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This meeting took place in 2010
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Islet Biology (Z5)
Organizer(s) Markus Stoffel, Doris A. Stoffers and Per-Olof Berggren
April 12—17, 2010
Whistler Conference Centre • Whistler, BC Canada
Abstract Deadline: Dec 14, 2009
Late Abstract Deadline: Jan 15, 2010
Scholarship Deadline: Dec 14, 2009
Early Registration Deadline: Feb 12, 2010
Sponsored by Bristol-Myers Squibb Company and Takeda Pharmaceutical Company Limited
Joint Meeting:
Diabetes (Z6)
Summary of Meeting:
This symposium will focus on advances in our understanding of normal pancreatic b-cell function and mechanisms of beta-cell failure in type 2 diabetes, which has become a pandemic disease with estimates of affected individuals reaching 350 millions in 2030. Defects in pancreatic b-cell function and reduced beta cell mass are now recognized as the event that triggers the transition from pre-diabetes/metabolic syndrome to overt type 2 diabetes. Major advances have been made in our understanding of fundamental beta-cell biology, signaling pathways regulating islet growth, apoptosis, regeneration in normal and disease states, and development of new strategies for enhancing beta-cell survival and function. Leading academic and industrial contributors alike will carefully discuss recent advances in several disciplines, including development, regeneration, stem cells, transcription factors, novel signaling pathways, cell biology, genetics, gene regulation, drug targeting, as well as emerging technologies in islet research.
View Scholarships/Awards
This symposium will focus on advances in our understanding of normal pancreatic b-cell function and mechanisms of beta-cell failure in type 2 diabetes, which has become a pandemic disease with estimates of affected individuals reaching 350 millions in 2030. Defects in pancreatic b-cell function and reduced beta cell mass are now recognized as the event that triggers the transition from pre-diabetes/metabolic syndrome to overt type 2 diabetes. Major advances have been made in our understanding of fundamental beta-cell biology, signaling pathways regulating islet growth, apoptosis, regeneration in normal and disease states, and development of new strategies for enhancing beta-cell survival and function. Leading academic and industrial contributors alike will carefully discuss recent advances in several disciplines, including development, regeneration, stem cells, transcription factors, novel signaling pathways, cell biology, genetics, gene regulation, drug targeting, as well as emerging technologies in islet research.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
MONDAY, APRIL 12
TUESDAY, APRIL 13
WEDNESDAY, APRIL 14
THURSDAY, APRIL 15
FRIDAY, APRIL 16
SATURDAY, APRIL 17
Conference Program Print | View meeting in 12 hr (am/pm) time
MONDAY, APRIL 12
19:30—21:30
Keynote Session (Joint)
Victor R. Ambros,
University of Massachusetts, USA
MicroRNAs in Model Systems and Human Disease
MicroRNAs in Model Systems and Human Disease
Jennifer A. Lippincott-Schwartz,
Howard Hughes Medical Institute - Janelia Farm, USA
Mitochondrial Role in Cell Cycle Control and Autophagy
Mitochondrial Role in Cell Cycle Control and Autophagy
08:00—11:00
From Stem Cell Development to Transplantation
*
Catherine Lee May,
University of Pennsylvania, USA
Bernhard J. Hering,
University of Minnesota, USA
Islet Transplantation: Today and Tomorrow
Islet Transplantation: Today and Tomorrow
Anne Grapin-Botton,
University of Copenhagen, Denmark
