Fairmont Empress Victoria / Victoria Conference Centre Floorplan
This meeting took place in 2020
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Stromal Cells in Immunity and Disease (Q5)
Organizer(s) Scott N. Mueller, Jason G. Cyster, Reina E. Mebius and Theresa T. Lu
February 19—23, 2020
Fairmont Empress Victoria / Victoria Conference Centre • Victoria, BC Canada
Discounted Abstract Deadline: Oct 17, 2019
Abstract Deadline: Nov 20, 2019
Scholarship Deadline: Oct 17, 2019
Discounted Registration Deadline: Dec 18, 2019
Sponsored by Merck & Co., Inc. and Roche
Joint Meeting:
Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
Summary of Meeting:
Non-hematopoietic stromal cells play important roles in many tissues, constructing tissue microenvironments, contributing to tissue repair, defense and immune responses. Within lymphoid organs, stromal cells organize and interact with leukocytes in an immunologically important manner. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, stromal cells support the migration and interactions between antigen presenting cells and naïve T and B cells during the initiation of immune responses and influence the outcome between tolerance and immunity. Stromal cells also play instrumental roles in coordinating immune responses in non-lymphoid tissues, in inflammatory and autoimmune diseases, and in chronic infection. For instance, stromal cell dysregulation has been seen in HIV infection and in cancer patients. Furthermore, stromal cells are being harnessed for therapeutic applications in several diseases, an area that holds great promise for improving human health. Our understanding of stromal cell populations and their contributions to innate and adaptive immunity as well as immunological diseases, cancer and vaccination has grown exponentially over the past few years. This emerging field has gained enormous momentum due to increasingly sophisticated tools to dissect the fundamental biology and clinical importance of this cellular compartment. This conference is being held jointly with Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches. This joint pairing will bring together basic and clinical scientists with interdisciplinary interests in stromal cell biology and disease treatment to discuss critical fundamental and translational advances. The goals of this conference are to showcase cutting-edge results and new directions in the field, stimulate interactions and provide a forum for trainees and new investigators to present their work and interact with leaders in the field.
View Scholarships/Awards
Non-hematopoietic stromal cells play important roles in many tissues, constructing tissue microenvironments, contributing to tissue repair, defense and immune responses. Within lymphoid organs, stromal cells organize and interact with leukocytes in an immunologically important manner. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, stromal cells support the migration and interactions between antigen presenting cells and naïve T and B cells during the initiation of immune responses and influence the outcome between tolerance and immunity. Stromal cells also play instrumental roles in coordinating immune responses in non-lymphoid tissues, in inflammatory and autoimmune diseases, and in chronic infection. For instance, stromal cell dysregulation has been seen in HIV infection and in cancer patients. Furthermore, stromal cells are being harnessed for therapeutic applications in several diseases, an area that holds great promise for improving human health. Our understanding of stromal cell populations and their contributions to innate and adaptive immunity as well as immunological diseases, cancer and vaccination has grown exponentially over the past few years. This emerging field has gained enormous momentum due to increasingly sophisticated tools to dissect the fundamental biology and clinical importance of this cellular compartment. This conference is being held jointly with Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches. This joint pairing will bring together basic and clinical scientists with interdisciplinary interests in stromal cell biology and disease treatment to discuss critical fundamental and translational advances. The goals of this conference are to showcase cutting-edge results and new directions in the field, stimulate interactions and provide a forum for trainees and new investigators to present their work and interact with leaders in the field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Wednesday, February 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Sunday, February 23 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Monday, February 24 in order to fully experience the meeting.
WEDNESDAY, FEBRUARY 19
THURSDAY, FEBRUARY 20
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
FRIDAY, FEBRUARY 21
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
SATURDAY, FEBRUARY 22
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
SUNDAY, FEBRUARY 23
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
MONDAY, FEBRUARY 24
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Wednesday, February 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Sunday, February 23 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Monday, February 24 in order to fully experience the meeting.
