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This meeting took place in 2016


Here are the related meetings in 2020:
Ubiquitin Biology (X7)

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Ubiquitin Signaling (X3)


Organizer(s) Philip Cohen, Michael Rape and Titia K. Sixma
March 13—17, 2016
Whistler Conference Centre • Whistler, BC Canada
Discounted Abstract Deadline: Nov 11, 2015
Abstract Deadline: Dec 14, 2015
Scholarship Deadline: Nov 11, 2015
Discounted Registration Deadline: Jan 13, 2016

Sponsored by Cell Research and Genentech, Inc.


Summary of Meeting:
Many components of the ubiquitin system are involved in controlling cellular processes, and the deregulation of this system underlies many diseases. The meeting will focus on how ubiquitylation controls processes such as autophagy, neurodegenerative diseases, hypertension, the immune system and the activation of NF-kappaB. It will include talks on how the ubiquitin system is controlled by protein phosphorylation, the specificity and regulation of deubiquitylases and the structural analysis of E3 ligases and large protein complexes that coordinate ubiquitylation and related events. Additional sessions will feature diseases caused by abnormalities in ubiquitylation and the progress that is being made in targeting the ubiquitin system for the development of improved drugs to treat cancer and other diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 17 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, March 18 in order to fully experience the meeting.

SUNDAY, MARCH 13

16:00—20:00
Arrival and Registration

Sea to Sky Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sea to Sky Foyer

MONDAY, MARCH 14

07:00—08:00
Breakfast

Sea to Sky A
08:00—09:30
Keynote Session (Joint)

Sea to Sky B/C
* Steven C. Ley, Francis Crick Institute, UK

* Michael Rape, University of California, Berkeley, USA

Louis M. Staudt, NCI, National Institutes of Health, USA
Blocking NF-kappaB Activation as a Therapeutic Approach in Cancer

Ning Zheng, University of Washington, USA
Targeting Regulatory Enzymes in Ubiquitin Signaling

09:30—09:50
Coffee Break

Grand Foyer
09:50—11:30
Regulation of the Ubiquitin System by Deubiquitylases and Phosphorylation

Sea to Sky B
* Philip Cohen, University of Dundee, UK

Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Controlling the Isopeptidases: Regulation of Deubiquitination Reactions

Mads Gyrd-Hansen, University of Oxford, UK
CYLD limits Lys63- and Met1-linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

Richard J. Youle, NINDS, National Institutes of Health, USA
Ubiquitin Signals on Mitochondria Promote Mitophagy via Autophagy Receptors

09:50—11:30
NF-kappaB Signaling in Cancer

Sea to Sky C
* Louis M. Staudt, NCI, National Institutes of Health, USA

Michael Karin, University of California, San Diego, USA
How NF-kappaB Orchestrates Inflammation

Daniel Krappmann, Helmholtz Zentrum München, Germany
CARMA1-BCL10-MALT1 Signaling in Adaptive Immunity and Lymphoma

Dinis P. Calado, Francis Crick Institute, UK
NF-kappaB Cooperating Events in Mature B Cell-Derived Malignancies

11:30—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:30—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Structural Biology and Biochemistry of Ubiquitylation

Sea to Sky B
* Rachel Klevit, University of Washington, USA

Maria Sunnerhagen, Linkoping University, Sweden
Structure of a TRIM21 - UBE2E1 Complex Reveals the Specificity of E2, Ubiquitin and Substrate Recognition by TRIM E3 RINGs

Katrin E. Rittinger, Francis Crick Institute, UK
Structural and Functional Characterization of TRIM Family E3 Ligases

Catherine L. Day, University of Otago, New Zealand
Activation of Ubiquitin Transfer by Secondary Ubiquitin–RING Docking

Seth F. Harris, Genentech, Inc., USA
Structural Insights Into WD-Repeat 48 Activation of Ubiquitin Specific Protease 46

Aysegul Ozen, Genentech, Inc., USA
Engineering the USP7 Catalytic Domain for Activity

Hirotaka Takahashi, Ehime University, Japan
Establishment of Deubiquitinating Enzyme Protein Array Based on Wheat Cell-Free System for a Novel Biochemical Tool

14:30—16:30
Workshop 1

Sea to Sky C
* Zhijian "James" Chen, University of Texas Southwestern Medical Center, USA

* Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA

Jian Zhang, Ohio State University, USA
Anti-Fungal Innate Immune Response Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b

Claire Tocheny, National Institutes of Health, USA
Inflammatory Disease and Immunodeficiency due to Mutation in IkappaBalpha

Marc Riemann, Leibniz Institute on Aging - Fritz Lipmann Institute, Germany
Classical NF-kappaB Signaling via RelA and c-Rel Controls the Development of Medullary Thymic Epithelial Cells

