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This meeting took place in 2016
Here are the related meetings in 2020:
Ubiquitin Biology (X7)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Ubiquitin Signaling (X3)
Organizer(s) Philip Cohen, Michael Rape and Titia K. Sixma
March 13—17, 2016
Whistler Conference Centre • Whistler, BC Canada
Discounted Abstract Deadline: Nov 11, 2015
Abstract Deadline: Dec 14, 2015
Scholarship Deadline: Nov 11, 2015
Discounted Registration Deadline: Jan 13, 2016
Sponsored by Cell Research and Genentech, Inc.
Joint Meeting:
NF-kappaB and MAP Kinase Signaling in Inflammation (X4)
Summary of Meeting:
Many components of the ubiquitin system are involved in controlling cellular processes, and the deregulation of this system underlies many diseases. The meeting will focus on how ubiquitylation controls processes such as autophagy, neurodegenerative diseases, hypertension, the immune system and the activation of NF-kappaB. It will include talks on how the ubiquitin system is controlled by protein phosphorylation, the specificity and regulation of deubiquitylases and the structural analysis of E3 ligases and large protein complexes that coordinate ubiquitylation and related events. Additional sessions will feature diseases caused by abnormalities in ubiquitylation and the progress that is being made in targeting the ubiquitin system for the development of improved drugs to treat cancer and other diseases.
View Scholarships/Awards
Many components of the ubiquitin system are involved in controlling cellular processes, and the deregulation of this system underlies many diseases. The meeting will focus on how ubiquitylation controls processes such as autophagy, neurodegenerative diseases, hypertension, the immune system and the activation of NF-kappaB. It will include talks on how the ubiquitin system is controlled by protein phosphorylation, the specificity and regulation of deubiquitylases and the structural analysis of E3 ligases and large protein complexes that coordinate ubiquitylation and related events. Additional sessions will feature diseases caused by abnormalities in ubiquitylation and the progress that is being made in targeting the ubiquitin system for the development of improved drugs to treat cancer and other diseases.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 17 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, March 18 in order to fully experience the meeting.
SUNDAY, MARCH 13
MONDAY, MARCH 14
TUESDAY, MARCH 15
WEDNESDAY, MARCH 16
THURSDAY, MARCH 17
FRIDAY, MARCH 18
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 17 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, March 18 in order to fully experience the meeting.
SUNDAY, MARCH 13
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Keynote Session (Joint)
*
Steven C. Ley,
Francis Crick Institute, UK
*
Michael Rape,
University of California, Berkeley, USA
Louis M. Staudt,
NCI, National Institutes of Health, USA
Blocking NF-kappaB Activation as a Therapeutic Approach in Cancer
Blocking NF-kappaB Activation as a Therapeutic Approach in Cancer
09:50—11:30
Regulation of the Ubiquitin System by Deubiquitylases and Phosphorylation
*
Philip Cohen,
University of Dundee, UK
Titia K. Sixma,
Netherlands Cancer Institute, Netherlands
Controlling the Isopeptidases: Regulation of Deubiquitination Reactions
Controlling the Isopeptidases: Regulation of Deubiquitination Reactions
Mads Gyrd-Hansen,
University of Oxford, UK
CYLD limits Lys63- and Met1-linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
CYLD limits Lys63- and Met1-linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
Richard J. Youle,
NINDS, National Institutes of Health, USA
Ubiquitin Signals on Mitochondria Promote Mitophagy via Autophagy Receptors
Ubiquitin Signals on Mitochondria Promote Mitophagy via Autophagy Receptors
09:50—11:30
NF-kappaB Signaling in Cancer
*
Louis M. Staudt,
NCI, National Institutes of Health, USA
Michael Karin,
University of California, San Diego, USA
How NF-kappaB Orchestrates Inflammation
How NF-kappaB Orchestrates Inflammation
Daniel Krappmann,
Helmholtz Zentrum München, Germany
CARMA1-BCL10-MALT1 Signaling in Adaptive Immunity and Lymphoma
CARMA1-BCL10-MALT1 Signaling in Adaptive Immunity and Lymphoma
Dinis P. Calado,
Francis Crick Institute, UK
NF-kappaB Cooperating Events in Mature B Cell-Derived Malignancies