WEDNESDAY, FEBRUARY 19
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session (Joint)
*
Scott N. Mueller,
University of Melbourne, Australia
Session Chair
Session Chair
*
Shannon J. Turley,
Genentech, Inc., USA
Session Chair
Session Chair
David A. Brenner,
Sanford Burnham Prebys, USA
Linking Inflammation and Myofibroblast Activation
Linking Inflammation and Myofibroblast Activation
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
Macrophage-Fibroblast Circuits
Macrophage-Fibroblast Circuits
10:00—12:00
Stromal Cells in Lymphoid Tissue Development
*
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Session Chair
Session Chair
Burkhard Ludewig,
Kantonsspital St. Gallen, Switzerland
Fibroblastic Stromal Cells Direct Lymphoid Organ Development and Immune Activation
Fibroblastic Stromal Cells Direct Lymphoid Organ Development and Immune Activation
Reina E. Mebius,
Amsterdam UMC-VUmc, Netherlands
Control of the Adaptive Immunity by Lymph Node Stromal Cells
Control of the Adaptive Immunity by Lymph Node Stromal Cells
Sanjiv A. Luther,
University of Lausanne, Switzerland
Fibroblasts of the Intestinal Lamina Propria are Important Niche Cells Regulating IgA+ Plasma Cell Homeostasis and Function
Fibroblasts of the Intestinal Lamina Propria are Important Niche Cells Regulating IgA+ Plasma Cell Homeostasis and Function
Mark C. Coles,
University of Oxford, UK
Short Talk: B-Cell Zone Reticular Cell Microenvironments Shape Chemotactic Gradient Formation
Short Talk: B-Cell Zone Reticular Cell Microenvironments Shape Chemotactic Gradient Formation
Anne Chauveau,
Oxford University, UK
Short Talk: Perivascular Pathways Direct One-Way Migration of T Cells into Splenic T Zones
Short Talk: Perivascular Pathways Direct One-Way Migration of T Cells into Splenic T Zones
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
10:00—12:00
Tissue Fibroblasts and Pericytes in Fibrosis
*
Shannon J. Turley,
Genentech, Inc., USA
Session Chair
Session Chair
*
Dean Sheppard,
University of California, San Francisco, USA
Session Chair
Session Chair
Jonathan M. Kurie,
University of Texas MD Anderson Cancer Center, USA
The Fibrotic Tumor Stroma
The Fibrotic Tumor Stroma
Yuval Rinkevich,
Helmholtz Zentrum München, GmbH, Germany
Two Succeeding Fibroblastic Lineages Drive Dermal Development and the Transition from Regeneration to Scarring
Two Succeeding Fibroblastic Lineages Drive Dermal Development and the Transition from Regeneration to Scarring
Scott M. Turner,
Pliant Therapeutics, USA
Identification and Evaluation of Small Molecule Integrin Inhibitors: From Cell Systems to Human Trials
Identification and Evaluation of Small Molecule Integrin Inhibitors: From Cell Systems to Human Trials
Tatsuya Tsukui,
University of California, San Francisco, USA
Short Talk: Collagen-Producing Lung Cell Atlas Identifies Multiple Subsets with Distinct Localization and Relevance to Fibrosis
Short Talk: Collagen-Producing Lung Cell Atlas Identifies Multiple Subsets with Distinct Localization and Relevance to Fibrosis
Dianhua Jiang,
Cedars-Sinai Medical Center, USA
Short Talk: Longitudinal Transcriptomics Identifies Fibroblast Subtypes during Lung Development and Fibrosis
Short Talk: Longitudinal Transcriptomics Identifies Fibroblast Subtypes during Lung Development and Fibrosis
14:30—16:30
Workshop 1: Stromal Orchestration and Immune Responses
*
Mandy J. McGeachy,
University of Pittsburgh, USA
Session Chair
Session Chair
*
Ruth Ganss,
Harry Perkins Institute of Medical Research, Australia
Session Chair
Session Chair
Catarina Gago da Graca,
Amsterdam UMC - VUMC, Netherlands
Characterization of MHC-II Expressing FRCs in Steady State and Inflammatory Conditions
Characterization of MHC-II Expressing FRCs in Steady State and Inflammatory Conditions
Ana Martínez-Riaño,
Francis Crick Institute, UK
Cellular Dynamics of Follicular Dendritic Cells Control Antigen Presentation during the Humoral Response
Cellular Dynamics of Follicular Dendritic Cells Control Antigen Presentation during the Humoral Response
Yannick Alexandre,
University of Melbourne, Australia
Mesenchymal Stromal Cells Coordinate Protective Adaptive Immune Responses during Viral Infections in the Spleen
Mesenchymal Stromal Cells Coordinate Protective Adaptive Immune Responses during Viral Infections in the Spleen
Joshua D. Brandstadter,
University of Pennsylvania, USA
Distinct Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes Express Individual Notch Ligands and Prime Graft-versus-Host Disease after Bone Marrow Transplantation
Distinct Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes Express Individual Notch Ligands and Prime Graft-versus-Host Disease after Bone Marrow Transplantation
