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This meeting took place in 2019
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Lipidomics and Functional Metabolic Pathways in Disease (C6)
Organizer(s) Sarah Spiegel, Charles N. Serhan and Valerie B. O'Donnell
March 31—April 4, 2019
Steamboat Grand • Steamboat Springs, CO USA
Discounted Abstract Deadline: Dec 11, 2018
Abstract Deadline: Dec 19, 2018
Scholarship Deadline: Dec 11, 2018
Discounted Registration Deadline: Jan 30, 2019
Supported by the Directors' Fund
Summary of Meeting:
Recently, our understanding of lipid metabolism has significantly advanced, at least in part through applying state-of-the-art lipidomic mass spectrometry approaches to cellular, cohort and animal models. A large body of evidence now exists demonstrating that bioactive lipids play key roles in regulation of biological processes important for health and disease. However, lipidomics also reveals major gaps in our knowledge, highlighting the enormous numbers and functional and structural diversity of bioactive lipids, their interactions, spatial and temporal changes and the complicated systems biology of lipid metabolism. This Keystone Symposia conference covers areas of bioactive lipid research that have been particularly impacted by these new technologies, which may have the potential to transform precision medicine. The conference covers recent progress and perspectives in the study of bioactive lipid metabolic pathways, how these interconnect and are cross-regulated, and their involvement in the regulation of disease. The conference brings together outstanding senior and junior scientists with expertise in functions of bioactive lipids as well as those with a background in mass spectrometry lipidomics, structural biology and systems biology of lipids. Goals and anticipated outcomes are: 1) To summarize new approaches and state-of-the-art mass spectrometry technology. combined with informatics and statistics, in bioactive lipid research and to gain broad understanding of their limitations and potential application to precision medicine; 2) To acquire a broader understanding of how lipidomics can be integrated with proteomics/genomics and other ‘omics technologies to develop a systems-wide view of the lipidome; 3) To gain new knowledge in spatial and temporal interactions of bioactive lipids in cellular and subcellular systems, to better understand their functions in health and diseases; and 4) To present recent findings on the biological importance of newly discovered lipids and their roles in immunity and inflammation.
View Scholarships/Awards
Recently, our understanding of lipid metabolism has significantly advanced, at least in part through applying state-of-the-art lipidomic mass spectrometry approaches to cellular, cohort and animal models. A large body of evidence now exists demonstrating that bioactive lipids play key roles in regulation of biological processes important for health and disease. However, lipidomics also reveals major gaps in our knowledge, highlighting the enormous numbers and functional and structural diversity of bioactive lipids, their interactions, spatial and temporal changes and the complicated systems biology of lipid metabolism. This Keystone Symposia conference covers areas of bioactive lipid research that have been particularly impacted by these new technologies, which may have the potential to transform precision medicine. The conference covers recent progress and perspectives in the study of bioactive lipid metabolic pathways, how these interconnect and are cross-regulated, and their involvement in the regulation of disease. The conference brings together outstanding senior and junior scientists with expertise in functions of bioactive lipids as well as those with a background in mass spectrometry lipidomics, structural biology and systems biology of lipids. Goals and anticipated outcomes are: 1) To summarize new approaches and state-of-the-art mass spectrometry technology. combined with informatics and statistics, in bioactive lipid research and to gain broad understanding of their limitations and potential application to precision medicine; 2) To acquire a broader understanding of how lipidomics can be integrated with proteomics/genomics and other ‘omics technologies to develop a systems-wide view of the lipidome; 3) To gain new knowledge in spatial and temporal interactions of bioactive lipids in cellular and subcellular systems, to better understand their functions in health and diseases; and 4) To present recent findings on the biological importance of newly discovered lipids and their roles in immunity and inflammation.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 4 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, April 5 in order to fully experience the meeting.
SUNDAY, MARCH 31
MONDAY, APRIL 1
TUESDAY, APRIL 2
WEDNESDAY, APRIL 3
THURSDAY, APRIL 4
FRIDAY, APRIL 5
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 31 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 4 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, April 5 in order to fully experience the meeting.
