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This meeting took place in 2020
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Gene Regulation: From Mechanisms to Disease (J3)
Organizer(s) Karen Adelman and Patrick Cramer
January 26—30, 2020
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 1, 2019
Abstract Deadline: Oct 29, 2019
Scholarship Deadline: Oct 1, 2019
Discounted Registration Deadline: Nov 26, 2019
Sponsored by Moderna
Summary of Meeting:
Organismal development, homeostasis and healthy aging all rely on precise control of gene expression programs. Recent technological advances in structural biology, real-time imaging, and next generation sequencing have shed new light on decades-old questions about gene regulation, and we seek to highlight these advances. This meeting aims to bring together pioneers in cryoEM, single-cell microscopy, single cell sequencing and three-dimensional genome architecture, with leading experts in transcriptional regulation, to seed new collaborations and discoveries. This conference provides an ideal environment to foster interactions between transcriptional biologists and experts in single cell imaging and genomic approaches and spur conversations about how to interweave new techniques for structural biology with our growing appreciation that many critical interactions involve intrinsically disordered domains (which are by definition not well behaved in most structural approaches). Participants will attend sessions that critically evaluate the impact of genome organization on gene expression. The conference will also expose trainees to the best science possible and instill in them the enthusiasm we feel for the future of the field. Finally, pairing of this meeting with Cancer Epigenetics is ideal as the topics are inherently related. This allows our meeting to focus on underlying mechanisms and normal developmental systems, while enabling the audience to attend lectures in gene dysregulation in cancer. We plan two joint sessions to maximize interactions.
View Scholarships/Awards
Organismal development, homeostasis and healthy aging all rely on precise control of gene expression programs. Recent technological advances in structural biology, real-time imaging, and next generation sequencing have shed new light on decades-old questions about gene regulation, and we seek to highlight these advances. This meeting aims to bring together pioneers in cryoEM, single-cell microscopy, single cell sequencing and three-dimensional genome architecture, with leading experts in transcriptional regulation, to seed new collaborations and discoveries. This conference provides an ideal environment to foster interactions between transcriptional biologists and experts in single cell imaging and genomic approaches and spur conversations about how to interweave new techniques for structural biology with our growing appreciation that many critical interactions involve intrinsically disordered domains (which are by definition not well behaved in most structural approaches). Participants will attend sessions that critically evaluate the impact of genome organization on gene expression. The conference will also expose trainees to the best science possible and instill in them the enthusiasm we feel for the future of the field. Finally, pairing of this meeting with Cancer Epigenetics is ideal as the topics are inherently related. This allows our meeting to focus on underlying mechanisms and normal developmental systems, while enabling the audience to attend lectures in gene dysregulation in cancer. We plan two joint sessions to maximize interactions.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 30 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, January 31 in order to fully experience the meeting.
SUNDAY, JANUARY 26
MONDAY, JANUARY 27
TUESDAY, JANUARY 28
WEDNESDAY, JANUARY 29
THURSDAY, JANUARY 30
FRIDAY, JANUARY 31
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 30 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, January 31 in order to fully experience the meeting.
