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This meeting took place in 2020
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B Cell Renaissance: Epigenetics, Regulation and Immunotherapy (X1)
Organizer(s) Paolo Casali, Nicole Baumgarth, Meinrad Busslinger and Elizabeth Leadbetter
March 1—5, 2020
Fairmont Banff Springs • Banff, AB Canada
Discounted Abstract Deadline: Nov 5, 2019
Abstract Deadline: Dec 4, 2019
Scholarship Deadline: Nov 5, 2019
Discounted Registration Deadline: Jan 8, 2020
Sponsored by BioLegend, Inc.
Joint Meeting:
T Cell Memory (X2)
Summary of Meeting:
This conference will bring together experts in B cell biology to discuss the most recent advances in B cell research. Studies on B cell formation, from initial development, maturation, effector or memory development, and terminal differentiation have made researchers more appreciative of the molecular changes, including epigenetic marks, modifications and factors that control and modulate development and differentiation in the functional role of B cells. The complexities of B cell differentiation pathways through germinal centers and extra-follicular foci in primary lymphoid organs, in addition to novel interactions in diverse secondary lymphoid tissues, are also under intense study in both mice and humans. Conference sessions will cover the interactions of B cells with lymphoid cells, non-lymphoid cells, and secreted factors in a myriad of environments. This will help elucidate the numerous factors which influence and ultimately dictate the contribution of each unique B cell subset to homeostasis, immune defense or immunopathology. Understanding the drivers of B cell differentiation and function will enable precise harnessing of these key elements to optimize the immuno-therapeutic effect of B cells and their antibodies in autoimmune disease, infection, and cancer.
View Scholarships/Awards
This conference will bring together experts in B cell biology to discuss the most recent advances in B cell research. Studies on B cell formation, from initial development, maturation, effector or memory development, and terminal differentiation have made researchers more appreciative of the molecular changes, including epigenetic marks, modifications and factors that control and modulate development and differentiation in the functional role of B cells. The complexities of B cell differentiation pathways through germinal centers and extra-follicular foci in primary lymphoid organs, in addition to novel interactions in diverse secondary lymphoid tissues, are also under intense study in both mice and humans. Conference sessions will cover the interactions of B cells with lymphoid cells, non-lymphoid cells, and secreted factors in a myriad of environments. This will help elucidate the numerous factors which influence and ultimately dictate the contribution of each unique B cell subset to homeostasis, immune defense or immunopathology. Understanding the drivers of B cell differentiation and function will enable precise harnessing of these key elements to optimize the immuno-therapeutic effect of B cells and their antibodies in autoimmune disease, infection, and cancer.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 5 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 6 in order to fully experience the meeting.
SUNDAY, MARCH 1
MONDAY, MARCH 2
TUESDAY, MARCH 3
WEDNESDAY, MARCH 4
THURSDAY, MARCH 5
FRIDAY, MARCH 6
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 5 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 6 in order to fully experience the meeting.
SUNDAY, MARCH 1
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Keynote Session (Joint)
*
Paolo Casali,
University of Texas Long School of Medicine, USA
*
David B. Masopust,