NF-kappaB Cooperating Events in Mature B Cell-Derived Malignancies
14:30—16:30
Workshop 1: Structural Biology and Biochemistry of Ubiquitylation
*
Rachel Klevit,
University of Washington, USA
Maria Sunnerhagen,
Linkoping University, Sweden
Structure of a TRIM21 - UBE2E1 Complex Reveals the Specificity of E2, Ubiquitin and Substrate Recognition by TRIM E3 RINGs
Structure of a TRIM21 - UBE2E1 Complex Reveals the Specificity of E2, Ubiquitin and Substrate Recognition by TRIM E3 RINGs
Katrin E. Rittinger,
Francis Crick Institute, UK
Structural and Functional Characterization of TRIM Family E3 Ligases
Structural and Functional Characterization of TRIM Family E3 Ligases
Catherine L. Day,
University of Otago, New Zealand
Activation of Ubiquitin Transfer by Secondary Ubiquitin–RING Docking
Activation of Ubiquitin Transfer by Secondary Ubiquitin–RING Docking
Seth F. Harris,
Genentech, Inc., USA
Structural Insights Into WD-Repeat 48 Activation of Ubiquitin Specific Protease 46
Structural Insights Into WD-Repeat 48 Activation of Ubiquitin Specific Protease 46
Aysegul Ozen,
Genentech, Inc., USA
Engineering the USP7 Catalytic Domain for Activity
Engineering the USP7 Catalytic Domain for Activity
Hirotaka Takahashi,
Ehime University, Japan
Establishment of Deubiquitinating Enzyme Protein Array Based on Wheat Cell-Free System for a Novel Biochemical Tool
Establishment of Deubiquitinating Enzyme Protein Array Based on Wheat Cell-Free System for a Novel Biochemical Tool
14:30—16:30
Workshop 1
*
Zhijian "James" Chen,
University of Texas Southwestern Medical Center, USA
*
Shao-Cong Sun,
University of Texas MD Anderson Cancer Center, USA
Jian Zhang,
Ohio State University, USA
Anti-Fungal Innate Immune Response Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b
Anti-Fungal Innate Immune Response Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b
Claire Tocheny,
National Institutes of Health, USA
Inflammatory Disease and Immunodeficiency due to Mutation in IkappaBalpha
Inflammatory Disease and Immunodeficiency due to Mutation in IkappaBalpha
Marc Riemann,
Leibniz Institute on Aging - Fritz Lipmann Institute, Germany
Classical NF-kappaB Signaling via RelA and c-Rel Controls the Development of Medullary Thymic Epithelial Cells
Classical NF-kappaB Signaling via RelA and c-Rel Controls the Development of Medullary Thymic Epithelial Cells
Firaz Mohideen,
Harvard Medical School, USA
Systematic Quantitative Proteomics in Response to TNFalpha Signaling Reveals Dynamic Alterations in the Architecture of the Cellular Phospho-proteome
Systematic Quantitative Proteomics in Response to TNFalpha Signaling Reveals Dynamic Alterations in the Architecture of the Cellular Phospho-proteome
Isabel Meininger,
Helmholtz Zentrum München, Germany
Alternative Splicing of MALT1 is Critical for Signaling and Activation of CD4+ T Cells
Alternative Splicing of MALT1 is Critical for Signaling and Activation of CD4+ T Cells
Meri Kaustio,
FIMM/University of Helsinki, Finland
Heterozygous Mutations in NFKB1 cause Immunodeficiency and Autoinflammation
Heterozygous Mutations in NFKB1 cause Immunodeficiency and Autoinflammation
Mélanie Juilland,
University of Lausanne, Switzerland
CARMA1- and MyD88-Dependent Activation of Specific AP-1 Complexes is a Hallmark of ABC Diffuse Large B-cell Lymphomas
CARMA1- and MyD88-Dependent Activation of Specific AP-1 Complexes is a Hallmark of ABC Diffuse Large B-cell Lymphomas
17:00—19:00
Role of Ubiquitylation in Control of Autophagy
*
Richard J. Youle,
NINDS, National Institutes of Health, USA
James H. Hurley,
University of California, Berkeley, USA
Mechanistic and Structural Insights into Autophagy Initiation
Mechanistic and Structural Insights into Autophagy Initiation
J. Wade Harper,
Harvard Medical School, USA
Ubiquitin Signaling for Mitophagy
Ubiquitin Signaling for Mitophagy
Xavier Jacq,
MISSION Therapeutics Ltd., UK
Short Talk: Inhibitors of USP30 as a Potential Treatment of Parkinson’s disease and Other Mitochondrial Dysfunctions
Short Talk: Inhibitors of USP30 as a Potential Treatment of Parkinson’s disease and Other Mitochondrial Dysfunctions
17:00—19:00
NF-kappaB Signaling in Immunity
*
Manolis Pasparakis,
University of Cologne, Germany
The Interplay between NEMO, NF-kB and RIPK1 in Cell Death and Inflammation
The Interplay between NEMO, NF-kB and RIPK1 in Cell Death and Inflammation
Steve D. Gerondakis,
Monash University, Australia
Is NF-kappaB1 a Tumor Suppressor?