SUNDAY, JANUARY 26
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address (Joint)
*
Karen Adelman,
Harvard Medical School, USA
*
Cigall Kadoch,
Dana-Farber Cancer Institute, Harvard Medical School, USA
09:00—11:00
Fundamentals of Gene Regulation (Joint)
*
Liling Wan,
University of Pennsylvania, USA
Eva Nogales,
University of California, Berkeley, USA
Structural Insights into the Regulation of the Gene Silencer PRC2
Structural Insights into the Regulation of the Gene Silencer PRC2
Coffee Break
Patrick Cramer,
Max Planck Institute for Biophysical Chemistry, Germany
Mechanisms of Chromatin Transcription
Mechanisms of Chromatin Transcription
Dylan J. Taatjes,
University of Colorado Boulder, USA
Selective Inhibition of Human CDK7 Reveals High-Confidence Targets and Suggests a New Model for TFIIH Function in Transcription
Selective Inhibition of Human CDK7 Reveals High-Confidence Targets and Suggests a New Model for TFIIH Function in Transcription
14:30—16:30
Workshop 1: Structure and Function of Chromatin
*
Patrick Cramer,
Max Planck Institute for Biophysical Chemistry, Germany
Ksenia Finogenova,
Max-Planck Institute of Biochemistry, Germany
Structural Basis of Nucleosome Binding by PRC2 and Its Inhibition by H3K36 Methylation
Structural Basis of Nucleosome Binding by PRC2 and Its Inhibition by H3K36 Methylation
François Robert,
Institut de Recherches Cliniques de Montreal, Canada
Transcribed Chromatin, Rather Than RNA Polymerase II Itself, Recruits FACT to Active Genes
Transcribed Chromatin, Rather Than RNA Polymerase II Itself, Recruits FACT to Active Genes
Jitendra Thakur,
Fred Hutchinson Cancer Research Center, USA
Architectural RNA Is Required for Heterochromatin Organization
Architectural RNA Is Required for Heterochromatin Organization
Gilad Yaakov,
Weizmann Institute of Israel, Israel
A Novel Histone Molecular Timer Reveals Minute-Resolution Nucleosome Turnover
A Novel Histone Molecular Timer Reveals Minute-Resolution Nucleosome Turnover
Keda Zhou,
University of Colorado Boulder, USA
FACT Caught in the Act of Manipulating the Nucleosome
FACT Caught in the Act of Manipulating the Nucleosome
Giulia Cova,
Max Planck Institute for Molecular Genetics, Germany
TAD-Shuffling at the FGF8 Locus Causes Split-Hand/Foot Malformation Type 3
TAD-Shuffling at the FGF8 Locus Causes Split-Hand/Foot Malformation Type 3
Yuan He,
Northwestern University, USA
Cryo-Electron Microscopy Structure of a Nucleosome-Bound SWI/SNF Chromatin Remodeling Complex
Cryo-Electron Microscopy Structure of a Nucleosome-Bound SWI/SNF Chromatin Remodeling Complex
14:30—16:30
Workshop 1
*
Yael David,
Memorial Sloan Kettering Cancer Center, USA
Ruhee Dere,
Baylor College of Medicine, USA
KDM4A Regulates Microtubule Methylation and Genomic Instability
KDM4A Regulates Microtubule Methylation and Genomic Instability
Gerard L. Brien,
Smurfit Institute of Genetics, Ireland
Disruption of Development Enhancer and PRC2 Function by H3K27M in DIPG
Disruption of Development Enhancer and PRC2 Function by H3K27M in DIPG
Tharu M. Fernando,
Genentech, Inc., USA
Characterization and Therapeutic Implications of SMARCA4 Mutations in Cancer
Characterization and Therapeutic Implications of SMARCA4 Mutations in Cancer
Noa Furth,
Weizmann Institute of Science, Israel
The Combinatorial Epigenetic Landscape of High Grade Pediatric Gliomas in Single Molecule Resolution
The Combinatorial Epigenetic Landscape of High Grade Pediatric Gliomas in Single Molecule Resolution
Brian J. Abraham,
St. Jude Children's Research Hospital, USA
Predicting Master Transcription Factors from Pan-Cancer Expression Data
Predicting Master Transcription Factors from Pan-Cancer Expression Data
Elizabeth Allene Martin,
University of California San Francisco, USA
OGT, a Nutrient-Sensing Enzyme, Controls DNA Methylation in Mouse Embryonic Stem Cells
OGT, a Nutrient-Sensing Enzyme, Controls DNA Methylation in Mouse Embryonic Stem Cells
17:00—19:00
Imaging of Transcriptional Dynamics
*
Karla M. Neugebauer,
Yale University, USA
Ibrahim Cissé,
Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Living Mammalian Cells
Super-Resolution Imaging of Transcription in Living Mammalian Cells
Danette L. Daniels,
Promega Corporation, USA
Kinetic Monitoring of Protein Interactions and Targeted Degradation in Live Cells
Kinetic Monitoring of Protein Interactions and Targeted Degradation in Live Cells
Jennifer F. Kugel,
University of Colorado Boulder, USA
Short Talk: Single-Molecule Studies Resolve Heterogeneity in the Activity of Transcribing Complexes to Reveal Steps in Transcription That Dictate the Activity of Pol II
Short Talk: Single-Molecule Studies Resolve Heterogeneity in the Activity of Transcribing Complexes to Reveal Steps in Transcription That Dictate the Activity of Pol II
Benjamin R. Sabari,
University of Texas Southwestern Medical Center, USA
Short Talk: Enhancer Features that Drive Formation of Transcriptional Condensates
Short Talk: Enhancer Features that Drive Formation of Transcriptional Condensates
Michael S. Levine,
Princeton University, USA
Visualizing Developmental Dynamics in Drosophila Embryos
Visualizing Developmental Dynamics in Drosophila Embryos
17:00—19:15
Enhancer Structure in Cancer
This session will feature talks on enhancer structure, variants, function in relation to cancer mechanisms.