University of Minnesota, USA
Max D. Cooper,
Emory University, USA
Evolution of B and T Cells
Evolution of B and T Cells
Rafi Ahmed,
Emory University School of Medicine, USA
Ontogeny of Immunological Memory
Ontogeny of Immunological Memory
09:50—12:00
B Cell Memory (Joint)
*
Jeremy M. Boss,
Emory University, USA
Ignacio Sanz,
Emory University, School of Medicine, USA
Remote Presentation: Pathways of B Cell Activation in Human SLE
Remote Presentation: Pathways of B Cell Activation in Human SLE
*
Marion Pepper,
University of Washington, USA
Memory B Cell Heterogeneity
Memory B Cell Heterogeneity
Tomohiro Kurosaki,
Osaka University, Japan
Two Functional Humoral Memory Compartments and Their Generation Mechanism
Two Functional Humoral Memory Compartments and Their Generation Mechanism
Abhijit A. Ambegaonkar,
NIAID, National Institutes of Health, USA
Short Talk: Chronic Human Infectious Diseases Blind Atypical Memory B Cells to Soluble but Not Membrane-Associated Antigens
Short Talk: Chronic Human Infectious Diseases Blind Atypical Memory B Cells to Soluble but Not Membrane-Associated Antigens
Youngmin Son,
Mayo Clinic, USA
Short Talk: Tissue-Resident CD4 T Helper Cells Co-Ordinate Local Protective B and CD8 Memory T Cell Responses
Short Talk: Tissue-Resident CD4 T Helper Cells Co-Ordinate Local Protective B and CD8 Memory T Cell Responses
14:30—16:30
Workshop 1
*
Marcus R. Clark,
University of Chicago, USA
*
Claudia Mauri,
University College London, UK
Sarah F. Andrews,
National Institutes of Health, USA
Fifty-Year-Old Memory B Cells Shape the Response to Influenza Vaccination in Humans
Fifty-Year-Old Memory B Cells Shape the Response to Influenza Vaccination in Humans
Ashley Braddom,
University of Texas Health Science Center, USA
Atypical Memory B Cells in Malaria-Exposed People Have a Unique B Cell Receptor Repertoire
Atypical Memory B Cells in Malaria-Exposed People Have a Unique B Cell Receptor Repertoire
Masaru Kanekiyo,
NIAID, National Institutes of Health, USA
Identification of a Vaccine-Elicited Broadly Neutralizing Nonhuman Primate Antibody Targeting the Conserved Stem on Influenza Hemagglutinin
Identification of a Vaccine-Elicited Broadly Neutralizing Nonhuman Primate Antibody Targeting the Conserved Stem on Influenza Hemagglutinin
Isaraphorn Pratumchai,
The Scripps Research, USA
IL-27-Producing B Cells Are Key Regulators of Anti-Viral Immunity and Antibody Responses
IL-27-Producing B Cells Are Key Regulators of Anti-Viral Immunity and Antibody Responses
David R. Glass,
Stanford University, USA
An Integrated Multi-Omic Single Cell Atlas to Redefine Human B Cell Memory
An Integrated Multi-Omic Single Cell Atlas to Redefine Human B Cell Memory
Andrea Largent,
Seattle Children's Research Institute, USA
Dysregulated Type 1 and Type 2 Interferon Signals Promote Humoral Autoimmunity in STAT1 Gain-of-Function Syndrome
Dysregulated Type 1 and Type 2 Interferon Signals Promote Humoral Autoimmunity in STAT1 Gain-of-Function Syndrome
James E. Voss,
The Scripps Research Institute, USA
Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B Cells
Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B Cells
15:00—16:30
Workshop 1
*
Lalit K. Beura,
Brown University, USA
*
Weiguo Cui,
Versiti Blood Center of Wisconsin, USA
Salix Boulet,
Université de Montréal, Canada
Opposing Role for the Notch Signaling Pathway in CD103+ and CD103- Tissue Resident Memory CD8 T Cells
Opposing Role for the Notch Signaling Pathway in CD103+ and CD103- Tissue Resident Memory CD8 T Cells
Yao Chen,
Medical College of Wisconsin, USA
BATF Epigenetically Programs Progenitor to Cytolytic CD8 T Cell Transition during Chronic Viral Infection
BATF Epigenetically Programs Progenitor to Cytolytic CD8 T Cell Transition during Chronic Viral Infection
Maximilien Evrard,