Is NF-kappaB1 a Tumor Suppressor?
Xiaoxia Li,
Cleveland Clinic Foundation, USA
IRAK Regulation of NF-kappaB and MAP Kinase Activation
IRAK Regulation of NF-kappaB and MAP Kinase Activation
*
Ulrich K. Siebenlist,
NIAID, National Institutes of Health, USA
Short Talk: The B-Cell Tumor Promoter Bcl-3 Controls Inflammation-Associated Colon Tumorigenesis
Short Talk: The B-Cell Tumor Promoter Bcl-3 Controls Inflammation-Associated Colon Tumorigenesis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Ubiquitination-Dependent Modulation of NF-kappaB Signaling I (Joint)
*
Vishva M. Dixit,
Genentech, Inc., USA
Zhijian "James" Chen,
University of Texas Southwestern Medical Center, USA
Regulation of Antiviral Innate Immunity by Ubiquitination and Phosphorylation
Regulation of Antiviral Innate Immunity by Ubiquitination and Phosphorylation
Domagoj Vucic,
Genentech, Inc., USA
Short Talk: Ubiquitin Ligase Activity of XIAP Regulates NOD2 Mediated Inflammatory Signaling
Short Talk: Ubiquitin Ligase Activity of XIAP Regulates NOD2 Mediated Inflammatory Signaling
Michaela U. Gack,
University of Chicago, USA
Regulation of Antiviral Signaling by TRIM E3 Ligases
Regulation of Antiviral Signaling by TRIM E3 Ligases
David Komander,
Walter and Eliza Hall Institute of Medical Research, Australia
Regulating Linear Ubiquitin Chains with OTULIN
Regulating Linear Ubiquitin Chains with OTULIN
14:30—16:30
Workshop 2: Physiology of Ubiquitin-Dependent Signaling
*
Michael Rape,
University of California, Berkeley, USA
Pieter J. Eichhorn,
National University Singapore, Singapore
USP15 Regulates SMURF2 Kinetics through C-Lobe Mediated Deubiquitination
USP15 Regulates SMURF2 Kinetics through C-Lobe Mediated Deubiquitination
Tohru Ishitani,
Medical Institute of Bioregulation, Kyushu University, Japan
Ubiquitin-Mediated NF-kappaB Degradation Directs Dorsal-Ventral Patterning in Vertebrate Early Embryo
Ubiquitin-Mediated NF-kappaB Degradation Directs Dorsal-Ventral Patterning in Vertebrate Early Embryo
Brooke L. Latour,
Radboudumc, Netherlands
De novo Loss of Function Mutations in the Deubiquitinating Enzyme USP9X cause a Female Specific Syndrome Characterized by Developmental Delay and Distinct Congenital Malformations
De novo Loss of Function Mutations in the Deubiquitinating Enzyme USP9X cause a Female Specific Syndrome Characterized by Developmental Delay and Distinct Congenital Malformations
Eli Arama,
Weizmann Institute of Science, Israel
Spatial Regulation of a CRL3 Complex by a Krebs Cycle Component Restricts Caspase Activation to the Vicinity of the Mitochondria during a Non-apoptotic Cellular Process in Drosophila
Spatial Regulation of a CRL3 Complex by a Krebs Cycle Component Restricts Caspase Activation to the Vicinity of the Mitochondria during a Non-apoptotic Cellular Process in Drosophila
Steven H. Spoel,
University of Edinburgh, UK
Transcriptional Activation by E3 and E4 Ubiquitin Ligases
Transcriptional Activation by E3 and E4 Ubiquitin Ligases
Alexandra Greer,
Genentech, Inc., USA
Ubiquilin1 is Uniquely Required for Cell Cycle Entry and Proliferation Downstream of B-cell Receptor Signaling
Ubiquilin1 is Uniquely Required for Cell Cycle Entry and Proliferation Downstream of B-cell Receptor Signaling
Satpal Virdee,
University of Dundee, UK
Engineered E2~Ub Conjugates as Probes of E3 ligase Transthiolation Activity
Engineered E2~Ub Conjugates as Probes of E3 ligase Transthiolation Activity
17:00—19:00
Large Machines
*
Brenda A. Schulman,
Max Planck Institute of Biochemistry, Germany
Andreas Martin,
University of California, Berkeley, USA
26S Proteasome Assembly and Conformational Changes Control Substrate Deubiquitination by Rpn11
26S Proteasome Assembly and Conformational Changes Control Substrate Deubiquitination by Rpn11