SUNDAY, MARCH 31
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Charles N. Serhan,
Brigham and Women's Hospital, USA
Resolvins and Pro-Resolving Mediators in Resolution of Inflammation and Tissue Regeneration: Targeted Metabolipidomics
Resolvins and Pro-Resolving Mediators in Resolution of Inflammation and Tissue Regeneration: Targeted Metabolipidomics
09:00—11:45
Resolution of Inflammation, Infection & Tissue Regeneration
*
Charles N. Serhan,
Brigham and Women's Hospital, USA
Gabrielle Fredman,
Albany Medical Center, USA
Dysregulation of Resolution Pathways in Atherosclerosis
Dysregulation of Resolution Pathways in Atherosclerosis
Coffee Break
Valerio Chiurchiù,
IRCCS Santa Lucia Foundation, Italy
Resolution of Inflammation is Altered in Chronic Inflammatory Diseases: From the Periphery to the Brain
Resolution of Inflammation is Altered in Chronic Inflammatory Diseases: From the Periphery to the Brain
Charles R. Brown,
University of Missouri, USA
Short Talk: Eicosanoid-Mediated Clearance of Apoptotic Cells Is Critical for the Resolution of Experimental Lyme Arthritis
Short Talk: Eicosanoid-Mediated Clearance of Apoptotic Cells Is Critical for the Resolution of Experimental Lyme Arthritis
Takehiko Yokomizo,
Juntendo University School of Medicine, Japan
Short Talk: Leukotriene B4 Promotes Neovascularization and Macrophage Recruitment in Age-Related Macular Degeneration (AMD)
Short Talk: Leukotriene B4 Promotes Neovascularization and Macrophage Recruitment in Age-Related Macular Degeneration (AMD)
Patricia C. Kane,
NeuroLipid Research Foundation, USA
Short Talk: The Application of Bioactive Lipids to Attenuate Epigenetic Insult, Unfolded Proteins and Ceramides in Neurological Disorders
Short Talk: The Application of Bioactive Lipids to Attenuate Epigenetic Insult, Unfolded Proteins and Ceramides in Neurological Disorders
15:00—16:30
Workshop 1: LIPID MAPS Tools and Advances in Lipidomics Techniques
The LIPID MAPS Lipidomics Gateway is a comprehensive online resource providing databases of lipid structures and lipid-associated genes or proteins, a variety of lipidomics tools, experimental data for lipids and genes along with protocols and standards, context specific cellular networks and pathways as well as guidelines, tutorials and instructional material for the research community. It features a lipid classification system which has gained worldwide acceptance and an interactive online lipid structure database, the LIPID MAPS structure database (LMSD) with over 43,000 unique curated structures making it the largest of its kind in the world. The LIPID MAPS in-silico structure database (LMISSD) of over a million computationally generated structures covers most of the commonly occurring lipid classes. The LIPID MAPS Proteome Database (LMPD) of lipid-related genes and proteins contains data for over 8,500 genes and over 12,500 proteins from 10 major research species. One can access annotations, such as genomic DNA, mRNA, protein domain, ontology and biochemical pathway information, with cross-links to external databases, relevant to each gene/protein of interest. The Lipidomics Gateway contains a comprehensive suite of online mass spectrometry search and prediction tools to provide an integrated search and reference resource for lipidomics MS researchers. A suite of structure-drawing tools has been developed and deployed which dramatically increase the efficiency of generating large and complex lipid structures, facilitate data entry into lipid-structure databases and permit "on-demand" structure generation in conjunction with a variety of mass spectrometry–based informatics resources.
LIPID MAPS is currently funded by a multi-institutional grant from the Wellcome Trust, held jointly by Cardiff University, University of California, San Diego and the Babraham Institute, Cambridge. Our international team includes programmers, curators and webmaster and is led by Valerie O’Donnell, Ed Dennis, Shankar Subramaniam and Michael Wakelam.