University of Melbourne, Australia
Sphingosine-1-Phosphate Receptor 5 (S1P5) Critically Regulates Tissue-Resident Memory T Cell Formation
Sphingosine-1-Phosphate Receptor 5 (S1P5) Critically Regulates Tissue-Resident Memory T Cell Formation
Oliver J. Harrison,
Benaroya Research Institute, USA
Commensal-Specific T Cell Plasticity Promotes Rapid Tissue Adaptation to Injury
Commensal-Specific T Cell Plasticity Promotes Rapid Tissue Adaptation to Injury
Rakshin P. Kharwadkar,
Indiana University School of Medicine, USA
A Single Cell Approach to Identify the Role of IL-9 in Allergic Recall Responses
A Single Cell Approach to Identify the Role of IL-9 in Allergic Recall Responses
Pamela Rosato,
University of Minnesota, USA
Harnessing Antiviral Memory T Cells for Tumor Immunotherapy
Harnessing Antiviral Memory T Cells for Tumor Immunotherapy
17:00—19:00
B Cell Development
*
Paolo Casali,
University of Texas Long School of Medicine, USA
*
Ari M. Melnick,
Weill Cornell Medical College, USA
Meinrad Busslinger,
Research Institute of Molecular Pathology, Austria
Role of Pax5 in Controlling Loop Extrusion and VH Gene Recombination at the Igh Locus
Role of Pax5 in Controlling Loop Extrusion and VH Gene Recombination at the Igh Locus
Mattia Lion,
Massachusetts General Hospital, USA
Short Talk: Alterations in Chromatin at Antigen Receptor Loci Define Lineage Progression during B-Lymphopoiesis
Short Talk: Alterations in Chromatin at Antigen Receptor Loci Define Lineage Progression during B-Lymphopoiesis
Bastien Moes,
University of Liege, Belgium
Short Talk: Role of the Lipid 5-Phosphatase Inpp5K in B Cell Differentiation and IL7-Receptor Signaling
Short Talk: Role of the Lipid 5-Phosphatase Inpp5K in B Cell Differentiation and IL7-Receptor Signaling
Robin Lee,
University of Minnesota, USA
Short Talk: The Nuclear Corepressors NCOR1/2 Orchestrate B Cell Development
Short Talk: The Nuclear Corepressors NCOR1/2 Orchestrate B Cell Development
Tina Nguyen,
Garvan Institute of Medical Research, Australia
Short Talk: Genetic Defects Altering PI3-kinase Signaling Disrupt Human B Cell Development and Function
Short Talk: Genetic Defects Altering PI3-kinase Signaling Disrupt Human B Cell Development and Function
17:00—19:00
Harnessing T Cells for Cancer
*
Tim Hand,
University of Pittsburgh, USA
*
Stephen J. Turner,
Monash University, Australia
Thomas Gebhardt,
Doherty Institute for Infection and Immunity, Australia
Localized T Cell Control of Persisting Melanoma
Localized T Cell Control of Persisting Melanoma
Kathleen M.E. Gallagher,
Mass General Hospital, USA
Role of Memory in CAR T Cells for Cancer
Role of Memory in CAR T Cells for Cancer
Aude G. Chapuis,
Fred Hutchinson Cancer Research Center, USA
Deciphering Responses/Resistance to Instruct Next Generations of T Cell Receptor Gene Therapy
Deciphering Responses/Resistance to Instruct Next Generations of T Cell Receptor Gene Therapy
Jaime L. Chao,
University of Chicago, USA
Short Talk: Effector T Cell Responses Unleashed by Treg Cell Ablation Promote Progression of Oral Squamous Cell Carcinoma
Short Talk: Effector T Cell Responses Unleashed by Treg Cell Ablation Promote Progression of Oral Squamous Cell Carcinoma
Nikhil S. Joshi,
Yale University School of Medicine, USA
Short Talk: Reservoir of Tumor Specific CD8 T Cells Maintains Anti-Tumor Immune Response
Short Talk: Reservoir of Tumor Specific CD8 T Cells Maintains Anti-Tumor Immune Response
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:30
Germinal Center B Cells
*
Mark R. Boothby,
Vanderbilt University Medical Center, USA
Hai Qi,
Tsinghua University, China
Remote Presentation: Regulation of Germinal Center Input and Output
Remote Presentation: Regulation of Germinal Center Input and Output
Coffee Break
Uttiya Basu,
, USA