*
Asifa Akhtar,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Gene Dysregulation, Condensates and Drugs
Gene Dysregulation, Condensates and Drugs
Bin Wu,
Agios Pharmaceuticals Inc, USA
Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1-mutant Relapsed or Refractory Acute Myeloid Leukemia
Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1-mutant Relapsed or Refractory Acute Myeloid Leukemia
Liling Wan,
University of Pennsylvania, USA
Short Talk: Chromatin Reader Dysregulation in Cell Fate Control and Cancer
Short Talk: Chromatin Reader Dysregulation in Cell Fate Control and Cancer
Lena Afeyan,
Massachusetts Institute of Technology, USA
Short Talk: Formation and Regulation of Estrogen Receptor-Mediated Transcriptional Condensates in Breast Cancer
Short Talk: Formation and Regulation of Estrogen Receptor-Mediated Transcriptional Condensates in Breast Cancer
Lukas Chavez,
University of California, San Diego, USA
Short Talk: Targeting of Tumors as Informed by Oncogenic 3D Genome Organization
Short Talk: Targeting of Tumors as Informed by Oncogenic 3D Genome Organization
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Epigenetic Modifications of Chromatin and RNA (Joint)
*
Ali Shilatifard,
Northwestern University, USA
Tony Kouzarides,
University of Cambridge, UK
Modifications of RNA: Their Function and Role in Cancer
Modifications of RNA: Their Function and Role in Cancer
Asifa Akhtar,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and lncRNAs
Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and lncRNAs
Coffee Break
Anne Brunet,
Stanford University, USA
Epigenetic Regulation of Stem Cell Aging
Epigenetic Regulation of Stem Cell Aging
Salvador Aznar Benitah,
ICREA and Institute for Research in Biomedicine, Spain
Epigenetic Influence of Our (Fatty) Diet on Metastatic-Initiating Cells
Epigenetic Influence of Our (Fatty) Diet on Metastatic-Initiating Cells
Peter Hsu,
University of Washington, USA
Short Talk: Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS
Short Talk: Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS
14:30—16:30
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Bin Wu,
Agios Pharmaceuticals Inc, USA
Krista Lynn Bledsoe,
Cell Press, USA
Senthilkumar Cinghu,
NIEHS, National Institutes of Health, USA
Scott A. Armstrong,
Dana-Farber Cancer Institute, USA
Yael David,
Memorial Sloan Kettering Cancer Center, USA
Raphaël Rodriguez,
Institut Curie, France
17:00—19:00
Coupling of Transcription and RNA Processing
*
Alexander Stark,
Research Institute of Molecular Pathology - IMP, Austria
Yongsheng Shi,
University of California, Irvine, USA
Probing 3’ End Formation of Coding and Non Coding RNAs
Probing 3’ End Formation of Coding and Non Coding RNAs
Karla M. Neugebauer,
Yale University, USA
Dynamics of Co-Transcriptional Splicing
Dynamics of Co-Transcriptional Splicing
Daisy Castillo-Guzman,
University of California, Davis, USA
Short Talk: Uncovering Novel Roles for Splicing Factor SF3B1 in Transcription Dynamics and R-Loop Metabolism
Short Talk: Uncovering Novel Roles for Splicing Factor SF3B1 in Transcription Dynamics and R-Loop Metabolism
Megan Insco,
Boston Children's Hospital, USA
Short Talk: CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts
Short Talk: CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts
Torben Heick Jensen,
Aarhus University, Denmark
Transcription Termination and Links to RNA Processing/Decay Pathways
Transcription Termination and Links to RNA Processing/Decay Pathways
17:00—19:00
Human Disease Models of Chromatin Regulation
This session will highlight the development of model systems for the study of chromatin regulatory genes in cancer.
