Keystone Symposia

Santa Fe Community Convention Center Floorplan

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This meeting took place in 2012


Here are the related meetings in 2021:
MEETING CHANGE TO VIRTUAL: Obesity: From Cell to Patient (J5)
Obesity: From Cell to Patient (EK17)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Genetic and Molecular Basis of Obesity and Body Weight Regulation (J7)


Organizer(s) Evan D. Rosen, Dawn L. Brasaemle and Bart Staels
January 29—February 3, 2012
Santa Fe Community Convention Center • Santa Fe, NM USA
Abstract Deadline: Sep 29, 2011
Late Abstract Deadline: Nov 1, 2011
Scholarship Deadline: Sep 29, 2011
Early Registration Deadline: Nov 29, 2011

Sponsored by Takeda Pharmaceutical Company Limited


Summary of Meeting:
This conference will cover the latest developments in molecular metabolism relevant to the burgeoning problem of human obesity. Topics of special relevance will include the biology of the adipocyte, novel mechanisms of lipid handling and central control of peripheral metabolism. In addition, new discoveries in epigenetics and fetal programming will be covered. Other topics will be discussed in joint sessions with the Keystone Symposia meeting on Pathogenesis of Diabetes: Emerging Insights into Molecular Mechanisms, including new developments in the genetics of metabolic disease, connections between insulin resistance and inflammation, novel mechanisms of intercellular communication between tissues in metabolism and systems approaches to obesity and diabetes. A scintillating array of world-class speakers has been selected to deliver these insights. Attendees of this meeting will be exposed to the best and the brightest thinkers in this area of critical biomedical importance.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 29

15:00—19:30
Registration

Sweeney Ballroom Foyer
18:15—19:15
Refreshments

Sweeney F, Main Level Breakout Rooms
19:15—21:30
Welcome and Keynote Session (Joint)

Sweeney Ballroom A-E
* Alan D. Attie, University of Wisconsin-Madison, USA

* Evan D. Rosen, Harvard University, USA

Aldons J. Lusis, University of California, Los Angeles, USA
Systems Genetics Analysis of Complex Interactions in Cardiometabolic Traits

Daniel J. Rader, University of Pennsylvania, USA
From GWAS to Gene Function: Genetics and Physiology of Lipid and Lipoprotein Metabolism


MONDAY, JANUARY 30

07:00—08:00
Breakfast

Sweeney F, Main Level Breakout Rooms
08:00—11:15
Inflammation, ER Stress, Insulin Resistance (Joint)

Sweeney Ballroom A-E
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Novel Aspects of Insulin Action and their Role in Development of Insulin Resistance

Jeffrey M. Friedman, Rockefeller University, USA
Leptin: From Production to Pathways

Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Inflammation and ER Stress in Obesity and Diabetes

Bruce M. Spiegelman, Harvard Medical School, USA
Irisin, a Novel Myokine that Browns Adipose Tissues and Ameliorates Metabolic Disease

Alexander Rauch, University of Southern Denmark, Denmark
Short Talk: Glucocorticoids Dampen Insulin Sensitivity via the Dimerisation of the Glucocorticoid Receptor in Peripheral Organs

Susan J. Gray, University of Massachusetts Medical School, USA
Short Talk: KLF15: A Critical Link between Insulin Resistance and ER Stress

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakout Rooms
11:15—13:00
Poster Setup

Sweeney F, Main Level Breakout Rooms
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakout Rooms
14:30—16:30
Workshop 1: Health Disparities (Joint). Supported by Novartis Institutes for BioMedical Research

Sweeney Ballroom A-B
* William C. Hsu, Harvard Medical School, Joslin Diabetes Center, USA
Biology and Clinical Implications of Diabetes in Asian Americans

Charles N. Rotimi, NHGRI, National Institutes of Health, USA
Genetics, Environment and Health Disparities in Diabetes among African Americans

Struan F. A. Grant, Children’s Hospital of Philadelphia Research Institute, USA
Genome Wide Studies of Pediatric Metabolic Traits in Multi-Ethnic Settings

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakout Rooms
17:00—19:00
Lipid Droplets and Lipid Handling

Sweeney Ballroom A-B
* Deborah M. Muoio, Duke University Medical Center, USA

Dawn L. Brasaemle, Rutgers University, USA
Control of Lipolysis by Perilipins

Rudolf Zechner, University of Graz, Austria
Mouse Models of Altered Lipolysis

Tobias C. Walther, Harvard School of Public Health, USA
Mechanisms of Lipid Droplet Growth