Junko Sawada,
Johns Hopkins All Children's Hospital, USA
TNFα Upregulates R-Ras Expression in High Endothelial Venule and Capillary Endothelium in Lymph Node, Facilitating T Cell Recruitment upon Inflammation
TNFα Upregulates R-Ras Expression in High Endothelial Venule and Capillary Endothelium in Lymph Node, Facilitating T Cell Recruitment upon Inflammation
Jennifer Eom,
University of Auckland, New Zealand
Phenotypically Distinct Fibroblastic Populations in Melanoma-Infiltrated Human Lymph Nodes Provide Unique Microenvironment for T Lymphocytes
Phenotypically Distinct Fibroblastic Populations in Melanoma-Infiltrated Human Lymph Nodes Provide Unique Microenvironment for T Lymphocytes
Ian Boothby,
University of California, San Francisco, USA
Neonatal Tregs Suppress the Development of a Stromal Niche for Th2 Cells in Skin
Neonatal Tregs Suppress the Development of a Stromal Niche for Th2 Cells in Skin
Ari B. Molofsky,
University of California, San Francisco, USA
Stromal Crosstalk with Type 2 Immunity at Tissue Adventitial Niches
Stromal Crosstalk with Type 2 Immunity at Tissue Adventitial Niches
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
14:30—16:30
Workshop 1: Core Mechanisms versus Organ Specific Mediators of Fibrosis
*
Thirumalai R. Ramalingam,
Genentech, Inc., USA
Session Chair
Session Chair
*
Karen Piper Hanley,
University of Manchester, UK
Session Chair
Session Chair
Daniel Abebayehu,
University of Virginia, USA
Inflammatory Cytokines Induce Unique Immuno-Fibroblast Subpopulations Prone to Myofibroblastic Differentiation
Inflammatory Cytokines Induce Unique Immuno-Fibroblast Subpopulations Prone to Myofibroblastic Differentiation
Daryle J. DePianto,
Genentech, Inc., USA
Molecular Mapping of Epithelial Cell Senescence in IPF
Molecular Mapping of Epithelial Cell Senescence in IPF
Tien Peng,
University of California, San Francisco, USA
Gli1+ Mesenchymal Cells Modulate Epithelial Progenitor Metaplasia in Lung Fibrosis
Gli1+ Mesenchymal Cells Modulate Epithelial Progenitor Metaplasia in Lung Fibrosis
Lynn M. Williams,
Kennedy Institute of Rheumatology, UK
CREBBP/EP300 Regulation of Collagen VI is a Key Determinant of the Myofibroblast Phenotype in Human Fibrosis
CREBBP/EP300 Regulation of Collagen VI is a Key Determinant of the Myofibroblast Phenotype in Human Fibrosis
Sonia Chothani,
Duke-NUS Medical School, Singapore
RNA-Binding Proteins: Drivers of Translational Regulation in Cardiac Fibrosis
RNA-Binding Proteins: Drivers of Translational Regulation in Cardiac Fibrosis
Preethi Vijayaraj,
University of California, Los Angeles, USA
Fibrotic Lung Disease is Associated with Proliferation and Desquamation of Ciliated Bronchiolar Epithelium
Fibrotic Lung Disease is Associated with Proliferation and Desquamation of Ciliated Bronchiolar Epithelium
Ahmad N. Nabhan,
Genentech, Inc., USA
A Molecular Cell Atlas of the Human Lung from Single Cell RNA Sequencing
A Molecular Cell Atlas of the Human Lung from Single Cell RNA Sequencing
Veronica Larcher,
Goethe University, Germany
Parallel Lineage Tracing Studies Establish Fibroblasts as the Prevailing in vivo Adipocyte Progenitor
Parallel Lineage Tracing Studies Establish Fibroblasts as the Prevailing in vivo Adipocyte Progenitor
17:00—19:00
Stromal Cells and Immunity in Non-Lymphoid Tissues
*
Ari B. Molofsky,
University of California, San Francisco, USA
Session Chair
Session Chair
Theresa T. Lu,
Hospital for Special Surgery/Weill Cornell Medicine, USA
Langerhans Cells and Skin Protection in Lupus Photosensitivity
Langerhans Cells and Skin Protection in Lupus Photosensitivity
Jeremiah Bernier-Latmani,
University of Lausanne, Switzerland
Blood Vessel / Telocyte Crosstalk at the Small Intestinal Villus Tip
Blood Vessel / Telocyte Crosstalk at the Small Intestinal Villus Tip
Matthew B. Buechler,
Genentech, Inc., USA
Short Talk: Tissue-Specific Programming Determines Tenor of Fibroblast and Mesothelial Cell Plasticity and Activation
Short Talk: Tissue-Specific Programming Determines Tenor of Fibroblast and Mesothelial Cell Plasticity and Activation
Bing Su,
Shanghai JiaoTong University School of Medicine, China
Short Talk: Map3k2-Regulated Intestinal Stromal Cells Define a Stem Cell Niche via Wnt Agonist R-spondin1
Short Talk: Map3k2-Regulated Intestinal Stromal Cells Define a Stem Cell Niche via Wnt Agonist R-spondin1
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
17:00—19:00
Myeloid Cells in Fibrosis
*
Neil C. Henderson,
University of Edinburgh, Queen's Medical Research Institute, UK
Session Chair
Session Chair
*
Tatiana Kisseleva,