*
Paola Grandi,
Cellzome AG, a GSK Company, Germany
Hao Zhu,
University of Texas Southwestern Medical Center, USA
Targeting Chromatin Remodeling Complexes for Tissue Regeneration
Targeting Chromatin Remodeling Complexes for Tissue Regeneration
Paola Grandi,
Cellzome AG, a GSK Company, Germany
Click Chemistry and Preclinical Evaluation of Targeted Epigenetic Therapies
Click Chemistry and Preclinical Evaluation of Targeted Epigenetic Therapies
Liis Uuskula-Reimand,
SickKids Research Institute, Canada
Short Talk: Enhancer Function and Topoisomerase II beta in Hepatocellular Carcinoma
Short Talk: Enhancer Function and Topoisomerase II beta in Hepatocellular Carcinoma
Nicholas C. Gomez,
Rockefeller University, USA
Short Talk: Stem Cell Reprogramming during Oncogenesis
Short Talk: Stem Cell Reprogramming during Oncogenesis
Raphaël Rodriguez,
Institut Curie, France
Short Talk: CD44 Regulates Epigenetic Plasticity by Mediating Iron Endocytosis
Short Talk: CD44 Regulates Epigenetic Plasticity by Mediating Iron Endocytosis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Communication between Promoters and Enhancers
*
Torben Heick Jensen,
Aarhus University, Denmark
Geeta J. Narlikar,
University of California, San Francisco, USA
Can Phase-Separation Explain the Biological Properties of Heterochromatin?
Can Phase-Separation Explain the Biological Properties of Heterochromatin?
Steven L. McKnight,
University of Texas Southwestern Medical Center, USA
Low Complexity Sequences in Gene Regulation
Low Complexity Sequences in Gene Regulation
Coffee Break
Jesse M. Engreitz,
Harvard University and Broad Institute, USA
Short Talk: Genome-Wide Maps of Enhancer-Gene Connections Link Immune Disease Risk Variants to Target Genes
Short Talk: Genome-Wide Maps of Enhancer-Gene Connections Link Immune Disease Risk Variants to Target Genes
Tom Owen-Hughes,
University of Dundee, UK
Short Talk: Selective Enhancer Decommissioning Following Acute Depletion of the ARID1A Subunit of Mammalian SWI/SNF Complexes
Short Talk: Selective Enhancer Decommissioning Following Acute Depletion of the ARID1A Subunit of Mammalian SWI/SNF Complexes
Alexander Stark,
Research Institute of Molecular Pathology - IMP, Austria
Decoding Regulation: Global Screens to Uncover How Sequence Dictates Gene Activity
Decoding Regulation: Global Screens to Uncover How Sequence Dictates Gene Activity
08:00—11:00
Synthetic Lethal Vulnerabilities in Cancer
This session will highlight new studies identifying synthetic lethal targets across a range of cancers, and exploring small molecule/ degrader-based inhibition of these targets.
