballrooms
8:00—11:30 AM
TB (and XDR)

Ballroom 2-3
Megan Murray, Harvard Medical School, USA
The Molecular Evolution of Extensively Drug Resistant Tuberculosis

* Valerie Mizrahi, University of Cape Town, South Africa
Environment-Dependent Mutators and their Role in the Evolution of Drug Resistance in Mycobacterium tuberculosis

Nacer Lounis, Tibotec, Belgium
Diarylquinolines Have the Potential to Shorten TB Treatment Duration

Douglas B. Young, Imperial College London, UK
Drugs for Latent TB: A Grand Challenge in Global Health

Martin W. Bratschi, National University of Singapore, Singapore
Short Talk: Development of a Lipid - Based Biomarker for TB Infection in Mouse

Priscille Marie Brodin, CIIL Institut Pasteur, France
Short Talk: High Content Screening of M. Tuberculosis Infected Macrophage and Impact on TB-drug Discovery

9:20—9:40 AM
Coffee Break

Riverside Foyer/Ballrooms
11:30 AM—12:30 PM

Ballroom 1/Riverside
12:00—2:00 PM
Poster Session 3

Riverside Ballrooms
2:00—4:30 PM
Respiratory Pathogens

Ballroom 2-3
Maria Rescigno, Humanitas University, Italy
Handling of Bacteria by Dendritic Cells at Mucosal Surfaces

* Birgitta Henriques Normark, Karolinska Institutet, Sweden
The Role of pneumococcal pili in Carriage and in Invasive Disease

Scott D. Gray-Owen, University of Toronto, Canada
The Pathogenic Neisseria: Dancing with Humans

Jeremy Farrar, Wellcome Trust, UK
Globalization and Infectious Diseases: A Threat and an Opportunity for Collaborative Clinical Science

4:30—5:00 PM
Coffee Available

Riverside Foyer/Ballrooms
5:00—7:30 PM
Workshop 2: Malaria

Ballroom 2-3
* Alan F. Cowman, Walter and Eliza Hall Institute of Medical Research, Australia

* Sumalee Kamchonwongpaisan, National Center for Genetic Engineering and Biotechnology, Thailand

Brendan S. Crabb, Burnet Institute, Australia
A Putative Protein Translocon at the Parasitophorous Vacuole Membrane of Plasmodium falcipaum

Charles F. Battrell, Micronics, Inc., USA
Rapid POC Molecular Detection of Fever Pathogens

Violet Vakunseh Bumah, University of Buea, Cameroon
Molecular Analysis of Parasite and Human Host Determinants in Sera from Individuals Susceptible or Immune to Malaria

Babalwa Zani, Medical Research Council, South Africa
The Suitability of Amodiaquine for Combination with Artesunate for the Treatment of Uncomplicated Malaria: A Systematic Review

Chairat Uthaipibull, National Center for Genetic Engineering and Biotechnology, Thailand
Development of P. falciparum Parasites Expressing P. vivax Dihydrofolate Reductase-Thymidylate Synthase Enzyme as Model for anti-P. vivax Screening

Eva-Rachele Pesce, Rhodes University, South Africa
Pfj4, a Plasmodium falciparum Hsp40 that Cooperates with the Molecular Chaperone PfHsp70-1

Raymond Hui, University of Toronto, Canada
Structural and Chemical Biology of Apicomplexan Parasites


7:00—8:00 AM

etc Restaurant
8:00—11:30 AM

Ballroom 1
Gordon Dougan, University of Cambridge, UK
Vaccines Against Invasive Salmonellosis

Cecil Czerkinsky, International Vaccine Institute, South Korea
Mucosal Immunity and Vaccine Development

Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Meningococcus and Neglected Diseases

Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Vectored Vaccines against Intracellular Pathogens

* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Translating Basic Research in Tuberculosis into Vaccine and Biomarker Development

9:20—9:40 AM
Coffee Break

Riverside Foyer/Ballrooms
11:30 AM—2:30 PM
On Own for Lunch

2:30—4:00 PM
Workshop 3: HIV

Ballroom 1
* Stephen Hughes, NCI-Frederick, NIH, USA

Peter D. Kwong, NIAID, National Institutes of Health, USA
Targeting the Receptor-Binding Sites on HIV-1 gp120

Elijah Martim Songok, Kenya Medical Research Institute, Kenya
Short Talk: Evidence of Nevirapine Resistance in Rural Kenya

Wiriya Rutvisuttinunt, Armed Forces Research Institute of Medical Sciences, Thailand
Short Talk: Interactions between HIV-1 Reverse Transcriptase and the Downstream Template Strand in Stable Complexes with Primer-Template

4:00—4:30 PM
Coffee Break

Riverside Foyer/Ballrooms
4:30—5:45 PM
Combatting Emerging Pathogens

Ballroom 1
* Robert E.W. Hancock, University of British Columbia, Canada
Selectively Modulating Innate Immunity

Sarah Randolph, University of Oxford, UK
Predicting Arrival, Establishment and Spread of Exotic Diseases

5:45—6:30 PM
Malaria Vaccines

Ballroom 1
Stefan Kappe, Seattle BioMed, USA
Live Attenuated Malaria Vaccine Design

7:00—8:00 PM
Social Hour with Lite Bites

Riverside Ballroom
8:00—11:00 PM

Riverside Ballroom



*Session Chair †Invited, not yet responded.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AI079916-01

We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Wellcome Trust

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Vaccines and Diagnostics, Inc.

Tibotec, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email:,
Phone:+1 970-262-2690

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