Role of Pancreas 3D Architecture in Endocrine Cell Development
Role of Pancreas 3D Architecture in Endocrine Cell Development
Lori Sussel,
University of Colorado Anschutz Medical Campus, USA
Regulation of Pancreatic Islet Cell Fates
Regulation of Pancreatic Islet Cell Fates
Maike Sander,
University of California, San Diego, USA
Control of Cell Fate Choice in the Pancreas
Control of Cell Fate Choice in the Pancreas
Dina Fomina-Yadlin,
Harvard University, USA
Short Talk: Altering Pancreatic Cell State with Small Molecules
Short Talk: Altering Pancreatic Cell State with Small Molecules
08:00—11:15
Genetics of Diabetes
Philippe Froguel,
Imperial College of London, UK
Genome Structure and Point DNA Variation: The Power of the Extreme in Diabesity
Genome Structure and Point DNA Variation: The Power of the Extreme in Diabesity
Mark I. McCarthy,
University of Oxford, UK
Type 2 Diabetes: Susceptibility Variants across the Allele Frequency Spectrum
Type 2 Diabetes: Susceptibility Variants across the Allele Frequency Spectrum
Jose C. Florez,
Massachusetts General Hospital, USA
Genetic Epidemiology of Type 2 Diabetes and Related Traits in General Populations
Genetic Epidemiology of Type 2 Diabetes and Related Traits in General Populations
Eric Schadt,
Mount Sinai School of Medicine, USA
Multi-Tissue Networks Elucidate Type 2 Diabetes Circuits
Multi-Tissue Networks Elucidate Type 2 Diabetes Circuits
Jussi A. Pihlajamäki,
Kuopio University Hospital, Finland
Short Talk: Alternative Splicing is Regulated by Weight Loss and Differs between Fat Depots in Humans
Short Talk: Alternative Splicing is Regulated by Weight Loss and Differs between Fat Depots in Humans
Jeremy B.M. Jowett,
Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Expression Profiling Identifies Biomarkers for Progression to Type 2 Diabetes
Short Talk: Expression Profiling Identifies Biomarkers for Progression to Type 2 Diabetes
17:00—19:00
Signaling in Pancreatic B-Cells
Eckhard Lammert,
Heinrich-Heine-University / German Diabetes Center, Germany
Role of Blood Vessels in Pancreatic Islet Development and Function
Role of Blood Vessels in Pancreatic Islet Development and Function
Marc Prentki,
Montreal Diabetes Research Center, Canada
Beta Cell Metabolic Signaling and Dysfunction in Type 2 Diabetes
Beta Cell Metabolic Signaling and Dysfunction in Type 2 Diabetes
Ingo B. Leibiger,
Karolinska Institutet, Sweden
Insulin Signaling in the Pancreatic Beta Cell
Insulin Signaling in the Pancreatic Beta Cell
Jocelyn E. Manning Fox,
University of Alberta, Canada
Short Talk: Small Ubiquitin-Like Modifier 1 (SUMO1) Directly and Acutely Regulates Insulin Exocytosis from Human beta-Cells
Short Talk: Small Ubiquitin-Like Modifier 1 (SUMO1) Directly and Acutely Regulates Insulin Exocytosis from Human beta-Cells
17:00—19:00
Cell and Tissue Signaling Mechanisms in Diabetes
*
Adria Giacca,
University of Toronto, Canada
Claire C. Bastie,
Albert Einstein College of Medicine, USA
Fyn Kinase and LKB1: A Novel Pathway Regulating Lipid Utilization and Energy Expenditure
Fyn Kinase and LKB1: A Novel Pathway Regulating Lipid Utilization and Energy Expenditure
Bei B. Zhang,
Pfizer Inc., USA
Modulation of Glucose, Amino Acid and Lipid Metabolism Pathways with Pharmacological Agents
Modulation of Glucose, Amino Acid and Lipid Metabolism Pathways with Pharmacological Agents
Philipp Gut,
Nestlé Institute of Health Sciences, Switzerland
Short Talk: In vivo Drug Discovery of New Regulators of Glucose Metabolism using Transgenic “Gluconeogenesis Reporter” Zebrafish