Firaz Mohideen, Harvard Medical School, USA
Systematic Quantitative Proteomics in Response to TNFalpha Signaling Reveals Dynamic Alterations in the Architecture of the Cellular Phospho-proteome

Isabel Meininger, Helmholtz Zentrum München, Germany
Alternative Splicing of MALT1 is Critical for Signaling and Activation of CD4+ T Cells

Meri Kaustio, FIMM/University of Helsinki, Finland
Heterozygous Mutations in NFKB1 cause Immunodeficiency and Autoinflammation

Mélanie Juilland, University of Lausanne, Switzerland
CARMA1- and MyD88-Dependent Activation of Specific AP-1 Complexes is a Hallmark of ABC Diffuse Large B-cell Lymphomas

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Role of Ubiquitylation in Control of Autophagy

Sea to Sky B
* Richard J. Youle, NINDS, National Institutes of Health, USA

James H. Hurley, University of California, Berkeley, USA
Mechanistic and Structural Insights into Autophagy Initiation

J. Wade Harper, Harvard Medical School, USA
Ubiquitin Signaling for Mitophagy

Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin Regulation of Selective Autophagy

Xavier Jacq, MISSION Therapeutics Ltd., UK
Short Talk: Inhibitors of USP30 as a Potential Treatment of Parkinson’s disease and Other Mitochondrial Dysfunctions

17:00—19:00
NF-kappaB Signaling in Immunity

Sea to Sky C
* Manolis Pasparakis, University of Cologne, Germany
The Interplay between NEMO, NF-kB and RIPK1 in Cell Death and Inflammation

Steve D. Gerondakis, Monash University, Australia
Is NF-kappaB1 a Tumor Suppressor?

Xiaoxia Li, Cleveland Clinic Foundation, USA
IRAK Regulation of NF-kappaB and MAP Kinase Activation

* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Short Talk: The B-Cell Tumor Promoter Bcl-3 Controls Inflammation-Associated Colon Tumorigenesis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 1

Sea to Sky A

TUESDAY, MARCH 15

07:00—08:00
Breakfast

Sea to Sky A
07:30—08:00
Poster Setup

Sea to Sky A
08:00—17:00
Poster Viewing

Sea to Sky A
08:00—11:00
Ubiquitination-Dependent Modulation of NF-kappaB Signaling I (Joint)

Sea to Sky B/C
* Vishva M. Dixit, Genentech, Inc., USA

Zhijian "James" Chen, University of Texas Southwestern Medical Center, USA
Regulation of Antiviral Innate Immunity by Ubiquitination and Phosphorylation

Pascal Meier, Institute of Cancer Research, UK
Tipping the Response to TNF in Favor of Death

Domagoj Vucic, Genentech, Inc., USA
Short Talk: Ubiquitin Ligase Activity of XIAP Regulates NOD2 Mediated Inflammatory Signaling

Michaela U. Gack, University of Chicago, USA
Regulation of Antiviral Signaling by TRIM E3 Ligases

David Komander, Walter and Eliza Hall Institute of Medical Research, Australia
Regulating Linear Ubiquitin Chains with OTULIN

09:40—10:00
Coffee Break

Grand Foyer
11:00—12:00
Lunch

Sea to Sky A
12:00—14:30
Poster Session 2

Sea to Sky A
14:30—16:30
Workshop 2: Physiology of Ubiquitin-Dependent Signaling

Sea to Sky B
* Michael Rape, University of California, Berkeley, USA

Pieter J. Eichhorn, National University Singapore, Singapore
USP15 Regulates SMURF2 Kinetics through C-Lobe Mediated Deubiquitination

Tohru Ishitani, Medical Institute of Bioregulation, Kyushu University, Japan
Ubiquitin-Mediated NF-kappaB Degradation Directs Dorsal-Ventral Patterning in Vertebrate Early Embryo

Brooke L. Latour, Radboudumc, Netherlands
De novo Loss of Function Mutations in the Deubiquitinating Enzyme USP9X cause a Female Specific Syndrome Characterized by Developmental Delay and Distinct Congenital Malformations

Eli Arama, Weizmann Institute of Science, Israel
Spatial Regulation of a CRL3 Complex by a Krebs Cycle Component Restricts Caspase Activation to the Vicinity of the Mitochondria during a Non-apoptotic Cellular Process in Drosophila

Steven H. Spoel, University of Edinburgh, UK
Transcriptional Activation by E3 and E4 Ubiquitin Ligases

Alexandra Greer, Genentech, Inc., USA
Ubiquilin1 is Uniquely Required for Cell Cycle Entry and Proliferation Downstream of B-cell Receptor Signaling

Satpal Virdee, University of Dundee, UK
Engineered E2~Ub Conjugates as Probes of E3 ligase Transthiolation Activity