Noncoding RNA Mediated Regulation of Antibody Gene Diversification
Noncoding RNA Mediated Regulation of Antibody Gene Diversification
Marcus R. Clark,
University of Chicago, USA
Novel Specialized Cell State and Spatial Compartments within the Germinal Center
Novel Specialized Cell State and Spatial Compartments within the Germinal Center
Andrew J. Gunderson,
Providence Cancer Center, USA
Short Talk: Germinal Centers in Tertiary Lymphoid Structures Distinguish Long-Term Pancreatic Cancer Survivors Associated with Neoantigen Expression and Immune Memory
Short Talk: Germinal Centers in Tertiary Lymphoid Structures Distinguish Long-Term Pancreatic Cancer Survivors Associated with Neoantigen Expression and Immune Memory
Mark P. Roberto,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: FoxO1 Pioneers Germinal Center B Cell Chromatin Landscapes
Short Talk: FoxO1 Pioneers Germinal Center B Cell Chromatin Landscapes
08:00—11:00
Migration and Resident Memory
*
Klaas P.J.M. Van Gisbergen,
Sanquin Research, Netherlands
*
Wolfgang Karl Kastenmueller,
Universität Würzburg, Germany
David B. Masopust,
University of Minnesota, USA
Relationships between Memory T Cell Magnitude, Quality, and Location
Relationships between Memory T Cell Magnitude, Quality, and Location
Heather D. Hickman,
NIAID, National Institutes of Health, USA
Antiviral T Cell Biology in Lymphoid and Peripheral Tissues
Antiviral T Cell Biology in Lymphoid and Peripheral Tissues
Coffee Break
Ulrich H. Von Andrian,
Harvard Medical School, USA
Peripheral T Cell Immunosurveillance
Peripheral T Cell Immunosurveillance
Rachael A. Clark,
Brigham and Women's Hospital, Harvard Medical School, USA
Human Skin Resident Memory T Cell Biology
Human Skin Resident Memory T Cell Biology
Daniel Fernández Ruiz,
University of Melbourne, Australia
Short Talk: Harnessing Liver Trm Cell-Mediated Immunity for Efficient Protection against Malaria
Short Talk: Harnessing Liver Trm Cell-Mediated Immunity for Efficient Protection against Malaria
Brian S. Sheridan,
Stony Brook University, USA
Short Talk: Lymph Node Priming Licenses Intestinal CD103+ CD8 Tissue-Resident Memory T Cell Development
Short Talk: Lymph Node Priming Licenses Intestinal CD103+ CD8 Tissue-Resident Memory T Cell Development
15:00—16:30
Workshop 2
*
Marcus Buggert,
Karolinska Institutet, Sweden
*
J. Scott Hale,
University of Utah, USA
Justin Spanier,
University of Minnesota, USA
XCR1+ Dendritic Cells Are Necessary for the Formation of Tolerant CD4 T Cells Induced by Chemically-Fixed Antigen-Coupled Splenocytes
XCR1+ Dendritic Cells Are Necessary for the Formation of Tolerant CD4 T Cells Induced by Chemically-Fixed Antigen-Coupled Splenocytes
Claire E. Depew,
University of California, Davis, USA
A Model to Study the Formation of Hepatic CD4 Trm for Protection against Salmonella
A Model to Study the Formation of Hepatic CD4 Trm for Protection against Salmonella
Carmen Gerlach,
Karolinska Institutet, Sweden
CX3CR1 Expression Levels Defining Human CD8 T Cell Subsets
CX3CR1 Expression Levels Defining Human CD8 T Cell Subsets
Taylor Heim,
Oregon Health and Sciences University, USA
The Chemokine Receptor CXCR6 Promotes Tissue Resident Memory Formation by Facilitating Antigen Recognition in Diverse Non-Lymphoid Tissues
The Chemokine Receptor CXCR6 Promotes Tissue Resident Memory Formation by Facilitating Antigen Recognition in Diverse Non-Lymphoid Tissues
Min-Seok Rha,
Korea Advanced Institute of Science & Technology, South Korea
Human Liver CD69+CD103-CD8+ T Cells Are Terminally Differentiated Memory Cells Regulated by HIF-2α
Human Liver CD69+CD103-CD8+ T Cells Are Terminally Differentiated Memory Cells Regulated by HIF-2α
Tim Hand,
University of Pittsburgh, USA
Microbiota-Induced Regulatory T Cells Induce a Localized Block In Intestinal CD4 T Cell Responses to Oral Vaccination