Sheila Collins, Vanderbilt University Medical Center, USA
Short Talk: Cardiac Natriuretic Peptides Act via p38 MAPK to Induce the Brown Fat Thermogenic Program in Mouse and Human Adipocytes

17:00—19:00
Islet Biology

Sweeney Ballroom C-E
* Christopher B. Newgard, Duke University Medical Center, USA

Debbie C. Thurmond, Indiana University School of Medicine, USA
Molecular Regulators of Insulin Exocytosis

Anil Bhushan, University of California, San Francisco, USA
Epigenetics Control of Islet Formation and Regeneration

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Growth Factor Signaling in the Regulation of Islet Function and Proliferation

Wook Kim, Ajou University, South Korea
Short Talk: Cannabinoids Induce Pancreatic Beta-Cell Death by Directly Inhibiting Insulin Receptor Activation

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakout Rooms
19:30—22:00
Poster Session 1

Sweeney F, Main Level Breakout Rooms

TUESDAY, JANUARY 31

07:00—08:00
Breakfast

Sweeney F, Main Level Breakout Rooms
08:00—11:15
Genetics (Joint)

Sweeney Ballroom A-E
* Aldons J. Lusis, University of California, Los Angeles, USA

Alan D. Attie, University of Wisconsin-Madison, USA
Genes for Type 2 Diabetes from Genetics and Genomics

Joseph H. Nadeau, Maine Medical Center Research Institute, USA
Epistasis, Fractal Genetics and Systems Properties of Metabolic Traits

Sadaf Farooqi, University of Cambridge, UK
Genetics of Human Obesity-Monogenic Disorders

Joel N. Hirschhorn, Children's Hospital, Boston, USA
Genome-Wide Association Studies and Genetics of Human Obesity

Nuno Rocha, Institute of Metabolic Science, University of Cambridge, UK
Short Talk: ARL15: A Novel Player in Metabolic Disease

Carl S. Thummel, University of Utah School of Medicine, USA
Short Talk: MPC1 Plays an Essential Role in Pyruvate Metabolism in Yeast, Drosophila, and Human Disease

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakout Rooms
11:15—13:00
Poster Setup

Sweeney F, Main Level Breakout Rooms
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakout Rooms
16:30—17:00
Coffee Available

Sweeney F, Main Level Breakout Rooms
17:00—19:00
Novel Aspects of Adipocyte Biology

Sweeney Ballroom A-B
* Sheila Collins, Vanderbilt University Medical Center, USA

Juleen R. Zierath, Karolinska Institutet, Sweden
Genetic and Environmental Modulators of Insulin Sensitivity

Barbara Cannon, Stockholm University, Sweden
Brown and Brite Adipose Tissues: Characteristics and Significance

Bart Staels, Institut Pasteur de Lille, Université Lille, France
Macrophage Polarization in Obesity and Atherosclerosis

J. Andrew Pospisilik, Van Andel Institute, USA
Short Talk: Rapid Rewiring of Adipocyte Metabolism by a Novel Hedgehog-Ampk Axis

17:00—19:00
Novel Regulatory Pathways in Metabolism

Sweeney Ballroom C-E
* Steven A. Kliewer, University of Texas Southwestern Medical Center, USA

Rana K. Gupta, University of Texas Southwestern Medical Center, USA
Developmental Origin and Molecular Control of Adipose Progenitors

Matthias Hebrok, University of California, San Francisco, USA
Hypoxia and Beta-Cell Dysfunction

Ajay Chawla, Merck Research Labs, USA
Innate Immune Cells Regulate Adipose Tissue Metabolism

Ron F. Morrison, University of North Carolina, Greensboro, USA
Short Talk: Novel Mechanism of Golgi-Mediated TNFalpha-Induced Inflammatory Gene Expression in Adipocytes

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakout Rooms
19:30—22:00
Poster Session 2

Sweeney F, Main Level Breakout Rooms

WEDNESDAY, FEBRUARY 1

07:00—08:00
Breakfast

Sweeney F, Main Level Breakout Rooms
08:00—11:15
Integration of -Omics Data in Diabetes Research (Joint)

Sweeney Ballroom A-E
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics and Metabolic Disease

Christopher K. Glass, University of California, San Diego, USA
Genomics and Lipidomics of Macrophage Activation

Markus Stoffel, ETH Zürich, Switzerland
Exploring the beta Cell Surface Proteome and Secretome

Elaine Holmes, Imperial College London, UK
Systems Biology of the Gut Microbiome and Mammalian Metabolism