Short Talk: In vivo Drug Discovery of New Regulators of Glucose Metabolism using Transgenic “Gluconeogenesis Reporter” Zebrafish
08:00—11:00
Transcriptional Networks Signaling
*
Maike Sander,
University of California, San Diego, USA
Catherine Lee May,
University of Pennsylvania, USA
Islet-1 and its Cofactor Ldb1 in the Endocrine Pancreas
Islet-1 and its Cofactor Ldb1 in the Endocrine Pancreas
Roland W. Stein,
Vanderbilt University Medical Center, USA
Alan D. Attie,
University of Wisconsin-Madison, USA
Networks of QTLs, mRNAs, and microRNAs in Beta Cell Growth and Function
Networks of QTLs, mRNAs, and microRNAs in Beta Cell Growth and Function
Melissa K. Thomas,
Massachusetts General Hospital, USA
Short Talk: TCF7L2 Deficiency Alters Mouse Metabolic and Islet Cell Functions with Aging
Short Talk: TCF7L2 Deficiency Alters Mouse Metabolic and Islet Cell Functions with Aging
08:00—11:15
Intertissue Communication
*
Jeffrey S. Elmendorf,
Indiana University School of Medicine, USA
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
A Novel Pathway in Adipose Tissue and Liver that Regulates Adiposity
A Novel Pathway in Adipose Tissue and Liver that Regulates Adiposity
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Discovery of Novel Adipokines
Discovery of Novel Adipokines
Fatima Bosch,
Universitat Autonoma Barcelona, Spain
Gene Therapy and Diabetes
Gene Therapy and Diabetes
Tsu-Shuen Tsao,
University of Arizona, USA
Short Talk: Inhibition of Adiponectin Oligomerization under Oxidizing Conditions and Induction of an Oxidizing Redox Environment in Endoplasmic Reticulum of 3T3-L1 Adipocytes Exposed to High Concentrations of Palmitate
Short Talk: Inhibition of Adiponectin Oligomerization under Oxidizing Conditions and Induction of an Oxidizing Redox Environment in Endoplasmic Reticulum of 3T3-L1 Adipocytes Exposed to High Concentrations of Palmitate
Marianna Sadagurski,
Wayne State University, USA
Short Talk: Inactivation of Foxo1 in Leptin Receptor (LepRb)-Expressing Neurons Reverses Obesity and Diabetes, Caused by Deletion of Insulin Receptor Substrate 2 (Irs2)
Short Talk: Inactivation of Foxo1 in Leptin Receptor (LepRb)-Expressing Neurons Reverses Obesity and Diabetes, Caused by Deletion of Insulin Receptor Substrate 2 (Irs2)
17:00—19:15
Molecular Mechanisms in Insulin Secretion and Action (Joint)
*
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
Insulin Signaling and Insulin Resistance: The Ultimate Systems Biology Problem
Insulin Signaling and Insulin Resistance: The Ultimate Systems Biology Problem
Per-Olof Berggren,
Karolinska Institutet, Sweden
Systems Biology Approach to Study Beta Cell Function and Survival
Systems Biology Approach to Study Beta Cell Function and Survival
Morris J. Birnbaum,
Pfizer Inc., USA
The Role of Akt in the Regulation of Hepatic Metabolism by Insulin
The Role of Akt in the Regulation of Hepatic Metabolism by Insulin
Weiping Han,
Singapore Bioimaging Consortium, Singapore
Short Talk: Molecular Regulation of Calcium-Dependent Insulin Secretion
Short Talk: Molecular Regulation of Calcium-Dependent Insulin Secretion
Jennifer L. Estall,
Institut de Recherches Cliniques de Montréal, Canada
Short Talk: PGC-1alpha Negatively Regulates Hepatic FGF21 Expression by Modulating the Heme/Rev-Erbalpha Axis
Short Talk: PGC-1alpha Negatively Regulates Hepatic FGF21 Expression by Modulating the Heme/Rev-Erbalpha Axis
08:00—11:15
Control of Insulin Secretory Machinery in Diabetes
Patrik Rorsman,
Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Calcium Channels and Insulin Exocytosis
Calcium Channels and Insulin Exocytosis