University of California, San Diego, USA
Session Chair
Session Chair
Akira Shizuo,
Osaka University, Japan
Molecular Mechanism of Bleomycin-Induced Lung Fibrosis
Molecular Mechanism of Bleomycin-Induced Lung Fibrosis
Harris Perlman,
Northwestern University, USA
Monocyte Derived Macrophages in Inflammation and Fibrosis
Monocyte Derived Macrophages in Inflammation and Fibrosis
Frank Tacke,
Charité Universitätsmedizin Berlin, Germany
Macrophage Heterogeneity in Liver Homeostasis, Inflammation, and Fibrosis
Macrophage Heterogeneity in Liver Homeostasis, Inflammation, and Fibrosis
Prakash Ramachandran,
University of Edinburgh, UK
Short Talk: Defining a Novel Macrophage Subpopulation Which Promotes Human Liver Fibrosis
Short Talk: Defining a Novel Macrophage Subpopulation Which Promotes Human Liver Fibrosis
Resat Cinar,
NIAAA, National Institutes of Health, USA
Short Talk: Cannabinoid 1 Receptors (CB1R) in Myeloid Cells Promote Fibrosis in Lung: Paracrine Control Drives Fibroproliferative Microenvironment via Multiple Mechanisms
Short Talk: Cannabinoid 1 Receptors (CB1R) in Myeloid Cells Promote Fibrosis in Lung: Paracrine Control Drives Fibroproliferative Microenvironment via Multiple Mechanisms
08:00—11:00
Stromal Cell Functions in Primary and Secondary Lymphoid Tissues
*
Reina E. Mebius,
Amsterdam UMC-VUmc, Netherlands
Session Chair
Session Chair
João Pereira,
Yale University School of Medicine, USA
Cell Circuits, B cells, and Systemic Responses to Microbial Infections
Cell Circuits, B cells, and Systemic Responses to Microbial Infections
Madelon M. E. de Jong,
Erasmus MC, Netherlands
Short Talk: A Unique Inflammatory Stromal Cell Population Associated with NFkappaB Signaling in the Multiple Myeloma Bone Marrow
Short Talk: A Unique Inflammatory Stromal Cell Population Associated with NFkappaB Signaling in the Multiple Myeloma Bone Marrow
Tomoya Katakai,
Niigata University, Japan
Stromal Cell Diversity in Lymph Nodes
Stromal Cell Diversity in Lymph Nodes
Coffee Break
Beth A. Tamburini,
University of Colorado Denver Anchutz Medical Campus, USA
Control of Immune Responses in Lymph Nodes by Lymphatic Endothelial Cells
Control of Immune Responses in Lymph Nodes by Lymphatic Endothelial Cells
Dragos Cristian Dasoveanu,
Hospital for Special Surgery, USA
Short Talk: Lymph Node Stromal CCL2 Limits Antibody Responses
Short Talk: Lymph Node Stromal CCL2 Limits Antibody Responses
Natalia Pikor,
ETH Zurich / KSSG, Switzerland
Short Talk: CXCL12-Dependent Remodeling of Light and Dark Zone Follicular Dendritic Cells Governs the Germinal Center Response
Short Talk: CXCL12-Dependent Remodeling of Light and Dark Zone Follicular Dendritic Cells Governs the Germinal Center Response
Lorenz Jahn,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Transcriptional Responses of Thymic Epithelium, Endothelium, and Mesenchyme to Acute Injury on a Single Cell Level
Short Talk: Transcriptional Responses of Thymic Epithelium, Endothelium, and Mesenchyme to Acute Injury on a Single Cell Level
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
08:00—11:00
Advances in Organ Fibrosis
*
Cory M. Hogaboam,
Cedars-Sinai Medical Center, USA
Session Chair
Session Chair
*
Katalin Susztak,
University of Pennsylvania, USA
Session Chair
Session Chair
Ivan O. Rosas,
Baylor College of Medicine, USA
Insights into the Complexity and Diversity of Cell Populations in IPF and COPD using Single Cell RNA-seq
Insights into the Complexity and Diversity of Cell Populations in IPF and COPD using Single Cell RNA-seq
Neil C. Henderson,
University of Edinburgh, Queen's Medical Research Institute, UK
Using Single Cell Genomics to Decode the Hepatic Fibrotic Niche
Using Single Cell Genomics to Decode the Hepatic Fibrotic Niche
Coffee Break
Katalin Susztak,
University of Pennsylvania, USA
Fatty Acid Oxidation in Tubular Epithelial Cells Regulates Kidney Fibrosis
Fatty Acid Oxidation in Tubular Epithelial Cells Regulates Kidney Fibrosis
Harry (Hal) C. Dietz,
Johns Hopkins University School of Medicine, Blade Therapeutics, USA
New Mechanisms and Vulnerabilities of Fibrosis
New Mechanisms and Vulnerabilities of Fibrosis
Ying Wei,
University of California, San Francisco, USA
Short Talk: Reversal of TGFbeta1-Driven Pro-Fibrotic State in Pulmonary Fibrosis Patients
Short Talk: Reversal of TGFbeta1-Driven Pro-Fibrotic State in Pulmonary Fibrosis Patients
Satish K. Madala,
Cincinnati Children's Hospital Medical Center, USA
Short Talk: Transcriptional Regulation of Fibroblast Activation in Severe Fibrotic Lung Disease
Short Talk: Transcriptional Regulation of Fibroblast Activation in Severe Fibrotic Lung Disease