Cole Trapnell, University of Washington, USA
Short Talk: Long Noncoding RNAs Regulate Adipogenesis

Ryan Berry, Yale University, USA
Short Talk: Analysis of Gene Networks in White Adipose Tissue Development Reveals a Role for ETS2 in Adipogenesis

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakout Rooms
11:15—13:00
Poster Setup

Sweeney F, Main Level Breakout Rooms
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakout Rooms
11:15
On Own for Lunch and Recreation

13:00—16:30
Workshop 2: New Therapeutic Targets and Challenges (Joint)

Sweeney Ballroom A-E
* David E. Moller, Eli Lilly and Company, USA

Richard D. DiMarchi, Indiana University and Novo Nordisk, USA
Keynote Address: Multi-Functional Peptides Targeting Metabolic Disease

Simeon Taylor, University of Maryland School of Medicine, USA
SGLT2 Inhibition - Target to Clinical Proof-of-Concept - Lessons Learned

Dominic P. Behan, Sentia Medical Sciences, Inc., USA
GPR 119 Agonists for the Treatment of Diabetes

Thomas Kjeldsen, Novo Nordisk, Denmark
Engineering of Next Generation Insulin Analogues

David E. Kelley, Merck & Co., Inc., USA
Glucokinase Activators - Target Validation to In-Depth Clinical Testing

Paul Emmerson, Eli Lilly and Company, USA
Short talk: Metabolic Actions through Modulation of FGF Receptor 1c Signaling

Yang Li, Amgen Inc., USA
Short Talk: Novel Approaches to Targeting the FGF21 Pathway

Rolf F. Kletzien, Metabolic Solutions Development, Inc., USA
Short Talk: Insulin Sensitization Through a Mitochondrial Metabolic Switch that Modulates Wnt Signaling

Patrick R. Griffin, The Scripps Research Institute, USA
Short Talk: PPARG Non-Agonists

14:40—15:00
Coffee Break

Sweeney F, Main Level Breakout Rooms
16:30—17:00
Coffee Available

Sweeney F, Main Level Breakout Rooms
17:00—19:00
Epigenetics

Sweeney Ballroom A-B
* Juleen R. Zierath, Karolinska Institutet, Sweden

Evan D. Rosen, Harvard University, USA
Epigenomics of Metabolic Dysfunction

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Cistromes and the Tissue-Specific Physiology of HDAC3

Susanne Mandrup, University of Southern Denmark, Denmark
Hotspots Orchestrating Adipocyte Differentiation

Hironori Waki, University of Tokyo, Japan
Short Talk: Global Mapping of Cell-Type-Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation

17:00—19:00
New Concepts in Glucose Metabolism

Sweeney Ballroom C-E
* Morris F. White, Boston Children's Hospital, Harvard Medical School, USA

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Regulation of Metabolic Pathways to Support Cell Proliferation

Donald A. McClain, University of Utah School of Medicine, USA
O-Glycosylation and Diabetes

Domenico Accili, Columbia University, USA
Identification of New Drug Targets to Treat Insulin Resistance in the CNS, Liver, and Pancreatic Beta-Cells

Nigel Beaton, Institute of Food, Nutrition and Health, Switzerland
Short Talk: Tusc5 Controls Insulin Mediated Glucose Uptake by Facilitating Glut4 Membrane Fusion

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakout Rooms
19:30—22:00
Poster Session 3

Sweeney F, Main Level Breakout Rooms

THURSDAY, FEBRUARY 2

07:00—08:00
Breakfast

Sweeney F, Main Level Breakout Rooms
07:30—08:00
Poster Setup

Sweeney F, Main Level Breakout Rooms
08:00—11:15
Hormones that Modulate Metabolism and Insulin Sensitivity (Joint)

Sweeney Ballroom A-E
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
FGF21: A New Player in Metabolic Homeostasis and Disease

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
FGF21: From Feast to Famine

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Mechanistic Insights into Adipose Tissue and Hepatic Insulin Sensitivity

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Mechanisms by which Adipocytes Regulate Systemic Insulin Sensitivity

Lei Cao, Ohio State University, USA
Short Talk: White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Sympathoneural-Adipocyte Axis

Stephanie E. Simonds, Monash University, Australia
Short Talk: Hypertension in Obesity, is Leptin the Culprit?