*
Adrian P. Bracken,
Trinity College Dublin, Ireland
Ali Shilatifard,
Northwestern University, USA
Principles of Epigenetics and Chromatin in Development and Human Disease
Principles of Epigenetics and Chromatin in Development and Human Disease
Scott A. Armstrong,
Dana-Farber Cancer Institute, USA
Targeting Chromatin Complexes in Leukemia
Targeting Chromatin Complexes in Leukemia
Coffee Break
Christopher Vakoc,
Cold Spring Harbor Laboratory, USA
Squamous Trans-Differentiation in Pancreatic Cancer
Squamous Trans-Differentiation in Pancreatic Cancer
Tannishtha Reya,
University of California, San Diego, USA
Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance
Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance
Jeff Magee,
Washington University, USA
Short Talk: KMT2C/MLL3 Deletions Convey a Selective Advantage to Multiply-Divided HSCs by Blunting Cytokine- and Stress-Induced Lineage Commitment
Short Talk: KMT2C/MLL3 Deletions Convey a Selective Advantage to Multiply-Divided HSCs by Blunting Cytokine- and Stress-Induced Lineage Commitment
Jiangbin Ye,
Stanford University, USA
Short Talk: Deciphering Warburg Effect: The Connection between Metabolism, Epigenetics and Tumor Differentiation
Short Talk: Deciphering Warburg Effect: The Connection between Metabolism, Epigenetics and Tumor Differentiation
17:00—19:00
Defining Regulation in Single-Cell Cells
*
Emma Farley,
University of California, San Diego, USA
Rickard Sandberg,
Karolinska Institutet, Sweden
Decoding Transcriptional Regulation and Kinetics Using Single-Cell Transcriptomics
Decoding Transcriptional Regulation and Kinetics Using Single-Cell Transcriptomics
William J. Greenleaf,
Stanford University, USA
A Single Cell Framework for Multi-Omic Analysis of Disease Identifies Malignant Regulatory Signatures
A Single Cell Framework for Multi-Omic Analysis of Disease Identifies Malignant Regulatory Signatures
Sarah Hainer,
University of Pittsburgh, USA
Short Talk: Profiling of Pluripotency Factors in Single Cells and Early Embryos
Short Talk: Profiling of Pluripotency Factors in Single Cells and Early Embryos
17:00—19:00
Developmental Epigenetics and Transcription
Highlighting the interplay between chromatin regulatory complexes and transcription factors in development and cancer.
*
Alessandro Gardini,
Wistar Institute, USA
Marcus Buschbeck,
Josep Carreras Leukaemia Research Institute, Spain
Histone Variants Regulate 3D Chromatin Architecture and the Inflammatory Response of Cancer Cells
Histone Variants Regulate 3D Chromatin Architecture and the Inflammatory Response of Cancer Cells
Yael David,
Memorial Sloan Kettering Cancer Center, USA
Revealing Cancer-Associated Epigenetic Events using Novel Chemical Tools
Revealing Cancer-Associated Epigenetic Events using Novel Chemical Tools
Siddhant U. Jain,
University of Wisconsin-Madison, USA
Short Talk: Inhibition of PRC2 Activity by EZHIP and H3 K27M in High-Grade Pediatric Gliomas
Short Talk: Inhibition of PRC2 Activity by EZHIP and H3 K27M in High-Grade Pediatric Gliomas
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Gene Control in Development
*
Michael S. Levine,
Princeton University, USA
Emma Farley,
University of California, San Diego, USA
Regulatory Principles Governing Enhancer Function in Development and Disease
Regulatory Principles Governing Enhancer Function in Development and Disease
François Fuks,
Université Libre de Bruxelles, Belgium
Transcriptome-Wide Distribution and Function of RNA Modifications
Transcriptome-Wide Distribution and Function of RNA Modifications
Coffee Break
Robert A. Martienssen,
Cold Spring Harbor Laboratory, USA
Small Non-Coding RNA in Replication and Quiescence
Small Non-Coding RNA in Replication and Quiescence
Laura A. Banaszynski,
University of Texas Southwestern Medical Center, USA
Short Talk: Mechanisms of Enhancer Activation Using the Histone Variant H3.3
Short Talk: Mechanisms of Enhancer Activation Using the Histone Variant H3.3
Wenqing Cai,
Boston Children's Hospital, USA
Short Talk: Enhancer-Dependence of Cell-Type-Specific Gene Expression Increases with Developmental Age
Short Talk: Enhancer-Dependence of Cell-Type-Specific Gene Expression Increases with Developmental Age
Raja Jothi,
NIEHS, National Institutes of Health, USA
Short Talk: Bivalent Chromatin Does Not Poise Genes for Rapid Activation
Short Talk: Bivalent Chromatin Does Not Poise Genes for Rapid Activation
Kathrin Plath,
University of California, Los Angeles, USA
A New Mode of Xist Action
A New Mode of Xist Action
08:00—11:00
Chromatin Regulatory Modulation: Novel Small Molecule-Based Approaches
This session will highlight new epigenetic strategies to treat cancers.