14:30—16:30
Workshop 2: Novel Technologies and Models in Stromal Cell Biology and Fibrosis (Joint)
*
Lucie Peduto,
Institut Pasteur, France
Session Chair
Session Chair
*
Michael Underhill,
University of British Columbia, Canada
Session Chair
Session Chair
Lee A. Borthwick,
Newcastle University, UK
A Bioreactor Technology for Modelling Fibrosis in Human and Rodent Precision-Cut Liver Slices
A Bioreactor Technology for Modelling Fibrosis in Human and Rodent Precision-Cut Liver Slices
Michael Jeffrey Podolsky,
Weill Cornell Medical College, USA
Genome-Wide Screens Identify Novel Regulators of Cell-Mediated Collagen Degradation
Genome-Wide Screens Identify Novel Regulators of Cell-Mediated Collagen Degradation
Maha AlSharqi,
McGill University, Canada
Development of CD109-Based Molecules as TGF-Beta Antagonists and Antifibrotic Agents in Scleroderma Fibroblasts
Development of CD109-Based Molecules as TGF-Beta Antagonists and Antifibrotic Agents in Scleroderma Fibroblasts
Laura Elisabeth Kähäri,
University of Turku, Finland
Targeted Delivery of Antibodies to the Draining Lymph Node through the Subcapsular Sinus Floor
Targeted Delivery of Antibodies to the Draining Lymph Node through the Subcapsular Sinus Floor
Kristine Lai,
Cornell University, USA
ImmuneChip with Stromal-Specific Chemokine Gradient to Capture Germinal Center B Cell Dynamics
ImmuneChip with Stromal-Specific Chemokine Gradient to Capture Germinal Center B Cell Dynamics
Heather J. Faust,
Brigham and Womens Hospital, USA
Utilization of 3D Organoids to Study Synovial Fibroblast-Immune Cell Interactions
Utilization of 3D Organoids to Study Synovial Fibroblast-Immune Cell Interactions
Anastasia Kousa,
Memorial Sloan Kettering Sloan Cancer Center, USA
Construction of a Cellular Interactome Across Epithelium, Endothelium, and Mesenchyme During Thymic Regeneration
Construction of a Cellular Interactome Across Epithelium, Endothelium, and Mesenchyme During Thymic Regeneration
17:00—19:00
Endothelial Cells in Immunity and Disease
*
Amanda Lund,
New York University, USA
Session Chair
Session Chair
Scott N. Mueller,
University of Melbourne, Australia
Disentangling the Splenic Stromal Cell Network in Health in Disease
Disentangling the Splenic Stromal Cell Network in Health in Disease
Ulrich H. Von Andrian,
Harvard Medical School, USA
Lymphocyte Patrol of Blood Vessel Endothelium
Lymphocyte Patrol of Blood Vessel Endothelium
Akira Takeda,
University of Turku, Finland
Short Talk: Human Lymphatic Endothelial Heterogeneity in Health and Disease
Short Talk: Human Lymphatic Endothelial Heterogeneity in Health and Disease
Madeline Churchill,
Oregon Health and Science University, USA
Short Talk: Dermal Lymphatic Capillary ‘Zippering' Enhances CD8+ T Cell Priming Following Cutaneous Viral Infection
Short Talk: Dermal Lymphatic Capillary ‘Zippering' Enhances CD8+ T Cell Priming Following Cutaneous Viral Infection
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
17:00—19:00
Unique Drivers of Inflammation and Fibrosis
*
Boris Hinz,
St. Michael's Hospital and University of Toronto, Canada
Session Chair
Session Chair
*
Maria Trojanowska,
Boston University School of Medicine, USA
Session Chair
Session Chair
Anissa A. Widjaja,
Duke-NUS Medical School, Singapore
Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity and Stromal Inflammation
Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity and Stromal Inflammation
Ning Ding,
Genentech, Inc., USA
Short Talk: WISP1 Activates MRTF to Promote the Progression of Established Liver Fibrosis
Short Talk: WISP1 Activates MRTF to Promote the Progression of Established Liver Fibrosis
Akiyoshi Uemura,
Nagoya City University, Japan
Short Talk: Activated Microglia Promote Fibrosis in Pericyte-Deficient Retina
Short Talk: Activated Microglia Promote Fibrosis in Pericyte-Deficient Retina
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Stromal Cells in Cancer and Anti-Tumor Immunity
*
Hélène Salmon,
Institut Curie and Mount Sinai School of Medicine, France
Session Chair
Session Chair
Anne Fletcher,
Monash University, Australia
Human T Cell Suppression Triggered through Cross-Talk with Cancer-Associated Fibroblasts
Human T Cell Suppression Triggered through Cross-Talk with Cancer-Associated Fibroblasts
Coffee Break
Ruth Ganss,
Harry Perkins Institute of Medical Research, Australia
Stromal Remodeling and Targeting in Cancer
Stromal Remodeling and Targeting in Cancer
Jacqui Shields,
University of Cambridge, UK
Beyond the Cancer Cell: Exploring the Tumour Stroma as Immune Modulators
Beyond the Cancer Cell: Exploring the Tumour Stroma as Immune Modulators