Michele Solimena,
Dresden University of Technology, Germany
Signaling from the Insulin Granule to the Nucleus
Signaling from the Insulin Granule to the Nucleus
Gerard Karsenty,
Columbia University Medical Center, USA
Regulation of Glucose Homeostasis by Osteocalcin
Regulation of Glucose Homeostasis by Osteocalcin
Herbert Y. Gaisano,
University of Toronto, Canada
Molecular Mechanism of Insulin Granule-Granule Fusion Contributing to Biphasic Insulin Secretion
Molecular Mechanism of Insulin Granule-Granule Fusion Contributing to Biphasic Insulin Secretion
Ja Young Kim-Muller,
Pfizer Inc, USA
Short Talk: Abnormal Regulation of Basal Insulin Secretion in Mice Homozygous for a Constitutively Deacetylated FoxO1 Allele
Short Talk: Abnormal Regulation of Basal Insulin Secretion in Mice Homozygous for a Constitutively Deacetylated FoxO1 Allele
Hail Kim,
Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Serotonin Regulates Pancreatic beta-Cell Mass during Pregnancy
Short Talk: Serotonin Regulates Pancreatic beta-Cell Mass during Pregnancy
08:00—11:15
Inflammatory Mechanisms and Insulin Resistance
*
Nancy A. Thornberry,
Kallyope, Inc., USA
Diane Mathis,
Harvard Medical School, USA
Lymphocyte Regulation of Adipose Tissue Inflammation
Lymphocyte Regulation of Adipose Tissue Inflammation
Roger J. Davis,
HHMI/University of Massachusetts Medical School, USA
Pathogenesis Mechanisms of the JNK Pathway
Pathogenesis Mechanisms of the JNK Pathway
Rémy G. Burcelin,
Institute of Molecular Medicine, France
Intestinal Microflora, Inflammation, and Metabolic Diseases
Intestinal Microflora, Inflammation, and Metabolic Diseases
Michael P. Czech,
University of Massachusetts Medical School, USA
RNAi-Based Strategies to Address Metabolic Dysfunction
RNAi-Based Strategies to Address Metabolic Dysfunction
Birgitte Lindegaard,
Rigshospitalet, Denmark
Short Talk: IL-18 Increases Intramuscular Fat Oxidation by Activating AMPK
Short Talk: IL-18 Increases Intramuscular Fat Oxidation by Activating AMPK
Heather C. Denroche,
University of British Columbia, Canada
Short Talk: Leptin Therapy Reverses Fasting Hyperglycemia and Enhances Insulin Sensitivity in Diabetic Mice, Independent of Hepatic Leptin Signaling
Short Talk: Leptin Therapy Reverses Fasting Hyperglycemia and Enhances Insulin Sensitivity in Diabetic Mice, Independent of Hepatic Leptin Signaling
17:00—19:15
Emerging Targets for Improving Insulin Action and Secretion (Joint)
Richard D. DiMarchi,
Indiana University and Novo Nordisk, USA
Novel Glucagon-Like Chimera Peptides – Virtues of Combinatorial Pharmacology
Novel Glucagon-Like Chimera Peptides – Virtues of Combinatorial Pharmacology
David E. Moller,
Eli Lilly and Company, USA
Challenges and Opportunities for Diabetes Drug Discovery
Challenges and Opportunities for Diabetes Drug Discovery
Johan Auwerx,
École Polytechnique Fédérale de Lausanne, Switzerland
Integrating Metabolic Control by NAD+ Sensors
Integrating Metabolic Control by NAD+ Sensors
Tian-Qiang Sun,
Rigel Pharmaceuticals, Inc., USA
Short Talk: Small Molecule Adiponectin Mimetics Improve Hepatic Steatosis and Insulin Sensitivity in Diabetic Mouse Models
Short Talk: Small Molecule Adiponectin Mimetics Improve Hepatic Steatosis and Insulin Sensitivity in Diabetic Mouse Models
Christine Esau,
Arcturus Therapeutics, USA
Short Talk: Inhibition of Let-7 with Anti-miR Oligonucleotides Improves Insulin Resistance in DIO Mice
Short Talk: Inhibition of Let-7 with Anti-miR Oligonucleotides Improves Insulin Resistance in DIO Mice
08:00—11:15
Insulin Secretion and Action in Humans (Joint)