Nicolas H. Thomä,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Regulation of Cullin-RING-ligase activity by CSN
Regulation of Cullin-RING-ligase activity by CSN
Jessica A. Gasser,
Broad Institute of MIT and Harvard, USA
Short Talk: Genome-Wide CRISPR-Cas9 Screen Reveals Genes Required for the Effect of Lenalidomide on the CRL4-CRBN Ubiquitin Ligase
Short Talk: Genome-Wide CRISPR-Cas9 Screen Reveals Genes Required for the Effect of Lenalidomide on the CRL4-CRBN Ubiquitin Ligase
17:00—19:00
Transcriptional Regulation in Inflammation
*
Michael Karin,
University of California, San Diego, USA
Irina A. Udalova,
University of Oxford, UK
IRF5 Orchestrated Regulation of Inflammatory Programme in Macrophages
IRF5 Orchestrated Regulation of Inflammatory Programme in Macrophages
Neal Silverman,
University of Massachusetts Medical School, USA
Short Talk: Regulation of Drosophila Innate Immune NF-kappaB Signaling by Amyloidal Proteins
Short Talk: Regulation of Drosophila Innate Immune NF-kappaB Signaling by Amyloidal Proteins
Stephen T. Smale,
University of California, Los Angeles, USA
Global Analysis of Transcriptional Cascades Induced by Inflammatory Stimuli
Global Analysis of Transcriptional Cascades Induced by Inflammatory Stimuli
08:00—11:00
Ubiquitylation and Human Disease
*
Ingrid E. Wertz,
Genentech, Inc., USA
Michael Rape,
University of California, Berkeley, USA
Ubiquitin-Dependent Regulation of Craniofacial Development
Ubiquitin-Dependent Regulation of Craniofacial Development
Noam Zelcer,
Academic Medical Center, University of Amsterdam, Netherlands
Short Talk: USP2 Regulates the LDLR Pathway through Deubiquitylation of the E3-ubiquitin Ligase IDOL
Short Talk: USP2 Regulates the LDLR Pathway through Deubiquitylation of the E3-ubiquitin Ligase IDOL
Heran Darwin,
New York University School of Medicine, USA
Proteasomal Regulation of Mycobacterium tuberculosis Pathogenesis
Proteasomal Regulation of Mycobacterium tuberculosis Pathogenesis
Jeffery S. Cox,
University of California, Berkeley, USA
Discrimination of Pathogens from Non-Pathogens by Innate Immune Cells
Discrimination of Pathogens from Non-Pathogens by Innate Immune Cells
08:00—11:00
NLR Signaling to NF-kappaB and IRF
*
Rudi Beyaert,
Ghent University - VIB, Belgium
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
NLRs as Regulators of NFkappaB and MAPK Signaling
NLRs as Regulators of NFkappaB and MAPK Signaling
Feng Shao,
National Institute of Biological Sciences, China
Pyroptosis in Anti-Bacterial Immunity: Sensing and Execution
Pyroptosis in Anti-Bacterial Immunity: Sensing and Execution
Benedict Seddon,
University College London, UK
Short Talk: TNF Activation of NF-kappaB is Essential for Development of Single Positive Thymocytes
Short Talk: TNF Activation of NF-kappaB is Essential for Development of Single Positive Thymocytes
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Regulators of Inflammatory Responses
Regulators of Inflammatory Responses
14:30—16:30
Workshop 3: The Interplay between Ubiquitylation and Phosphorylation in Cell Regulation
*
David Komander,
Walter and Eliza Hall Institute of Medical Research, Australia
Maria Isabel Acosta Lopez,
University of Nice Sophia Antipolis, France
New Regulatory Mechanism and Cellular Function of the Tumor Suppressor HACE1
New Regulatory Mechanism and Cellular Function of the Tumor Suppressor HACE1
Niall Dillon,
Medical Research Council, UK
Phosphorylation of the E2 Ubiquitin Conjugating Enzyme UBE2D3 Regulates Polycomb-Mediated Gene Priming in Pluripotent ES Cells
Phosphorylation of the E2 Ubiquitin Conjugating Enzyme UBE2D3 Regulates Polycomb-Mediated Gene Priming in Pluripotent ES Cells
Jeffrey R. Johnson,