John Andrew Grout,
Mount Sinai School of Medicine, USA
Short Talk: Single Cell Transcriptomic Dissection of the Stromal Cell Compartment in Early-Stage Non-Small Cell Lung Carcinoma (NSCLC)
Short Talk: Single Cell Transcriptomic Dissection of the Stromal Cell Compartment in Early-Stage Non-Small Cell Lung Carcinoma (NSCLC)
Anthony B. Rodriguez,
University of Virginia School of Medicine, USA
Short Talk: Tumor-Associated Fibroblasts Act As Surrogate Lymphoid Tissue Organizer Cells That Orchestrate Tumor-Associated Tertiary Lymphoid Structure Development
Short Talk: Tumor-Associated Fibroblasts Act As Surrogate Lymphoid Tissue Organizer Cells That Orchestrate Tumor-Associated Tertiary Lymphoid Structure Development
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
08:00—11:00
Novel Pathways and Strategies to Ameliorate Fibrosis
*
Derek A. Mann,
Newcastle University, UK
Session Chair
Session Chair
Tatiana Kisseleva,
University of California, San Diego, USA
The Role of Mesothelin in the Pathogenesis of Parenchymal Organs
The Role of Mesothelin in the Pathogenesis of Parenchymal Organs
Coffee Break
Scott L. Friedman,
Icahn School of Medicine at Mount Sinai, USA
Target Selection and Validation for Antifibrotic Therapies in Liver
Target Selection and Validation for Antifibrotic Therapies in Liver
Christine Kim Garcia,
Columbia University Medical Center, USA
Pulmonary Fibrosis: Inherited Susceptibilities and Personalized Prognostics
Pulmonary Fibrosis: Inherited Susceptibilities and Personalized Prognostics
Jennifer Y. Chen,
University of California, San Francisco, USA
Short Talk: Targeting Acid Ceramidase Inhibits YAP/TAZ Mechanosignaling to Ameliorate Fibrosis
Short Talk: Targeting Acid Ceramidase Inhibits YAP/TAZ Mechanosignaling to Ameliorate Fibrosis
Andreas Schlitzer,
University of Bonn, Germany
Short Talk: Inflammation Experienced Trem2+ Monocyte-Derived Alveolar Macrophages Control Pulmonal Inflammatory Reactivity and Protect from Lung Fibrosis
Short Talk: Inflammation Experienced Trem2+ Monocyte-Derived Alveolar Macrophages Control Pulmonal Inflammatory Reactivity and Protect from Lung Fibrosis
17:00—19:00
Stroma Cell Contributions During Infection and Inflammation
*
Sanjiv A. Luther,
University of Lausanne, Switzerland
Session Chair
Session Chair
Melody A. Swartz,
University of Chicago, USA
Role of Lymphatic Endothelial Cells in the Regulation of T Cell Memory
Role of Lymphatic Endothelial Cells in the Regulation of T Cell Memory
Susan R. Schwab,
New York University School of Medicine, USA
Exit Strategies: S1P Gradients in Inflammation
Exit Strategies: S1P Gradients in Inflammation
Marc Bajénoff,
Centre d'Immunologie Marseille-Luminy, France
Lymphoid Stromal Cells are Essential Components of Macrophage Niches
Lymphoid Stromal Cells are Essential Components of Macrophage Niches
Mandy J. McGeachy,
University of Pittsburgh, USA
Short Talk: IL-17 Signals to Lymphoid Stroma to Support Function during Th17 Autoimmune and Th1/CTL Anti-Viral Responses
Short Talk: IL-17 Signals to Lymphoid Stroma to Support Function during Th17 Autoimmune and Th1/CTL Anti-Viral Responses
David F. Boyd,
St. Jude Children's Research Hospital, USA
Short Talk: Inflammatory Fibroblasts Determine the Outcome of Severe Respiratory Infection in an ADAMTS4-Dependent Manner
Short Talk: Inflammatory Fibroblasts Determine the Outcome of Severe Respiratory Infection in an ADAMTS4-Dependent Manner
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
17:00—19:00
Distinct and Common Mechanisms of Fibrosis Revealed by Different Tissues
*
Robert V. Martinez,
Pfizer Inc., USA
Session Chair
Session Chair
*
Anna Burkart Sadusky,
NIDDK, National Institutes of Health, USA
Session Chair
Session Chair
Florian Rieder,
Cleveland Clinic, USA
Mechanisms and Future Clinical Trial Endpoints of Intestinal Fibrosis
Mechanisms and Future Clinical Trial Endpoints of Intestinal Fibrosis
Valerie M. Weaver,
University of California, San Francisco, USA
Tissue Tension Induces Matricellular Fibrosis and Tumor Progression in Pancreas
Tissue Tension Induces Matricellular Fibrosis and Tumor Progression in Pancreas
Tapas Mukherjee,
University of Toronto, Canada
Short Talk: Deciphering the Influence of Crohn's Disease-Associated Genetic Risk Factor, NOD2 in Intestinal Fibrosis
Short Talk: Deciphering the Influence of Crohn's Disease-Associated Genetic Risk Factor, NOD2 in Intestinal Fibrosis
Ji Zhang,
Merck & Co., Inc., USA
Short Talk: Molecular Profiling Reveals A Common Metabolic Signature of Tissue Fibrosis
Short Talk: Molecular Profiling Reveals A Common Metabolic Signature of Tissue Fibrosis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Interrogating Stromal Functions in Disease