*
Alfred H. Merrill, Jr.,
Georgia Institute of Technology, USA
Introduction: A Brief History of LIPID MAPS
Introduction: A Brief History of LIPID MAPS
Eoin Fahy,
University of California, San Diego, USA
The LIPID MAPS Lipidomics Gateway
The LIPID MAPS Lipidomics Gateway
Paul R.S. Baker,
Avanti Polar Lipids, USA
The Essential Union Between Standards and Methodology for Quantitative Lipidomics
The Essential Union Between Standards and Methodology for Quantitative Lipidomics
17:00—19:00
Lipidomics/Metabolomics – Global Profiling vs. Targeted Analysis
Craig E. Wheelock,
Karolinska Institutet, Sweden
Lipid Mediator Metabolic Profiling: Sub-Phenotyping of Respiratory Disease
Lipid Mediator Metabolic Profiling: Sub-Phenotyping of Respiratory Disease
Markus R. Wenk,
National University of Singapore, Singapore
Translation of Lipidomic Technologies towards Quantification of Blood Lipids
Translation of Lipidomic Technologies towards Quantification of Blood Lipids
*
Edward A. Dennis,
University of California, San Diego, USA
Lipidomic Profiling in Nonalcoholic Steatohepatitis
Lipidomic Profiling in Nonalcoholic Steatohepatitis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address
*
Jesper Z. Haeggström,
Karolinska Institute, Sweden
09:00—12:00
Novel Approaches to Lipid Metabolism
*
Jesper Z. Haeggström,
Karolinska Institute, Sweden
Deciphering Molecular Mechanisms of Enzymes in the 5-Lipoxygenase Pathway
Deciphering Molecular Mechanisms of Enzymes in the 5-Lipoxygenase Pathway
Coffee Break
Steffany A.L. Bennett,
University of Ottawa, Canada
The Lipogenetics of Dementia: Lipidomic Pathways Differentially Disrupted in Alzheimer’s Disease, Parkinson’s Disease with Dementia and Dementia with Lewy Bodies.
The Lipogenetics of Dementia: Lipidomic Pathways Differentially Disrupted in Alzheimer’s Disease, Parkinson’s Disease with Dementia and Dementia with Lewy Bodies.
Antonio J. Vidal-Puig,
University of Cambridge, UK
Molecular Mechanisms of Energy Balance
Molecular Mechanisms of Energy Balance
Junken Aoki,
Tohoku University, Japan
Short Talk: A Versatile Method to Determine the Positional Specificity of Lysophospholipid Acyltransferases (LPLATs) and its Application to Identification of an sn-1 LPLAT
Short Talk: A Versatile Method to Determine the Positional Specificity of Lysophospholipid Acyltransferases (LPLATs) and its Application to Identification of an sn-1 LPLAT
Joseph P. Dewulf,
de Duve Institute, UCLouvain, Belgium
Short Talk: ECHDC1 Prevents the Formation of Branched Chain Fatty Acids
Short Talk: ECHDC1 Prevents the Formation of Branched Chain Fatty Acids
Nicholas Vincent DiPatrizio,
University of California, Riverside, School of Medicine, USA
Short Talk: Endocannabinoids in the Gut: Lipid-Derived Mediators of Gut-Brain Signaling
Short Talk: Endocannabinoids in the Gut: Lipid-Derived Mediators of Gut-Brain Signaling
Jessica M. Ellis,
East Carolina University, USA
Short Talk: Acyl-CoA Synthetase 6-Mediates Docosahexaenoic Acid (DHA) Enrichment in Brain and Testis
Short Talk: Acyl-CoA Synthetase 6-Mediates Docosahexaenoic Acid (DHA) Enrichment in Brain and Testis
12:00—13:00
Workshop 2: The Lipidomics Standards Initiative
*
Gerhard Liebisch,
University of Regensburg, Germany
*
Kim Ekroos,
Lipidomics Consulting Ltd., Finland
17:00—19:15
Systems Biology of Lipids/’Omics
*
Peter Ghazal,
Cardiff University, UK
The ‘Molecular Wires’ that Link the Immune System to Cholesterol Metabolism
The ‘Molecular Wires’ that Link the Immune System to Cholesterol Metabolism
Manuel Mayr,
King's College, University of London, UK
The Future of Lipidomics: A Multi-Omics Approach to Cardiovascular Disease Risk
The Future of Lipidomics: A Multi-Omics Approach to Cardiovascular Disease Risk
Gary Siuzdak,
The Scripps Research Institute, USA
Activity Metabolomics and Discovering Metabolites that Alter Physiology
Activity Metabolomics and Discovering Metabolites that Alter Physiology
Stephanie M. Cologna,
University of Illinois at Chicago, USA
Short Talk: Integrating Proteomics and Lipidomics Reveals Converging Pathway Alterations in Niemann-Pick Disease Type C
Short Talk: Integrating Proteomics and Lipidomics Reveals Converging Pathway Alterations in Niemann-Pick Disease Type C
Elena Lian,
Colorado State University, USA
Short Talk: The Paradox of Arachidonic Acid: Can a Proinflammatory Precursor Act as a Pro-Viral Molecule to Support Flavivirus Infection?