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Large Machines

Sea to Sky B
* Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany

Andreas Martin, University of California, Berkeley, USA
26S Proteasome Assembly and Conformational Changes Control Substrate Deubiquitination by Rpn11

Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
Regulation of Cullin-RING-ligase activity by CSN

Raymond J. Deshaies, Amgen, Inc., USA
Regulation of CRL Assembly: The Adaptive Exchange Hypothesis

Jessica A. Gasser, Broad Institute of MIT and Harvard, USA
Short Talk: Genome-Wide CRISPR-Cas9 Screen Reveals Genes Required for the Effect of Lenalidomide on the CRL4-CRBN Ubiquitin Ligase

17:00—19:00
Transcriptional Regulation in Inflammation

Sea to Sky C
* Michael Karin, University of California, San Diego, USA

Alexander Hoffmann, University of California, Los Angeles, USA
Dynamic Control of NFkB

Irina A. Udalova, University of Oxford, UK
IRF5 Orchestrated Regulation of Inflammatory Programme in Macrophages

Neal Silverman, University of Massachusetts Medical School, USA
Short Talk: Regulation of Drosophila Innate Immune NF-kappaB Signaling by Amyloidal Proteins

Stephen T. Smale, University of California, Los Angeles, USA
Global Analysis of Transcriptional Cascades Induced by Inflammatory Stimuli

19:00
On Own for Dinner


WEDNESDAY, MARCH 16

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:00
Ubiquitylation and Human Disease

Sea to Sky B
* Ingrid E. Wertz, Genentech, Inc., USA

Michael Rape, University of California, Berkeley, USA
Ubiquitin-Dependent Regulation of Craniofacial Development

Dario Alessi, University of Dundee, UK
Control of Blood Pressure

Noam Zelcer, Academic Medical Center, University of Amsterdam, Netherlands
Short Talk: USP2 Regulates the LDLR Pathway through Deubiquitylation of the E3-ubiquitin Ligase IDOL

Heran Darwin, New York University School of Medicine, USA
Proteasomal Regulation of Mycobacterium tuberculosis Pathogenesis

Jeffery S. Cox, University of California, Berkeley, USA
Discrimination of Pathogens from Non-Pathogens by Innate Immune Cells

08:00—11:00
NLR Signaling to NF-kappaB and IRF

Sea to Sky C
* Rudi Beyaert, Ghent University - VIB, Belgium

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs as Regulators of NFkappaB and MAPK Signaling

Feng Shao, National Institute of Biological Sciences, China
Pyroptosis in Anti-Bacterial Immunity: Sensing and Execution

Benedict Seddon, University College London, UK
Short Talk: TNF Activation of NF-kappaB is Essential for Development of Single Positive Thymocytes

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulators of Inflammatory Responses

Vishva M. Dixit, Genentech, Inc., USA
RIPK3: Role of the Kinase Activity in Necroptosis

09:40—10:00
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 3: The Interplay between Ubiquitylation and Phosphorylation in Cell Regulation

Sea to Sky B
* David Komander, Walter and Eliza Hall Institute of Medical Research, Australia

Maria Isabel Acosta Lopez, University of Nice Sophia Antipolis, France
New Regulatory Mechanism and Cellular Function of the Tumor Suppressor HACE1

Niall Dillon, Medical Research Council, UK
Phosphorylation of the E2 Ubiquitin Conjugating Enzyme UBE2D3 Regulates Polycomb-Mediated Gene Priming in Pluripotent ES Cells

Jeffrey R. Johnson, University of California, San Francisco, USA
Ubiquitin Remnant Profiling Identifies a Novel Substrate of HIV-Mediated Ubiquitination and Degradation

R. Jeremy Nichols, Parkinson's Institute, USA
The LRRK2 Phosphorylation-Ubiquitination Cycle

Camillo Palmieri, Università Magna Grecia of Catanzaro, Italy
Regulation of IBtk-alpha Activity by mTOR-Mediated Phosphorylation

Nicolas Bidère, INSERM, France
The Paracaspase MALT1 Cleaves the LUBAC Subunit HOIL1 during Antigen Receptor Signaling

14:30—16:30
Workshop 2

Sea to Sky C
* Steve D. Gerondakis, Monash University, Australia

* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA

Simon Rousseau, McGill University, Canada
Differential Contributions of theTPL2-MKK1/MKK2-ERK1/ERK2 and NFkB Pathways to Oncogenic Transformation in Lymphoid Neoplasms

Nadine Mikuda, Max-Delbrück-Center for Molecular Medicine, MDC, Germany
The IkappaB Kinase Complex is a Universal Regulator of mRNA Stability in Response to Stress