*
Theresa T. Lu,
Hospital for Special Surgery/Weill Cornell Medicine, USA
Session Chair
Session Chair
Michael B. Brenner,
Harvard Medical School, USA
Fibroblast Positional Identity Controlled by Inductive Notch Signaling Underlies Pathologic Damage in Inflammatory Arthritis
Fibroblast Positional Identity Controlled by Inductive Notch Signaling Underlies Pathologic Damage in Inflammatory Arthritis
Lucie Peduto,
Institut Pasteur, France
Mesenchymal Cells in Pathology and Tissue Repair
Mesenchymal Cells in Pathology and Tissue Repair
Coffee Break
George A. Kollias,
Alexander Fleming Biomedical Sciences Research Center, Greece
Mesenchymal Causalities in Inflammation, Immunity and Cancer
Mesenchymal Causalities in Inflammation, Immunity and Cancer
Ankur Singh,
Cornell University, USA
Immune Organoids to Study Immunity and Epigenetics in Health and Diseases
Immune Organoids to Study Immunity and Epigenetics in Health and Diseases
Manolis Roulis,
Yale University, USA
Short Talk: Paracrine Orchestration of Intestinal Tumorigenesis by a Confined Mesenchymal Niche
Short Talk: Paracrine Orchestration of Intestinal Tumorigenesis by a Confined Mesenchymal Niche
Viviana Cremasco,
Novartis Institutes for BioMedical Research, USA
Short Talk: TGFβ-Blockade Uncovers Stromal Plasticity in Tumors by Revealing the Existence of a Novel Subset of Interferon-Licensed Fibroblasts
Short Talk: TGFβ-Blockade Uncovers Stromal Plasticity in Tumors by Revealing the Existence of a Novel Subset of Interferon-Licensed Fibroblasts
Guillaume Harlé,
University of Geneva, Switzerland
Short Talk: Autophagy in Lymphatic Endothelial Cells Dampens Collagen-Induced Arthritis Severity by Regulating Sphingosine-1-Phosphate Production
Short Talk: Autophagy in Lymphatic Endothelial Cells Dampens Collagen-Induced Arthritis Severity by Regulating Sphingosine-1-Phosphate Production
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
08:00—11:00
Progenitor Cells in Tissue Repair and Organ Regeneration
*
Andrew Leask,
University of Saskatoon, Canada
Session Chair
Session Chair
Dean Sheppard,
University of California, San Francisco, USA
Enhancement of Anti-Tumor Immunity by Inhibition of TGFbeta Activation by the Integrin alphavbeta8
Enhancement of Anti-Tumor Immunity by Inhibition of TGFbeta Activation by the Integrin alphavbeta8
Harold A. Chapman,
University of California, San Francisco, USA
Lung Progenitors in Epithelial Renewal Following Injury
Lung Progenitors in Epithelial Renewal Following Injury
Coffee Break
Joseph R. Arron,
Sonoma Biotherapeutics, USA
Reprogramming Pathogenic Cells to Promote Tissue Repair
Reprogramming Pathogenic Cells to Promote Tissue Repair
Chris Cox,
Genentech, Inc., USA
Short Talk: Interleukin 1 Maintains the Intestinal Stem Cell Compartment during C. rodentium Infection through Grem1+ Stromal Derived R-spondin 3
Short Talk: Interleukin 1 Maintains the Intestinal Stem Cell Compartment during C. rodentium Infection through Grem1+ Stromal Derived R-spondin 3
Miriam Hohmann,
Cedars-Sinai Medical Center, USA
Short Talk: Role of the C-C Chemokine Receptor (CCR10) in Mesenchymal Progenitor Cells in IPF
Short Talk: Role of the C-C Chemokine Receptor (CCR10) in Mesenchymal Progenitor Cells in IPF
Wilder Scott,
University of British Columbia, Canada
Short Talk: ScRNA-seq and scATAC-seq Uncover the Fate and Function of Adult Mesenchymal Progenitors at Homeostasis and during Regeneration
Short Talk: ScRNA-seq and scATAC-seq Uncover the Fate and Function of Adult Mesenchymal Progenitors at Homeostasis and during Regeneration
Farshad Babaeijandaghi,
University of British Columbia, Canada
Short Talk: CSF1R-Dependent Tissue-Resident and Infiltrating Macrophages Play Distinct Roles in Muscle Regeneration and are Promising Targets to Treat Muscular Dystrophies
Short Talk: CSF1R-Dependent Tissue-Resident and Infiltrating Macrophages Play Distinct Roles in Muscle Regeneration and are Promising Targets to Treat Muscular Dystrophies
14:30—16:30
Workshop 3: Role of Stromal Cells in Inflammation and Anti-Tumor Immunity
*
Viviana Cremasco,
Novartis Institutes for BioMedical Research, USA
Session Chair
Session Chair
*
Anne Fletcher,
Monash University, Australia
Session Chair
Session Chair
Hung N. Nguyen,
Brigham and Women's Hospital, USA
Transcriptional Regulation of Fibroblasts in Inflammation
Transcriptional Regulation of Fibroblasts in Inflammation
Fumitaka Mizoguchi,
Tokyo Medical and Dental University, Japan
Gene Expression Profiling of Synovial Fibroblast Subsets Revealed Novel Transcription Factors Driving Their Pathogenic Functions in Rheumatoid Arthritis