*
Michael P. Czech,
University of Massachusetts Medical School, USA
Andrew Hattersley,
University of Exeter Medical School, UK
Learning from Genetic Beta Cell Defects in Man
Learning from Genetic Beta Cell Defects in Man
Anna Moore,
Michigan State University, USA
Imaging Pancreatic Islets in vivo: Current Status
Imaging Pancreatic Islets in vivo: Current Status
Juleen R. Zierath,
Karolinska Institutet, Sweden
Gene/Environment Influence on Skeletal Muscle Insulin Sensitivity in Type 2 Diabetic Patients
Gene/Environment Influence on Skeletal Muscle Insulin Sensitivity in Type 2 Diabetic Patients
Peter Arner,
Karolinska Institutet, Sweden
Dysfunction in Human Adipose Tissue and Insulin Resistance
Dysfunction in Human Adipose Tissue and Insulin Resistance
Michael Ristow,
Swiss Federal Institute of Technology Zurich - ETH, Switzerland
Short Talk: Impaired Insulin Signaling Extends Life Span by Increasing Oxidative Stress
Short Talk: Impaired Insulin Signaling Extends Life Span by Increasing Oxidative Stress
Mary Armanios,
Johns Hopkins University School of Medicine, USA
Short Talk: Short Telomeres Lead to beta-cell Dysfunction and Impair Glucose Tolerance
Short Talk: Short Telomeres Lead to beta-cell Dysfunction and Impair Glucose Tolerance
17:00—19:00
Beta Cell Stress in Diabetes
*
Marc Prentki,
Montreal Diabetes Research Center, Canada
Marc Y. Donath,
University Hospital Basel, Switzerland
Islet Inflammation in Type 2 Diabetes: Novel Mechanisms and Treatment
Islet Inflammation in Type 2 Diabetes: Novel Mechanisms and Treatment
Thomas Mandrup-Poulsen,
Hagedorn Research Institute, Denmark
Cytokine Signaling in Inflammatory beta-Cell Destruction
Cytokine Signaling in Inflammatory beta-Cell Destruction
Rohit N. Kulkarni,
Joslin Diabetes Center, Harvard Medical School, USA
Insulin/IGF-I Signaling, Mitochondrial Function and Endoplasmic Stress in Pancreatic beta-Cells
Insulin/IGF-I Signaling, Mitochondrial Function and Endoplasmic Stress in Pancreatic beta-Cells
Raghavendra G. Mirmira,
Indiana University School of Medicine, USA
Short Talk: The Unique Hypusine Modification of eIF5A Promotes Islet Inflammation and Dysfunction during the Development of Diabetes
Short Talk: The Unique Hypusine Modification of eIF5A Promotes Islet Inflammation and Dysfunction during the Development of Diabetes
17:00—19:00
Type 2 Diabetes in Children and Adolescents
Rebecca Anne Simmons,
University of Pennsylvania School of Medicine, USA
Epigenetic Mechanisms in the Development of Type 2 Diabetes
Epigenetic Mechanisms in the Development of Type 2 Diabetes
Susan Ozanne,
University of Cambridge, UK
Early Life Programming of Type 2 Diabetes
Early Life Programming of Type 2 Diabetes
Phil Zeitler,
University of Colorado, Denver, USA
Type 2 Diabetes in Children and Adolescents: Epidemiology, Pathophysiology, and Comorbidities
Type 2 Diabetes in Children and Adolescents: Epidemiology, Pathophysiology, and Comorbidities
Kasper Rud,
University of Copenhagen, Denmark
Short Talk: Effects of Gestational Low Protein Diet Followed by Postnatal High Fat or High Sucrose Diet on the Interplay between Fat and Carbohydrate Metabolism in Rat Mitochondria
Short Talk: Effects of Gestational Low Protein Diet Followed by Postnatal High Fat or High Sucrose Diet on the Interplay between Fat and Carbohydrate Metabolism in Rat Mitochondria
*Session Chair †Invited, not yet responded.
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We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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