Short Talk: The Paradox of Arachidonic Acid: Can a Proinflammatory Precursor Act as a Pro-Viral Molecule to Support Flavivirus Infection?
Erin Nanette Shepheard McGowan,
University of Melbourne, Australia
Short Talk: Macrophage Fatty Acid Desaturase 1 (FADS1) Is Important for the Survival of the Intracellular Parasite Leishmania Mexicana
Short Talk: Macrophage Fatty Acid Desaturase 1 (FADS1) Is Important for the Survival of the Intracellular Parasite Leishmania Mexicana
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Lipidomics and Metabolic Syndrome
*
Alfred H. Merrill, Jr.,
Georgia Institute of Technology, USA
Claudio J. Villanueva,
University of California, Los Angeles, USA
Global Analysis of Plasma Lipids and Adaptive Thermogenesis
Global Analysis of Plasma Lipids and Adaptive Thermogenesis
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Intracellular Lipid Metabolism Impairs β Cell Compensation during Diet-induced Obesity
Intracellular Lipid Metabolism Impairs β Cell Compensation during Diet-induced Obesity
Coffee Break
Morris J. Birnbaum,
Pfizer Inc., USA
Pharma and Academia Cross-Talk and the Metabolic Syndrome
Pharma and Academia Cross-Talk and the Metabolic Syndrome
L. Ashley Cowart,
Virginia Commonwealth University, USA
Short Talk: Sphingosine Kinase 1 Regulates Sexual Dimorphism in Non-Alcoholic Fatty Liver Disease via Estrogen-Dependent Suppression of Fibrosis
Short Talk: Sphingosine Kinase 1 Regulates Sexual Dimorphism in Non-Alcoholic Fatty Liver Disease via Estrogen-Dependent Suppression of Fibrosis
Cory P. Johnson,
University of Maine, USA
Short Talk: Sending Signals: Adipose Sensory Nerves May Communicate with the Brain via Lipid Metabolites
Short Talk: Sending Signals: Adipose Sensory Nerves May Communicate with the Brain via Lipid Metabolites
Anna Alexanova,
Tampere University, Finland
Short Talk: Modeling Lipid Metabolism of Coronary Artery Disease Patients with Induced Pluripotent Stem Cell-Derived Hepatocytes
Short Talk: Modeling Lipid Metabolism of Coronary Artery Disease Patients with Induced Pluripotent Stem Cell-Derived Hepatocytes
Habtamu B. Beyene,
Monash University, Australia
Short Talk: High-Throughput Plasma Lipidomic Profiling Identifies Differential Association of Lipid Signatures with Insulin Resistance in Men versus Women
Short Talk: High-Throughput Plasma Lipidomic Profiling Identifies Differential Association of Lipid Signatures with Insulin Resistance in Men versus Women
17:00—19:00
Cancer Lipidomics
*
Sarah Spiegel,
Virginia Commonwealth University, USA
Michael J.O. Wakelam,
Babraham Institute, UK
Lipidomic Analysis of Cancer Identifies Potential Therapeutic Targets
Lipidomic Analysis of Cancer Identifies Potential Therapeutic Targets
Yusuf A. Hannun,
Stony Brook Cancer Center, USA
Neutral Ceramidase in Colon Cancer
Neutral Ceramidase in Colon Cancer
Lipin Kao,
East Carolina University, USA
Short Talk: Chemotherapy Selection Pressure Elicits Marked Alterations of Sphingolipid Composition in Acute Myelogenous Leukemia Cells
Short Talk: Chemotherapy Selection Pressure Elicits Marked Alterations of Sphingolipid Composition in Acute Myelogenous Leukemia Cells
Justin M. Snider,
Stony Brook University, USA
Short Talk: Probing Sphingolipid Flux in Response to Chemotherapeutics
Short Talk: Probing Sphingolipid Flux in Response to Chemotherapeutics