Gene Expression Profiling of Synovial Fibroblast Subsets Revealed Novel Transcription Factors Driving Their Pathogenic Functions in Rheumatoid Arthritis
Maria Steele,
Oregon Health & Science University, USA
Lymphatic-Mediated Egress of Tumor-Specific CD8+ T Cells Limits Anti-Tumor Immunity in Melanoma
Lymphatic-Mediated Egress of Tumor-Specific CD8+ T Cells Limits Anti-Tumor Immunity in Melanoma
Hafsa Munir,
University of Cambridge, UK
Cancer-Associated Fibroblast-Derived Amyloid β Drives Neutrophil Extracellular Trap Formation to Promote Tumor Progression
Cancer-Associated Fibroblast-Derived Amyloid β Drives Neutrophil Extracellular Trap Formation to Promote Tumor Progression
Sandra Ring,
Kantonsspital St. Gallen, Switzerland
IL-33 Provision by Reprogrammed Tumor Fibroblastic Stromal Cells Promotes Local T Cell Activity and Grants Melanoma Eradication
IL-33 Provision by Reprogrammed Tumor Fibroblastic Stromal Cells Promotes Local T Cell Activity and Grants Melanoma Eradication
Laura Donlin,
Hospital for Special Surgery & Weill Cornell Medicine, USA
Fibroblast Activation by ‘Pro-Invasive' Macrophages in Human Autoimmunity
Fibroblast Activation by ‘Pro-Invasive' Macrophages in Human Autoimmunity
Elisabetta Dondi,
INSERM, France
Chronic Lymphocytic Leukemia Nurse-Like Cells are an Alternative Source of CCL21 Homeostatic Chemokine in Disorganized Lymph Nodes
Chronic Lymphocytic Leukemia Nurse-Like Cells are an Alternative Source of CCL21 Homeostatic Chemokine in Disorganized Lymph Nodes
Following Session is for Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches (Q6)
14:30—16:30
Workshop 3: Moving Anti-Fibrotic Strategies and Targets to the Clinic
*
Edda Fiebiger,
AbbVie, Inc., USA
Session Chair
Session Chair
*
Paul J. Yaworsky,
Mediar Therapeutics, USA
Session Chair
Session Chair
Claude Jourdan Le Saux,
University of California, San Francisco, USA
Serum Biomarker Responses of Pulmonary Fibrosis Patients after Treatment with the LOXL2/TGFβ1 Inhibitor EGCG
Serum Biomarker Responses of Pulmonary Fibrosis Patients after Treatment with the LOXL2/TGFβ1 Inhibitor EGCG
Guiquan Jia,
Genentech, Inc., USA
Modulation of a Plasma Cell Signature by Interleukin 6 in Systemic Sclerosis Skin Tissue
Modulation of a Plasma Cell Signature by Interleukin 6 in Systemic Sclerosis Skin Tissue
Juan Juan Marugan,
NCATS, National Institutes of Health, USA
ML290 Ameliorates Fibrosis in Multiple in vivo Models
ML290 Ameliorates Fibrosis in Multiple in vivo Models
Alex Peidl,
Western University, Canada
Therapeutic Peptides Based on CCN3 Treat Systemic Sclerosis in a Mouse Model of the Disease
Therapeutic Peptides Based on CCN3 Treat Systemic Sclerosis in a Mouse Model of the Disease
Martin Hausmann,
University Hospital Zurich, Switzerland
New Therapeutic Approach to Intestinal Fibrosis by Inhibition of pH-Sensing Receptor GPR4-Induced Rho Activation
New Therapeutic Approach to Intestinal Fibrosis by Inhibition of pH-Sensing Receptor GPR4-Induced Rho Activation
Martin Leduc,
Liminal R&D BioSciences Inc., Canada
Fezagepras (PBI-4050) Reduces Pulmonary Fibroblast Activation, Proliferation, and AKT/mTORC/4E-BP1 Signaling
Fezagepras (PBI-4050) Reduces Pulmonary Fibroblast Activation, Proliferation, and AKT/mTORC/4E-BP1 Signaling
Piotr L. Sklepkiewicz,
OncoArendi Therapeutics SA, Poland
Chitotriosidase (CHIT1) as a Novel Therapeutic Target in Idiopathic Pulmonary Fibrosis (IPF)
Chitotriosidase (CHIT1) as a Novel Therapeutic Target in Idiopathic Pulmonary Fibrosis (IPF)
17:00—19:00
New Directions in Dissecting Stromal Cell Functions (Joint)
*
Burkhard Ludewig,
Kantonsspital St. Gallen, Switzerland
Session Chair
Session Chair
*
Thomas A. Wynn,
Pfizer, USA
Session Chair
Session Chair
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Stromal Cells as Orchestrators of Humoral Immunity
Stromal Cells as Orchestrators of Humoral Immunity
Shannon J. Turley,
Genentech, Inc., USA
Stromal Cells in Cancer Immunology and Immunotherapy
Stromal Cells in Cancer Immunology and Immunotherapy
Lesley A. Hill,
University of British Columbia, Canada
Short Talk: Fate and Function of “Mesenchymal” Progenitors in Liver Regeneration and Fibrosis
Short Talk: Fate and Function of “Mesenchymal” Progenitors in Liver Regeneration and Fibrosis
Ruth A. Franklin,
Harvard University, USA
Short Talk: Environmental Sensing by Fibroblasts Controls Growth Factor Production
Short Talk: Environmental Sensing by Fibroblasts Controls Growth Factor Production
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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