University of California, San Francisco, USA
Ubiquitin Remnant Profiling Identifies a Novel Substrate of HIV-Mediated Ubiquitination and Degradation
Ubiquitin Remnant Profiling Identifies a Novel Substrate of HIV-Mediated Ubiquitination and Degradation
R. Jeremy Nichols,
Parkinson's Institute, USA
The LRRK2 Phosphorylation-Ubiquitination Cycle
The LRRK2 Phosphorylation-Ubiquitination Cycle
Camillo Palmieri,
Università Magna Grecia of Catanzaro, Italy
Regulation of IBtk-alpha Activity by mTOR-Mediated Phosphorylation
Regulation of IBtk-alpha Activity by mTOR-Mediated Phosphorylation
Nicolas Bidère,
INSERM, France
The Paracaspase MALT1 Cleaves the LUBAC Subunit HOIL1 during Antigen Receptor Signaling
The Paracaspase MALT1 Cleaves the LUBAC Subunit HOIL1 during Antigen Receptor Signaling
14:30—16:30
Workshop 2
*
Steve D. Gerondakis,
Monash University, Australia
*
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
Simon Rousseau,
McGill University, Canada
Differential Contributions of theTPL2-MKK1/MKK2-ERK1/ERK2 and NFkB Pathways to Oncogenic Transformation in Lymphoid Neoplasms
Differential Contributions of theTPL2-MKK1/MKK2-ERK1/ERK2 and NFkB Pathways to Oncogenic Transformation in Lymphoid Neoplasms
Nadine Mikuda,
Max-Delbrück-Center for Molecular Medicine, MDC, Germany
The IkappaB Kinase Complex is a Universal Regulator of mRNA Stability in Response to Stress
The IkappaB Kinase Complex is a Universal Regulator of mRNA Stability in Response to Stress
Marina Kolesnichenko,
Max Delbrueck Center for Molecular Medicine, Germany
Senescence Associated NFkappaB Inflammatory Response is Driven by an mRNA Destabilization Mechanism
Senescence Associated NFkappaB Inflammatory Response is Driven by an mRNA Destabilization Mechanism
Benjamin E. Gewurz,
Brigham and Women's Hospital, Harvard Medical School, USA
The NF-kB Genomic Landscape in CD40-Stimulated Primary Human B-cells
The NF-kB Genomic Landscape in CD40-Stimulated Primary Human B-cells
Anetta Svitorka Härtlova,
University of Gothenburg, Sweden
Scavenger Receptor MSR-JNK Pathway Control Phenotypic Switch of Alternatively Activated Macrophages
Scavenger Receptor MSR-JNK Pathway Control Phenotypic Switch of Alternatively Activated Macrophages
Ricardo Antonia,
University of North Carolina, USA
IKK Promotes AMPK Activity by Phosphorylating Threonine 172 in Response to IL-1beta
IKK Promotes AMPK Activity by Phosphorylating Threonine 172 in Response to IL-1beta
Ruaidhri Carmody,
University of Glasgow, UK
Control of MAP Kinase and NF-kappaB Pathways by the Nuclear IkappaB-like factor Bcl-3
Control of MAP Kinase and NF-kappaB Pathways by the Nuclear IkappaB-like factor Bcl-3
17:00—19:00
Structural Analysis of E3 Ligases and DUBs
*
Titia K. Sixma,
Netherlands Cancer Institute, Netherlands
Rachel Klevit,
University of Washington, USA
Mechanistic Strategies of RING-Between-RING (RBR) E3 Ligases
Mechanistic Strategies of RING-Between-RING (RBR) E3 Ligases
Bernhard Clemens Lechtenberg,
Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Structure of the HOIP-RBR/E2~ubiquitin Transfer Complex Reveals a Universal Mechanism for RBR E3 Ubiquitin Ligases
Short Talk: Structure of the HOIP-RBR/E2~ubiquitin Transfer Complex Reveals a Universal Mechanism for RBR E3 Ubiquitin Ligases
Brenda A. Schulman,
Max Planck Institute of Biochemistry, Germany
Cullin-RING E3 Ligation Mechanisms
Cullin-RING E3 Ligation Mechanisms
Christopher D. Lima,
Memorial Sloan Kettering Cancer Center, USA
E3 Ligases: Activities and Specificity
E3 Ligases: Activities and Specificity
17:00—19:00
MAP Kinase Signaling in Inflammation
*
Xiaoxia Li,
Cleveland Clinic Foundation, USA
Ana Cuenda,
Spanish National Biotechnology Centre, Spain
Regulation of Inflammation by p38gamma/delta