Microbiota-Induced Regulatory T Cells Induce a Localized Block In Intestinal CD4 T Cell Responses to Oral Vaccination
17:00—19:15
Epigenetic and (Post) Transcriptional Control of B Cell Differentiation
*
Meinrad Busslinger,
Research Institute of Molecular Pathology, Austria
Katia Georgopoulos,
Massachusetts General Hospital, USA
Regulation of Chromatin Structure and Organization in Early B Cell Differentiation
Regulation of Chromatin Structure and Organization in Early B Cell Differentiation
Jacqueline E. Payton,
Washington University, USA
Mechanisms of Dysregulated Enhancer Activity in B Cell Cancers
Mechanisms of Dysregulated Enhancer Activity in B Cell Cancers
Jeremy M. Boss,
Emory University, USA
Antibody Secreting Cell Destiny Emerges during the Initial Stages of B Cell Activation
Antibody Secreting Cell Destiny Emerges during the Initial Stages of B Cell Activation
Paolo Casali,
University of Texas Long School of Medicine, USA
HDACs and HDAC Inhibitors as Epigenetic Modulators of the Antibody Response
HDACs and HDAC Inhibitors as Epigenetic Modulators of the Antibody Response
Chris Scharer,
Emory University, USA
Short Talk: Epigenetic Priming Accelerates Memory B Cell Reactivation
Short Talk: Epigenetic Priming Accelerates Memory B Cell Reactivation
17:00—19:00
Chronic Infection
*
Koichi Araki,
Cincinnati Children's Hospital Medical Center, USA
*
Emma Teixeiro,
University of Missouri, USA
Elina I. Zuniga,
University of California, San Diego, USA
T Cell Adaptations During Chronic Viral Infection
T Cell Adaptations During Chronic Viral Infection
E. John Wherry,
University of Pennsylvania, USA
T Cell Diversity and Plasticity in the Face of Persistent Antigen
T Cell Diversity and Plasticity in the Face of Persistent Antigen
Ben A. Youngblood,
St. Jude Children's Research Hospital, USA
Maintenance of Memory T Cell Acquired Gene Expression Programs
Maintenance of Memory T Cell Acquired Gene Expression Programs
Daniel T. Utzschneider,
Doherty Institute for Infection and Immunity, Australia
Short Talk: Early Precursor T Cells Propagate and Establish T Cell Exhaustion in Chronic Infection
Short Talk: Early Precursor T Cells Propagate and Establish T Cell Exhaustion in Chronic Infection
Sara Van Den Berg,
National Institute of Public Health and Environment, Netherlands
Short Talk: T Cell Longevity in CMV-Infection: Unique Insights from in vivo Deuterium Labelling in Humans
Short Talk: T Cell Longevity in CMV-Infection: Unique Insights from in vivo Deuterium Labelling in Humans
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
B Cells and Immune Regulation
*
Elizabeth A. Leadbetter,
University of Texas Long School of Medicine, USA
Nicole Baumgarth,
University of California, Davis, USA
B-1 Cells and the Regulation of Natural Antibody Production
B-1 Cells and the Regulation of Natural Antibody Production
Lars Nitschke,
University of Erlangen, Germany
Siglec-G Controls the Severity of B-Cell Chronic Lymphocytic Leukemia
Siglec-G Controls the Severity of B-Cell Chronic Lymphocytic Leukemia
Coffee Break
Shannon J. Turley,
Genentech, Inc., USA
Stromal Cells Direct Lymphoid Architecture and Immune Cell Homeostasis
Stromal Cells Direct Lymphoid Architecture and Immune Cell Homeostasis
Gary Winslow,
SUNY Upstate Medical University, USA
Short Talk: Developing T-Bet+ B Cells Require Both IL-21 and IFN-gamma from TFH1 Cells
Short Talk: Developing T-Bet+ B Cells Require Both IL-21 and IFN-gamma from TFH1 Cells
Ian A. Cockburn,
Australian National University, Australia
Short Talk: Single Cell RNA-seq Reveals that CD11c+ Atypical Cells are a Normal Component of B Cell Responses to Vaccination and Infection
Short Talk: Single Cell RNA-seq Reveals that CD11c+ Atypical Cells are a Normal Component of B Cell Responses to Vaccination and Infection