*
Jane A. Skok,
New York University School of Medicine, USA
Eric R. Olson,
Syros Pharmaceuticals, USA
Therapeutic Applications of Altering Tumor Cell Gene Expression
Therapeutic Applications of Altering Tumor Cell Gene Expression
Rab K. Prinjha,
GlaxoSmithKline, UK
Epigenetic Inhibition in Cancer: Emerging Strategies and Approaches
Epigenetic Inhibition in Cancer: Emerging Strategies and Approaches
Coffee Break
Jane A. Skok,
New York University School of Medicine, USA
CTCFL and its Impact on Gene Regulation and Interplay with CTCF Function
CTCFL and its Impact on Gene Regulation and Interplay with CTCF Function
Daniel De Carvalho,
University Health Network, Canada
Epigenetic Regulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer
Epigenetic Regulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer
Allyson M. Freedy,
Harvard University, USA
Short Talk: CRISPR-suppressor Scanning Reveals a Nonenzymatic Role of LSD1 in AML
Short Talk: CRISPR-suppressor Scanning Reveals a Nonenzymatic Role of LSD1 in AML
Jacob G. Kirkland,
Stanford University, USA
Short Talk: Chromatin Regulators Mediate Anthracycline Sensitivity in Breast Cancer
Short Talk: Chromatin Regulators Mediate Anthracycline Sensitivity in Breast Cancer
14:30—16:30
Workshop 2: Dynamic Gene Regulation
*
Jennifer F. Kugel,
University of Colorado Boulder, USA
Alon Goren,
University of California, San Diego, USA
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing
Gabriella E. Martyn,
University of New South Wales, Australia
Revealing the Mechanism Behind Naturally Occurring Mutations which Elevate Fetal Hemoglobin
Revealing the Mechanism Behind Naturally Occurring Mutations which Elevate Fetal Hemoglobin
Kirstin Meyer,
University of California, San Francisco, USA
Optogenetic Dissection of YAP Transcriptional Regulation
Optogenetic Dissection of YAP Transcriptional Regulation
Linda Z. Penn,
Princess Margaret Cancer Centre, Canada
Discovering the MYC Proteome Reveals Novel Mechanisms of Oncogenesis
Discovering the MYC Proteome Reveals Novel Mechanisms of Oncogenesis
Xavier J. Rambout,
University of Rochester Medical Center, USA
Transcriptional Coactivator PGC-1α Contains a Novel CBP80-Binding Motif That Orchestrates Efficient Target-Gene Expression
Transcriptional Coactivator PGC-1α Contains a Novel CBP80-Binding Motif That Orchestrates Efficient Target-Gene Expression
Haoze Vincent Yu,
University of Southern California, USA
Feed-Forward Pioneer Factor Activity Underlies Mammalian Mechanoreceptor Cell Differentiation
Feed-Forward Pioneer Factor Activity Underlies Mammalian Mechanoreceptor Cell Differentiation
14:30—16:30
Workshop 2
*
Chao Lu,
Columbia University, USA
SrinivasVinod Saladi,
Harvard Medical School, USA
Revealing Oncogenic Role of ACTL6A, Subunit of SWI/SNF Chromatin Remodeling Complex in Squamous Cancers
Revealing Oncogenic Role of ACTL6A, Subunit of SWI/SNF Chromatin Remodeling Complex in Squamous Cancers
Riyad N.H. Seervai,
Baylor College of Medicine, USA
The Histone Methyltransferase SETD2 Is a Tumor Suppressor with Actin Lysine Methyltransferase Activity
The Histone Methyltransferase SETD2 Is a Tumor Suppressor with Actin Lysine Methyltransferase Activity
Michelle M. Mitchener,
Princeton University, USA
Biochemical and Cellular Libraries Reveal Cancer-Associated Histone Mutations that Perturb Nucleosome Structure
Biochemical and Cellular Libraries Reveal Cancer-Associated Histone Mutations that Perturb Nucleosome Structure