Marina Kolesnichenko, Max Delbrueck Center for Molecular Medicine, Germany
Senescence Associated NFkappaB Inflammatory Response is Driven by an mRNA Destabilization Mechanism

Benjamin E. Gewurz, Brigham and Women's Hospital, Harvard Medical School, USA
The NF-kB Genomic Landscape in CD40-Stimulated Primary Human B-cells

Anetta Svitorka Härtlova, University of Gothenburg, Sweden
Scavenger Receptor MSR-JNK Pathway Control Phenotypic Switch of Alternatively Activated Macrophages

Ricardo Antonia, University of North Carolina, USA
IKK Promotes AMPK Activity by Phosphorylating Threonine 172 in Response to IL-1beta

Ruaidhri Carmody, University of Glasgow, UK
Control of MAP Kinase and NF-kappaB Pathways by the Nuclear IkappaB-like factor Bcl-3

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Structural Analysis of E3 Ligases and DUBs

Sea to Sky B
* Titia K. Sixma, Netherlands Cancer Institute, Netherlands

Rachel Klevit, University of Washington, USA
Mechanistic Strategies of RING-Between-RING (RBR) E3 Ligases

Bernhard Clemens Lechtenberg, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Structure of the HOIP-RBR/E2~ubiquitin Transfer Complex Reveals a Universal Mechanism for RBR E3 Ubiquitin Ligases

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Cullin-RING E3 Ligation Mechanisms

Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
E3 Ligases: Activities and Specificity

17:00—19:00
MAP Kinase Signaling in Inflammation

Sea to Sky C
* Xiaoxia Li, Cleveland Clinic Foundation, USA

Steven C. Ley, Francis Crick Institute, UK
Regulation of Inflammation by TPL-2 MAP 3-kinase

Ana Cuenda, Spanish National Biotechnology Centre, Spain
Regulation of Inflammation by p38gamma/delta

Mathieu JM Bertrand, VIB / Ghent University, Belgium
Short Talk: NF-kB-Independent Role of IKKa/IKKb in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Role of JNK in Metabolic Stress Signaling

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
19:30—22:00
Poster Session 3

Sea to Sky A

THURSDAY, MARCH 17

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:00
Small Molecules and Therapeutics

Sea to Sky B
* Raymond J. Deshaies, Amgen, Inc., USA

Zhihao Zhuang, University of Delaware, USA
Targeting Deubiquitinase in DNA Damage Response for Anticancer Therapy

Alessio Ciulli, University of Dundee, School of Life Sciences, UK
Short Talk: Small Molecules for the VHL Cul2 E3 Ligase: VHL-HIF Inhibitors and Proteolysis Targeting Chimeras (PROTACs)

Georg Petzold, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: Structural Basis of Lenalidomide-induced CK1alpha Degradation by the CRL4-CRBN Ubiquitin Ligase

Ingrid E. Wertz, Genentech, Inc., USA
Phosphorylation and Linear Ubiquitin Direct A20 Inhibition of Inflammation

Frank Sicheri, Lunenfeld-Tanenbaum Research Institute, Canada
The Structural basis for Poly-Ubiquitin Chain Cleavage and Regulation: Lessons Learned from BRCC36

08:00—11:00
Therapeutic Targeting of Inflammation

Sea to Sky C
* Daniel Krappmann, Helmholtz Zentrum München, Germany

Stefan Knapp, University of Oxford, UK
Targeting Bromodomains in Inflammation

Vanessa C. Taylor, Rigel Inc., USA
R191, A Small Molecule IRAK1/4 Kinase Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases

Eric P. Hanson, National Institutes of Health, USA
Short Talk: Recruitment of A20 by the C-Terminal Domain of NEMO Suppresses NF-kappaB Activation and Autoinflammatory Disease

Vikram R. Rao, Pfizer, USA
The Role of IRAK4 in NFkB and MAPK Signaling: Implications for Drug Development

09:20—09:40
Coffee Break

Grand Foyer
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:15
Ubiquitin-Dependent Modulation of NF-kappaB Signaling II (Joint)

Sea to Sky B/C
* Ivan Dikic, Goethe University Medical School, Germany

Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Epigenetic Regulation of NF-kB Function and Inflammation by Ubiquitination

Shigeki Miyamoto, University of Wisconsin, Madison, USA
Investigation of NF-kappaB Signaling Induced by Genotoxic Agents and Potentially Novel Activators

Rudi Beyaert, Ghent University - VIB, Belgium
The Dual Faces of Paracaspase MALT1 in Inflammation and Immunity

Philip Cohen, University of Dundee, UK
Re-Writing the Interleukin-1 Signaling Network

19:15—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Joint)

Sea to Sky B/C
Philip Cohen, University of Dundee, UK

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky A
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sea to Sky A

FRIDAY, MARCH 18

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Genentech, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Nurix, Inc.

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