Ryosuke Hiwa,
University of California, San Francisco, USA
Short Talk: Negative Regulation of B Cell Responses by Nr4a1 and Nr4a3
Short Talk: Negative Regulation of B Cell Responses by Nr4a1 and Nr4a3
08:00—11:00
Memory T Cell Longevity and Maintenance
Stephen C. Jameson,
University of Minnesota Medical School, USA
Requirements for Establishment and Maintenance of Resident Memory CD8+ T Cells
Requirements for Establishment and Maintenance of Resident Memory CD8+ T Cells
Ananda W. Goldrath,
University of California, San Diego, USA
Transcriptional Regulation of T Cell Memory
Transcriptional Regulation of T Cell Memory
Coffee Break
Luigia Pace,
Italian Institute for Genomic Medicine, Italy
Short Talk: Epigenetic and Transcriptional Control during CD8+ T Cell Fate Commitment
Short Talk: Epigenetic and Transcriptional Control during CD8+ T Cell Fate Commitment
Emma Teixeiro,
University of Missouri, USA
Short Talk: NFkB Signaling Differentially Regulates Tissue Resident Memory Generation and Maintenance
Short Talk: NFkB Signaling Differentially Regulates Tissue Resident Memory Generation and Maintenance
14:30—16:30
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Ananda W. Goldrath,
University of California, San Diego, USA
Marion Pepper,
University of Washington, USA
Nicole Baumgarth,
University of California, Davis, USA
Pablo Penaloza-MacMaster,
Northwestern University, USA
Ifor Williams,
Science Immunology, USA
Haochu Huang,
Genentech, Inc., USA
17:00—19:00
B Cells in Adipose, Thymus, Mucosa, and Digestive Mucosae
*
Nicole Baumgarth,
University of California, Davis, USA
Haochu Huang,
Genentech, Inc., USA
Thymic B Cells and T Cell Tolerance
Thymic B Cells and T Cell Tolerance
Elizabeth A. Leadbetter,
University of Texas Long School of Medicine, USA
T-bet+ B Cells Exacerbate Metabolic Disorder in Obesity
T-bet+ B Cells Exacerbate Metabolic Disorder in Obesity
Andrea Reboldi,
University of Massachusetts Medical School, USA
Cholesterol Metabolism in Gut Mucosal B Cell Responses
Cholesterol Metabolism in Gut Mucosal B Cell Responses
Sébastien This,
Centre International de Recherche en Infectiology, France
Short Talk: Avß8 Integrin-Expression by BATF3-Dependent Dendritic Cells Facilitates IgA Responses to Rotavirus
Short Talk: Avß8 Integrin-Expression by BATF3-Dependent Dendritic Cells Facilitates IgA Responses to Rotavirus
Milena Bogunovic,
University of Massachusetts Medical School, USA
Short Talk: Intestinal IgA Response to Infection from the Macrophage Perspective
Short Talk: Intestinal IgA Response to Infection from the Macrophage Perspective
17:00—19:00
CD4 T Cell Memory
*
Marc K. Jenkins,
University of Minnesota Medical School, USA
Remote Presentation: Ontogeny and Maintenance of CD4+ Memory T Cell Subsets
Remote Presentation: Ontogeny and Maintenance of CD4+ Memory T Cell Subsets
*
Donna L. Farber,
Columbia University Medical Center, USA
Distribution of Human Memory CD4 T Cell Subsets
Distribution of Human Memory CD4 T Cell Subsets
Daniel L. Barber,
NIAID, National Institutes of Health, USA
CD4 T Cell-Mediated Control of Tuberculosis
CD4 T Cell-Mediated Control of Tuberculosis
Lin-Xi Li,
University of Arkansas for Medical Sciences, USA
Short Talk: Memory CD4 T Cells in Chlamydia Female Reproductive Tract Infection
Short Talk: Memory CD4 T Cells in Chlamydia Female Reproductive Tract Infection
Thomas Ciucci,
NCI, National Institutes of Health, USA
Short Talk: Non-Redundant Antagonism of Memory CD4+ T Cell Differentiation by Bcl6 and Blimp1
Short Talk: Non-Redundant Antagonism of Memory CD4+ T Cell Differentiation by Bcl6 and Blimp1
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
B Cell Activation in Immunity and Autoimmunity
*
Katia Georgopoulos,