Adam D. Durbin,
Dana-Farber Cancer Institute, USA
EP300 Controls the Oncogenic Enhancer Landscape of High-Risk Neuroblastoma
EP300 Controls the Oncogenic Enhancer Landscape of High-Risk Neuroblastoma
Chao Lu,
Columbia University, USA
Combinatorial Targeting of Chromatin and Metabolism for Cancer Therapy
Combinatorial Targeting of Chromatin and Metabolism for Cancer Therapy
Bethany A. Buck-Koehntop,
University of Utah, USA
Investigating the Methyl-CpG Binding Protein ZBTB38 in Mediating Epigenetic-Based Transcription in Cancer
Investigating the Methyl-CpG Binding Protein ZBTB38 in Mediating Epigenetic-Based Transcription in Cancer
Jarod Waybright,
University of North Carolina at Chapel Hill, USA
Reader's Block: Development of Chemical Tools Targeting the Methyl-Lysine Reader MPP8
Reader's Block: Development of Chemical Tools Targeting the Methyl-Lysine Reader MPP8
17:00—19:00
Higher Order Interactions in Transcription Regulation
Eileen E.M. Furlong,
European Molecular Biology Laboratory, Germany
Enhancer Promoter Communication During Embryonic Development
Enhancer Promoter Communication During Embryonic Development
Shasha Chong,
University of California, Berkeley, USA
Dynamic and Selective Low-Complexity Domain Interactions Control Gene Transcription: A Single-Molecule Study
Dynamic and Selective Low-Complexity Domain Interactions Control Gene Transcription: A Single-Molecule Study
Valerio Orlando,
King Abdullah University of Science and Technology, Saudi Arabia
Short Talk: L1 RNA Knockdown Averts Heterochromatin Loss and Premature Ageing Phenotypes
Short Talk: L1 RNA Knockdown Averts Heterochromatin Loss and Premature Ageing Phenotypes
Clodagh C. O'Shea,
The Salk Institute for Biological Studies, USA
Cracking the Nuclear Codes: Finding Order in Chaos
Cracking the Nuclear Codes: Finding Order in Chaos
Aaron Johnson,
University of Colorado School of Medicine, USA
Short Talk: RNA Matchmaking Remodels LncRNA Structure and Promotes PRC2 Activity
Short Talk: RNA Matchmaking Remodels LncRNA Structure and Promotes PRC2 Activity
17:00—19:00
Chromatin Structure and Function in Cancer
This session will highlight novel advances in our understanding of chromatin structure and modifications in cancer.
*
Christopher Vakoc,
Cold Spring Harbor Laboratory, USA
Luciano Di Croce,
CRG - Center for Genomic Regulation, Spain
Molecular Mechanisms Governing Cell Identity, Differentiation and Cancer Processes
Molecular Mechanisms Governing Cell Identity, Differentiation and Cancer Processes
Jikui Song,
University of California, Riverside, USA
Structural Studies in DNA Methylation and Links to Human Cancer
Structural Studies in DNA Methylation and Links to Human Cancer
Agata E. Lemiesz,
Rockefeller University, USA
Short Talk: Novel H2B “Oncohistones” Impact Cellular Differentiation and Signaling
Short Talk: Novel H2B “Oncohistones” Impact Cellular Differentiation and Signaling
Nazar Mashtalir,
Dana-Farber Cancer Institute, USA
Short Talk: Mechanism of Cancer-Specific SWI/SNF Complex Targeting by the SS18-SSX Fusion Oncogene
Short Talk: Mechanism of Cancer-Specific SWI/SNF Complex Targeting by the SS18-SSX Fusion Oncogene
19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions
Christopher Vakoc†,
Cold Spring Harbor Laboratory, USA
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
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