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Lipid Signaling in Inflammation
*
Valerie B. O'Donnell,
Cardiff University, UK
Journal of Lipid Research Lectureship: Dysregulation of the Lysophospholipid/Autotaxin Axis Defines the Cardiovascular Risk SNP rs10757274 on Chromosome 9p21
Journal of Lipid Research Lectureship: Dysregulation of the Lysophospholipid/Autotaxin Axis Defines the Cardiovascular Risk SNP rs10757274 on Chromosome 9p21
Diane K. Jorkasky,
Complexa Inc., USA
From the Fires of Inflammation to a Drug that Quenches the Flames: The Clinical Development of the Nitro Fatty Acid, CXA-10
From the Fires of Inflammation to a Drug that Quenches the Flames: The Clinical Development of the Nitro Fatty Acid, CXA-10
Coffee Break
Marcus Conrad,
Helmholtz Zentrum München, Germany
Oxidized Phospholipids in Ferroptosis and Neurodegeneration
Oxidized Phospholipids in Ferroptosis and Neurodegeneration
Gerhard Krönke,
Universitätsklinikum Erlangen, Germany
Lipid Oxidation as Regulative Element during Immune Tolerance and Hemostasis
Lipid Oxidation as Regulative Element during Immune Tolerance and Hemostasis
John-Demian Sauer,
University of Wisconsin-Madison, USA
Short Talk: Cyclooxygenase-2 Dependent Prostaglandin E2 Signaling through the EP3 Receptor Is Required for Cell-Mediated Immunity to Listeria Monocytogenes
Short Talk: Cyclooxygenase-2 Dependent Prostaglandin E2 Signaling through the EP3 Receptor Is Required for Cell-Mediated Immunity to Listeria Monocytogenes
Emily Bowman,
Ohio State University, USA
Short Talk: Lipidome Abnormalities May Contribute to Altered Macrophage Phenotype in HIV Infection
Short Talk: Lipidome Abnormalities May Contribute to Altered Macrophage Phenotype in HIV Infection
Kirsten Dee Krieger,
Colorado State University, USA
Short Talk: Phosphatidylcholine: A Membrane Brick or Key to Replication of Dengue Viruses?
Short Talk: Phosphatidylcholine: A Membrane Brick or Key to Replication of Dengue Viruses?
17:00—19:15
Lipid Recognition by the Adaptive Immune System
Chyung-Ru Wang,
Northwestern University Feinberg School of Medicine, USA
Impact of Hyperlipidemia on CD1-Restricted Lipid Antigen-Specific T Cells
Impact of Hyperlipidemia on CD1-Restricted Lipid Antigen-Specific T Cells
Mauro Corrado,
Max Planck Institute of Immunology and Epigenetics, Germany
Short Talk: Cardiolipin Controls CD8+ Memory T Cell Metabolism and Function
Short Talk: Cardiolipin Controls CD8+ Memory T Cell Metabolism and Function
Nicole Lane Starr,
University of Wisconsin-Madison, USA
Short Talk: Lipidomic Analysis of Nasal Lavage Fluid from Healthy Subjects following Experimental Rhinovirus Inoculation
Short Talk: Lipidomic Analysis of Nasal Lavage Fluid from Healthy Subjects following Experimental Rhinovirus Inoculation
Julia Esser-von Bieren,
Technical University and Helmholtz Centre Munich, Germany
Short Talk: Remodeling of Myeloid Arachidonic Acid Metabolism Imparts Helminth-Driven Control of Type 2 Inflammation
Short Talk: Remodeling of Myeloid Arachidonic Acid Metabolism Imparts Helminth-Driven Control of Type 2 Inflammation
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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We gratefully acknowledge the generous grant for this conference provided by:
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