Massachusetts General Hospital, USA
*
Jayanta Chaudhuri,
Memorial Sloan Kettering Cancer Center, USA
Claudia Mauri,
University College London, UK
Getting to the "Bottom" of Arthritis: A Role for Regulatory B Cells in the Gut
Getting to the "Bottom" of Arthritis: A Role for Regulatory B Cells in the Gut
Alessandra Pernis,
Weill Cornell Medicine, USA
ABC Cell Generation and Transcriptional Makeup
ABC Cell Generation and Transcriptional Makeup
Coffee Break
Mikael C. I. Karlsson,
Karolinska Institutet, Sweden
Neutrophil and NKT Cell Regulation of Autoreactive B Cell Responses
Neutrophil and NKT Cell Regulation of Autoreactive B Cell Responses
Mélanie Rogier,
Institute of Genetics and Molecular and Cellular Biology, France
Short Talk: Fam72a Recruits UNG2 to AID-Generated Uracils in DNA during CSR
Short Talk: Fam72a Recruits UNG2 to AID-Generated Uracils in DNA during CSR
Irene Chernova,
Yale University, USA
Short Talk: Enhanced Na-K-ATPase Expression Mediates B Cell Survival in Lupus Kidneys
Short Talk: Enhanced Na-K-ATPase Expression Mediates B Cell Survival in Lupus Kidneys
Anthony Lau,
Garvan Institute of Medical Research, Australia
Short Talk: Activated PI3Kdelta Breaks Multiple B Cell Tolerance Checkpoints, Resulting in Auto-Antibody Production
Short Talk: Activated PI3Kdelta Breaks Multiple B Cell Tolerance Checkpoints, Resulting in Auto-Antibody Production
Minakshi Rana,
Feinstein Institutes for Medical Research, USA
Short Talk: Vagus Nerve Activity Modulates B-Cell Mediated T Cell-Dependent Humoral Response in Sepsis-Survivors
Short Talk: Vagus Nerve Activity Modulates B-Cell Mediated T Cell-Dependent Humoral Response in Sepsis-Survivors
08:00—11:00
New Vaccine Concepts
*
Sara E. Hamilton,
University of Minnesota, USA
*
Pablo Penaloza-MacMaster,
Northwestern University, USA
Robert A. Seder,
NIAID, National Institutes of Health, USA
Vaccines Against HIV, Malaria, TB, and Cancer
Vaccines Against HIV, Malaria, TB, and Cancer
Louis J. Picker,
Oregon Health & Science University, USA
CMV-Vectored Vaccination
CMV-Vectored Vaccination
Coffee Break
Joseph E. Craft,
Yale University, USA
Tick Vaccines: Old Ideas, New Data
Tick Vaccines: Old Ideas, New Data
Katharine E. Block,
University of Minnesota, USA
Short Talk: Memory T Cells Do Not Protect Against Heterologous Influenza Infection in “Dirty” Mice with Physiologically Transmitted Murine Microbes
Short Talk: Memory T Cells Do Not Protect Against Heterologous Influenza Infection in “Dirty” Mice with Physiologically Transmitted Murine Microbes
Klaas P.J.M. Van Gisbergen,
Sanquin Research, Netherlands
Short Talk: Tissue-Resident Memory CD8+ T Cells Shape Secondary T Cell Responses
Short Talk: Tissue-Resident Memory CD8+ T Cells Shape Secondary T Cell Responses
Laura Su,
University of Pennsylvania, USA
Short Talk: Longitudinal CD4+ T Cell Analyses Reveal Defining Features of Pre-Vaccine State That Influence Post-Vaccination Response
Short Talk: Longitudinal CD4+ T Cell Analyses Reveal Defining Features of Pre-Vaccine State That Influence Post-Vaccination Response
14:30—16:30
Workshop 2
*
Wendy Beguelin,
Weill Cornell Medicine, USA
*
Gary Winslow,
SUNY Upstate Medical University, USA
Wenzhi Song,
Yale University, USA
Development of CD11c-Expressing Inflammatory B Cells Is Dependent upon Help Delivered by T Follicular Helper Cells Outside of Germinal Centers
Development of CD11c-Expressing Inflammatory B Cells Is Dependent upon Help Delivered by T Follicular Helper Cells Outside of Germinal Centers
Fahd Al Qureshah,
University of Washington, USA
Distinct Function for Activated PI3Kδ in B Cells vs. T Cells during the Germinal Center Response
Distinct Function for Activated PI3Kδ in B Cells vs. T Cells during the Germinal Center Response
Rachel Cederberg,