08:00—19:00
Poster Viewing

Sweeney F, Main Level Breakout Rooms
09:00—09:20
Coffee Break

Sweeney F, Main Level Breakout Rooms
11:15—12:00
Lunch

Sweeney F, Main Level Breakout Rooms
12:00—14:30
Poster Session 4

Sweeney F, Main Level Breakout Rooms
14:30—16:30
Workshop 3: Late Breaking Developments

Sweeney Ballroom C-E
* Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

Ahmed Kablan, National Institutes of Health, USA
Gs-alpha Deficiency in POMC Neurons Leads to Hyperglycemia with Reduced Serum Insulin Levels and Impaired Counterregulation to Hypoglycemia

Craig Hammond, Eli Lilly and Company, USA
A Novel Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor Increases Plasma GLP-1 Levels and Reduces Body Weight Gain

Shirly Pinto, Kallyope, USA
Mechanisms Underlying Diacylglycerol Acyltransferase 1 Inhibition – Potential insight into Modulation of Gut Peptides Release

Sharon M. Blättler, Genomics Institute of the Novartis Research Foundation, USA
Yin Yang 1 Deficiency in Skeletal Muscle Protects Against Rapamycin-induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling

Zheng Sun, Baylor College of Medicine, USA
Dissociation of Fatty Liver and Insulin Resistance in Mice Lacking Hepatic HDAC3

Lale Ozcan, Columbia University, USA
Inhibition of Hepatic Calcium/Calmodulin-Dependent Protein Kinase II Protects against Obesity-Induced Insulin Resistance and Fatty Liver Formation

Jose M. Irimia-Dominguez, Indiana University, USA
Inability to Synthesize Glycogen in Liver Leads to Enhanced Lipid Synthesis and Liver Insulin Resistance

14:30—16:30
Workshop 3: Late Breaking Developments

Sweeney Ballroom A-B
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA

Marin Gantner, Lowy Medical Research Institute, USA
Identification of a Novel Energy Expenditure Regulatory Pathway in Brown Adipose Tissue

Wen Kong, Joslin Diabetes Center, USA
STARS Regulates AMPK Phosphorylation and Oxidative Capacity

Susana Rodriguez, Johns Hopkins University School of Medicine, USA
Targeted Chemical-Genetic Metabolic Regulation in vivo

Michael Lutter, University of Texas Southwestern Medical Center, USA
Melanocortin 4 Receptor Signaling in Habit/Procedural Memory Learning

Kristy L. Townsend, University of Maine, USA
Deletion of Bone Morphogenetic Protein Receptor 1a (BMPR1a) in POMC Neurons Results in Hyperphagia and Increased Sympathetic Outflow to Brown and White Adipose Tissues

Florian W. Kiefer, Brigham and Women's Hospital, Harvard Medical School, USA
Retinaldehyde Dehydrogenase 1 Determines a Thermogenic Program in White Adipose Tissue

James E. Minchin, Duke University, USA
Longitudinal in vivo Imaging in Zebrafish Reveals Oscillatory Hyperplastic and Hypertrophic Adipose Tissue Growth is Regulated by a Pre-Patterned Vascular Network

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakout Rooms
17:00—19:00
CNS Control of Metabolism

Sweeney Ballroom A-B
* Martin G. Myers, Jr., University of Michigan, USA
Leptin Signaling in the Brain

Allison W. Xu, University of California, San Francisco, USA
Adaptive Regulation of Energy Balance by Central Melanocortinergic Neurons

Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
CNS Control of Metabolism

Yong Xu, Baylor College of Medicine, USA
Short Talk: CNS Circuitry Mediating Estrogenic Effects on Energy Homeostasis

17:00—19:00
Insulin Action

Sweeney Ballroom C-E
* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Michael P. Czech, University of Massachusetts Medical School, USA
New Insights into the Insulin Signaling Pathway

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
The Regulation of Insulin Signaling by Serine/Threonine Phosphorylation of Irs1

Deborah M. Muoio, Duke University Medical Center, USA
Journal of Lipid Research Lectureship: Mechanisms of Fatty Acid-Induced Insulin Resistance

Min Lu, Merck Research Laboroatory, USA
Short Talk: Neuronal SIRT1 Deficiency Causes Central and Whole-Body Insulin Sensitivity

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakout Rooms
20:00—23:00
Entertainment

Sweeney F, Main Level Breakout Rooms

FRIDAY, FEBRUARY 3

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Takeda Pharmaceutical Company Limited

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-03

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

AdipoGen International CEDARLANE
Mercodia, Inc. Novartis Institutes for BioMedical Research

Takeda California
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Bristol-Myers Squibb Company


Eli Lilly and Company


Metabolic Solutions Development Company, LLC.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations

If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179