Regulation of Inflammation by p38gamma/delta
Mathieu JM Bertrand,
VIB / Ghent University, Belgium
Short Talk: NF-kB-Independent Role of IKKa/IKKb in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
Short Talk: NF-kB-Independent Role of IKKa/IKKb in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
Roger J. Davis,
HHMI/University of Massachusetts Medical School, USA
Role of JNK in Metabolic Stress Signaling
Role of JNK in Metabolic Stress Signaling
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Small Molecules and Therapeutics
*
Raymond J. Deshaies,
Amgen, Inc., USA
Zhihao Zhuang,
University of Delaware, USA
Targeting Deubiquitinase in DNA Damage Response for Anticancer Therapy
Targeting Deubiquitinase in DNA Damage Response for Anticancer Therapy
Alessio Ciulli,
University of Dundee, School of Life Sciences, UK
Short Talk: Small Molecules for the VHL Cul2 E3 Ligase: VHL-HIF Inhibitors and Proteolysis Targeting Chimeras (PROTACs)
Short Talk: Small Molecules for the VHL Cul2 E3 Ligase: VHL-HIF Inhibitors and Proteolysis Targeting Chimeras (PROTACs)
Georg Petzold,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: Structural Basis of Lenalidomide-induced CK1alpha Degradation by the CRL4-CRBN Ubiquitin Ligase
Short Talk: Structural Basis of Lenalidomide-induced CK1alpha Degradation by the CRL4-CRBN Ubiquitin Ligase
Ingrid E. Wertz,
Genentech, Inc., USA
Phosphorylation and Linear Ubiquitin Direct A20 Inhibition of Inflammation
Phosphorylation and Linear Ubiquitin Direct A20 Inhibition of Inflammation
Frank Sicheri,
Lunenfeld-Tanenbaum Research Institute, Canada
The Structural basis for Poly-Ubiquitin Chain Cleavage and Regulation: Lessons Learned from BRCC36
The Structural basis for Poly-Ubiquitin Chain Cleavage and Regulation: Lessons Learned from BRCC36
08:00—11:00
Therapeutic Targeting of Inflammation
*
Daniel Krappmann,
Helmholtz Zentrum München, Germany
Stefan Knapp,
University of Oxford, UK
Targeting Bromodomains in Inflammation
Targeting Bromodomains in Inflammation
Vanessa C. Taylor,
Rigel Inc., USA
R191, A Small Molecule IRAK1/4 Kinase Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases
R191, A Small Molecule IRAK1/4 Kinase Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases
Eric P. Hanson,
National Institutes of Health, USA
Short Talk: Recruitment of A20 by the C-Terminal Domain of NEMO Suppresses NF-kappaB Activation and Autoinflammatory Disease
Short Talk: Recruitment of A20 by the C-Terminal Domain of NEMO Suppresses NF-kappaB Activation and Autoinflammatory Disease
Vikram R. Rao,
Pfizer, USA
The Role of IRAK4 in NFkB and MAPK Signaling: Implications for Drug Development
The Role of IRAK4 in NFkB and MAPK Signaling: Implications for Drug Development
17:00—19:15
Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Joint)
*
Ivan Dikic,
Goethe University Medical School, Germany
Shao-Cong Sun,
University of Texas MD Anderson Cancer Center, USA
Epigenetic Regulation of NF-kB Function and Inflammation by Ubiquitination
Epigenetic Regulation of NF-kB Function and Inflammation by Ubiquitination
Shigeki Miyamoto,
University of Wisconsin, Madison, USA
Investigation of NF-kappaB Signaling Induced by Genotoxic Agents and Potentially Novel Activators
Investigation of NF-kappaB Signaling Induced by Genotoxic Agents and Potentially Novel Activators
Rudi Beyaert,
Ghent University - VIB, Belgium
The Dual Faces of Paracaspase MALT1 in Inflammation and Immunity
The Dual Faces of Paracaspase MALT1 in Inflammation and Immunity
19:15—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
Philip Cohen,
University of Dundee, UK
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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