BC Cancer Research Centre, Canada
B-1 Cells Secrete “Natural” Tumor-Specific Antibodies and Restrict Lung Metastasis
B-1 Cells Secrete “Natural” Tumor-Specific Antibodies and Restrict Lung Metastasis
Sara Erlan Sagadiev,
Seattle Children's Research Institute, USA
Non-Canonical Autophagy and Regulation of B Cell Responses
Non-Canonical Autophagy and Regulation of B Cell Responses
Andrea Di Pietro,
Monash University, Australia
The Epigenetic Regulation of B Cells Mediated by Polycomb Repressive Complexes during Acute and Chronic Infections
The Epigenetic Regulation of B Cells Mediated by Polycomb Repressive Complexes during Acute and Chronic Infections
Daisy H. Luff,
Francis Crick Institute, UK
Elucidating Novel Pathways of BAFF-Receptor Signalling for B Cell Survival
Elucidating Novel Pathways of BAFF-Receptor Signalling for B Cell Survival
Dominik Schmiedel,
Weizmann Institute of Sciences, Israel
The Chromatin Remodeling Complex Ino80 Regulates Critical Stages of the Antibody Immune Response
The Chromatin Remodeling Complex Ino80 Regulates Critical Stages of the Antibody Immune Response
Holly R. Steach,
Yale University, USA
Making Heads and Tails of Lipid Metabolism in B Cells
Making Heads and Tails of Lipid Metabolism in B Cells
14:30—16:30
Panel Discussion: T Cell Nomenclature
This workshop will attempt to highlight ambiguity and provide solutions for nomenclature problems that have impeded discourse and advances related to memory T cell ontogeny.
*
David B. Masopust,
University of Minnesota, USA
Rafi Ahmed,
Emory University School of Medicine, USA
Carmen Gerlach,
Karolinska Institutet, Sweden
Stephen C. Jameson,
University of Minnesota Medical School, USA
Donna L. Farber,
Columbia University Medical Center, USA
Marion Pepper,
University of Washington, USA
17:00—18:45
Harnessing B Cells for Cancer Immunotherapy
*
Haochu Huang,
Genentech, Inc., USA
Jayanta Chaudhuri,
Memorial Sloan Kettering Cancer Center, USA
G-quadruplex Binding Enables Normal and Aberrant AID Chromatin Localization
G-quadruplex Binding Enables Normal and Aberrant AID Chromatin Localization
Yuliya Pylayeva-Gupta,
University of North Carolina at Chapel Hill, USA
Short Talk: B Cells Establish Immunosuppressive Network in Pancreatic Ductal Adenocarcinoma
Short Talk: B Cells Establish Immunosuppressive Network in Pancreatic Ductal Adenocarcinoma
Ari M. Melnick,
Weill Cornell Medical College, USA
Epigenetic Control of the Germinal Center Reaction and Lymphomagenesis
Epigenetic Control of the Germinal Center Reaction and Lymphomagenesis
17:00—18:45
Molecular Regulation of T Cell Memory
*
Tessa Bergsbaken,
Rutgers New Jersey Medical School, USA
Dietmar Zehn,
Technical University of Munich, Germany
Selective Sensitivity to Nucleotide Starvation Defines a Novel Metabolic Checkpoint for Effector T-Cell Differentiation
Selective Sensitivity to Nucleotide Starvation Defines a Novel Metabolic Checkpoint for Effector T-Cell Differentiation
Andrea Schietinger,
Memorial Sloan Kettering Cancer Center, USA
T Cell Differentiation in Tumors
T Cell Differentiation in Tumors
Pamela L. Schwartzberg,
NIAID, NHGRI, National Institutes of Health, USA
PI3 Kinase and the Control Of Effector: Memory T Cell Decisions
PI3 Kinase and the Control Of Effector: Memory T Cell Decisions
Stephen J. Turner,
Monash University, Australia
Short Talk: Dynamic Changes in 3D Spatial Chromatin Organization Underpin Virus Specific Killer T Cell Differentiation
Short Talk: Dynamic Changes in 3D Spatial Chromatin Organization Underpin Virus Specific Killer T Cell Differentiation
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions
*
Ananda W. Goldrath,
University of California, San Diego, USA
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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